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The SCIentinel study - prospective multicenter study to define the
... cord injury and qualify as independent risk factor for poor neurological outcome (”disease modifying factor”). The enhanced susceptibility for infections is not stringently explained by the increased risk of aspiration in tetraplegic patients, neurogenic bladder dysfunction, or by high-dose methylpr ...
... cord injury and qualify as independent risk factor for poor neurological outcome (”disease modifying factor”). The enhanced susceptibility for infections is not stringently explained by the increased risk of aspiration in tetraplegic patients, neurogenic bladder dysfunction, or by high-dose methylpr ...
ACTIVATION OF HUMAN NATURAL KILLER CELLS BY
... focuses on P. Jalciparum as it is the most virulent and pathogenic of the four and accounts for the vast majority of malaria cases and almost all malaria-related deaths. Figure 1.2 illustrates the developmental cycle of the parasite. The sexual phase of the life-cycle takes place in the mosquito and ...
... focuses on P. Jalciparum as it is the most virulent and pathogenic of the four and accounts for the vast majority of malaria cases and almost all malaria-related deaths. Figure 1.2 illustrates the developmental cycle of the parasite. The sexual phase of the life-cycle takes place in the mosquito and ...
Early Life Microbiota, Neonatal Immune Maturation and
... shown to influence development of immune related diseases, like asthma, diabetes and inflammatory bowl disease, later in life. The intestinal epithelium makes up a physical and biochemical barrier between the bacteria in the gut lumen and the immune cells in the submocusal tissue. This monolayer of ...
... shown to influence development of immune related diseases, like asthma, diabetes and inflammatory bowl disease, later in life. The intestinal epithelium makes up a physical and biochemical barrier between the bacteria in the gut lumen and the immune cells in the submocusal tissue. This monolayer of ...
3 - bioRxiv
... they are equipped with a diversity of innate receptors, including pattern recognition receptors such as Toll Like Receptors (TLRs). Engagement of TLRs by TLR ligands leads to DC maturation, a complex process which includes migration to draining lymph nodes, secretion of a diversity of chemokines and ...
... they are equipped with a diversity of innate receptors, including pattern recognition receptors such as Toll Like Receptors (TLRs). Engagement of TLRs by TLR ligands leads to DC maturation, a complex process which includes migration to draining lymph nodes, secretion of a diversity of chemokines and ...
Immune response to tuberculosis infection
... response based on immunological recognition of mycobacterial antigens in exposed animals [2], shows poor sensitivity (16.7%) and specificity (74.2%) in elephants [5]. Similar to the Mantoux test applied in humans, a small volume of purified protein derivative (PPD), prepared by precipitation of prot ...
... response based on immunological recognition of mycobacterial antigens in exposed animals [2], shows poor sensitivity (16.7%) and specificity (74.2%) in elephants [5]. Similar to the Mantoux test applied in humans, a small volume of purified protein derivative (PPD), prepared by precipitation of prot ...
Proliferation T Cell + Nonredundantly Stimulates CD8
... N. brasiliensis because these stimuli induce strong Th2 responses in IL-4R␣-deficient mice (32). Both GaMD immunization and N. brasiliensis inoculation induced dramatic proliferation by wildtype but not by IL-4R␣-deficient donor CD8⫹ T cells transferred into IL-4R␣-deficient recipients, with ⬃10-fol ...
... N. brasiliensis because these stimuli induce strong Th2 responses in IL-4R␣-deficient mice (32). Both GaMD immunization and N. brasiliensis inoculation induced dramatic proliferation by wildtype but not by IL-4R␣-deficient donor CD8⫹ T cells transferred into IL-4R␣-deficient recipients, with ⬃10-fol ...
Mapping of murine Thl and Th2 helper T
... Summary. Thl- and Th2-derived cytokine production in response to synthetic peptides of the fimbrial subunit protein (fimbrilin) from Porphyromonas gingivalis strain 38 1 was assessed in spleen mononuclear cells (MNC) of BALB/c mice (H-2d haplotype) immunised with the fimbrial protein antigen and adj ...
