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... Anti-native DNA Fairly specific for SLE but present only in 60% of cases at best Titers correlate with disease activity Higher titers with nephritis ...
... Anti-native DNA Fairly specific for SLE but present only in 60% of cases at best Titers correlate with disease activity Higher titers with nephritis ...
Lennert et al
... The malignant nature of Hodgkin's lymphoma was disputed. The majority of investigators, Virchow, Wilks, and most modern students of the disorder, considered it a neoplasm of the lymphoid system. ...
... The malignant nature of Hodgkin's lymphoma was disputed. The majority of investigators, Virchow, Wilks, and most modern students of the disorder, considered it a neoplasm of the lymphoid system. ...
Lecture 21 – hip and back pain in adults Should know differentials
... findings are titers of dsDNA antibodies. Need 4 of the 11 to have Lupus. susceptibility: C4 deficiency, HLA-DR3-2, defective immune complex clearance, drugs (temporarily induced). The autoantibody production is similar to RA. Immune complex clearance and apoptosis with C4 is similar problems. B cel ...
... findings are titers of dsDNA antibodies. Need 4 of the 11 to have Lupus. susceptibility: C4 deficiency, HLA-DR3-2, defective immune complex clearance, drugs (temporarily induced). The autoantibody production is similar to RA. Immune complex clearance and apoptosis with C4 is similar problems. B cel ...
Toll-Like Receptor 4 in Ventilator
... Toll like receptors (TLRs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens (1). In their bridging role, TLR downstream signals link innate and adaptive immunity, particularly by medi ...
... Toll like receptors (TLRs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens (1). In their bridging role, TLR downstream signals link innate and adaptive immunity, particularly by medi ...
Stimulation of Cytokine Expression by Peripheral Blood
... control for expression of IFN␥, TNF␣, and IL-6. The remaining aliquot of PBMCs was incubated with only media for 24 h as a negative control. After incubation, total RNA was extracted from the cells, reverse transcribed, and subjected to real-time polymerase chain reaction (PCR) to determine levels o ...
... control for expression of IFN␥, TNF␣, and IL-6. The remaining aliquot of PBMCs was incubated with only media for 24 h as a negative control. After incubation, total RNA was extracted from the cells, reverse transcribed, and subjected to real-time polymerase chain reaction (PCR) to determine levels o ...
Genetically Engineered Probiotics
... Abstract: Intestinal microbiota is a key component of both the metabolism and immunity. These can be helpful in healthcare, especially for the management of digestive diseases and food-borne illnesses. Through genetic engineering it is possible to fully express biologically active copies of such pow ...
... Abstract: Intestinal microbiota is a key component of both the metabolism and immunity. These can be helpful in healthcare, especially for the management of digestive diseases and food-borne illnesses. Through genetic engineering it is possible to fully express biologically active copies of such pow ...
Intranasal immunization of mice with Echinococcus
... a liposome (Morein & Simons 1985), or an immuno stimulating complex (iscom) (Morein et al. 1984). An inadequate immune response is not only irrelevant but may even favor the invading organism (Heinzel, Sadick, Mutha et al. 1991), thus induction of a proper response is a relevant research goal. A sim ...
... a liposome (Morein & Simons 1985), or an immuno stimulating complex (iscom) (Morein et al. 1984). An inadequate immune response is not only irrelevant but may even favor the invading organism (Heinzel, Sadick, Mutha et al. 1991), thus induction of a proper response is a relevant research goal. A sim ...
deficiency
... marrow of the youngest infant with X-linked SCID was relatively high for their size. This finding indicates that the pool of progenitor cells could be expanded in patients with X-linked SCID because of the absence of the c-chain, which is required for cytokine signalling and differentiation of CLP. ...
... marrow of the youngest infant with X-linked SCID was relatively high for their size. This finding indicates that the pool of progenitor cells could be expanded in patients with X-linked SCID because of the absence of the c-chain, which is required for cytokine signalling and differentiation of CLP. ...
Regulatory T Cells + CD25 + Despite Normal Thymic Deletion of
... incapacity of T cells to eliminate tumors (19) as well as in tolerance to allogeneic grafts induced under cover of anti-CD4, -CD11a, -CD40 ligand, -CD25, or -CD3 Ab or CTLA4-Ig treatment (11, 20). Combined with reports on deletional and nondeletional peripheral tolerance (1), these data emphasize th ...
... incapacity of T cells to eliminate tumors (19) as well as in tolerance to allogeneic grafts induced under cover of anti-CD4, -CD11a, -CD40 ligand, -CD25, or -CD3 Ab or CTLA4-Ig treatment (11, 20). Combined with reports on deletional and nondeletional peripheral tolerance (1), these data emphasize th ...
- Nottingham ePrints
... Many chemotherapeutic agents induce short-lived, inhibitory effects on innate and adaptive immunity [23-25]. However, different drugs and regimens may augment anticancer immunity, both humoral and cellular [23-25]. Chemotherapy-induced cancer cell stress/damage results in the release of immunogenic ...
... Many chemotherapeutic agents induce short-lived, inhibitory effects on innate and adaptive immunity [23-25]. However, different drugs and regimens may augment anticancer immunity, both humoral and cellular [23-25]. Chemotherapy-induced cancer cell stress/damage results in the release of immunogenic ...
Normal cellular counterparts of B cell chronic
... Normal cellular counterparts of B cell chronic lymphocytic leukemia AS Freedman, AW Boyd, FR Bieber, J Daley, K Rosen, JC Horowitz, DN Levy and LM Nadler ...
... Normal cellular counterparts of B cell chronic lymphocytic leukemia AS Freedman, AW Boyd, FR Bieber, J Daley, K Rosen, JC Horowitz, DN Levy and LM Nadler ...
