... system provides specific defence against foreign substances that enter the body. It is likely that the two types of responses referred to as humoral and cellular immunity co-exist, and when circulating antibodies are present, a cellular response is often demonstrable. Isocyanate-induced asthma, on t ...
Immunological studies on Swine Influenza Virus in Massimiliano Baratelli
... Additionally, T cells epitopes were empirically identified. Proteins M1 and NP of a human IAV were selected as target and thus dissected by using overlapping peptides and functional methods (IFN and proliferation responses) until finding T cells epitopes. The tests were performed using cells from ...
... Additionally, T cells epitopes were empirically identified. Proteins M1 and NP of a human IAV were selected as target and thus dissected by using overlapping peptides and functional methods (IFN and proliferation responses) until finding T cells epitopes. The tests were performed using cells from ...
Modulation of chemokine receptor function by cholesterol: new
... (Ogilvie et al., 2004). Along this line, pretreatment of naïve T cells with PTx also completely blocks their ability to arrest on high endothelial venules and home to lymph nodes (Warnock et al., 1998). In contrast, pretreatment of effector T cells with PTx does not abrogate cell arrest on inflamed ...
... (Ogilvie et al., 2004). Along this line, pretreatment of naïve T cells with PTx also completely blocks their ability to arrest on high endothelial venules and home to lymph nodes (Warnock et al., 1998). In contrast, pretreatment of effector T cells with PTx does not abrogate cell arrest on inflamed ...
CARBON NANOTUBES AS CARRIERS FOR DELIVERY OF BIOACTIVE AND THERAPEUTIC AGENTS: AN OVERVIEW Review Article
... is very important as more CNT surface area is available for the attachment with active molecules and the solubility of the CNTs can also be improved. The advantages of this functionalization strategy include its simplicity, its ability to produce highly soluble materials and ...
... is very important as more CNT surface area is available for the attachment with active molecules and the solubility of the CNTs can also be improved. The advantages of this functionalization strategy include its simplicity, its ability to produce highly soluble materials and ...
Elevated Serum Levels of Interleukin-5 in Patients
... several days before maximal eosinophilia and then declined. This patient’s lymphocytes showed an increased percentage, ...
... several days before maximal eosinophilia and then declined. This patient’s lymphocytes showed an increased percentage, ...
Chapter 8: Lactate Dehydrogenase
... Resistant LDV quasispecies are predominantly found in _________ infected mice. In vivo, ___ ____________ is produced at high levels about ___ hours after LDV infection, and it may be involved in bringing about the decline in ________ viral titers that begins about ___ hours after infection. T or F: ...
... Resistant LDV quasispecies are predominantly found in _________ infected mice. In vivo, ___ ____________ is produced at high levels about ___ hours after LDV infection, and it may be involved in bringing about the decline in ________ viral titers that begins about ___ hours after infection. T or F: ...
UNIVERSITAT DE BARCELONA IMMUNE PROFILING OF OPERATIONAL TOLERANCE IN LIVER TRANSPLANTATION
... life by the replacement of damaged or non-functional organs and tissues. This procedure, which nowadays is almost routine clinical practice in developed countries, has been made possible by remarkable progresses in surgical, immunological and medical research that have taken place over the last cent ...
... life by the replacement of damaged or non-functional organs and tissues. This procedure, which nowadays is almost routine clinical practice in developed countries, has been made possible by remarkable progresses in surgical, immunological and medical research that have taken place over the last cent ...
Neuroendocrine Tumors - Somatostatin Receptor Scintigraphy
... Non-neural cell tumors Lymphoma Breast cancer Renal-cell cancer Hepatocellular cancer Prostate cancer Sarcoma Gastric carcinoma ...
... Non-neural cell tumors Lymphoma Breast cancer Renal-cell cancer Hepatocellular cancer Prostate cancer Sarcoma Gastric carcinoma ...
tuberculosis Mycobacterium Early Infection with Dynamic Roles of
... immune responses to intracellular bacteria, including M. tuberculosis. The absolute requirement for IFN-g in the immune control of TB is well established in animal models (3) and humans (4). IFNg–dependent protection is commonly believed to act through increasing the mycobactericidal activity of mac ...