... Summary. Thl- and Th2-derived cytokine production in response to synthetic peptides of the fimbrial subunit protein (fimbrilin) from Porphyromonas gingivalis strain 38 1 was assessed in spleen mononuclear cells (MNC) of BALB/c mice (H-2d haplotype) immunised with the fimbrial protein antigen and adj ...
The non-steroidal SEGRA, BAY1155975, in contrast to
... Glucocorticoids (GCs) are the most effective therapeutic agents for the treatment of acute and chronic inflammatory diseases. Their use is often accompanied with numerous and sometimes irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflamm ...
... Glucocorticoids (GCs) are the most effective therapeutic agents for the treatment of acute and chronic inflammatory diseases. Their use is often accompanied with numerous and sometimes irreversible side-effects. Therefore, new glucocorticoid receptor (GR) ligands with should have potent anti-inflamm ...
Prognostic significance of FOXP3+ tumor
... Studies addressing the prognostic significance of FOXP3+ Tregs have shown conflicting results. The presence of FOXP3+ tumor-infiltrating lymphocytes (TILs) has been reported to be associated with poor clinical outcome in a variety of cancer types, including prostatic, lung, hepatocellular and renal ...
... Studies addressing the prognostic significance of FOXP3+ Tregs have shown conflicting results. The presence of FOXP3+ tumor-infiltrating lymphocytes (TILs) has been reported to be associated with poor clinical outcome in a variety of cancer types, including prostatic, lung, hepatocellular and renal ...
Hemophagocytosis in adults (Hemophagocytic Syndrome) Brady Miller Hematology Oncology Fellow
... - Fulfill 5 of 8 above clinical/laboratory criteria (do not need to fulfill this if have a family history or molecular diagnosis that is consistent with HLH). Note that these current diagnostic criteria from the Histiocyte Society do not differentiate between “major” and “minor” criteria that are di ...
... - Fulfill 5 of 8 above clinical/laboratory criteria (do not need to fulfill this if have a family history or molecular diagnosis that is consistent with HLH). Note that these current diagnostic criteria from the Histiocyte Society do not differentiate between “major” and “minor” criteria that are di ...
The Thymus Gland
... The thymus will, if examined when its growth is most active, be found to consist of two lateral lobes placed in close contact along the middle line, situated partly in the thorax, partly in the neck, and extending from the fourth costal cartilage upward, as high as the lower border of the thyroid gl ...
... The thymus will, if examined when its growth is most active, be found to consist of two lateral lobes placed in close contact along the middle line, situated partly in the thorax, partly in the neck, and extending from the fourth costal cartilage upward, as high as the lower border of the thyroid gl ...
this PDF file - Smart Science Technology
... toxic or allergic particles that cross the protective barriers of our respiratory tract. Similarly, peritoneal macrophages present in the peritoneum and Kupffer cells of the liver act to confront infectious agents encountered effectively. Although a major portion of the tissue macrophages is derived ...
... toxic or allergic particles that cross the protective barriers of our respiratory tract. Similarly, peritoneal macrophages present in the peritoneum and Kupffer cells of the liver act to confront infectious agents encountered effectively. Although a major portion of the tissue macrophages is derived ...
... ABSTRACT: The aetiology of sarcoidosis is still unknown. An infectious microorganism as causal agent for this disease could not be identified, but high titres of antibodies against Borrelia burgdorferi were detected in Chinese studies implying a causality with this disease. These findings, however, ...
Candida Infections: An Update on Host Immune Defenses and Anti
... the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithelial cells, and for N-cadherin on endothelial cells and extracellular matrix proteins[23, 24]. ALS3 expression, whic ...
... the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithelial cells, and for N-cadherin on endothelial cells and extracellular matrix proteins[23, 24]. ALS3 expression, whic ...
