2013 Holiday Lectures on Science Medicine in the Genomic Era
... After sequencing Tasha’s genome, scientists sequenced the genomes of many dogs from a variety of breeds, comparing them to one another. They identified millions of common variations among these genomes and ...
... After sequencing Tasha’s genome, scientists sequenced the genomes of many dogs from a variety of breeds, comparing them to one another. They identified millions of common variations among these genomes and ...
X chromosome gene expression in human tissues
... genes that apparently escape X inactivation. We compared the expression of X-linked genes with autosomal genes and among different tissues. In each tissue, about 13% of our analyzed Xlinked genes demonstrated greater than 1.5-fold change in expression between males and females; most were genes not p ...
... genes that apparently escape X inactivation. We compared the expression of X-linked genes with autosomal genes and among different tissues. In each tissue, about 13% of our analyzed Xlinked genes demonstrated greater than 1.5-fold change in expression between males and females; most were genes not p ...
Full-Text PDF
... large subunit (on the complementary strand). It can be involved in the regulation of transcription or in post-transcriptional modifications of rRNA. HCE 299. The mitochondrial nad2 and nad7 genes have opposite orientations and close positions in Oligohymenophorea; each of them starts a long operon. ...
... large subunit (on the complementary strand). It can be involved in the regulation of transcription or in post-transcriptional modifications of rRNA. HCE 299. The mitochondrial nad2 and nad7 genes have opposite orientations and close positions in Oligohymenophorea; each of them starts a long operon. ...
this PDF file - Trends in Pharmaceutical Sciences
... analyses, 295 representative taxa were chosen for final tree construction. These sequences are well conserved and allowed the selection of 369 aligned amino acid positions for analysis. The resulting unrooted phylogenetic tree is shown in Figure 1. The prokaryotic part of the tree is not congruent w ...
... analyses, 295 representative taxa were chosen for final tree construction. These sequences are well conserved and allowed the selection of 369 aligned amino acid positions for analysis. The resulting unrooted phylogenetic tree is shown in Figure 1. The prokaryotic part of the tree is not congruent w ...
The Evolution of CONSTANS-Like Gene Families
... of a gene family with 17 members that are subdivided into three classes, termed Group I to III here. All members of the family have a CCT (CO, CO-like, TOC1) domain near the carboxy terminus. Group I genes, which include CO, have two zinc finger B-boxes near the amino terminus. Group II genes have o ...
... of a gene family with 17 members that are subdivided into three classes, termed Group I to III here. All members of the family have a CCT (CO, CO-like, TOC1) domain near the carboxy terminus. Group I genes, which include CO, have two zinc finger B-boxes near the amino terminus. Group II genes have o ...
Genetic Control of Meat Quality Traits
... These are major welfare problems as well as threatening productivity. In addition, the inadvertent selection for genetic defects linked to desirable production characteristics is a potential risk, especially when selection programes focus on a limited number of breeding individuals. The traits that ...
... These are major welfare problems as well as threatening productivity. In addition, the inadvertent selection for genetic defects linked to desirable production characteristics is a potential risk, especially when selection programes focus on a limited number of breeding individuals. The traits that ...
We need an optimality criterion to choose a best estimate (tree
... How strongly is a phylogenetic hypothesis supported by the data? Bootstrap replicates generate new data sets by randomly sampling from the actual data, with replacement. These new data sets should contain phylogenetic signal similar to that in the original data. A high percentage of replicates (75%+ ...
... How strongly is a phylogenetic hypothesis supported by the data? Bootstrap replicates generate new data sets by randomly sampling from the actual data, with replacement. These new data sets should contain phylogenetic signal similar to that in the original data. A high percentage of replicates (75%+ ...
Constitutive Mutations of the Saccharomyces
... pMAL64R10 transformants under noninduced conditions is twice that under induced conditions, andtwice that observed in transformants carrying the inducible MALG? allele (plasmid YCpMAL63) grown in maltose. This is likely due to glucose repression resulting from the potentially high levels of intracel ...
