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What Makes the “Blue” in Blueberries?
What Makes the “Blue” in Blueberries?

... • Localizes to recently replicated DNA in mitotically cycling and endocycling cells ...
Clustered alignments of gene-expression time series data
Clustered alignments of gene-expression time series data

... – a one-channel time series : the expression profile of a single gene a multi-channel time series : the expression profile of a set of genes The only difference between these two cases is in how the correlations are calculated. – COW is apt to align segments which differ greatly in magnitude. ...
forever young: a gene facilitating the study of the third larval instar of
forever young: a gene facilitating the study of the third larval instar of

... publication in preparation), we discovered two alleles of the gene forever young (genetic symbol fey). When balanced over TM6B, Tb e, homozygous fey larvae are identifiable by their Tb+ phenotype. Tubby (Tb) causes short, thick individuals; the phenotype is visible in larvae, pupae and adults. fey 1 ...
Low X/Y divergence in four pairs of papaya sex
Low X/Y divergence in four pairs of papaya sex

... library is particularly challenging. We used the genomic resources of a recently developed papaya unigene database and whole-genome shotgun (WGS) sequences for this purpose. Papaya’s MSY DNA sequences were used to search the unigene set of 8571 genes derived from five cDNA libraries of male, female ...
Patterns of Segmental Duplication in the Human Genome
Patterns of Segmental Duplication in the Human Genome

... divided into 500-kb segments and Blasting was performed on all-against-all segments using the default parameters. In this study, we were interested in examining duplications with size  1 kb and sequence similarity  90%; we did not consider older duplications, because they are more difficult to def ...
S3 Text.
S3 Text.

... parameters, i.e. 3-V for Test Cases 1 and 3, and 3-E for Test Case 2. For a given number of clusters, the mixture model will assign a score (the Bayesian Information Criterion, BIC) that reflects how likely this specific model fits the data. In Fig 3., we show the BIC scores assigned by the differen ...
Gene Expression Profiles and Microarray Data Analysis - BIDD
Gene Expression Profiles and Microarray Data Analysis - BIDD

... • mRNA expression represents dynamic aspects of cell • mRNA expression can be measured by latest technology • mRNA is isolated and labeled with fluorescent protein • mRNA is hybridized to the target; level of hybridization corresponds to light emission which is measured with a laser ...
Supplementary Information
Supplementary Information

software development and application in bioinformatics: single
software development and application in bioinformatics: single

... detection. I present some of the most popular and most used applications with a brief evaluation (strengths and weakness) of each one. The outcome can either be used as a guide for choosing the most appropriate application for SNP detection project at hand, or as a guiding resource for developing a ...
- American Diabetes Association
- American Diabetes Association

... and interleukin-2 receptor, have been discovered. When combined with a susceptible genetic background, largely unknown random environmental factors probably contribute to the breakdown of self-tolerance. For instance, dietary factors, such as early exposure to foreign complex proteins (2) and vitami ...
Deletion Upstream of the Human a Globin
Deletion Upstream of the Human a Globin

... blood count showed a hypochromic microcytic anemia in the absence of iron deficiency. H b electrophoresis showed normal proportions of HbA, (2.7%) and H b F (1.1%). A diagnosis of a-thalassemia was confirmed by demonstrating HbH inclusions in the peripheral red blood cells (RBCs) and a reduced a/B g ...
pdf file - Department of Statistics
pdf file - Department of Statistics

... significance of all 4096 possible hexamers, the null hypothesis being that the hexamer is not an ESE. A statistic was formed based on the location of the hexamers in 4817 human genes where the exon-intron structure has been well characterized. The end product is a p-value associated with each of th ...
iGenetics: A Molecular Approach, 3e (Russell/Bose)
iGenetics: A Molecular Approach, 3e (Russell/Bose)

... raw material for framing an extensive array of hypotheses about gene and genome function, integration, and evolution. This is a good example of how descriptive knowledge is a necessary first step in understanding biological systems. Skill: Conceptual understanding 48) Sequencing the dog genome is cu ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... Fitch algorithm can be carried out in a number of operations that is proportional to the number of species (tips) on the tree. Don‘t we need to multiply this by the number of sites n ? Any site that is invariant (which has the same base in all species, e.g. AAAAA) can be dropped. Other sites with a ...
Dynamics of insertion sequence elements during experimental
Dynamics of insertion sequence elements during experimental

... load of IS-mediated deleterious mutations, with the difference being whether horizontal transfer of the elements, or selection of beneficial mutations generated by the elements, is the main force responsible for maintaining them in genomes. The field of evolutionary biology has long been interested ...
PDF
PDF

... homonomous - though there is at present no way of knowing where to place that ancestor on the phylogenetic tree. We do question whether homonomy is generally a primitive trait among extant arthropods. In an environment where it is useful for all segments to have legs, this adaptive change may be rel ...
Evolutionary population genomics
Evolutionary population genomics

... Field enclosure experiment (3x3) Stocking with 90 lab-reared, marked individuals (lake, stream, F1 hybrid) Tracking of survival by recapture over 29 weeks ...
Coexpression of Linked Genes in Mammalian
Coexpression of Linked Genes in Mammalian

... among coexpressed neighboring genes (Spellman and Rubin 2002). In humans, clusters of coexpressed linked genes that belong to the same functional category, as defined by GO, are rare (Fukuoka et al. 2004). Furthermore, although the evolutionary conservation of linkage between coexpressed genes in se ...
Arsenite as an Electron Donor for Anoxygenic Photosynthesis
Arsenite as an Electron Donor for Anoxygenic Photosynthesis

... respectively. The arxA gene is aligned more closely with arrA yet is comparatively distant from aioA, implying an evolutionary relationship with the former but not the latter [12]. Ectothiorhodospira strain PHS-1 also lacks the aio gene cluster but contains arx genes (including arxA) in a similar ar ...
PDF
PDF

... acting at different times and always in the same sequence. At first, such a model seems to be in contradiction to some observations that suggest that, in some systeffiS, posterior body parts can regenerate anterior portions (e.g.Slack, 1980). However, it is not clear whether, in these particular cas ...
PHI-Canto video tutorial slides - PHI-base
PHI-Canto video tutorial slides - PHI-base

... curation team ...
Malate dehydrogenase and glucose-6
Malate dehydrogenase and glucose-6

E.Publication
E.Publication

... learn a great deal more, at a much faster pace. They are figuring out how genes work to do what they do. And they are uncovering the functions of specific genes. These discoveries are teaching us a great deal about the genetic instructions that construct and operate the human body. This new informat ...
Toxicity Mechanisms Identification via Gene Set
Toxicity Mechanisms Identification via Gene Set

... analysis of high-dimensional toxicogenomics data, such as time series data, faces a great challenge, however, since most current techniques are mainly designed for the analysis of biological system snapshots.13 The commonly used pathway analysis techniques, such as the gene set enrichment analysis ( ...
Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers
Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers

... two markers on the Z chromosome (birds are female-heterogametic with a ZZ/ZW sex chromosome system) were found to be fixed for the Spanish sparrow allele in one case (CHD1Z) and nearly fixed for the house sparrow allele in the other (PLAA), indicating strong mosaicism on the Z chromosome not paralle ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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