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Induced Pluripotent Stem Cells: Therapeutic Applications in
... 3. Advanced therapies for monogenic and metabolic diseases The progression of the different areas of biology, biotechnology and medicine leads to the development of highly innovative new treatments and pharmacological products. In this regard, advanced therapies based on the by-products of gene ther ...
... 3. Advanced therapies for monogenic and metabolic diseases The progression of the different areas of biology, biotechnology and medicine leads to the development of highly innovative new treatments and pharmacological products. In this regard, advanced therapies based on the by-products of gene ther ...
Insights into Seven and Single Transmembrane
... (Taub et al., 1995; Inngjerdingen et al., 2001) or cytokines such as granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-␣, or IFN-␥ (Biron et al., 1999; Cooper et al., 2001). In the circulation, human NK cells are classified into two major subsets: those that express CD16 and lo ...
... (Taub et al., 1995; Inngjerdingen et al., 2001) or cytokines such as granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-␣, or IFN-␥ (Biron et al., 1999; Cooper et al., 2001). In the circulation, human NK cells are classified into two major subsets: those that express CD16 and lo ...
Regulation of type 2 immunity to helminths by mast cells
... detect a significant induction of Lin- MC progenitors in Hp infected WT mice that expressed both endogenous IL-25 and IL-33 but only a small induction of type 2 iLC cells. One possibility is that a higher threshold of IL-25 expression is required for the induction of type 2 iLC populations than is n ...
... detect a significant induction of Lin- MC progenitors in Hp infected WT mice that expressed both endogenous IL-25 and IL-33 but only a small induction of type 2 iLC cells. One possibility is that a higher threshold of IL-25 expression is required for the induction of type 2 iLC populations than is n ...
Gut flora in health and disease
... Eubacterium aerofaciens. Although the evidence is not conclusive, colonic flora seem to be a major environmental factor that modulates risk of colonic cancer in human beings. ...
... Eubacterium aerofaciens. Although the evidence is not conclusive, colonic flora seem to be a major environmental factor that modulates risk of colonic cancer in human beings. ...
Global Monoclonal Antibodies Pipeline Analysis Brochure
... were more than 25 monoclonals in US and the EU. Currently, there are about 10 monoclonals which have already achieved category of "blockbuster", that is they are widely used medications that have been able to generate profits of more than US$ 1 Billion (each) to companies that market them. It has be ...
... were more than 25 monoclonals in US and the EU. Currently, there are about 10 monoclonals which have already achieved category of "blockbuster", that is they are widely used medications that have been able to generate profits of more than US$ 1 Billion (each) to companies that market them. It has be ...
T Cell Receptor (TCR)
... 1. TCR functions to recognize Ag peptides presented by MHC complexes => Ag peptide specificity => MHC restriction 2. Two classes of MHC molecules. - Class-I MHC => peptides from cytosolic (intracellular) proteins => CD8 T cells - Class-II MHC => peptides from extracellular (exogenous) proteins from ...
... 1. TCR functions to recognize Ag peptides presented by MHC complexes => Ag peptide specificity => MHC restriction 2. Two classes of MHC molecules. - Class-I MHC => peptides from cytosolic (intracellular) proteins => CD8 T cells - Class-II MHC => peptides from extracellular (exogenous) proteins from ...
Adenosine triphosphate acts as a paracrine signaling molecule to
... calcium (Fig 5E). The projected migration tracks of the T cells from the time-lapse videos are shown in Supplementary Fig S3. In these experiments, when the ATP-induced intracellular calcium increase was buffered by the calcium chelator BAPTA, we no longer observed the slowing down of T-cell chemota ...
... calcium (Fig 5E). The projected migration tracks of the T cells from the time-lapse videos are shown in Supplementary Fig S3. In these experiments, when the ATP-induced intracellular calcium increase was buffered by the calcium chelator BAPTA, we no longer observed the slowing down of T-cell chemota ...
Immunoexpression of Interleukin 17, Transforming Growth Factor
... IL-17 induces inflammatory responses, contributes to the development of Th1 immunity, and stimulates osteoclastic bone resorption in combination with receptor activator of nuclear factor kappa B and its ligand (7, 20). It is speculated that IL-17 exerts protective effects and is also involved in bon ...
... IL-17 induces inflammatory responses, contributes to the development of Th1 immunity, and stimulates osteoclastic bone resorption in combination with receptor activator of nuclear factor kappa B and its ligand (7, 20). It is speculated that IL-17 exerts protective effects and is also involved in bon ...
Chapter 13 - IARC Publications
... a clone have the same antigenic specificity as the original lymphocyte. Clonal expansion accounts for the two fundamental properties of acquired immunity recognized since ancient times: memory and specificity. Memory comes from the expanded population of lymphocytes that persists after initial antig ...
... a clone have the same antigenic specificity as the original lymphocyte. Clonal expansion accounts for the two fundamental properties of acquired immunity recognized since ancient times: memory and specificity. Memory comes from the expanded population of lymphocytes that persists after initial antig ...