Full-Text PDF
... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
... murine studies to involve NF-κB activation and is once again characterised by the production of cytokines, such as IL-6, IL-1, and TNFα, resulting in both hepatic and systemic insulin resistance [36]. Mitochondrial ROS, induced by SFAs, appear to contribute to JNK activation and cellular insulin res ...
All Activated CD8 T Cells A Transgenic Mouse Model Genetically Tags
... populations of activated CD8⫹ T cells specific for various Ags can be identified and followed independent of tetramer binding and peptide-induced cytokine production. We have previously described a transgenic mouse model system in which both effector and memory CD8⫹ T lymphocytes are tagged via Cre- ...
... populations of activated CD8⫹ T cells specific for various Ags can be identified and followed independent of tetramer binding and peptide-induced cytokine production. We have previously described a transgenic mouse model system in which both effector and memory CD8⫹ T lymphocytes are tagged via Cre- ...
BIOENGINEERED SKIN TISSUES AND THEIR MEDICAL
... Skin is the largest organ in our bodies and provides many important functions necessary for life. According to the Wound Care Centers’ website, the skin provides protection from the external environment, regulates body temperature, allows for sensations of touch and pain, and aids in endocrine funct ...
... Skin is the largest organ in our bodies and provides many important functions necessary for life. According to the Wound Care Centers’ website, the skin provides protection from the external environment, regulates body temperature, allows for sensations of touch and pain, and aids in endocrine funct ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,
... NK-cell cytokines can affect priming of naïve T helper cells and may play a role in development of allergic reactions. Therefore we evaluated CB NK cells from children that developed early allergy. Children that became allergic at the age of five years had a smaller proportion of CD56bright NK cells ...
... NK-cell cytokines can affect priming of naïve T helper cells and may play a role in development of allergic reactions. Therefore we evaluated CB NK cells from children that developed early allergy. Children that became allergic at the age of five years had a smaller proportion of CD56bright NK cells ...
- Journal of Clinical Investigation
... high levels of B cell trophic and chemotactic mediators that parallel findings in classic autoantibody diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and Sjögren’s syndrome) (27–30). Nonetheless, the precise roles of autoantibodies and neoantigens in the development and/or progr ...
... high levels of B cell trophic and chemotactic mediators that parallel findings in classic autoantibody diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, and Sjögren’s syndrome) (27–30). Nonetheless, the precise roles of autoantibodies and neoantigens in the development and/or progr ...
Experimental Biology and Medicine
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
... Exaggerated T-helper 2 (Th2)-biased immune responses result in the development of asthma.1 Immunotherapies that can regulate an allergen-specific Th2 immune response may provide long-lasting control of asthma. Recently, there have been an increasing number of studies demonstrating a therapeutic role ...
NOD2 Variants and Antibody Response to Microbial Antigens in
... Serologic Analysis and Classification All blood samples were taken at the time of consent and enrollment. Sera were analyzed for expression of ASCA, anti-I2, and anti-OmpC in a blinded fashion by enzyme-linked immunosorbent assay (ELISA) as previously described.23,55 Antibody levels were determined ...
... Serologic Analysis and Classification All blood samples were taken at the time of consent and enrollment. Sera were analyzed for expression of ASCA, anti-I2, and anti-OmpC in a blinded fashion by enzyme-linked immunosorbent assay (ELISA) as previously described.23,55 Antibody levels were determined ...
as a PDF
... response to vaccine, although in a few studies immunological responses have been found to be impaired with large quantities of nutrients. Studies using low-dose supplementation of zinc alone (Boukaiba et al, 1993) or zinc associated with selenium (Girodon et al, 1999) in elderly patients, provide a ...
... response to vaccine, although in a few studies immunological responses have been found to be impaired with large quantities of nutrients. Studies using low-dose supplementation of zinc alone (Boukaiba et al, 1993) or zinc associated with selenium (Girodon et al, 1999) in elderly patients, provide a ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.