Fish and Shellfish Immunology
... capacity of fish to resist pathogens before a specific immune response [2,8,9]. Innate immune response mechanisms against A. hydrophila have been studied in several fish species [3,4,9]; however little is known on gilthead seabream. Understanding the immune defence mechanisms of fish against bacteria is ...
... capacity of fish to resist pathogens before a specific immune response [2,8,9]. Innate immune response mechanisms against A. hydrophila have been studied in several fish species [3,4,9]; however little is known on gilthead seabream. Understanding the immune defence mechanisms of fish against bacteria is ...
Molecular Events in Cells Transformed by Rous Sarcoma
... the src gene (29). Others have also reported similar results from their studies on pp60g" (20, 30). Thus, it appeared that the presence of pp60"` was an obligatory requirement for the IgG kinase activity . This unexpected observation has proven to be a useful assay for additional studies on pp60'". ...
... the src gene (29). Others have also reported similar results from their studies on pp60g" (20, 30). Thus, it appeared that the presence of pp60"` was an obligatory requirement for the IgG kinase activity . This unexpected observation has proven to be a useful assay for additional studies on pp60'". ...
Treatment name Type Focus of Studies Company or Organization
... Eli Lilly Brain Resource Center ...
... Eli Lilly Brain Resource Center ...
Psychoneuroimmunology: Psychological Influences
... one of the most robust findings in PNI (Uchino et al., 1996). For example, higher NK cell activity and stronger proliferative responses of peripheral blood leukocytes to mitogen stimulation were associated with higher social support in women whose husbands were being treated for urologic cancer than ...
... one of the most robust findings in PNI (Uchino et al., 1996). For example, higher NK cell activity and stronger proliferative responses of peripheral blood leukocytes to mitogen stimulation were associated with higher social support in women whose husbands were being treated for urologic cancer than ...
EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOID MALIGNANCIES
... accompanied by lymphadenopathy. Other symptoms and signs are thrombocytopenia, anemia, skin rash, diarrhea, and uveitis. Laboratory tests show abnormal liver function tests and often an abnormal EBV serology with high anti-viral capsid antigen IgG antibodies. The disease is sometimes complicated by ...
... accompanied by lymphadenopathy. Other symptoms and signs are thrombocytopenia, anemia, skin rash, diarrhea, and uveitis. Laboratory tests show abnormal liver function tests and often an abnormal EBV serology with high anti-viral capsid antigen IgG antibodies. The disease is sometimes complicated by ...
Mycobacterium and the coat of many lipids
... the local immune response to limit its efficacy at the site of infection. With respect to reducing the host cell’s antigenicity, antigen presentation by the infected macrophage is minimized by several mechanisms. First, the vacuoles in which the bacteria reside do not lie within the antigen-sampling ...
... the local immune response to limit its efficacy at the site of infection. With respect to reducing the host cell’s antigenicity, antigen presentation by the infected macrophage is minimized by several mechanisms. First, the vacuoles in which the bacteria reside do not lie within the antigen-sampling ...
What is Good`s syndrome? - Journal of Clinical Pathology
... thymic stromal cell line can promote the growth of a pre-B cell line,51 which suggests that the thymus may have the potential to influence precursor B cell growth and maturation. The recent identification of a thymic epithelial stem cell population52 53 will facilitate studies into the signals requi ...
... thymic stromal cell line can promote the growth of a pre-B cell line,51 which suggests that the thymus may have the potential to influence precursor B cell growth and maturation. The recent identification of a thymic epithelial stem cell population52 53 will facilitate studies into the signals requi ...
the quest for a universal vaccine
... pathogens, secrete cytokines that promote inflammation and release chemicals that attract and activate other immune cells.1 The adaptive immune system responds to specific areas in the infected cell or pathogen called ‘epitopes’. The adaptive immune system has two elements: humoral and cellular. F ...
... pathogens, secrete cytokines that promote inflammation and release chemicals that attract and activate other immune cells.1 The adaptive immune system responds to specific areas in the infected cell or pathogen called ‘epitopes’. The adaptive immune system has two elements: humoral and cellular. F ...
The integration of T cell migration, differentiation and function
... remarkable feat is mediated by the antigen collecting capacity of SLOs coupled with the selective migration of naive T cells to these sites. Enough lymphocytes leave lymph and enter the subclavian vein to replace all blood-borne lymphocytes 11 times daily3. Half a century ago, Gowans traced the fate ...
... remarkable feat is mediated by the antigen collecting capacity of SLOs coupled with the selective migration of naive T cells to these sites. Enough lymphocytes leave lymph and enter the subclavian vein to replace all blood-borne lymphocytes 11 times daily3. Half a century ago, Gowans traced the fate ...
Posttranslational Modifications of Proteins in Type 1 Diabetes: The
... evidence shows that b-cell antigens undergo modifications through alternative splicing. Alternative splicing occurs in about 90% of human genes, meaning that a single gene may result in multiple protein isoforms. Importantly, there is a tissue-specific factor, and alternative splicing generates enormo ...
... evidence shows that b-cell antigens undergo modifications through alternative splicing. Alternative splicing occurs in about 90% of human genes, meaning that a single gene may result in multiple protein isoforms. Importantly, there is a tissue-specific factor, and alternative splicing generates enormo ...
Characterization of the T-Cell Response to
... Several mechanisms have been proposed to explain this putative link with type 1 diabetes pathogenesis, including “molecular mimicry” (18,19), bystander activation (20), and superantigen effects (21,22). Dissection of these models requires an understanding of the nature of the T-cell response to cand ...
... Several mechanisms have been proposed to explain this putative link with type 1 diabetes pathogenesis, including “molecular mimicry” (18,19), bystander activation (20), and superantigen effects (21,22). Dissection of these models requires an understanding of the nature of the T-cell response to cand ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.