... pMAL64R10 transformants under noninduced conditions is twice that under induced conditions, andtwice that observed in transformants carrying the inducible MALG? allele (plasmid YCpMAL63) grown in maltose. This is likely due to glucose repression resulting from the potentially high levels of intracel ...
Mutations in a member of the ADAMTS gene family cause
... locus, providing considerably greater genetic power than would be available from analysis of the clinical phenotype alone. ...
... locus, providing considerably greater genetic power than would be available from analysis of the clinical phenotype alone. ...
TAN Huarong
... and sequenced from Streptomyces ansochromogenes. Disruption of sanG abolished nikkomycin biosynthesis. This phenotype was complemented by a single copy of sanG which was integrated into the chromosome. Like most pathway-specific transcriptional regulatory gene, the introduction of multiple copies of ...
... and sequenced from Streptomyces ansochromogenes. Disruption of sanG abolished nikkomycin biosynthesis. This phenotype was complemented by a single copy of sanG which was integrated into the chromosome. Like most pathway-specific transcriptional regulatory gene, the introduction of multiple copies of ...
TimeClust: a clustering tool for gene expression time series
... TimeClust refer to genes involved in the human cell cycle. The data were collected by Whitfield et al. and are described in [1]. Original data are available for download at the site http://genome-www.stanford.edu/Human-CellCycle/Hela. Whitfield et al. performed different experiments in which they us ...
... TimeClust refer to genes involved in the human cell cycle. The data were collected by Whitfield et al. and are described in [1]. Original data are available for download at the site http://genome-www.stanford.edu/Human-CellCycle/Hela. Whitfield et al. performed different experiments in which they us ...
Allele- and parent-of-origin-specific effects on expression of the
... Our results are consistent with those from other studies in humans (Locke et al., 2015), in which the KCNJ11 gene was found to be in allelic imbalance in beta cells. Even though this pattern is consistent between both species comparing different tissues, the observed pattern may vary within tissues ...
... Our results are consistent with those from other studies in humans (Locke et al., 2015), in which the KCNJ11 gene was found to be in allelic imbalance in beta cells. Even though this pattern is consistent between both species comparing different tissues, the observed pattern may vary within tissues ...
Sample Chapter 3 (PDF, 30 Pages
... Identifying even a single gene is a daunting task; biologist Joseph Levine and geneticist David Suzuki (1993) once compared it to searching for someone when all you know is that the person lives somewhere on earth. However, new technologies now allow scientists to survey hundreds of thousands of “le ...
... Identifying even a single gene is a daunting task; biologist Joseph Levine and geneticist David Suzuki (1993) once compared it to searching for someone when all you know is that the person lives somewhere on earth. However, new technologies now allow scientists to survey hundreds of thousands of “le ...
S010
... are located in introns of protein-coding genes. In these cases, the microRNA and the protein-coding mRNA are processed from the same transcript. Similarly, around a third of animal microRNAs are located in close proximity in the genome to other microRNAs. Here, one transcript may be processed to pro ...
... are located in introns of protein-coding genes. In these cases, the microRNA and the protein-coding mRNA are processed from the same transcript. Similarly, around a third of animal microRNAs are located in close proximity in the genome to other microRNAs. Here, one transcript may be processed to pro ...
Document
... 1.1 Background Next generation parallel sequencing technologies make m6A-specific methylated RNA immunoprecipitation followed by sequencing a popular strategy to study transcriptome-wide RNA modifications, while creating challenges for analysis , especially in peak-finding. However, there have been ...
... 1.1 Background Next generation parallel sequencing technologies make m6A-specific methylated RNA immunoprecipitation followed by sequencing a popular strategy to study transcriptome-wide RNA modifications, while creating challenges for analysis , especially in peak-finding. However, there have been ...
Restriction Fragment Length Polymorphism of hsp70
... Previous studies from our laboratory have demonstrated that the intermediate phenotype of thermosensitivity is present in hypertensive mice and rats. Increased expression of hsp70 caused by increased transcription rate was demonstrated in vivo, in organs, and in cultured cells from spontaneously hyp ...
