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... – Lack of high quality example sentences: training sentences are sentences written by the FlyBase curators to explain their database decisions. – Domain bias: only sentences about Drosophila melanogaster are used for training the GS. => have problems on summarizing other organisms’ genes. ...
Potential alteration of U37K paleothermometer due to selective
Potential alteration of U37K paleothermometer due to selective

... were sequenced by GATC Biotech AG (Konstanz, Germany). The partial sequences were aligned with the same region of the closest-relative strains available in the GenBank database using BLAST (http://blast.ncbi.nlm.nih.gov/). Sequence alignment was achieved using CLUSTALW (Thompson et al., 1994). The p ...
Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers
Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers

... two markers on the Z chromosome (birds are female-heterogametic with a ZZ/ZW sex chromosome system) were found to be fixed for the Spanish sparrow allele in one case (CHD1Z) and nearly fixed for the house sparrow allele in the other (PLAA), indicating strong mosaicism on the Z chromosome not paralle ...
How do I identify exon number with the UCSC Genome Browser
How do I identify exon number with the UCSC Genome Browser

... [1:11] If you’re interested to know which exon you are at if you are in a zoomed position where you can only see one or a few exons, let’s go there first by clicking on the region and dragging it to the right or left to highlight the area. We will zoom into this region and now we can see by the stri ...
PA ALKF-[FY]-[STA]-[STAD]-[VM]
PA ALKF-[FY]-[STA]-[STAD]-[VM]

... extraordinary depth of detail about a given entry, 3-D structure (PDB), protein motifs (Prosite), families of related genes (Pfam), the DNA sequence (EMBL) and a couple of specialist E.coli added-value databases. SRS is one program that makes these hypertext links. All these databases are made up of ...
Extent of Gene Duplication in the Genomes of
Extent of Gene Duplication in the Genomes of

... Gene family clustering is a difficult problem for two reasons. First, domain shuffling, which is a common mode for protein evolution, might mislead the clustering of two nonhomologous proteins into the same family because of the shared domain alone. Second, deciding whether two proteins are homologo ...
Diplosporous development in Boehmeria tricuspis: Insights
Diplosporous development in Boehmeria tricuspis: Insights

Mitonuclear linkage disequilibrium in human populations
Mitonuclear linkage disequilibrium in human populations

... factors such as mitochondrial and nuclear mutation rates, effective population size, mating system, generation time and population subdivision [55–59]. There is some reason to think that mitonuclear co-adaptation within human populations may be less extensive because of recent demographic expansion ...
“The Genetics of Depression and Related Traits,” by Patricia Huezo
“The Genetics of Depression and Related Traits,” by Patricia Huezo

... assortment, resulting in them being inherited together. The closer together the loci are, the less likely they are to be separated by cross-overs of chromosomes at meiosis (recombination). Essentially, the aim of standard linkage analysis is to show that a disease and a genetic marker co-segregate w ...
Phylogeny, taxonomy, and evolution of the endothelin receptor gene
Phylogeny, taxonomy, and evolution of the endothelin receptor gene

... positions point to those sites that are most likely responsible for the functional differences between protein groups (Gaucher et al., 2002). In the LRT of site-specific evolutionary rates, the aligned EDNRA and EDNRB for all species were separately removed from their full multiple sequence alignment ...
Computational Biology
Computational Biology

... These clusters, or CpG islands, are targets for proteins that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patte ...
Conservation and Coevolution in the Scale
Conservation and Coevolution in the Scale

... expressed (expression breadth) and total level of expression were determined (see Materials and Methods). These values were compared to several measures of humanmouse orthologous gene sequence divergence: the synonymous (dS) and nonsynonymous (dN) protein-coding sequence substitution rates as well a ...
nCounter PanCancer Pathways Panel
nCounter PanCancer Pathways Panel

... Studying the deregulation of molecular pathways impacted by mutational events as well as monitoring expression of these driver genes is critical to gaining a complete understanding of the biology underlying cancer. Molecular pathways are an attractive organizing principle for analysis of gene expres ...
21 principles of genetics
21 principles of genetics

Combining Whole-exome and RNA-Seq Data Improves the Quality
Combining Whole-exome and RNA-Seq Data Improves the Quality

The costs of immunity and the evolution of immunological defense
The costs of immunity and the evolution of immunological defense

Discovery of Muscle Atrophy Gene Regulatory Network Using
Discovery of Muscle Atrophy Gene Regulatory Network Using

... Brandon King Gilberto Hernandez, M.D. ...
The ISME Journal
The ISME Journal

... be very densely colonized by these organisms (Figure 1) and it can be assumed that many microbes are associated with epiphytes rather than with the host plant. Bacterial communities on leaves are limited by nutrient availability and it is known that mainly simple sugars, which leach from the interio ...
Is there a genetic susceptibility to engage in criminal acts?
Is there a genetic susceptibility to engage in criminal acts?

... This brief paper summarises this evidence. Recent twin studies show persuasive evidence that both genetic and environmental factors contribute to antisocial behaviour. However the genetic evidence indicates that there is no single gene, or even a small number of genes, that predict an increased risk ...
Expression analysis of a chicory fructan 1‐exohydrolase gene
Expression analysis of a chicory fructan 1‐exohydrolase gene

... approach was used to clone the 1149 nt promoter fragment of FEHIIa (Michiels et al., 2003b). After obtaining the sequence for the HE-TAIL-PCR product, two gene-speci®c primers ±1149 HindIII-for (5¢-GTAAGCTTCGCAGACCTCTATCCATATATTAGTTC-3¢) and ATGKpnI-rev (5¢-AAAGGTACCTCTTCATGATGAGTGTGTGTGTTTGG-3¢) we ...
srep09383-s1
srep09383-s1

... Strains and plasmids, used in this study are listed in Tables S1 and S2. B. subtilis 1779 was isolated from marine sediment sample collected from the Red Sea during our 2010 research cruise. All Bacillus and Escherichia coli strains used in this study were routinely grown on solid Luria-Bertani (LB, ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... The exons were then lined up continuously without gaps to be used as the exon-data-set for filter analysis. 2.2 Proposed Numerical Representation Since digital signal processing deals with analysis of numerical sequences, various approaches for numerical representation of genomic data and subsequent ...
Supplemental File 1 - Poly(A) Tag (PAT) analysis pipeline The
Supplemental File 1 - Poly(A) Tag (PAT) analysis pipeline The

... used for this project are listed in the table at the end of this document. After sequencing, the first bases read will be the “NN”, followed by the bar code, the oligo-dT tract, and finally the cDNA sequence. A. Demultiplex and trim The raw data, downloaded in fastq format (available in Bioproject P ...
(2) in ppt - NYU Computer Science
(2) in ppt - NYU Computer Science

... 90 humans, 1 SNP (A=0.48) ...
Molecular function - SGD-Wiki - Saccharomyces Genome Database
Molecular function - SGD-Wiki - Saccharomyces Genome Database

... History and background How to stay current Basic org. (homepage, search, LSP) Tabs, access to detailed info (sequence, gene ontology, phenotype, interaction, expression and regulation) • Data analysis: GO tools, YeastMine basics and use-cases ...
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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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