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Journal of Molecular Biology
Journal of Molecular Biology

... genes phoB and phoK of the Eschrrichin coli K-12 pho regulon have been cloned using two types of selection. The genes were localized on one of the hybrid plasmids, pJP,50. by analysis of mutant, plasmids generat,ed by Tn5 insertions. Restriction mappmg of the other plasmid, pPRX0, indicated that the ...
Käfer, E. and D.  Luk
Käfer, E. and D. Luk

... Results for UV, mitomycin C (MC) and HIS are summarized in Table 1. All new mutants were found to be cross-sensitive to some mutagenic agents and are, therefore, likely to be defective in DNA repair rather than uptake or metabolism of MMS. Most of the mutants listed in Tables 1 and 2 have been induc ...
Evolution by the birth-and-death process in multigene
Evolution by the birth-and-death process in multigene

... MHC loci, heterozygotes for all these loci should have substantial selective advantage over homozygotes. Evidence supporting overdominant selection is also increasing (19, 31). In recent years a number of authors (19, 32) presented evidence that new alleles can be created by interallelic recombinati ...
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli

... positions on the chromosomes of different strains. In contrast, P-fimbrial determinants may be located in different regions on the chromosomes of extra-intestinal E. coli isolates. Very often the genetic determinants of P or P-related fimbriae are linked to gene clusters coding for hemolysin (hly), ...
Cloning, DNA nucleotide sequence and distribution
Cloning, DNA nucleotide sequence and distribution

... mAb, designated 69/25, bound specifically to a fimbrialike structure, designated SEFA, but not to type 1 fimbriae, which were also present on the cell surface of S. enteritidis. Analysis o f the fimbrial antigen indicated a fimbrial subunit of M , 14300 (Thorns et al., 1990). Three discrete fimbrial ...
Genomic Screening for Artificial Selection during Domestication and
Genomic Screening for Artificial Selection during Domestication and

- Genetics
- Genetics

... We cannot estimate frequencies of alleles at most of the PAR loci studied, because the phase of variants is generally not known. Therefore we cannot directly test whether alleles differ in frequencies between the sexes. Instead, we used Tajima’s D, which can detect an excess of intermediate frequenc ...
The molecular evolution of development
The molecular evolution of development

... cies patterns of conservation and change in developmental regulatory gene expression and attempting to correlate these with morphological differences between taxa.(3,4) This developmental genetic approach is complemented by efforts among evolutionary geneticists who study the molecular evolution of ...
Mechanisms of Nucleolar Dominance in Animals and Plants
Mechanisms of Nucleolar Dominance in Animals and Plants

... laevis ribosomal DNA is dominant even though the egg supplies all the stored transcription machinery that is used when the ribosomal genes first turn on in early development. A maternal effect is observed, however, when X. laevis animals carrying the anucleolate deletion (which deletes at least 95% ...
Elimination of Markings - Huzulen im Club Hucul Austria
Elimination of Markings - Huzulen im Club Hucul Austria

... champions, are active and have a high mating rate - that’s to say reproduction takes place on a limited basis of genes. Well known this also accelerates the increment of the inbred factor. When breeding for “preservation” it is much more important to have as much stallions of fair quality as possibl ...
Low diversity in the major histocompatibility complex class II DRB1
Low diversity in the major histocompatibility complex class II DRB1

... PCR-RFLP and sequence analyses of the Capy-DRB1 gene in three subspecies of the SI allowed us to detect six distinct alleles (Genbank accession numbers AF461692AF46196 and AY351788). One of these DRB1 alleles (Capy-DRB1.6) was found only in CPV whereas two other alleles (Capy-DRB1.4 and Capy-DRB1.5) ...
Tutorial - 1000 Genomes
Tutorial - 1000 Genomes

... SNPs are color-coded; the nucleotide changes for each SNP position are annotated at the bottom of the page. Below the reference transcript track is a track of ALL SNPs, including dbSNP SNPs, and SNPs discovered in all individuals sequenced in the 1000 Genome project so far. Many SNPs in this track a ...
12864_2008_1659_MOESM3_ESM
12864_2008_1659_MOESM3_ESM

