3d bio-printing - Ulster Institutional Repository
... In oncology research, due to the ethical concerns associated with human experimentation, animal models and cell culture studies have become an important source of information. However, the average rate of successful clinical translation from animal models to clinical trials are not very encouraging; ...
... In oncology research, due to the ethical concerns associated with human experimentation, animal models and cell culture studies have become an important source of information. However, the average rate of successful clinical translation from animal models to clinical trials are not very encouraging; ...
research design and methods
... for DNA binding, making vitamin D hormone-dependent gene transcription impossible. After backcrosses of male VDR −/+ heterozygotes to female NOD mice (N10 and N14), VDR −/+ NOD mice were intercrossed to produce experimental animals of three genotypes: homozygous VDR −/− as well as heterozygous VDR − ...
... for DNA binding, making vitamin D hormone-dependent gene transcription impossible. After backcrosses of male VDR −/+ heterozygotes to female NOD mice (N10 and N14), VDR −/+ NOD mice were intercrossed to produce experimental animals of three genotypes: homozygous VDR −/− as well as heterozygous VDR − ...
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... corticosteroid-induced cleft palate (Melnick et al. 1981a), corticosteroid treatment does not appear to alter the detectable spatiotemporal distribution of H-2 antigens in developing palates of embryonic BIO.A mice. These data suggest that we should look elsewhere for the mechanism of steroid-induce ...
... corticosteroid-induced cleft palate (Melnick et al. 1981a), corticosteroid treatment does not appear to alter the detectable spatiotemporal distribution of H-2 antigens in developing palates of embryonic BIO.A mice. These data suggest that we should look elsewhere for the mechanism of steroid-induce ...
Canine Vaccines:
... Results of Rabies Challenge (NYC-Ga Strain) at 1 and 3 years after a single intramuscular immunization with various vaccines ...
... Results of Rabies Challenge (NYC-Ga Strain) at 1 and 3 years after a single intramuscular immunization with various vaccines ...
Review: The microstructure of secondary lymphoid organs that
... venules (HEVs) allow recirculating lymphocytes to transmigrate from the blood directly, and recirculating T cells form a cluster with dendritic cells (DCs) to survey antigen invasions even in a steady state. This cluster becomes an actual site for the antigen presentation when DCs have captured anti ...
... venules (HEVs) allow recirculating lymphocytes to transmigrate from the blood directly, and recirculating T cells form a cluster with dendritic cells (DCs) to survey antigen invasions even in a steady state. This cluster becomes an actual site for the antigen presentation when DCs have captured anti ...
Apparent scarcity of glial fibrillary acidic protein expression in the
... mice (strain C57BL/6Jx129Ola) were intraperitoneally anesthetized with pentobarbital (100 mg/kg) and perfused transcardially, first with saline (0.9% NaCl), followed by 4% freshly depolymerized paraformaldehyde in 0.1 M phosphate buffer, pH 7.4. Their brains were removed from the skulls, postfixed i ...
... mice (strain C57BL/6Jx129Ola) were intraperitoneally anesthetized with pentobarbital (100 mg/kg) and perfused transcardially, first with saline (0.9% NaCl), followed by 4% freshly depolymerized paraformaldehyde in 0.1 M phosphate buffer, pH 7.4. Their brains were removed from the skulls, postfixed i ...
lec 9-17
... These are what gives each person their identity. This is why you can’t transplant tissues (except identical twins). The reason for diversity is so that when a new disease breaks out, at least some people will be able to respond to it (their MHC’s are better at presenting that Ag), and helps keep the ...
... These are what gives each person their identity. This is why you can’t transplant tissues (except identical twins). The reason for diversity is so that when a new disease breaks out, at least some people will be able to respond to it (their MHC’s are better at presenting that Ag), and helps keep the ...
1 Elevated IL-17 produced byTH17 cells promotes myeloma cell
... observed that combination of IL-17 and IL-22 significantly inhibited the production of TH1mediated cytokines, including IFN-γ, by healthy donor PBMCs. In conclusion, IL-17-producing TH17 cells play an important role in MM pathobiology and may be an important therapeutic target for anti-MM activity a ...