Immune-Mediated Thrombocytopenia (IMT)
... shapes of proteins present on a cell’s surface. These shapes are similar to ID cards. The immune system recognizes shapes defined as “self” and does not attack but when it sees a cell expressing protein shapes that are “non-self,” it will respond. If the immune system is responding to a blood parasi ...
... shapes of proteins present on a cell’s surface. These shapes are similar to ID cards. The immune system recognizes shapes defined as “self” and does not attack but when it sees a cell expressing protein shapes that are “non-self,” it will respond. If the immune system is responding to a blood parasi ...
Pulp responses
... bind to the same cellular receptor. This receptor is composed of two related, but non-identical, subunits that transmit intracellular signals via a pathway that is mostly shared with certain other receptors. These include the Toll family of innate immune receptors and the receptor for IL-18. IL-1α … ...
... bind to the same cellular receptor. This receptor is composed of two related, but non-identical, subunits that transmit intracellular signals via a pathway that is mostly shared with certain other receptors. These include the Toll family of innate immune receptors and the receptor for IL-18. IL-1α … ...
Pulparesponser
... increased body temperature which expresses itself as fever. IL-1 is therefore called an endogenous pyrogen. The increased body temperature helps the body's immune system to fight infection. IL-1 is also important in the regulation of hematopoiesis. IL-1β production in peripheral tissue has also been ...
... increased body temperature which expresses itself as fever. IL-1 is therefore called an endogenous pyrogen. The increased body temperature helps the body's immune system to fight infection. IL-1 is also important in the regulation of hematopoiesis. IL-1β production in peripheral tissue has also been ...
MOLD TOXICITY - Park Ridge MultiMed
... b. As a growth factor, TGF-beta 1 regulates immune and tissue cell growth and proliferation. c. TGF-beta 1 is not immune suppressive if T-reg cells (known by their CD4+/CD25+ cell surface markers) are normal. If T-regs are low, TGFbeta 1 can transform them into becoming pathogenic T-cells in tissues ...
... b. As a growth factor, TGF-beta 1 regulates immune and tissue cell growth and proliferation. c. TGF-beta 1 is not immune suppressive if T-reg cells (known by their CD4+/CD25+ cell surface markers) are normal. If T-regs are low, TGFbeta 1 can transform them into becoming pathogenic T-cells in tissues ...
Vicente G. Villarrubia, MD, PhD
... disease are restored by glicophosphopeptical (Inmunoferón). Am J Respir Crit Care M ed 2001; 163:1578-83. ...
... disease are restored by glicophosphopeptical (Inmunoferón). Am J Respir Crit Care M ed 2001; 163:1578-83. ...
as Adobe PDF - Edinburgh Research Explorer
... The specificity of rotaviruses, an important cause of childhood death (from dehydration secondary to acute gastroenteritis) in developing countries, also lies in the specificity of their glycan attachment. Host susceptibility to specific human rotavirus strains and disease pathogenesis appear to be infl ...
... The specificity of rotaviruses, an important cause of childhood death (from dehydration secondary to acute gastroenteritis) in developing countries, also lies in the specificity of their glycan attachment. Host susceptibility to specific human rotavirus strains and disease pathogenesis appear to be infl ...
View PDF - OMICS Group
... cells to the damaged peripheral nerves, thus inducing an inflammatory burst in the infected nerves, chronically followed by axonal and myelin degeneration. In fact, while lack of IL-1β and TNF signaling impaired immune cell influx towards injured peripheral nerves in mice, higher levels of TNF were ...
... cells to the damaged peripheral nerves, thus inducing an inflammatory burst in the infected nerves, chronically followed by axonal and myelin degeneration. In fact, while lack of IL-1β and TNF signaling impaired immune cell influx towards injured peripheral nerves in mice, higher levels of TNF were ...
vaccines
... antigen-specific serum IgG levels compared to pOVA alone as well as strong antigen-specific CD4+/8+ cellular immune responses [5]. Importantly, we also showed that the pFliC-Tm adjuvant delivered with a DNA-encoded nucleoprotein gene from Influenza A resulted in a strong antigen-specific CD4+/8+ cel ...
... antigen-specific serum IgG levels compared to pOVA alone as well as strong antigen-specific CD4+/8+ cellular immune responses [5]. Importantly, we also showed that the pFliC-Tm adjuvant delivered with a DNA-encoded nucleoprotein gene from Influenza A resulted in a strong antigen-specific CD4+/8+ cel ...
Innate Immune Cells: Key Regulators of Homeostasis and
... tryptophan catabolites are able to induce interleukin (IL)-22 expression in the murine gut. This cytokine is able to improve epithelial barrier functions [16]. While the intestine harbors a vast amount of microorganisms, it was believed for a long time that the airways are sterile [17]. Interestingl ...
... tryptophan catabolites are able to induce interleukin (IL)-22 expression in the murine gut. This cytokine is able to improve epithelial barrier functions [16]. While the intestine harbors a vast amount of microorganisms, it was believed for a long time that the airways are sterile [17]. Interestingl ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.