... immune responses to intracellular bacteria, including M. tuberculosis. The absolute requirement for IFN-g in the immune control of TB is well established in animal models (3) and humans (4). IFNg–dependent protection is commonly believed to act through increasing the mycobactericidal activity of mac ...
autoimmunity - Thyroid Disease Manager
... in normal immune responses, and in presentation of self-antigens. In many instances -including autoimmune thyroid disease (AITD) as detailed below -- inheritance of a specific HLA gene correlates with increased susceptibility to disease. In some cases this can be related to a gene coding for a speci ...
... in normal immune responses, and in presentation of self-antigens. In many instances -including autoimmune thyroid disease (AITD) as detailed below -- inheritance of a specific HLA gene correlates with increased susceptibility to disease. In some cases this can be related to a gene coding for a speci ...
CD161 defines the subset of FoxP3+ T cells capable of producing
... SYBR-green emission data were collected. Relative concentrations were calculated using a standard curve; values were normalized to amplification products of b-actin. In vitro proliferation and suppression assays To assess in vitro proliferation or anergy, sorted cells (CD1611 Treg [CD41 CD25hiCD127lo ...
... SYBR-green emission data were collected. Relative concentrations were calculated using a standard curve; values were normalized to amplification products of b-actin. In vitro proliferation and suppression assays To assess in vitro proliferation or anergy, sorted cells (CD1611 Treg [CD41 CD25hiCD127lo ...
A Review Part-1 (Experimental Studies)
... administered orally once every day for a period of 28 days in both the sexes of Wistar rats upon oral administration was found to be 1000 mg/Kg bw. b. 90 day repeated dose oral toxicity study of DCP in Rodents8 The 90 day repeated dose oral toxicity study was conducted at Althea Life Sciences in Jul ...
... administered orally once every day for a period of 28 days in both the sexes of Wistar rats upon oral administration was found to be 1000 mg/Kg bw. b. 90 day repeated dose oral toxicity study of DCP in Rodents8 The 90 day repeated dose oral toxicity study was conducted at Althea Life Sciences in Jul ...
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... inflammation of the ocular surface microenvironment. Most cases of dry eye disease are secondary to any of a vast array of inflammatory conditions and disorders, including auto- and alloimmune diseases, infection, aging, neuroinflammation, and sterile Inflammation. Sterile inflammation is induced by ...
... inflammation of the ocular surface microenvironment. Most cases of dry eye disease are secondary to any of a vast array of inflammatory conditions and disorders, including auto- and alloimmune diseases, infection, aging, neuroinflammation, and sterile Inflammation. Sterile inflammation is induced by ...
Sex differences in carotenoid status and immune performance in
... (Hill, 1995; Bortolotti et al., 1996; Figuerola and Gutierrez, 1998; Negro et al., 1998). Circulating carotenoids can also serve a number of physiological functions, including scavenging potentially damaging free-radicals as well as stimulating the immune system (Bendich, 1989; Lozano, 1994; Vershin ...
... (Hill, 1995; Bortolotti et al., 1996; Figuerola and Gutierrez, 1998; Negro et al., 1998). Circulating carotenoids can also serve a number of physiological functions, including scavenging potentially damaging free-radicals as well as stimulating the immune system (Bendich, 1989; Lozano, 1994; Vershin ...
Licentiate thesis from the Department of Immunology,
... failure, hypoglycaemia, pulmonary oedema, convulsion and shock are the common complications of severe malaria. ...
... failure, hypoglycaemia, pulmonary oedema, convulsion and shock are the common complications of severe malaria. ...
Optimization of peripheral blood mononuclear cell
... In Study 5 it was noted that subjects #1002 and #1036 had highly variable SMN levels. The subjects were re-collected at a subsequent timepoint developing signs and symptoms of an initial or recurrent respiratory infection. Samples were collected at Day 0, Day 7, and Day 30, and Day 76 !2-3 days afte ...