... observed that combination of IL-17 and IL-22 significantly inhibited the production of TH1mediated cytokines, including IFN-γ, by healthy donor PBMCs. In conclusion, IL-17-producing TH17 cells play an important role in MM pathobiology and may be an important therapeutic target for anti-MM activity a ...
Please make notes legible and use indentations when appropriate.
... • The immune system can malfunction with some immune syndromes. – One such syndrome is AIDS which is caused by the HIV virus. ...
... • The immune system can malfunction with some immune syndromes. – One such syndrome is AIDS which is caused by the HIV virus. ...
Antibody Feedback Regulation
... The immune system as a whole is tightly regulated. Given its destructive potential it is very important that an adequate response is initiated and eventually terminated in a controlled manner. Disturbances in the regulation could result in undesired responses, such as hypersensitivity and autoimmuni ...
... The immune system as a whole is tightly regulated. Given its destructive potential it is very important that an adequate response is initiated and eventually terminated in a controlled manner. Disturbances in the regulation could result in undesired responses, such as hypersensitivity and autoimmuni ...
Staining
... – Phages are specific to their host – One bacterial strain is susceptible while another is not – Bacteria is lawned on media – Drops of different phage solutions are placed on ...
... – Phages are specific to their host – One bacterial strain is susceptible while another is not – Bacteria is lawned on media – Drops of different phage solutions are placed on ...
Analysis of immune deviation elicited by antigens injected
... chamber (AC) has been described in detail in the literature.1"7 The main characteristics of anterior chamber-associated immune deviation (ACAID) are impaired delayed-type hypersensitivity (DTH), T cells that suppress DTH, and the inability to produce complement-fixing antibodies.1 Antigenspecific im ...
... chamber (AC) has been described in detail in the literature.1"7 The main characteristics of anterior chamber-associated immune deviation (ACAID) are impaired delayed-type hypersensitivity (DTH), T cells that suppress DTH, and the inability to produce complement-fixing antibodies.1 Antigenspecific im ...
Innate lymphoid cells - Utrecht University Repository
... associated cytokines respectively32-34. All types of ILCs are derived from a common precursor cell, the common lymphoid precursor3;34. One of the common characteristics of ILCs is their expression of the transcriptional repressor inhibitor of DNA binding 2 (id2), which prevents transcription of gene ...
... associated cytokines respectively32-34. All types of ILCs are derived from a common precursor cell, the common lymphoid precursor3;34. One of the common characteristics of ILCs is their expression of the transcriptional repressor inhibitor of DNA binding 2 (id2), which prevents transcription of gene ...
Managing people in sport organisations: A strategic human resource
... Roles for chemokine receptors and possible therapeutic manipulation in cutaneous T-cell lymphoma. Chemokine receptors may have important roles in enabling malignant T-cells to enter and survive in the skin. (1) Homing: Activation of T-cell integrins permits T-cell adhesion to endothelial cells in th ...
... Roles for chemokine receptors and possible therapeutic manipulation in cutaneous T-cell lymphoma. Chemokine receptors may have important roles in enabling malignant T-cells to enter and survive in the skin. (1) Homing: Activation of T-cell integrins permits T-cell adhesion to endothelial cells in th ...
PLATELET
... Cells (b) or subendothelial matrix (c) to form mural thromb providing a substrate for adhesion of leukocytes (e) which also adhere to activated endothelium (f) prior to extravasation through the vessel wall (g). (B) Vascular cell adhesion receptors: adhesive interactions in the vasculature [(A), a–g ...
... Cells (b) or subendothelial matrix (c) to form mural thromb providing a substrate for adhesion of leukocytes (e) which also adhere to activated endothelium (f) prior to extravasation through the vessel wall (g). (B) Vascular cell adhesion receptors: adhesive interactions in the vasculature [(A), a–g ...
IMMUNOLOGICAL UNRESPONSIVENESS TO
... 40 x 106 Spleen cells from 1 mo old mice were transferred alone or together with an equal number of cells from 3 mo old mice into the irradiated recipients with or without an immunogenic dose of native dextran. In addition, transfers were made with mixtures where one part had been irradiated with 6, ...
... 40 x 106 Spleen cells from 1 mo old mice were transferred alone or together with an equal number of cells from 3 mo old mice into the irradiated recipients with or without an immunogenic dose of native dextran. In addition, transfers were made with mixtures where one part had been irradiated with 6, ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.