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Neuronal plasticity and cellular immunity: shared
... long-term depression LTP long-term potentiation MHCI major histocompatibility complex, class I NF-AT nuclear factor of activated T cells κB NF-κ nuclear factor-kappa B NHEJ non-homologous end joining NK natural killer NMDA N-methyl D-aspartate RAG-1,2 recombination activating gene -1,-2 TAP1 transpo ...
... long-term depression LTP long-term potentiation MHCI major histocompatibility complex, class I NF-AT nuclear factor of activated T cells κB NF-κ nuclear factor-kappa B NHEJ non-homologous end joining NK natural killer NMDA N-methyl D-aspartate RAG-1,2 recombination activating gene -1,-2 TAP1 transpo ...
MDS Glossary - MDS Foundation
... and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be hereditary (less common, passed down from parent to child). Cellularity How much of the bone marrow volume is occupied by various types of blood cells. Chemotherapy The use of medici ...
... and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be hereditary (less common, passed down from parent to child). Cellularity How much of the bone marrow volume is occupied by various types of blood cells. Chemotherapy The use of medici ...
Natural Killer cells in Innate Defense against Infective Pathogens
... human NK cell education has also been discovered recently. Fauriat C et al. found that NK cells expressing KIR2DS1 are hyporesponsive against cellular targets from donors homozygous for HLA-C2, the ligand of KIR2DS1. These results suggest that the education of human NK cells via activating receptors ...
... human NK cell education has also been discovered recently. Fauriat C et al. found that NK cells expressing KIR2DS1 are hyporesponsive against cellular targets from donors homozygous for HLA-C2, the ligand of KIR2DS1. These results suggest that the education of human NK cells via activating receptors ...
Blood and its function
... caused by parasitic worms and involvement in allergic reactions Secrete anti-inflammatory substances in allergic reactions ...
... caused by parasitic worms and involvement in allergic reactions Secrete anti-inflammatory substances in allergic reactions ...
Antibody structure
... 1. Antibodies belong to a class of proteins called immunoglobulins 2. Antibody molecules belong to one of five classes i.e. IgG, IgM, IgA, IgD & IgE 3. Immunoglobulins are “Y” shaped proteins. The “arms” of the “Y” bind antigens. The tail of the “Y” is responsible for biological activity eg. C’ acti ...
... 1. Antibodies belong to a class of proteins called immunoglobulins 2. Antibody molecules belong to one of five classes i.e. IgG, IgM, IgA, IgD & IgE 3. Immunoglobulins are “Y” shaped proteins. The “arms” of the “Y” bind antigens. The tail of the “Y” is responsible for biological activity eg. C’ acti ...
Session A
... B. Recommended review: Martin, G. The hunting of the Src. Nature Rev. Mol. Cell Bio. 2:467-475 (2001). LINK: Click to go to article C. Required primary papers for discussion: 1. Eckhart W, Hutchinson MA, Hunter T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell. 19 ...
... B. Recommended review: Martin, G. The hunting of the Src. Nature Rev. Mol. Cell Bio. 2:467-475 (2001). LINK: Click to go to article C. Required primary papers for discussion: 1. Eckhart W, Hutchinson MA, Hunter T. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell. 19 ...
Antoine Roquilly, MD (1-2), Alexis Broquet, PhD (1), Cedric Jacqueline,... Gautreau, PhD (3-4), Jean Pierre Segain, PhD (5), Pierre de... TLR-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural...
... anti-bacterial response, particularly through cytotoxic activity against infected cells and production of cytokines [5]. A defect in early activation of natural killer (NK) cells functions was associated with an impaired antibacterial response in brain-injured mice and patients [6]. Collaboration of ...
... anti-bacterial response, particularly through cytotoxic activity against infected cells and production of cytokines [5]. A defect in early activation of natural killer (NK) cells functions was associated with an impaired antibacterial response in brain-injured mice and patients [6]. Collaboration of ...
Is atherosclerosis an autoimmune disease? Open Access
... disease of the arterial vessel [26], and it is therefore not surprising that the chronic inflammatory disorder RA is associated with an increased cardiovascular risk. But autoimmunity also plays a role, because patients with RA who are rheumatoid negative or anti-cyclic citrullinated peptide negativ ...
... disease of the arterial vessel [26], and it is therefore not surprising that the chronic inflammatory disorder RA is associated with an increased cardiovascular risk. But autoimmunity also plays a role, because patients with RA who are rheumatoid negative or anti-cyclic citrullinated peptide negativ ...
Document
... From van der Meijden et al. 1998. IL-6 receptor (CD126’IL-6R’) expression is increased on monocytes and B lymphocytes in HIV Infection. Cell. Immunol. 190:156-166. ...
... From van der Meijden et al. 1998. IL-6 receptor (CD126’IL-6R’) expression is increased on monocytes and B lymphocytes in HIV Infection. Cell. Immunol. 190:156-166. ...
The influence of sex and gender on immunity, infection and
... to sex-specific development of immuno-mediated diseases [47]. A dysregulated miRNA expression and/or function has been associated with various autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis and estrogen may contribute to the pathogenesis of au ...
... to sex-specific development of immuno-mediated diseases [47]. A dysregulated miRNA expression and/or function has been associated with various autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis and estrogen may contribute to the pathogenesis of au ...
Citation: Saxton, John, Daley, Amanda, Woodroofe, Nicola
... induce a positive effect on psychological well being in obese women and breast cancer survivors [41-44]. Weight loss interventions that reduce dietary intake of fat to 18– 25% of the total calories can also evoke a significant reduction in serum estrogen levels in pre and postmenopausal women [45]. ...