... In Study 5 it was noted that subjects #1002 and #1036 had highly variable SMN levels. The subjects were re-collected at a subsequent timepoint developing signs and symptoms of an initial or recurrent respiratory infection. Samples were collected at Day 0, Day 7, and Day 30, and Day 76 !2-3 days afte ...
Maternal endotoxin-induced fetal growth restriction in rats: Fetal
... infection through the expression of a family of natural immune receptors, toll-like receptor (TLR). Purpose: the aims of study were to identify endotoxin concentration in maternal blood serum of Porphyromonas gingivalis-infected pregnant rats, to characterize the TLR-4 expression in trophoblast cell ...
... infection through the expression of a family of natural immune receptors, toll-like receptor (TLR). Purpose: the aims of study were to identify endotoxin concentration in maternal blood serum of Porphyromonas gingivalis-infected pregnant rats, to characterize the TLR-4 expression in trophoblast cell ...
Psoriasis and Stress–Psoriasis Aspect of Psychoneuroendocrinology
... changes required to cope with the demands of a homeostatic challenge (Miller et al., 2002). The strongest stressors produce specific and nonspecific responses. The specific stress responses alter an individual to the presence of the stressors, which involve neuroendocrine responses such as increased ...
... changes required to cope with the demands of a homeostatic challenge (Miller et al., 2002). The strongest stressors produce specific and nonspecific responses. The specific stress responses alter an individual to the presence of the stressors, which involve neuroendocrine responses such as increased ...
Complement Opsonization of HIV-1 Enhances Endocytic Lectin and Integrin Receptor
... the lymphoid organs, where they are essential for the priming of T cell responses [5,6]. DC express an array of receptors including the surface proteins CD4 and CCR5/CXCR4, which are the main receptors utilized by HIV-1 for infection of immune cells. In addition, they express several other receptors ...
... the lymphoid organs, where they are essential for the priming of T cell responses [5,6]. DC express an array of receptors including the surface proteins CD4 and CCR5/CXCR4, which are the main receptors utilized by HIV-1 for infection of immune cells. In addition, they express several other receptors ...
Fatty acids and lymphocyte functions
... system and lymphocytes are central to these effects. First, in the course of its activity to recognise and eliminate foreign antigens, the immune system is responsible for the rejection of transplanted tissues. Second, in some individuals the immune system appears to recognise host antigens as ‘nons ...
... system and lymphocytes are central to these effects. First, in the course of its activity to recognise and eliminate foreign antigens, the immune system is responsible for the rejection of transplanted tissues. Second, in some individuals the immune system appears to recognise host antigens as ‘nons ...
What Do We Know about How Hantaviruses Interact with Their
... Asia. In the Americas, HCPS presents with pulmonary edema, and although cases are less frequent (hundreds per year), hantaviruses, such as the Andes virus (ANDV) in South America and the Sin Nombre virus (SNV) in the US, can give rise to mortality rates of up to 50% of infected individuals. Despite ...
... Asia. In the Americas, HCPS presents with pulmonary edema, and although cases are less frequent (hundreds per year), hantaviruses, such as the Andes virus (ANDV) in South America and the Sin Nombre virus (SNV) in the US, can give rise to mortality rates of up to 50% of infected individuals. Despite ...
Mediated by Heat Shock Factor-1 (HSF1) Protective Stress
... T cells were purified from spleen and lymph nodes using anti-CD3 magnetic beads and the autoMACS (Miltenyi Biotec). For proliferation assays, 2 ⫻ 105 T cells were cultured in RPMI 1640 medium supplemented with 10% FBS, 1 mM glutamine, 1 mM sodium pyruvate, 1⫻ MEM nonessential amino acids, 50 M 2-ME ...
... T cells were purified from spleen and lymph nodes using anti-CD3 magnetic beads and the autoMACS (Miltenyi Biotec). For proliferation assays, 2 ⫻ 105 T cells were cultured in RPMI 1640 medium supplemented with 10% FBS, 1 mM glutamine, 1 mM sodium pyruvate, 1⫻ MEM nonessential amino acids, 50 M 2-ME ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.