Pro- and anti-inflammatory actions in coronary artery disease with
... goal is to reveal basic mechanisms that will lead to the development of biomarkers, which may be used for individualized treatment and monitoring. The AnxA1 protein was constitutively expressed in both neutrophils and peripheral blood mononuclear cells (PBMCs). However, it varied considerably across ...
... goal is to reveal basic mechanisms that will lead to the development of biomarkers, which may be used for individualized treatment and monitoring. The AnxA1 protein was constitutively expressed in both neutrophils and peripheral blood mononuclear cells (PBMCs). However, it varied considerably across ...
AQUAPORINS IN INFECTION AND INFLAMMATION ANGELIKA HOLM
... When cells of the innate immune system encounter pathogens they need to respond and prepare for migration and phagocytosis and do so through volume regulatory processes. The Gramnegative bacterium Pseudomonas aeruginosa utilizes a small molecule-based communication system, called quorum sensing (QS) ...
... When cells of the innate immune system encounter pathogens they need to respond and prepare for migration and phagocytosis and do so through volume regulatory processes. The Gramnegative bacterium Pseudomonas aeruginosa utilizes a small molecule-based communication system, called quorum sensing (QS) ...
Z-DNA-specific Antibodies in Human Systemic
... Robert B. Brigham Division of the Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 A B S T R A C T Naturally occurring antibodies to lefthanded Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies ...
... Robert B. Brigham Division of the Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 A B S T R A C T Naturally occurring antibodies to lefthanded Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies ...
Differential Leukocyte Counts of SJL/J Mice with
... in defence against parasitic infections. Very small numbers of eosinophils are normally present in the circulation; most are in fact found in the tissues, especially connective tissues. Few eosinophils are produced in the absence of infection or other immune stimulation; but upon stimulation, there ...
... in defence against parasitic infections. Very small numbers of eosinophils are normally present in the circulation; most are in fact found in the tissues, especially connective tissues. Few eosinophils are produced in the absence of infection or other immune stimulation; but upon stimulation, there ...
Norepinephrine and octopamine - Invertebrate Survival Journal
... of immunosuppression, such as apoptosis, require an increase in energy expenditure (Dhabhar, 2002). At present there is little direct evidence supporting the ‘energy-crisis’ hypothesis (Adamo and Parsons, 2006). 2. The ‘resource crunch’ hypothesis. Animals make a number of physiological changes in o ...
... of immunosuppression, such as apoptosis, require an increase in energy expenditure (Dhabhar, 2002). At present there is little direct evidence supporting the ‘energy-crisis’ hypothesis (Adamo and Parsons, 2006). 2. The ‘resource crunch’ hypothesis. Animals make a number of physiological changes in o ...
Title Natural killer cells become tolerogenic after
... to induce tolerogenic properties of innate immune cells, including macrophages and dendritic cells, but not NK cells. In this study, we demonstrated that after interaction with ACs, NK cells released TGF-β1, which in turn suppressed the production of interferon (IFN)-γ by NK cells upon IL-12 and IgG ...
... to induce tolerogenic properties of innate immune cells, including macrophages and dendritic cells, but not NK cells. In this study, we demonstrated that after interaction with ACs, NK cells released TGF-β1, which in turn suppressed the production of interferon (IFN)-γ by NK cells upon IL-12 and IgG ...
Andrea Cerutti Regulation of B cell Responses by the Innate Immune System
... structures and biological processes that protect our body against disease. This protection involves the recognition and clearance of foreign agents also referred to as antigens that range from toxic molecules to complex microorganisms, including viruses, bacteria, fungi and parasites. In addition, t ...
... structures and biological processes that protect our body against disease. This protection involves the recognition and clearance of foreign agents also referred to as antigens that range from toxic molecules to complex microorganisms, including viruses, bacteria, fungi and parasites. In addition, t ...
N E W S L E T T E R - Australasian Society for Immunology
... has established novel strategies underpinning two vaccines which will go into Phase I clinical trials this year – a whole parasite vaccine for malaria and a synthetic peptide vaccine to prevent group A strep infection. The malaria project in the lab has a major goal of developing a whole parasite va ...
