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03. Cell Mediated Immunityx
03. Cell Mediated Immunityx

... unresponsiveness called “anergy” develops • Production of co-stimulatory protein depends on activation of the toll like receptor on antigen presenting cell • Foreign antigens such as bacterial proteins induce B7 protein where as self proteins do not ...
Ch. 19: Blood
Ch. 19: Blood

... ▫ “AB” (AB) ...
No Slide Title - Cal State LA
No Slide Title - Cal State LA

... Binding by this type of antigen somehow provides both signals that are required for B cell stimulation (by causing extensive cross-linking the surface antibodies?) The outcome from this type of stimulation is clearly different from that which occurs in T-dependent stimulation, since with the T-indep ...
Inadequate flow of oxygen into the respiratory system due to
Inadequate flow of oxygen into the respiratory system due to

... bacteria, viruses, and other foreign substances harmful to the body. ...
Vaccination ppt
Vaccination ppt

... (attenuated) and are unable to cause disease. • Dead micro-organisms. • Some part or product of the micro-organism that can produce an immune response. Vaccine production. ...
Immunity B1 1.9
Immunity B1 1.9

... immunity against a particular disease ...
phys chapter 35 [12-11
phys chapter 35 [12-11

... and will almost always continue to live normally and indefinitely if adequate blood supply provided  With xenografts, immune reactions almost always occur, causing death of cells in graft within 1 day to 5 weeks unless specific therapy used to prevent immune reactions  Tissues and organs that have ...
Vaccine Shows Response in Some Leukemia Patients Drug`s
Vaccine Shows Response in Some Leukemia Patients Drug`s

... the development of gastrointestinal stromal tumor (GIST), and Bcr-Abl kinase, which is involved in CML. The cumulative incidence of complete cytogenetic response in CML with imatinib therapy was 91%, according to a recent M. D. Anderson study led by Hagop Kantarjian, M.D., a professor in and chair o ...
32_Immune responses to viruses BA
32_Immune responses to viruses BA

... is still increasing, but seems to be reaching a maximum ...
BIOT 307 Kuby, Ch. 3, Antigens
BIOT 307 Kuby, Ch. 3, Antigens

... PROPERTIES DETERMINING IMMUNOGENICITY Foreignness or non-self • Non-self antigens are eliminated by recognition and response • lymphocytes that recognize self antigens are eliminated by inactivation • Antigens that are more foreign are more immunogenic ...
Dousing the Flames of Allergic Eye Disease
Dousing the Flames of Allergic Eye Disease

... hormone (TSH) receptor occurs that simulates the effect of TSH on its receptor thereby causing hyperthyroidism. • In myasthenia gravis antibodies to the acetylcholine receptor occurs and in pregnancy 20% of mothers have an infant affected by neonatal MG for 3 weeks. This is a transient myasthenia du ...
16. The Body`s Line of Defence
16. The Body`s Line of Defence

allergiy.eng
allergiy.eng

... Examples: skin rashes, serum sickness, glomerulonephritis. Delayed-type hypersensitivity ...
Asthma and immune dysregulation: A tale of antibodies “gone bad”
Asthma and immune dysregulation: A tale of antibodies “gone bad”

... Monoclonal antibodies specific for IgE have been proposed as adjunct treatment for severe (high-dose steroid-dependent) asthma. These targeted therapies are proposed as “steroidsparing” agents that might decrease the adverse immunological and endocrinological effects of long-term steroid use. High c ...
Immune Notes - The Lesson Locker
Immune Notes - The Lesson Locker

... Humoral immunity involves B cell activation and clonal selection and results in the production of antibodies that circulate in the blood plasma and lymph. a. Circulating antibodies defend mainly against free bacteria, toxins, and viruses in the body fluids. ...
Tumor immunity
Tumor immunity

... clones of neoplastic cells. In general, the immune response against tumor cells is weak and can be overcome experimentally by a large dose of tumor cells. Some tumor cells can escape surveillance by “modulation” (i.e., internalizing the surface antigen so that it no longer presents a target for immu ...
Ac-225 and her daughters: the many faces of Shiva
Ac-225 and her daughters: the many faces of Shiva

... which radioiodine or radioastatine are examples, are often rapidly excreted from the cell following catabolism 6 reducing the efficacy of the dose administered and increasing doses to non-target tissues such as the thyroid, stomach and urinary tract. The requirement for reliable sources of pure reac ...
The Lymphoid System and Immunity Overview Chapter 22
The Lymphoid System and Immunity Overview Chapter 22

Cells, Tissues and Organs of the Immune System
Cells, Tissues and Organs of the Immune System

... Purpose/function? • First line of defense= epithelial integrity= skin, mucosal surfaces • Defense against pathogens – Inside cells= kill the infected cell (Viruses) – Systemic= kill- Bacteria, Fungi, Parasites ...
RESPON IMUN TERHADAP INFEKSI
RESPON IMUN TERHADAP INFEKSI

...  Contain a surface protein called CD4  Regulate both cellular and humoral immune systems  This regulation reduces autoimmunity. ...
Immune System
Immune System

Immune System
Immune System

... Receptor proteins on the cytotoxic T cells (TC) bind to viral antigens displayed by infected cells Cytotoxic T cells (TC) punch a hole in the cell’s membrane Your body produces many cytotoxic T cells (TC) - each specific to a particular antigen ...
BONE MARROW FAILURE SYNDROMES
BONE MARROW FAILURE SYNDROMES

... Maj Gen (R) Masood Anwar ...
Autoimmune Diseases
Autoimmune Diseases

... CD25+FoxP3+ CD4+T cells block the effect of autoimmune responses mediated by autoreactive T cells. This blocking may or may not require the secretion of suppressive cytokines such as TGF and IL-10. Some autoimmune diseases appear to correlate with the compromised function of regulatory T cells. Suc ...
Cells of the Immune System-I
Cells of the Immune System-I

... 1. Lymphocytes are the key players of the adaptive immunity. 2. Lymphocytes are able to specifically recognize and respond to diverse antigens. => Antigen (Ag) receptors on lymphocytes => Specificity (Clone), Diversity (Repertoire: total number of Ag-specific lymphocytes in an individual; 107-9), & ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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