Vaccines
... • By using the plasmid in the vaccinee to code for antigen synthesis, the antigenic protein(s) that are produced are processed (post-translationally modified) in the same way as the proteins of the virus against which protection is to be produced. This makes a far better antigen than purifying that ...
... • By using the plasmid in the vaccinee to code for antigen synthesis, the antigenic protein(s) that are produced are processed (post-translationally modified) in the same way as the proteins of the virus against which protection is to be produced. This makes a far better antigen than purifying that ...
Innate Immune Cells: Key Regulators of Homeostasis and
... tryptophan catabolites are able to induce interleukin (IL)-22 expression in the murine gut. This cytokine is able to improve epithelial barrier functions [16]. While the intestine harbors a vast amount of microorganisms, it was believed for a long time that the airways are sterile [17]. Interestingl ...
... tryptophan catabolites are able to induce interleukin (IL)-22 expression in the murine gut. This cytokine is able to improve epithelial barrier functions [16]. While the intestine harbors a vast amount of microorganisms, it was believed for a long time that the airways are sterile [17]. Interestingl ...
Relationship between chronic inflammation and depression.
... The mechanisms by which stress produces ATP is not completely understood. It is thought that stress leads to an increase of glutamate at the hippocampus, which in turn stimulates the release of ATP from astrocytes by a Ca2+ -dependent mechanism . Other sources of ATP acting on microglial P2X7R are d ...
... The mechanisms by which stress produces ATP is not completely understood. It is thought that stress leads to an increase of glutamate at the hippocampus, which in turn stimulates the release of ATP from astrocytes by a Ca2+ -dependent mechanism . Other sources of ATP acting on microglial P2X7R are d ...
a cohort study investigating autoantibody levels
... possible cause is viral infections. The scope of this thesis study was to examine if autoantibodies levels in individuals without autoimmune disorders increase during or after infection with influenza A virus. Blood was collected from volunteers (n=11) at time intervals of 0, 7, 42 and 63 days, resp ...
... possible cause is viral infections. The scope of this thesis study was to examine if autoantibodies levels in individuals without autoimmune disorders increase during or after infection with influenza A virus. Blood was collected from volunteers (n=11) at time intervals of 0, 7, 42 and 63 days, resp ...
Anti-Inflammatory - Pinhook Chiropractic Clinic
... pathways through which they interact. The loops and feedbacks of those pathways mean inflammation can be turned on and off in any number of ways. The problem comes when it is left on, for no apparent reason. For simplicity's sake, immunologists still describe inflammation as depen dent on two basic ...
... pathways through which they interact. The loops and feedbacks of those pathways mean inflammation can be turned on and off in any number of ways. The problem comes when it is left on, for no apparent reason. For simplicity's sake, immunologists still describe inflammation as depen dent on two basic ...
Exercise and Psychosocial Factors Modulate Immunity to Influenza
... infection and is considered to be a good predictor of resistance to infection (22). In our study, the subjects who exercised vigorously had a higher concentration of both IgG and IgM, suggesting a greater degree of protection, and our data on symptom incidence are consistent with this possibility. C ...
... infection and is considered to be a good predictor of resistance to infection (22). In our study, the subjects who exercised vigorously had a higher concentration of both IgG and IgM, suggesting a greater degree of protection, and our data on symptom incidence are consistent with this possibility. C ...
Filip Čulo
... cells which escape the direct killing with sublethal dose of cyclophosphamide are, for about three weeks, more sensitive to an immunological attack of immunological cells. When these cells are transferred into normal recipient, their translatability is decreased and sensitivity to lytic action of im ...
... cells which escape the direct killing with sublethal dose of cyclophosphamide are, for about three weeks, more sensitive to an immunological attack of immunological cells. When these cells are transferred into normal recipient, their translatability is decreased and sensitivity to lytic action of im ...
The Complement system
... • Eventially enough C3b is cleaved that the surface of the bacteria begins to become saturated with it. • C2b and C4b which make up the C3 activation complex has a slight affinity for C3b and C3b binds to them • When C3b binds to C2b and C4b it forms a new complex referred to as the C5 activation ...
... • Eventially enough C3b is cleaved that the surface of the bacteria begins to become saturated with it. • C2b and C4b which make up the C3 activation complex has a slight affinity for C3b and C3b binds to them • When C3b binds to C2b and C4b it forms a new complex referred to as the C5 activation ...
Hepatitis C IMO-2125 - Noble Capital Markets
... IMO-2125: Antiviral Activity • IMO-2125 induced a broad array of antiviral cytokines and chemokines, including interferon-alpha in both patient populations • At all dose levels IMO-2125 induced declines in viral levels at 48 hours after the first dose in treatment-naïve patients • IMO-2125 at all d ...