... induce a positive effect on psychological well being in obese women and breast cancer survivors [41-44]. Weight loss interventions that reduce dietary intake of fat to 18– 25% of the total calories can also evoke a significant reduction in serum estrogen levels in pre and postmenopausal women [45]. ...
Proc R Soc B template (v. 1.0)
... factors such as vitamin A deficiency and environmental enteropathy 15. At least for polio virus type 1, it is highly likely that interference by concurrent infections such as non-polio enteroviruses contribute substantially to impaired vaccine efficacy, and efficacy is also lower in the presence of ...
... factors such as vitamin A deficiency and environmental enteropathy 15. At least for polio virus type 1, it is highly likely that interference by concurrent infections such as non-polio enteroviruses contribute substantially to impaired vaccine efficacy, and efficacy is also lower in the presence of ...
Human T-cell leukemia virus type I (HTLV
... in the rat fibroblast cell line Rat-1, indicating that this domain is responsible for the transforming activity of HTLV-I [43]. To understand the pleiotropic actions of Tax protein more clearly, transcriptome analyses are essential. The transcriptional changes induced by Tax expression have been stu ...
... in the rat fibroblast cell line Rat-1, indicating that this domain is responsible for the transforming activity of HTLV-I [43]. To understand the pleiotropic actions of Tax protein more clearly, transcriptome analyses are essential. The transcriptional changes induced by Tax expression have been stu ...
A review of the human vs. porcine female genital tract
... Full list of author information is available at the end of the article ...
... Full list of author information is available at the end of the article ...
A Review of Artificial Immune System Based Security Frameworks
... tem identifies non-self states and upon identification of a non-self the cause must be contained. This can only be achieved upon reconfiguration of the device and performing test patterns at a low level. The process used hand selection in order to pick a detector set. In [2] they have used negative ...
... tem identifies non-self states and upon identification of a non-self the cause must be contained. This can only be achieved upon reconfiguration of the device and performing test patterns at a low level. The process used hand selection in order to pick a detector set. In [2] they have used negative ...
Document
... cytokines and stimulates B-cells to make antibodies. • The CD8 suppressor is the regulator of this activity • The thyroid cells have the ability to ingest antigens and ...
... cytokines and stimulates B-cells to make antibodies. • The CD8 suppressor is the regulator of this activity • The thyroid cells have the ability to ingest antigens and ...
Differential In Situ Cytokine Profiles of Langerhans
... the specimen produces that certain cytokine. This high level of expression is illustrated in Fig 1C and D. Double staining for cell type and cytokine was performed in at least 7 specimens for each cytokine profile. We defined LCH cells as being CD1a1 and T cells as CD31. Eosinophils were identified ...
... the specimen produces that certain cytokine. This high level of expression is illustrated in Fig 1C and D. Double staining for cell type and cytokine was performed in at least 7 specimens for each cytokine profile. We defined LCH cells as being CD1a1 and T cells as CD31. Eosinophils were identified ...
The role of Fc–Fc R interactions in IgG-mediated microbial
... conformation that suppresses engagement of type II FcRs and promotes interactions with type I FcR members (Sondermann et al., 2013; Ahmed et al., 2014; Pincetic et al., 2014). Several previous studies clearly demonstrated that type II FcR engagement by sialylated IgG Fcs results in active suppres ...
... conformation that suppresses engagement of type II FcRs and promotes interactions with type I FcR members (Sondermann et al., 2013; Ahmed et al., 2014; Pincetic et al., 2014). Several previous studies clearly demonstrated that type II FcR engagement by sialylated IgG Fcs results in active suppres ...
C-type lectins in immunity: recent developments
... recognises uric acid and proteinaceous ligand(s) on necrotic cells [69]. MICL functions as an inhibitory receptor, blocking signalling from Syk-coupled activation receptors, and loss of this CLR results in hyperinflammation in the presence of cellular necrosis [69]. MICL is also highly expressed o ...
... recognises uric acid and proteinaceous ligand(s) on necrotic cells [69]. MICL functions as an inhibitory receptor, blocking signalling from Syk-coupled activation receptors, and loss of this CLR results in hyperinflammation in the presence of cellular necrosis [69]. MICL is also highly expressed o ...
Express Inducible NKG2D Ligands That Mouse NK Cell Activity
... and channels them, in a receptor-mediated manner, into the MHC class I presentation pathway of professional APCs, which then prime peptide-specific CTL (12). Therefore, HSP70 derived from tumors can be used as tumor-specific vaccines (13). HSP70 also elicits the release of proinflammatory cytokines ...
... and channels them, in a receptor-mediated manner, into the MHC class I presentation pathway of professional APCs, which then prime peptide-specific CTL (12). Therefore, HSP70 derived from tumors can be used as tumor-specific vaccines (13). HSP70 also elicits the release of proinflammatory cytokines ...
Difference in cytokine production and cell cycle
... Figure 2 Cytokine expression is differently regulated by LMP1 variants. Cytokines expressed by KMH2-pRT-LMP1 cells (non-induced, WT, del30 and del69) were intracellularly stained and detected by flow-cytometry 24 h after induction of LMP1 expression. The percentages of cells expressing (a) IFN-γ, (b ...
... Figure 2 Cytokine expression is differently regulated by LMP1 variants. Cytokines expressed by KMH2-pRT-LMP1 cells (non-induced, WT, del30 and del69) were intracellularly stained and detected by flow-cytometry 24 h after induction of LMP1 expression. The percentages of cells expressing (a) IFN-γ, (b ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.