... has established novel strategies underpinning two vaccines which will go into Phase I clinical trials this year – a whole parasite vaccine for malaria and a synthetic peptide vaccine to prevent group A strep infection. The malaria project in the lab has a major goal of developing a whole parasite va ...
the complement system
... Proteins of the alternative pathway: The protein of the alternative pathway is designated by factor B, D, P, H and I. The serum concentration of these factors varies from 3 to 1500 μg/ml and molecular weight from 25 to 180 KD. In this, C3 retains its numerical notation as central component of the co ...
... Proteins of the alternative pathway: The protein of the alternative pathway is designated by factor B, D, P, H and I. The serum concentration of these factors varies from 3 to 1500 μg/ml and molecular weight from 25 to 180 KD. In this, C3 retains its numerical notation as central component of the co ...
"Magnesium should not be on the surface of Europa unless it`s
... A gene previously shown to be linked to obesity may also increase the risk of a deadly form of skin cancer, say researchers writing in Nature Genetics. Analysis of data from 73,000 people, led by the University of Leeds, found a specific section of the "fat gene" was associated with malignant melano ...
... A gene previously shown to be linked to obesity may also increase the risk of a deadly form of skin cancer, say researchers writing in Nature Genetics. Analysis of data from 73,000 people, led by the University of Leeds, found a specific section of the "fat gene" was associated with malignant melano ...
Novel pebbles in the mosaic of autoimmunity Open Access Carlo Perricone
... for infections [15]. Ramagopalan et al. [16] analyzed hospital admissions and death certificates across England, and found that the risk of tuberculosis (TB) is significantly increased in patients with immune-mediated diseases, highlighting the need for TB screening control and treatment policies in ...
... for infections [15]. Ramagopalan et al. [16] analyzed hospital admissions and death certificates across England, and found that the risk of tuberculosis (TB) is significantly increased in patients with immune-mediated diseases, highlighting the need for TB screening control and treatment policies in ...
Immunopathology of multiple sclerosis
... figure). Although axons and neurons are mostly preserved in early multiple sclerosis, ongoing disease results in gradual neuroaxonal loss that correlates with patient disability, and the brain atrophy that occurs is accompanied by ventricular enlargement (see the coronal view in the figure). Astrocy ...
... figure). Although axons and neurons are mostly preserved in early multiple sclerosis, ongoing disease results in gradual neuroaxonal loss that correlates with patient disability, and the brain atrophy that occurs is accompanied by ventricular enlargement (see the coronal view in the figure). Astrocy ...
Origin and evolution of the adaptive immune system: genetic events
... from separate genes, are present in multiple taxa; these short forms are believed to neutralize pathogens without activation of inflammatory responses. IgA is found first in reptiles and seems to serve the same functions in all animals. Interestingly, in lower taxa, other isotypes — for example, IgX ...
... from separate genes, are present in multiple taxa; these short forms are believed to neutralize pathogens without activation of inflammatory responses. IgA is found first in reptiles and seems to serve the same functions in all animals. Interestingly, in lower taxa, other isotypes — for example, IgX ...
28-29_Per_tolerance_Regulatory T-cells_LA
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
PDF
... be useful in stimulating an immune response against all HA types, however, this has yet to be proven. Antibodies against NA limit virus spread by inhibiting enzymatic activity and additionally by facilitating antibody-dependent cell-mediated cytotoxicity (ADCC). M2-specific antibodies are produced t ...
... be useful in stimulating an immune response against all HA types, however, this has yet to be proven. Antibodies against NA limit virus spread by inhibiting enzymatic activity and additionally by facilitating antibody-dependent cell-mediated cytotoxicity (ADCC). M2-specific antibodies are produced t ...
- 13th International Workshop on Langerhans Cells
... of the dendritic cell and its role in adaptive immunity" underlines the importance of dendritic cells. Dendritic cells, including epidermal skin Langerhans cells are considered to be master regulators for protective immunity and tolerance. Langerhans cell research is an established niche within re ...