... IMO-2125: Antiviral Activity • IMO-2125 induced a broad array of antiviral cytokines and chemokines, including interferon-alpha in both patient populations • At all dose levels IMO-2125 induced declines in viral levels at 48 hours after the first dose in treatment-naïve patients • IMO-2125 at all d ...
HIV Testing - UCLA Health
... An estimated 1,148,200 persons in the United States live with HIV About 50,000 new HIV infections occur in the United States each year Each year, approximately 16-22 million persons in the United States are tested for HIV An estimated 38%-44% of all adults had been tested for HIV Approximatel ...
... An estimated 1,148,200 persons in the United States live with HIV About 50,000 new HIV infections occur in the United States each year Each year, approximately 16-22 million persons in the United States are tested for HIV An estimated 38%-44% of all adults had been tested for HIV Approximatel ...
HIV Testing - UCLA Health
... An estimated 1,148,200 persons in the United States live with HIV About 50,000 new HIV infections occur in the United States each year Each year, approximately 16-22 million persons in the United States are tested for HIV An estimated 38%-44% of all adults had been tested for HIV Approximatel ...
... An estimated 1,148,200 persons in the United States live with HIV About 50,000 new HIV infections occur in the United States each year Each year, approximately 16-22 million persons in the United States are tested for HIV An estimated 38%-44% of all adults had been tested for HIV Approximatel ...
Do mitochondria play a role in ME/CFS?
... Changes in cellular chemicals (i.e. ATP) in a disease or with treatment. > 17,000 metabolities ...
... Changes in cellular chemicals (i.e. ATP) in a disease or with treatment. > 17,000 metabolities ...
Kinetics of tumor-specific T-cell response development after active
... both HER-2/neu peptide- and protein-specific T cell immunity. While generation of peptide-specific immunity after peptide immunization is a reflection of a patient’s immune competence and their ability to be immunized, detection of protein-specific response implies that the native protein was taken ...
... both HER-2/neu peptide- and protein-specific T cell immunity. While generation of peptide-specific immunity after peptide immunization is a reflection of a patient’s immune competence and their ability to be immunized, detection of protein-specific response implies that the native protein was taken ...
Asymptomatic Apical Periodontitis
... A cyst is lined by squamous epithelium and containing necrotic material in the lumen. The cyst wall or capsule contains dense fibrous connective tissue with slight chronic inflammation and cholesterin slits surrounded by foreign body-type giant cells. There are "foam" cells in the epithelial lining. ...
... A cyst is lined by squamous epithelium and containing necrotic material in the lumen. The cyst wall or capsule contains dense fibrous connective tissue with slight chronic inflammation and cholesterin slits surrounded by foreign body-type giant cells. There are "foam" cells in the epithelial lining. ...
MDS Glossary - MDS Foundation
... and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be hereditary (less common, passed down from parent to child). Cellularity How much of the bone marrow volume is occupied by various types of blood cells. Chemotherapy The use of medici ...
... and paroxysmal nocturnal hemoglobinuria (PNH). Bone marrow failure can be acquired (begin any time in life) or can be hereditary (less common, passed down from parent to child). Cellularity How much of the bone marrow volume is occupied by various types of blood cells. Chemotherapy The use of medici ...
Natural Killer cells in Innate Defense against Infective Pathogens
... human NK cell education has also been discovered recently. Fauriat C et al. found that NK cells expressing KIR2DS1 are hyporesponsive against cellular targets from donors homozygous for HLA-C2, the ligand of KIR2DS1. These results suggest that the education of human NK cells via activating receptors ...
... human NK cell education has also been discovered recently. Fauriat C et al. found that NK cells expressing KIR2DS1 are hyporesponsive against cellular targets from donors homozygous for HLA-C2, the ligand of KIR2DS1. These results suggest that the education of human NK cells via activating receptors ...
Neuronal plasticity and cellular immunity: shared
... long-term depression LTP long-term potentiation MHCI major histocompatibility complex, class I NF-AT nuclear factor of activated T cells κB NF-κ nuclear factor-kappa B NHEJ non-homologous end joining NK natural killer NMDA N-methyl D-aspartate RAG-1,2 recombination activating gene -1,-2 TAP1 transpo ...
... long-term depression LTP long-term potentiation MHCI major histocompatibility complex, class I NF-AT nuclear factor of activated T cells κB NF-κ nuclear factor-kappa B NHEJ non-homologous end joining NK natural killer NMDA N-methyl D-aspartate RAG-1,2 recombination activating gene -1,-2 TAP1 transpo ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.