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What`s hiding behind IgA nephropathy?
What`s hiding behind IgA nephropathy?

... entirely specific for Fabry´s disease • Long-term treatment with cationic amphiphilic drugs (chloroquine and amiodarone) • Chloroquine-induced lipidosis in the kidney is not so rare • Specific curvilinear inclusions in podocytes are not present in FD (Prof. Ferluga in his lecture, 23rd ECP, Helsinki ...
Immune - lymphatic system
Immune - lymphatic system

A138PN AFFINITY PURIFIED ANTIBODIES
A138PN AFFINITY PURIFIED ANTIBODIES

... 1: 10,000 by direct ELISA. Optimal working dilution must be determined by end user in their individual assay system. ...
Pattern Recognition with an AIS
Pattern Recognition with an AIS

... Affinity. The number of receptors that bind to pathogens will determine the affinity that the lymphocyte has for a given pathogen. If a bond is very likely to occur, then many receptors will bind to pathogen epitopes, resulting in a high affinity for that pathogen; if a bond is unlikely to occur, th ...
Disease Unit Review
Disease Unit Review

Immunity
Immunity

METABOLIC SYNDROME AND THE IMMUNE SYSTEM Authors
METABOLIC SYNDROME AND THE IMMUNE SYSTEM Authors

... increasing prevalence and morbidity associated affect health systems and quality of life of the people who have it. Its pathophysiology has not been fully explained because of complex biological processes and complex cellular interactions. However, epidemiological and clinical evidence suggest a mul ...
Innate Immunity: From Flies to Humans
Innate Immunity: From Flies to Humans

... Dr. Hoffmann’s research has focused on the development and the defence reactions of insects. Since 1990, he and his laboratory have explored the potent antimicrobial mechanisms of Drosophila as a paradigm for innate immune defences. In particular, the group is credited with having unravelled the rol ...
TB quick facts - WHO Western Pacific Region
TB quick facts - WHO Western Pacific Region

... since 2006 (from 9.4 million in 2009 to 8.8 million in 2010). • 46% of HIV-positive TB patients were enrolled on antiretrovirals and 77% started ...
Multiple sclerosis: a two-stage disease - CCIS
Multiple sclerosis: a two-stage disease - CCIS

Innate Immunity I
Innate Immunity I

tib4handout
tib4handout

... 3. Natural Killer Cells: NK cells may directly lyse some virus-infected cells without prior sensitization to the virus by failing to recognize the cell as normal self. Viruses can sometimes interfere with the ability of the infected cell to express MHC-I molecules. Without the signal from the kille ...
Development of Mouse Hybridomas by Fusion of Myeloma Cells
Development of Mouse Hybridomas by Fusion of Myeloma Cells

... the interstitial tissue fluid.(12) Different classes of lymphocytes (T and B cells) and nonlymphoid accessory cells (dendritic cells, macrophages) are sequestered in particular areas of the node. Follicles are the B cell–rich areas of lymph nodes and T cells are located in parafollicular areas. Most ...
The Immune System
The Immune System

... In localized allergies such as hay fever, IgE antibodies produced after first exposure to an allergen attach to receptors on mast cells ...
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus

... a normochromic, normocytic anemia is frequently found in SLE. They appears to be related to chronic inflammation, drug-related haemorrhage. haemolytic anemia due to presence of a serum ...
The Immune System - Sinoe Medical Association
The Immune System - Sinoe Medical Association

... When a localized area exhibits increased  capillary filtration, hyperemia, and swelling, this  is an indication of  a) Antigens are present b) Antibodies are phagocytizing target cells c) Inflammation is occurring d) An immune response is underway e) Fever is developing ...
"Immune System Clues: Understanding Cold Virus Protein May Help Transplant Patients"
"Immune System Clues: Understanding Cold Virus Protein May Help Transplant Patients"

... proteins that attack infections and kill them off. The problem with transplants is that the immune system recognizes the new tissues as foreign and attacks them. "Your immune system is walking a tight rope between fighting off an infection and causing too many problems," said Cooper, an associate pr ...
Concept check 31 - Plain Local Schools
Concept check 31 - Plain Local Schools

... B cells defend against bacteria and viruses by secreting antibiotics (humoral). T cells directly attack infected cells (cell-mediated immunity) 3. Explain why a second exposure to chicken pox does not usually result in illness. Memory B and T cells rapidly produce large number of plasma cells and cy ...
Antigen recognition in innate and adaptive immunity
Antigen recognition in innate and adaptive immunity

... Intracellular signalling molecules Dynamic region that forms rapidly to concentrate events into a tight junction between cells. Clustering of intracellular kinases or phosphatases ...
Biomolecular chemistry 5. What proteins do: catalysts and binders
Biomolecular chemistry 5. What proteins do: catalysts and binders

... system. An antigen is a substance capable of inducing a specific immune response. The term ‘antigen’ is derived from the generation of antibodies to such substances. • Often antigens are foreign proteins (or parts of them) that enter the body via an infection. Sometimes, however, the body's own prot ...
Viruses, HIV, and Aids
Viruses, HIV, and Aids

... HIV antiretroviral drug treatment is the main treatment for the disease. It is not a cure but it can stop people from getting sick for many years. The treatment consists of drugs that have to be taken every day for the rest of a person’s life. Antiretroviral treatment keeps HIV at a low level not al ...
Module 11 Notes
Module 11 Notes

Specific immune response
Specific immune response

... immune response as to eliminate antigens (microorganisms, transplants, tumour cells) in order to retain the molecular integrity and individuality of its own. Immune response – the complex of reactions mediated through lymphoreticular system that follow an invasion of the foreign antigen into the bod ...
MICROBIO320 EXAM 1-Fall 2009 Name 1 True/False (1 point each
MICROBIO320 EXAM 1-Fall 2009 Name 1 True/False (1 point each

... __F__ 2. The intrinsic pathway of programmed cell death relies on the death receptor called FAS. __F__ 3. Natural Killer cells proliferate in response to antigen. __F__ 4. In the 21st century, the leading cause of death in the United States is infectious disease. __T__ 5. MHC Class I molecules are f ...
APSpring14_142Q2Aans..
APSpring14_142Q2Aans..

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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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