O A RIGINAL RTICLES
... Pneumolysin as a vaccine candidate Notwithstanding their improved efficacy, particularly in children, the major limitation of pneumococcal polysaccharideprotein conjugate vaccines is that they only elicit protective antibodies against the limited range of serotypes contained in the vaccine. The vali ...
... Pneumolysin as a vaccine candidate Notwithstanding their improved efficacy, particularly in children, the major limitation of pneumococcal polysaccharideprotein conjugate vaccines is that they only elicit protective antibodies against the limited range of serotypes contained in the vaccine. The vali ...
Sinusoid-lining cells are novel myeloid- endothelial innate cells that form splenic
... developing countries. Secondly, conjugated vaccines are poorly effective in patients with primary or acquired immunodeficiencies that compromise the number and/or function of CD4+ T cells. Thirdly, conjugated vaccines contain CPS from only three serotypes of encapsulated bacteria, whereas unconjugat ...
... developing countries. Secondly, conjugated vaccines are poorly effective in patients with primary or acquired immunodeficiencies that compromise the number and/or function of CD4+ T cells. Thirdly, conjugated vaccines contain CPS from only three serotypes of encapsulated bacteria, whereas unconjugat ...
T Cell Nitric Oxide Regulates BAFF Expression and
... A previous study showed that naive WT and NOS22/2 mice do not differ in serum levels of IgM or IgG subclasses (10). In the present study, we examined whether NO regulates Ab responses to TI-2 Ags and found that compared with WT control mice, NOS22/2 mice had a 2- to 3-fold increase in serum NP-speci ...
... A previous study showed that naive WT and NOS22/2 mice do not differ in serum levels of IgM or IgG subclasses (10). In the present study, we examined whether NO regulates Ab responses to TI-2 Ags and found that compared with WT control mice, NOS22/2 mice had a 2- to 3-fold increase in serum NP-speci ...
Programme du cours "Immunité innée et maladies
... last years, and a precise role of each of the players is now better understood. Not only innate immunity is common to all animal species, but for those which also have at their disposal an adaptive immunity, the contribution of innate immunity is a prerequisite for its involvement. Most recently, a ...
... last years, and a precise role of each of the players is now better understood. Not only innate immunity is common to all animal species, but for those which also have at their disposal an adaptive immunity, the contribution of innate immunity is a prerequisite for its involvement. Most recently, a ...
Respiratory and systemic humoral and cellular immune responses
... The level of heterosubtypic immunity (Het-I) and the immune mechanisms stimulated by a heterosubtypic influenza virus infection were investigated in pigs. Pigs are natural hosts for influenza virus and, like humans, they host both subtypes H1N1 and H3N2. Marked Het-I was observed when pigs were infe ...
... The level of heterosubtypic immunity (Het-I) and the immune mechanisms stimulated by a heterosubtypic influenza virus infection were investigated in pigs. Pigs are natural hosts for influenza virus and, like humans, they host both subtypes H1N1 and H3N2. Marked Het-I was observed when pigs were infe ...
NOG Mice Transgenic − Using Human IL-3/GM
... Accumulating evidence suggests that these human lymphocytes can mediate proper immune reactions, even if the response remains suboptimal. In contrast, the differentiation of human myeloid lineage cells, especially granulocytes and mast cells, in conventional huHSC NOG mice has been inefficient (23, ...
... Accumulating evidence suggests that these human lymphocytes can mediate proper immune reactions, even if the response remains suboptimal. In contrast, the differentiation of human myeloid lineage cells, especially granulocytes and mast cells, in conventional huHSC NOG mice has been inefficient (23, ...
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... were doubtful, between 40-49 percentage of inhibition, while 155 (94.38%) were found to be devoid of Mmm antibodies. Sex distribution of CBPP positive sera of slaughtered cattle in Maiduguri, Nigeria is presented on Table 2. Out of the total of 97 sera samples tested, 1(1.03%) was found to be positi ...
... were doubtful, between 40-49 percentage of inhibition, while 155 (94.38%) were found to be devoid of Mmm antibodies. Sex distribution of CBPP positive sera of slaughtered cattle in Maiduguri, Nigeria is presented on Table 2. Out of the total of 97 sera samples tested, 1(1.03%) was found to be positi ...
Immunotherapy in the battle against c
... de last decades, hold promise for the future. The immune system In steady state conditions, when invading pathogens or malignant cell transformation perturbs normal tissue homeostasis, tissue responses result in innate immune cell infiltration and initiate an acute inflammatory response (Figure 1). ...
... de last decades, hold promise for the future. The immune system In steady state conditions, when invading pathogens or malignant cell transformation perturbs normal tissue homeostasis, tissue responses result in innate immune cell infiltration and initiate an acute inflammatory response (Figure 1). ...
Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are
... interferon-␥ (12). Although the mechanisms by which DCs induce oral tolerance have yet to be elucidated, it has been reported that feeding of high doses of antigen induces anergy or deletion of antigen-specific T cells, while repeated feeding of low doses of antigen favors the induction of active im ...
... interferon-␥ (12). Although the mechanisms by which DCs induce oral tolerance have yet to be elucidated, it has been reported that feeding of high doses of antigen induces anergy or deletion of antigen-specific T cells, while repeated feeding of low doses of antigen favors the induction of active im ...
