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The Human Genome Project
The Human Genome Project

... What we’ve learned from our genome so far… • There are a relatively small number of human genes, less than 30,000, but they have a complex architecture that we are only beginning to understand and appreciate. -We know where 85% of genes are in the sequence. -We don’t know where the other 15% are be ...
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Can the process of advanced retinal degeneration

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Is it ethical to use gene therapy to cure genetic
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... A desired gene is selected and inserted into a genome to replace an “abnormal”, disease-causing gene. The genome is then transferred into a vector, most commonly an adenovirus, which will transport the gene into the patient. The vector is sent to a target cell in the patient’s genome and then “unloa ...
GTRC Declaration
GTRC Declaration

... (c) must not code for a toxin with an LD50 of 100 g/kg or more, if the intention is to express the toxin at high levels; and (d) must not be uncharacterised nucleic acid from a toxin-producing organism; and (e) must not include a viral sequence, unless the donor nucleic acid: (i) is missing at leas ...
Reproductive Technology
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viruses - biology3u
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Ebola lol
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REGISTRATION DOCUMENT FOR RECOMBINANT DNA RESEARCH
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Penn rDNA Registration Forms
Penn rDNA Registration Forms

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Binary Vectors
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Life Under a Microscope: Viruses Questions
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... have a living cell to do its work. A virus attaches to a cell. It finds a way to get its genetic material into the cell. The virus's genetic material lets the virus take control of the cell. It turns the cell into a virus factory. The cell stops doing its normal work and begins making copies of the ...
CDC select agent survey form
CDC select agent survey form

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REN Ee Chee
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... We have developed a model for infecting liver cancer cells using a HBV replicon under the control of the native viral promoter. Using this system we have identified a host liver factor – hnRNP K – that regulates HBV replication. A naturally occurring base substitution (SNP) in the viral core promote ...
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Adeno-associated virus



Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease. The virus causes a very mild immune response, lending further support to its apparent lack of pathogenicity. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell, although in the native virus some integration of virally carried genes into the host genome does occur. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Recent human clinical trials using AAV for gene therapy in the retina have shown promise.AAV belongs to the genus Dependoparvovirus, which in turn belongs to the family Parvoviridae. The virus is a small (20 nm) replication-defective, nonenveloped virus.
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