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When Is a Genome Project Finished?
When Is a Genome Project Finished?

... Match the correct term with each definition or select the best answer for each question. 1. A series of codons from a single strand of DNA sequence which can be "read" in three different ways, depending on whether one starts at the first nucleotide position, the second or third Reading Frame (RF) Al ...
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Location and Characterization of the Bovine Herpesvirus Type 2

... as defined by Kozak (1987) there is an A at position - 3 which results in 60 to 90~o of the translation efficiency obtained by a perfect Kozak sequence (Kozak, 1987). Apart from the disease caused by BHV-2 this virus is also of interest as it is one of the few nonhuman herpesviruses whose D N A bear ...
American Scientist Online
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... however, has been quite low. For one thing, the host's immune system registers the adenoviral vector as foreign and eliminates it from the system. In addition, some of the vectors cause an inflammatory response at the high levels required to achieve therapeutic doses. One of the most promising vehic ...
mobile genetic elements and cancer. from mutations to gene therapy
mobile genetic elements and cancer. from mutations to gene therapy

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GenomeAnnot - Nematode bioinformatics. Analysis tools and data
GenomeAnnot - Nematode bioinformatics. Analysis tools and data

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File

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Alison Keiper - The Progress of Gene Therapy
Alison Keiper - The Progress of Gene Therapy

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FILLED BY VECTOR CORE PROJECT: RECEIVED: LOT

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Guidance for Working with Viral Vectors
Guidance for Working with Viral Vectors

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retrovirus
retrovirus

... disease to be confident that the gene transfer will have the desired effect • Appropriate regulation of the gene expression: tissue specific and levels • Appropriate target cell with either a long half life or high replicative potential • Adequate data from tissue culture and animal studies to suppo ...
SNC4M Unit 2 – Pathogens and Disease Viruses – an overview
SNC4M Unit 2 – Pathogens and Disease Viruses – an overview

... lymphoma, chicken pox, Colorado tick fever, dengue, encephalitis, genital warts, gastroenteritis, genital herpes, German measles, hepatitis, influenza, leukemia, liver cancer, measles, mononucleosis, mumps, oral herpes, polio, rabies, shingles, smallpox, virus hemorrhagic fever, warts , yellow fever ...
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Adeno-associated virus



Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease. The virus causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell, although in the native virus some integration of virally carried genes into the host genome does occur. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Recent human clinical trials using AAV for gene therapy in the retina have shown promise.AAV belongs to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. The virus is a small (20 nm) replication-defective, nonenveloped virus.
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