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The Staphylococci123.5 KB
The Staphylococci123.5 KB

... responsible for human disease with streptococcus among gram-positive cocci “enteric cocci” Possess the group D cell wall antigen 16 species in the genus E. faecalis & E. faecium are most commonly isolated ...
Mendelian traits causing susceptibility to mucocutaneous fungal
Mendelian traits causing susceptibility to mucocutaneous fungal

... Candida species, primarily Candida albicans, which are commensal yeasts in the orogastrointestinal flora of healthy subjects, are the most prevalent opportunistic pathogens in patients with PIDs. Some Candida species, including Candida albicans, can either grow as unicellular yeast or as branching f ...
Immune response and virus population composition: HIV as a case
Immune response and virus population composition: HIV as a case

ICI 2016 SUNDAY 21 August 2016
ICI 2016 SUNDAY 21 August 2016

... 2847: Protective Efficacy of TuberculosisSpecific T Cell Immunity in the Lung After Aerosol Delivery of Adenoviral Vaccines in Nonhuman Primates Patricia Darrah ...
Replication-Competent Recombinant Porcine Reproductive and
Replication-Competent Recombinant Porcine Reproductive and

EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOID MALIGNANCIES
EPSTEIN-BARR VIRUS-ASSOCIATED LYMPHOID MALIGNANCIES

... EBV-infected cells to evade CTL.10) Although EBV latency patterns can be classified grossly into these four types, this classification is not very strict, and heterogeneous patterns are reported in EBV-associated diseases.24, 25) Patterns of viral gene expression can differ between different cell su ...
The role of nitric oxide in the regulation of adaptive immune responses
The role of nitric oxide in the regulation of adaptive immune responses

Full Text PDF - Journal of Innovations in Pharmaceutical and
Full Text PDF - Journal of Innovations in Pharmaceutical and

... tuberculosis has led to a search for novel drug targets. We have performed an in silico comparative analysis of metabolic pathways of the host Homo sapiens and the pathogen M. tuberculosis. Current therapy targets for TB treatment are based on the inhibiting of main proteins: the fatty-acid enoyl-ac ...
Engineering the Immune System to Recognize Myeloma Cells
Engineering the Immune System to Recognize Myeloma Cells

... 1. Patient’s T cells are harvested and then engineered in a lab to be able to identify specific surface markers on MM cells 2. These engineering T cells are then stimulated in a lab to make them more active and to proliferate and grow • Infused, MM-directed T cells directly kill MM cells and stimula ...
Mutation and Control of the Human Immunodeficiency Virus
Mutation and Control of the Human Immunodeficiency Virus

... Tens of millions of people have been infected by the human immunodeficiency virus (HIV) since it was first recognized in the early 1980s, and more than 20 million have died from ensuing disease [1]. The virus attacks CD4-presenting cells – helper T cells, macrophages, dendritic cells, eosinophils, mic ...
Mechanisms of Maternal Immune Tolerance During
Mechanisms of Maternal Immune Tolerance During

MHC structure, function: Why can be the MHC molecules considered
MHC structure, function: Why can be the MHC molecules considered

Golli Protein Negatively Regulates Store Depletion
Golli Protein Negatively Regulates Store Depletion

... the myelin basic protein (mbp) gene, plays in the regulation of store depletion-induced Ca2+ entry into T cells. The mbp gene encodes two families of structurally related proteins generated through alternative splicing (i.e., classic MBPs and golli-MBPs, as shown in Figure S1; see the Supplemental D ...
View PDF
View PDF

2016 Detailed Program
2016 Detailed Program

... 2847: Protective Efficacy of TuberculosisSpecific T Cell Immunity in the Lung After Aerosol Delivery of Adenoviral Vaccines in Nonhuman Primates Patricia Darrah ...
Induction of immune responses in sheep by vaccination with
Induction of immune responses in sheep by vaccination with

Improving the clinical development of immunotherapies
Improving the clinical development of immunotherapies

... the most interest. This represents an exciting and rapidly developing field, but understanding which patients will benefit most remains uncertain. It is not yet clear in all tumor types whether these drugs can be used to treat all patients or need to be targeted to selected populations, using precis ...
immune system - Bio-Inspired Artificial Intelligence
immune system - Bio-Inspired Artificial Intelligence

... • We say that a detector D equipped with receptors of type r recognizes an antigen a if d(a, r) is below a certain threshold θ. – The value of the threshold determines the specificity of the detector – The region of shape space thus defined is the recognition region of D ...
Immunogerontology Ed`s update
Immunogerontology Ed`s update

... Old people are more likely to be sick than young people. You’ll be told this means that the immune system weakens as part of normal aging. But white cell total and differential counts and lymphoid tissue morphology in healthy old folks are identical to those of healthy young adults. So the weakening ...
Systemically dispersed innate IL-13–expressing cells in type 2
Systemically dispersed innate IL-13–expressing cells in type 2

... infections at mucosal barriers and the development of allergic inflammation. These responses are characterized by eosinophilia, elevated IgE, goblet cell metaplasia with enhanced mucus production, and smooth muscle hyperreactivity, all of which rely critically on production of the canonical type 2-as ...
Full Text Article - European Journal of Biomedical and
Full Text Article - European Journal of Biomedical and

... differentiation of CD4+ T cells while suppressing Th1 differentiation through independent pathways that IL-6 promotes allergic airway inflammation.[14][15] and could also influence lung physiology by promoting an increase in airway wall thickness, subepithelial fibrosis and smooth muscle hypertrophy ...
Inflammation Regulation Drug Traumeel
Inflammation Regulation Drug Traumeel

... Purposeful: This term is extremely important in the homotoxicological definition of disease. It means that the reaction of the defense system will be in proportion to the needs to reach the target. This encompasses every regulation aspect homotoxicology is referring to. Mobilization of defense will ...
Natural killer cell deficiency - Journal of Allergy and Clinical
Natural killer cell deficiency - Journal of Allergy and Clinical

... viruses.8 Many viruses have evolved strategies to evade the cytotoxic T lymphocyte (CTL) response by specifically downregulating class I MHC in the infected cell.9 Although this allows the virus to prevent its host cell from presenting viral protein–derived peptides to virus-specific CTLs, it also m ...
MicroRNAs of the immune system - Laboratory of Lymphocyte Biology
MicroRNAs of the immune system - Laboratory of Lymphocyte Biology

... be critical for a particular biologic process. Alternatively, there are hints that a particular miRNA may target multiple components that belong to a common regulatory pathway;45 therefore, the impact of miRNA control of a process may be additive and much more important than the moderate effects on ...
Factors Regulating Immunoglobulin Production by Normal and
Factors Regulating Immunoglobulin Production by Normal and

... initial response to infection. Others migrate into the follicles where they form GCs [16]. GCs are scaffolded with follicular dendritic cells (FDCs). These follicular dendritic cells function as Ag presenting cells (APCs) and provide cytokine and chemokine signals along with a special subset of T-ce ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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