History of Immunology
... disease that the sick and the dying found most compassion. These knew what it was from experience, and had now no fear for themselves; for the same man was never attacked twice - never at least fatally” Resistance to re-infection-Immunity Department of Immunology ...
... disease that the sick and the dying found most compassion. These knew what it was from experience, and had now no fear for themselves; for the same man was never attacked twice - never at least fatally” Resistance to re-infection-Immunity Department of Immunology ...
Wall in Acute Kawasaki Disease Oligoclonal IgA Response in the
... based upon possible selective expansion of V2 and V8 T cell receptor families in peripheral blood in acute KD (4, 5); however, other investigators have been unable to confirm this finding (6 – 10). Toxic shock syndrome toxin-1 or streptococcal superantigens were proposed to be related etiologicall ...
... based upon possible selective expansion of V2 and V8 T cell receptor families in peripheral blood in acute KD (4, 5); however, other investigators have been unable to confirm this finding (6 – 10). Toxic shock syndrome toxin-1 or streptococcal superantigens were proposed to be related etiologicall ...
Pathobiology of Aspergillus fumigatus, a saprotrophic pathogenic
... study of the response of the major phagocytic cell of the lung, the alveolar macrophage against the fungus and the identification of A. fumigatus virulence determinants. Conidial engulfment by the alveolar macrophage (AM) is very quick (1-2h) and not affected by the immune status of the host. Killin ...
... study of the response of the major phagocytic cell of the lung, the alveolar macrophage against the fungus and the identification of A. fumigatus virulence determinants. Conidial engulfment by the alveolar macrophage (AM) is very quick (1-2h) and not affected by the immune status of the host. Killin ...
meriones shawi - ISI International Scientific Indexing
... the environment. Accordingly, there is ample evidence indicating a bidirectional relationship between the neuroendocrine and immune systems, in which the immune system acts on the neuroendocrine system through its cytokines, and the neuroendocrine system, in return modulates the immune system throug ...
... the environment. Accordingly, there is ample evidence indicating a bidirectional relationship between the neuroendocrine and immune systems, in which the immune system acts on the neuroendocrine system through its cytokines, and the neuroendocrine system, in return modulates the immune system throug ...
White blood cells, C-reactive protein and erythrocyte sedi
... The method by which PNC infection was diagnosed (by antigen, antibody or immune complex assays) had no significant influence on the results. In clinical practice, an alveolar-type infiltration is used to indicate bacterial pneumonia, and an interstitial-type to indicate viral pneumonia, though this ...
... The method by which PNC infection was diagnosed (by antigen, antibody or immune complex assays) had no significant influence on the results. In clinical practice, an alveolar-type infiltration is used to indicate bacterial pneumonia, and an interstitial-type to indicate viral pneumonia, though this ...
ASH 2008 Advances in ITP Research both Basic and Clinical
... • Pts n=165 （refractory or non refractory） • 75% of refractory patients achieved plt counts ≥50000/uL and 2Xbaseline, compared to 84% of non-refractory pts (p=0.1425). • Weekly median plt counts in both groups remained at or above 50000/uL from week 1 through week 39. • The proportion of pts with si ...
... • Pts n=165 （refractory or non refractory） • 75% of refractory patients achieved plt counts ≥50000/uL and 2Xbaseline, compared to 84% of non-refractory pts (p=0.1425). • Weekly median plt counts in both groups remained at or above 50000/uL from week 1 through week 39. • The proportion of pts with si ...
the manipulations of magromolecular substances during fertilization
... of certain substances carried on and in the respective gametes. F. R. Lillie (1913) applied the term fertilizin to a spermagglutinating material obtained from eggs. Fertilizin and the complementary antifertilizin from sperm are now considered to represent the specific receptor substances located in ...
... of certain substances carried on and in the respective gametes. F. R. Lillie (1913) applied the term fertilizin to a spermagglutinating material obtained from eggs. Fertilizin and the complementary antifertilizin from sperm are now considered to represent the specific receptor substances located in ...
Dialogue between skin microbiota and immunity
... controlled by defined members of the microbiota such as Propionibacterium species (31, 32). How AMPs, and more particularly the ones induced by the microbiota, shape microbial communities remains unclear, but this dialogue is likely to play a fundamental role in the skin microbial ecology. The skin ...
... controlled by defined members of the microbiota such as Propionibacterium species (31, 32). How AMPs, and more particularly the ones induced by the microbiota, shape microbial communities remains unclear, but this dialogue is likely to play a fundamental role in the skin microbial ecology. The skin ...
Kuby`s Immunology
... chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
... chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
Tissue specific HPV expression and downregulation of local
... amounts of pro-inflammatory cytokines.7 8 Therefore, either directly or indirectly, HPV transcription is an important factor in influencing the status of local immunity. HPVs express diVerent sets of genes, some of them termed “early” genes. These early genes, such as E6 and E7 are responsible for m ...
... amounts of pro-inflammatory cytokines.7 8 Therefore, either directly or indirectly, HPV transcription is an important factor in influencing the status of local immunity. HPVs express diVerent sets of genes, some of them termed “early” genes. These early genes, such as E6 and E7 are responsible for m ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.