Treatment of rheumatoid arthritis and other inflammatory disorders
... Traditionally, RA was treated symptomatically with non-steroidal and steroidal anti-inflammatory drugs, which still have a place in the management of RA. The use of these drugs is self-limiting through the corrosive effects of nonsteroidal drugs such as aspirin on the gut and the serious effects of ...
... Traditionally, RA was treated symptomatically with non-steroidal and steroidal anti-inflammatory drugs, which still have a place in the management of RA. The use of these drugs is self-limiting through the corrosive effects of nonsteroidal drugs such as aspirin on the gut and the serious effects of ...
Is Fever Beneficial to the Host: A Clinical Perspective
... antiviral properties of interferon at febrile temperatures. At 390C, interferon completely blocked the generation of suppressor cells in vitro and, in vivo, augmented both delayed-type hypersensitivity and antibody responses [16]. Additionally, fibroblasts treated with interferon at febrile temperat ...
... antiviral properties of interferon at febrile temperatures. At 390C, interferon completely blocked the generation of suppressor cells in vitro and, in vivo, augmented both delayed-type hypersensitivity and antibody responses [16]. Additionally, fibroblasts treated with interferon at febrile temperat ...
Krishnaswamy
... C CD40 ligand expression by C. flow D. CD40 expression by flow E. T cell receptor rearrangement study for clonality ...
... C CD40 ligand expression by C. flow D. CD40 expression by flow E. T cell receptor rearrangement study for clonality ...
1 Modulation of HLA-G and HLA-E expression in - HAL
... IFN- transcription in human neurons [8, 38]. We have previously shown that HSV-1 and RABV infections modulate the expression of the HLA-G gene in different ways: HSV-1 up regulated mainly the isoforms HLA-G5 and G3, whereas RABV up regulated mainly HLAG1[8]. This emphasizes that human neurons use s ...
... IFN- transcription in human neurons [8, 38]. We have previously shown that HSV-1 and RABV infections modulate the expression of the HLA-G gene in different ways: HSV-1 up regulated mainly the isoforms HLA-G5 and G3, whereas RABV up regulated mainly HLAG1[8]. This emphasizes that human neurons use s ...
Pathogen Associated Molecular Patterns, Pattern Recognition Receptors and Pediatric Sepsis Lesley
... cellular components including flagellin, microbial RNA and DNA, viral structures such as envelopes and capsids, as well as many other proteins, glycoproteins and glycolipids. In addition PRRs can respond to some host derived “danger signals” that include molecules exposed/released during cellular st ...
... cellular components including flagellin, microbial RNA and DNA, viral structures such as envelopes and capsids, as well as many other proteins, glycoproteins and glycolipids. In addition PRRs can respond to some host derived “danger signals” that include molecules exposed/released during cellular st ...
Introduction Tuberculosis (TB) is a global public health hazard. Out
... and further transmission of this disease. Enzyme-linked immunosorbent assay (ELISA) is a potentially valuable technique and simple to perform. Crude as well purified forms of antigens of M. tuberculosis have been employed in the ELISA in an attempt to improve both the sensitivity and specificity in ...
... and further transmission of this disease. Enzyme-linked immunosorbent assay (ELISA) is a potentially valuable technique and simple to perform. Crude as well purified forms of antigens of M. tuberculosis have been employed in the ELISA in an attempt to improve both the sensitivity and specificity in ...
The origins of the identification and isolation of hematopoietic stem
... lymphocytes.12-16 In perhaps the most brilliant experiment of the series, they induced clonal markers in donor marrow by sublethal irradiation, then transplanted cells in numbers that made visible day 10 spleen colonies; each colony that had a chromosomal marker had one that was distinctive for that ...
... lymphocytes.12-16 In perhaps the most brilliant experiment of the series, they induced clonal markers in donor marrow by sublethal irradiation, then transplanted cells in numbers that made visible day 10 spleen colonies; each colony that had a chromosomal marker had one that was distinctive for that ...
Bcl-2: Regulator of the Cellular Life-or
... • Adams, J. M and Cory, S. The Bcl-2 protein family: arbitrators of cell survival. Science 281,1322-1326 (1998) • Cory, S., Adams, J.M. The Bcl2 family: regulators of the life or death switch. Nature Reviews 2, 647-656 (2002) • Gross, A. McDonnell, J.M. and Korsmeyer, S.J. Bcl-2 family members and t ...
... • Adams, J. M and Cory, S. The Bcl-2 protein family: arbitrators of cell survival. Science 281,1322-1326 (1998) • Cory, S., Adams, J.M. The Bcl2 family: regulators of the life or death switch. Nature Reviews 2, 647-656 (2002) • Gross, A. McDonnell, J.M. and Korsmeyer, S.J. Bcl-2 family members and t ...
Short-Lived IFN-c Effector Responses, but Long-Lived IL
... ¤ Current address: MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London. ...
... ¤ Current address: MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London. ...
doctor degree
... Systemic inflammation response prevents inflammation in other tissues by neutralizing the inflammation-inducing molecules such as cytokines, proteases and oxidants by reducing proinflamator response of circulating leukocytes. Although local response of damaged tissue is predominantly proinflamator, ...
... Systemic inflammation response prevents inflammation in other tissues by neutralizing the inflammation-inducing molecules such as cytokines, proteases and oxidants by reducing proinflamator response of circulating leukocytes. Although local response of damaged tissue is predominantly proinflamator, ...