... sequence similarity, we assume that YWHAB spawned the retrogene YWHAH. The latter covers all of the exons (no corresponding introns) of the parent gene and has been preserved from fish to mammals. After the retroposition event, YWHAG probably was derived from YWHAH, or vice versa, by segmental dupli ...
PowerPoint-presentatie - the biopsychology research group
PowerPoint-presentatie - the biopsychology research group

... Recent data suggest that copy number variants (CNVs) can contribute to complex disease susceptibility. The relative impact of CNVs compared to single nucleotide polymorphisms (SNPs) on one of the processes underlying disease vulnerability, variable gene expression, has been estimated at 18% (1). The ...
Phylogenetic Analysis of Low-Pathogenicity Avian Influenza
Phylogenetic Analysis of Low-Pathogenicity Avian Influenza

... in September 2002, and OSZA03N158 (II[g]) from ostriches near Johannesburg in March 2003. Analysis of the peptide sequences surrounding the NA stalk region (data not shown) indicated that sublineage I viruses all contained a 22–amino acid deletion in the stalk region, which was absent from sublineag ...
Informed Consent for Prenatal Diagnosis by
Informed Consent for Prenatal Diagnosis by

... procedure. Therefore, most miscarriages that happen after having an amniocentesis would have happened anyway. 5) I understand that there is less than a 1 in 100 (1%) chance that the doctor may not be able to get enough amniotic fluid from the first try and may have to try a second time. Sometimes ev ...
REVIEW Why Do Bacterial Plasmids Carry Some Genes and Not
REVIEW Why Do Bacterial Plasmids Carry Some Genes and Not

... In addition, both gall and root nodule bacteria have an alternate habitat (free in the soil outside of host plants). Different strains differ in their abilities to survive and compete with other bacteria in different soil types, and plasmid genes are known to be responsible for some of these differe ...
Uniprot - European Bioinformatics Institute
Uniprot - European Bioinformatics Institute

... • Ensembl and UniProt collaboration to cover the gaps in gene predictions in UniProtKB (one sequence for each protein coding transcript in Ensembl) • Ensembl high quality gene/transcript models (quality checks remove gene models with erroneous structures or supported by dubious evidence – e.g. cDNA ...
papaya X-specific BACs monoica corresponding
papaya X-specific BACs monoica corresponding

... (XX), and hermaphrodite (XYh) individuals. Close relative Vasconcellea monoica, which diverged from a shared common ancestor with papaya 6.8-14.7 mya, is monoecious, having separate male and female flowers on a single individual, with the lack of sexual dimorphism, signifying the absence of sex chro ...
Genetics Notes PDF
Genetics Notes PDF

... January 18, 2017 ...
Similarities and differences of gene expression in yeast stress
Similarities and differences of gene expression in yeast stress

... Motivation and Methods: All living organisms and the survival of all cells critically depend on their ability to sense and quickly adapt to changes in the environment and to other stress conditions. We study stress response mechanisms in Saccharomyces cerevisiae by identifying genes that, according ...
A forkhead-domain gene is mutated in a severe speech and
A forkhead-domain gene is mutated in a severe speech and

... In addition to the forkhead domain, the FOXP2 protein also contains a stretch of 40 consecutive glutamines followed by a second stretch of only 10 glutamines. Abnormal expansion of variable polyglutamine tracts has been implicated in several hereditary neurodegenerative disorders30. The polyglutamin ...
View Full Text-PDF
View Full Text-PDF

... sterile transport medium, after obtaining due permission from the concerned health authorities. Samples collected were immediately transported to the laboratory and processed. ...
Article The Pseudoautosomal Regions of the U/V Sex
Article The Pseudoautosomal Regions of the U/V Sex

Association genetics of complex traits in conifers
Association genetics of complex traits in conifers

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Pathogenomics

Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world. Until recently, it has been difficult to compile information to understand the generation of pathogen virulence factors as well as pathogen behaviour in a host environment. The study of Pathogenomics attempts to utilize genomic and metagenomics data gathered from high through-put technologies (e.g. sequencing or DNA microarrays), to understand microbe diversity and interaction as well as host-microbe interactions involved in disease states. The bulk of pathogenomics research concerns itself with pathogens that affect human health; however, studies also exist for plant and animal infecting microbes.
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