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Central European Institute of Technology BRNO | CZECH REPUBLIC Jules A. Hoffmann Molecular and Cellular Biology Institut, CRNS, France Innate Immunity: From Flies to Humans Mendel Lecture May 21, 2015 Thursday, 17:00 – 18:00 Mendel Museum, Mendel Square Telecast Seminar room 114, pavilion A11 University campus Bohunice Visit our website HERE. Dr. Hoffmann’s research has focused on the development and the defence reactions of insects. Since 1990, he and his laboratory have explored the potent antimicrobial mechanisms of Drosophila as a paradigm for innate immune defences. In particular, the group is credited with having unravelled the role of Toll receptors in fighting infections. Hoffmann and Bruce Beutler were jointly awarded a half share of the 2011 Nobel Prize in Physiology or Medicine for "their discoveries concerning the activation of innate immunity". Hoffmann and Lemaitre discovered the function of the fruit fly Toll gene in innate immunity. Its mammalian homologs, the Toll-like receptors, were discovered by Beutler. Toll-like receptors identify constituents of other organisms like fungi and bacteria, and trigger an immune response, explaining, for example, how septic shock can be triggered by bacterial remains. www.ceitec.eu www.mendellectures.muni.cz Co-funded by the 7th Framework Programme of the European Union