... Previous studies from our laboratory have demonstrated that the intermediate phenotype of thermosensitivity is present in hypertensive mice and rats. Increased expression of hsp70 caused by increased transcription rate was demonstrated in vivo, in organs, and in cultured cells from spontaneously hyp ...
Inferring Process from Pattern In Fungal Population Genetics 3
... versus single sporulation. The goals would be to predict or measure the fitness of pathogen genotypes and to determine the effects of specific pathogen genotypes on the fitness of host genotypes (see also: Antonovics and Kareiva 1988; Brunet and Mundt 2000). McDonald (1997) reviewed genetic markers ...
... versus single sporulation. The goals would be to predict or measure the fitness of pathogen genotypes and to determine the effects of specific pathogen genotypes on the fitness of host genotypes (see also: Antonovics and Kareiva 1988; Brunet and Mundt 2000). McDonald (1997) reviewed genetic markers ...
Archaeal phylogenomics provides evidence in support of a
... the informational genes is less ambiguous, displaying an almost exclusively archaeal ancestry, the identification of the precise archaeal lineage involved remains elusive. Previous studies have shown that several eukaryotic informational genes, such as DNA pol D [6], ...
... the informational genes is less ambiguous, displaying an almost exclusively archaeal ancestry, the identification of the precise archaeal lineage involved remains elusive. Previous studies have shown that several eukaryotic informational genes, such as DNA pol D [6], ...
Target selected insertional mutagenesis on chromosome IV of
... In order to further establish a system that could be used in reverse genetics screens in Arabidopsis, to complement the already available T-DNA populations, we used a modified two component maize Enhancer– Inhibitor (En– I or Spm– dSpm) transposable element system. A stable transposase locus T-En5, ...
... In order to further establish a system that could be used in reverse genetics screens in Arabidopsis, to complement the already available T-DNA populations, we used a modified two component maize Enhancer– Inhibitor (En– I or Spm– dSpm) transposable element system. A stable transposase locus T-En5, ...
A New Sequencing Primer and Workflow Increase 5` Resolution and
... High quality and high accuracy are the hallmarks of Sanger resequencing projects. We have developed a new sequencing primer and workflow that improves 5’ sequence resolution, increases throughput, and reduces hands-on time. The novel sequencing primer chemistry produces high quality bases from base ...
... High quality and high accuracy are the hallmarks of Sanger resequencing projects. We have developed a new sequencing primer and workflow that improves 5’ sequence resolution, increases throughput, and reduces hands-on time. The novel sequencing primer chemistry produces high quality bases from base ...
Autosomal monoallelic expression in the mouse
... variation beyond the phenotypic variation dictated by genotypic variation. Thus, it is important to take into account random monoallelic expression when examining genotype-phenotype correlation. ...
... variation beyond the phenotypic variation dictated by genotypic variation. Thus, it is important to take into account random monoallelic expression when examining genotype-phenotype correlation. ...
Using gene networks to drug target identification
... methods with increasing depth of inference, such as cluster analysis [36,37], correlation statistics analysis [38,39], weight matrices [40,41], neural networks [42], genetic algorithms [43], and supervised learning algorithms [44]. For the purpose of capturing the interrelated regulatory mechanisms ...
... methods with increasing depth of inference, such as cluster analysis [36,37], correlation statistics analysis [38,39], weight matrices [40,41], neural networks [42], genetic algorithms [43], and supervised learning algorithms [44]. For the purpose of capturing the interrelated regulatory mechanisms ...
—1— User Guide © Copyright 2009 Robert C. Edgar, all rights
... each chromosome. This process is called a cycle. The output from one cycle can be used as input to another cycle. It is generally better to run many short cycles rather than one or a few long cycles as longer cycles are less biologically accurate. This is because, viewed as operators that transform ...
... each chromosome. This process is called a cycle. The output from one cycle can be used as input to another cycle. It is generally better to run many short cycles rather than one or a few long cycles as longer cycles are less biologically accurate. This is because, viewed as operators that transform ...
