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Understanding Immunity: A Modeling Activity
Understanding Immunity: A Modeling Activity

the use of i NKT cell ligands as vaccine adjuvants Priyanka B
the use of i NKT cell ligands as vaccine adjuvants Priyanka B

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Big_Idea_2-4D_Immune_Response

... the body, most innate immune leukocytes cannot divide or reproduce on their own, but are the products of multipotent hematopoietic stem cells present in the bone marrow.  The innate leukocytes include: Natural killer cells, mast cells, eosinophils, basophils; and the phagocytic cells including macr ...
Chapter 43 Guided Reading
Chapter 43 Guided Reading

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Lecture 5 T Cell-Mediated Immunity

... Mechanisms that are used by the immune system to eliminate pathogens (or other substances) from the body Cellular effector mechanisms ...
Chapter 14 - Dr. Jennifer Capers
Chapter 14 - Dr. Jennifer Capers

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... several ways  Antibody can cross-link several antigens, making it easier to be ingested by phagocytic cells  Activate complement system resulting in lysis of microorganism ...
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The Immune System and Disease

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... ACTIVITY OF OTHER CELLS OF THE IMMUNE SYSTEM. • DEFENSE AGAINST: • BACTERIA AND VIRUSES THAT ARE INSIDE HOST CELLS AND ARE INACCESSIBLE TO ANTIBODIES. • FUNGI, PROTOZOA, AND WORMS ...
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Adaptive immunity - Dr. Jerry Cronin

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Saliva - Duplin County Schools
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... White Blood Cells ~T-Cells~ • T-Cells, often called “natural killer” cells, recognize infected human cells and cancer cells • T-cells will attack these infected cells, quickly kill them, and then continue to search for more cells to kill ...
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IMMUNOLOGY (Ms. Lucky Juneja)

... distinguish subtle differences among antigens.  Antibodies can distinguish between two protein molecules that differ in only a single amino acid.  The immune system is capable of generating tremendous diversity in its recognition molecules,allowing it to recognize billions of unique structures on ...
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... 16. Describe three differences between humoral and cell-mediated responses of the immune system to pathogen invasion. List the cells that are involved in each type of response. ...
Defense against Disease: White Blood Cells
Defense against Disease: White Blood Cells

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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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