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1 - What a Year!
1 - What a Year!

... treated? Lyme disease is an infection caused by the Borrelia burgodorferi bacteria transmitted by deer ticks. Initially the disease causes a characteristic rash in the shape of a bullseye in around 80 percent of infected people. Symptoms can include flu-like symptoms, muscle pain, and joint stiffnes ...
UNIT 5 NOTES Communication Between Unicellular Organisms
UNIT 5 NOTES Communication Between Unicellular Organisms

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Positive or Negative Involvement of Heat Shock Proteins in Multiple
Positive or Negative Involvement of Heat Shock Proteins in Multiple

... and bypass the peripheral activation mechanism. This additional type of activation makes T cells the main actors in the epitope-spreading process. Cumulative data indicate that, after the CNS is damaged, sensitization to other antigens may also arise, contributing to the development of chronic disea ...
a stochastic model of the immune system in two
a stochastic model of the immune system in two

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A Transgenic Mouse Strain with Antigen
A Transgenic Mouse Strain with Antigen

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How HIV Defeats the Immune System
How HIV Defeats the Immune System

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gp allergy 310713

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Canine Herpesvirus-1: A New Pathogenic Role for an Old Virus

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the involvement of innate immunity in development of autism

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What`s in your DNA?

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Topic Number Nine-Antibiotics mode of action and mechanisms of

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Can We Selectively Shut Off Immune Responses?

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Vaccines for Ebola

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... The spleen is, like the lymph nodes, a discriminatory filter. Unlike the lymph nodes, the spleen is inserted into the blood stream. The spleen clears the blood of aged blood cells and foreign particles and is the site of immune reactions to blood-borne antigens. The spleen is not essential to life i ...
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Supplementary Information (doc 107K)

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Targeting of immune signalling networks by bacterial pathogens

... with their targets, using several key examples. Immune signalling pathways as scale-free networks Global analyses of protein–protein interactions in several experimental systems have revealed that biological systems show properties of scale-free networks21. Components of the networks are defined as ...
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and Factor H on fungal surface. Complement evasion Immune

... The first defensive cells that inhaled conidia The conidia are internalized by the macrophages and prevented from growth for several hours until the macrophage begins to destroy them. At 24 h after internalization, 90% of the conidia are killed. The conidia then germinate to hyphae The hyphae are to ...
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Flu, Flu Vaccines, and Why We Need to Do Better

... A feature of all living things is their ability to replicate (make copies of ­themselves). The cells that make up your body are constantly making copies of themselves to replace the ones that get washed, scratched, or rubbed away. Replication is a carefully controlled process and requires an instruc ...
The Gell–Coombs classification of hypersensitivity reactions: a re
The Gell–Coombs classification of hypersensitivity reactions: a re

type_III_and_IV_HS_r..
type_III_and_IV_HS_r..

... 1- CD8+ CTLs specific for an antigen recognize cells expressing the target antigen and kill these cells. 2- Class I MHC molecules bind to intracellular peptide antigens and present the peptides to CD8+ T lymphocytes, stimulating the differentiation of these T cells into effector cells called CTLs. 3 ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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