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Bacterial Cell Walls as Revealed by the Specific Cell
Bacterial Cell Walls as Revealed by the Specific Cell

Immune Cell Responses to the Cattle Lungworm, Dictyocaulus
Immune Cell Responses to the Cattle Lungworm, Dictyocaulus

... moult and develop to young adults, which migrate up through the bronchial tree as they mature. Mature adult worms are macroscopic, up to 8 cm long, and the females produce eggs that hatch almost immediately into first stage larvae (L1). The L1 are coughed up from the lungs, swallowed down, and can b ...
RECEPTOR TYROSINE KINASES AND THE REGULATION OF
RECEPTOR TYROSINE KINASES AND THE REGULATION OF

... expression of SOCS1 and SOCS3 in a Stat3-dependent manner[50, 51] and studies of SOCS1 -/mice have demonstrated that SOCS1 is a critical regulator of both IFN-γ and LPS signaling in vivo[52, 53], while SOCS3 appears to prevent IFN-γ-like responses in cells stimulated with IL6[54, 55]. Several RTKs ...
Osteoarthritic articular chondrocytes stimulate autologous T cell
Osteoarthritic articular chondrocytes stimulate autologous T cell

... OA, various proteins derived from cartilage or chondrocytes, e.g. collagens and proteoglycans, are recognized as being a target of specific immune responses in OA patients (6-8). More recently, we found that cartilage intermediate layer protein (CILP), a protein with increased expression in older pe ...
Arthritis an autoimmune disorder: Demonstration of In
Arthritis an autoimmune disorder: Demonstration of In

... In the normal knee jo int, the synovium consists of a synovial membrane (usually one or two cells thick) and underlying loose connective tissue. Synovial-lin ing cells are designated type a (macrophage-like synoviocytes) or type B (fibroblast-like synoviocytes). Arthritis is an auto immune disorder ...
Perpetuation of immunological memory
Perpetuation of immunological memory

... very special situations leading to the presentation of exogenous antigens by major histocompatibility complex (MHC) class I6 or CD1 molecules.7 A theoretical, all comprehensive, `peptidic self' model has been proposed for the working of the immune system, in which immunological memory forms a subset ...
Immunity and how vaccines work
Immunity and how vaccines work

Toll-like receptors and human pathology
Toll-like receptors and human pathology

CONNECTIVE TISSUE
CONNECTIVE TISSUE

... B. dense connective tissue 1. dense irregularly arranged connective tissue (DIACT) - fibrous tissue with fewer cells (cells are mostly fibroblasts) - collagen fibers are bundles, without definite orientation - found in dermis, prostate, mammary glands, outer capsule of many organs 2. dense regularly ...
Principles of Asepsis - McGraw Hill Higher Education
Principles of Asepsis - McGraw Hill Higher Education

... pathogens (microorganisms capable of causing disease) have developed ways to evade the host defenses. There are pathogens in each classification of microorganism. Some examples of these are given in Table 1-2. Additional discussion about microorganisms and disease will be covered later in this chapt ...
Effect of Antigen/Antibody Ratio on Macrophage
Effect of Antigen/Antibody Ratio on Macrophage

Characteristics Of Living Organisms
Characteristics Of Living Organisms

... called “specific” because a new immune response arises each time a new pathogen is introduced. Also known as the acquired immune response. if non-specific defences fail, specific defences begin. If successful, the 3rd line of defence leads to acquired immunity many foreign invaders have specific pro ...
EBV infection B cells and lymphomagenesis
EBV infection B cells and lymphomagenesis

... – Initiates transcription of LMPs and increases transcription of various cellular genes – Mimics the intracellular notch signalling pathway • EBNA3 and LP: regulate EBNA2 functions ...
Vaccines – current status and future needs
Vaccines – current status and future needs

Synergistic Communication between CD4+ T Cells and Monocytes
Synergistic Communication between CD4+ T Cells and Monocytes

The hepatitis C virus enigma
The hepatitis C virus enigma

Sequential follow up observations of a patient with rubella
Sequential follow up observations of a patient with rubella

... with a synthetic peptide which may represent a neutralisation domain on rubella virus El protein. The absence of detectable antibody by this technique, despite the observation of levels of antibody directed to other rubella virus structural proteins as shown by immunoblot, suggests that the patient ...
File
File

... 2. Briefly describe how a cell that has been infected by a virus can be recognized and destroyed. Write your answer in the space below. ANS: Macrophages contact infected cells and release interleukin-1. This protein activates helper T cells that secrete another protein, interleukin-2. This substance ...
Self Antigens Expressed by Solid Tumors Do Not Efficiently
Self Antigens Expressed by Solid Tumors Do Not Efficiently

... 19). Since such antigens are expressed only in selected tissues and/or at low levels they may be less accessible for lymphocytes, but it is still possible that autoimmune disease may occur if CTLs are activated for therapeutic purposes. Nonetheless, if tissue-specific self antigens were used as targ ...
Immunity in the female sheep reproductive tract
Immunity in the female sheep reproductive tract

S. aureus infection
S. aureus infection

... anatomic structure and function ...
Biopharmaceuticals: an overview
Biopharmaceuticals: an overview

Immunization
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... Hypersensitivity disorder – involves allergic response and tissue rejection ...
The Immune System
The Immune System

... • Antibody changes an antigen, rendering it harmless to the body. The antibody accomplishes this by binding to the antigen, forming an antigen– antibody complex. – Complement fixation ...
Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot C. Jafari*, M. Ernst
Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot C. Jafari*, M. Ernst

... with other pulmonary pathologies. In active PTB, antigenspecific T-cells are, therefore, expanded among other lymphocytes in the lungs, and it is possible that most of the lymphocytes found at the site of infection in PTB are, indeed, not MTB-specific. The limitations of the present study need to be ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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