... of the dendritic cell and its role in adaptive immunity" underlines the importance of dendritic cells. Dendritic cells, including epidermal skin Langerhans cells are considered to be master regulators for protective immunity and tolerance. Langerhans cell research is an established niche within re ...
Innate immunity: an integrated overview
... of differentiation 14, a co-receptor; CLR: c-type lectin receptors; CpG DNA: a DNA site, cytosine and guanine separated by one phosphate; CRD: conserved carbohydrate recognition domains; DAI: DNA-dependent activator of IFN-regulatory factors; DAMP: danger associated molecular patterns; DC: dendritic ...
... of differentiation 14, a co-receptor; CLR: c-type lectin receptors; CpG DNA: a DNA site, cytosine and guanine separated by one phosphate; CRD: conserved carbohydrate recognition domains; DAI: DNA-dependent activator of IFN-regulatory factors; DAMP: danger associated molecular patterns; DC: dendritic ...
Population dynamics of immune repertoires
... which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes from antigens. Strong antigenic recognition by mature lymphocytes generally triggers clonal expansion into effector and memory cells. These strong signals are usually ...
... which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes from antigens. Strong antigenic recognition by mature lymphocytes generally triggers clonal expansion into effector and memory cells. These strong signals are usually ...
Publication : Down syndrome and coexistent autoimmune
... trafficking and activation of leukocytes. Accordingly, cells with trisomy 21 have increased sensitivity to interferons (INFs) (Murphy et al. 1992). The enhanced vulnerability to INF-γ, the most potent interferon in the immune system produced by activated T cells, may cause increased expression of th ...
... trafficking and activation of leukocytes. Accordingly, cells with trisomy 21 have increased sensitivity to interferons (INFs) (Murphy et al. 1992). The enhanced vulnerability to INF-γ, the most potent interferon in the immune system produced by activated T cells, may cause increased expression of th ...
Diagnosis and treatment of patients with virus induced inflammatory cardiomyopathy U. Kühl
... If there is no history of virus-induced disease, then the observed clinical outcome is referred to as DCM. Persistent T-cell activation, induced by intrinsic myocardial antigens that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and es ...
... If there is no history of virus-induced disease, then the observed clinical outcome is referred to as DCM. Persistent T-cell activation, induced by intrinsic myocardial antigens that cross-react with viral peptides (molecular mimicry), may induce an inflammatory process that is not terminated and es ...
The NLRP12 Sensor Negatively Regulates Autoinflammatory
... NLRP12-Deficient Mice Develop Atypical EAE Disease To delineate the role of NLRP12 in the regulation of T-cell-driven autoimmune disease progression, we evaluated demyelinating neuroinflammatory disease in the experimental autoimmune encephalomyelitis (EAE) model. Given our initial observation that ...
... NLRP12-Deficient Mice Develop Atypical EAE Disease To delineate the role of NLRP12 in the regulation of T-cell-driven autoimmune disease progression, we evaluated demyelinating neuroinflammatory disease in the experimental autoimmune encephalomyelitis (EAE) model. Given our initial observation that ...
Analysis of Cell-Mediated Immune Responses in Support of Dengue
... subsets with cytokine profiles similar to several of the CD4 subsets listed in Table 1 have been described, ...
... subsets with cytokine profiles similar to several of the CD4 subsets listed in Table 1 have been described, ...
Immunology and Immunodeficiency for the Hematologist
... counts and CD19 counts. Thus b and c are incorrect. The overall white count is likewise elevated in infants, therefore d is wrong. Both the absolute lymphocyte count and absolute neutrophil count are higher, therefore e is wrong. 3. A newborn with a family history of X-linked severe combined immunod ...
... counts and CD19 counts. Thus b and c are incorrect. The overall white count is likewise elevated in infants, therefore d is wrong. Both the absolute lymphocyte count and absolute neutrophil count are higher, therefore e is wrong. 3. A newborn with a family history of X-linked severe combined immunod ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.