Bacterial Toxigenesis
... LPS Mode of Action • Bound by plasma proteins LPS-binding proteins (LBP). • LBP interacts with receptors on monocytes and macrophages and other types of receptors on endothelial cells. • In monocytes and macrophages three types of events are triggered during their interaction with LPS: 1) Production ...
... LPS Mode of Action • Bound by plasma proteins LPS-binding proteins (LBP). • LBP interacts with receptors on monocytes and macrophages and other types of receptors on endothelial cells. • In monocytes and macrophages three types of events are triggered during their interaction with LPS: 1) Production ...
Intro to paper (draft)
... macrophages, can ‘present’ viral antigens to the body’s T and B cells directly. This would again massively improve the likelihood that the immune cells react to the presence of the antigen. This is another incredible example of nanotechnology’s ability to mimic natural processes on a molecular leve ...
... macrophages, can ‘present’ viral antigens to the body’s T and B cells directly. This would again massively improve the likelihood that the immune cells react to the presence of the antigen. This is another incredible example of nanotechnology’s ability to mimic natural processes on a molecular leve ...
The plasmacytoid dendritic cell: at the cross-roads in asthma
... differences exist as human, but not murine, pDCs express the surface markers blood DC antigen (BDCA)-2 (CD303), BDCA-4 (CD304), immunoglobulin-like transcript 7 (ILT7), and the IL-3 receptor-a chain (CD123). In contrast, murine, but not human, pDCs express Siglec H, B220 (CD45R), bone marrow stromal ...
... differences exist as human, but not murine, pDCs express the surface markers blood DC antigen (BDCA)-2 (CD303), BDCA-4 (CD304), immunoglobulin-like transcript 7 (ILT7), and the IL-3 receptor-a chain (CD123). In contrast, murine, but not human, pDCs express Siglec H, B220 (CD45R), bone marrow stromal ...
The Integumentary System - Sinoe Medical Association
... the body. It is rich in collagenous and elastic fibers. The part of the dermis underlying the epithelium is called the papillary layer. The deeper part is the reticular layer, in which sebaceous glands are found. In addition, hair follicles, sweat glands, and Pacinian corpuscles occur in this layer. ...
... the body. It is rich in collagenous and elastic fibers. The part of the dermis underlying the epithelium is called the papillary layer. The deeper part is the reticular layer, in which sebaceous glands are found. In addition, hair follicles, sweat glands, and Pacinian corpuscles occur in this layer. ...
(EGFR) in breast cancer - Romanian Journal of Morphology and
... metastases, and more frequently to systemic metastases. In our study, the expression of EGFR strongly correlates with the presence of systemic metastases and an inverse correlation was found with lymph node status. Tyrosine kinase inhibitors are effective anti-cancer therapies but resistance to thes ...
... metastases, and more frequently to systemic metastases. In our study, the expression of EGFR strongly correlates with the presence of systemic metastases and an inverse correlation was found with lymph node status. Tyrosine kinase inhibitors are effective anti-cancer therapies but resistance to thes ...
Original Research Article
... infiltration with large lymphoid follicles with germinal centres. In addition, if large thyroid cells having an acidophilic staining character called Hurthle or Askanazy cells are present, it is called Hashimotos Thyroiditis (HT). All patients with histological findings of AIT and with or without hi ...
... infiltration with large lymphoid follicles with germinal centres. In addition, if large thyroid cells having an acidophilic staining character called Hurthle or Askanazy cells are present, it is called Hashimotos Thyroiditis (HT). All patients with histological findings of AIT and with or without hi ...
Leukemia--Chronic Lymphocytic What is cancer?
... Each human cell contains 23 pairs of chromosomes. In most cases of CLL, a change can be found in at least one of these chromosomes. Most often this change is a deletion − that is, loss of part of a chromosome. The loss of part of chromosome 13 is the most common deletion, but other chromosomes such ...
... Each human cell contains 23 pairs of chromosomes. In most cases of CLL, a change can be found in at least one of these chromosomes. Most often this change is a deletion − that is, loss of part of a chromosome. The loss of part of chromosome 13 is the most common deletion, but other chromosomes such ...
Placental regulation of maternal-fetal interactions and
... and soluble factors in the local microenvironment. Signaling of cytokines, growth factors and hormones are central to the cross-talk between maternal and fetal cells in the placenta, dictating the gene expression changes that modulate their physiological functions. Also, the activation states of dec ...
... and soluble factors in the local microenvironment. Signaling of cytokines, growth factors and hormones are central to the cross-talk between maternal and fetal cells in the placenta, dictating the gene expression changes that modulate their physiological functions. Also, the activation states of dec ...
Chapter 43 Internal Defense
... the surface of an infected cell • A co-stimulatory signal and interleukins are also required • Activated TC cells multiply, giving rise to a clone Copyright © 2005 Brooks/Cole — Thomson Learning ...
... the surface of an infected cell • A co-stimulatory signal and interleukins are also required • Activated TC cells multiply, giving rise to a clone Copyright © 2005 Brooks/Cole — Thomson Learning ...
Document
... Anti-native DNA Fairly specific for SLE but present only in 60% of cases at best Titers correlate with disease activity Higher titers with nephritis ...
... Anti-native DNA Fairly specific for SLE but present only in 60% of cases at best Titers correlate with disease activity Higher titers with nephritis ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.