Imprinting evolution and the price of silence
... Uniparental disomies (UPDs) result when an individual inherits two copies of the same chromosome or subchromosomal region from only one parent. The karyotype of these individuals appears normal since they are diploid, but because of the uniparental chromosome inheritance, they can exhibit problems n ...
... Uniparental disomies (UPDs) result when an individual inherits two copies of the same chromosome or subchromosomal region from only one parent. The karyotype of these individuals appears normal since they are diploid, but because of the uniparental chromosome inheritance, they can exhibit problems n ...
Exome sequencing as a tool for Mendelian disease gene discovery
... parent–child transmission patterns) and extreme phenotypes (to increase efficiency, FIG. 2d). In families in which multiple individuals are affected with a common trait, one approach is to sequence the most distally related individuals: the more distantly related the individuals, the fewer genetic v ...
... parent–child transmission patterns) and extreme phenotypes (to increase efficiency, FIG. 2d). In families in which multiple individuals are affected with a common trait, one approach is to sequence the most distally related individuals: the more distantly related the individuals, the fewer genetic v ...
Antibacterial Resistance and Antibiotic Use in Animals
... Approaches to confront the antibiotic resistance situation: The emergence of antimicrobial resistance among human and veterinary bacterial pathogens is a serious crisis and several strategies have been proposed to try to circumvent and control this dilemma. Prevention should be the ultimate goal an ...
... Approaches to confront the antibiotic resistance situation: The emergence of antimicrobial resistance among human and veterinary bacterial pathogens is a serious crisis and several strategies have been proposed to try to circumvent and control this dilemma. Prevention should be the ultimate goal an ...
Comparative Metagenomic Analysis Reveals Mechanisms for Stress
... and the projections of climate-change-related expansion of arid ecosystems (Pointing and Belnap 2012). It is currently unclear how changing environmental conditions in desert ecosystems will affect microbial functionality. For example, the extent to which climate change may change the ecological str ...
... and the projections of climate-change-related expansion of arid ecosystems (Pointing and Belnap 2012). It is currently unclear how changing environmental conditions in desert ecosystems will affect microbial functionality. For example, the extent to which climate change may change the ecological str ...
Clin Infect Dis. - Repositorio Académico UPC
... Several epidemiological studies from developing countries have been conducted in children to determine age-related differences in diarrheagenic E. coli infections [7, 13–19]. Similar to these studies, we found a relationship between age and symptoms. Our analysis showed that, in children ,12 months ...
... Several epidemiological studies from developing countries have been conducted in children to determine age-related differences in diarrheagenic E. coli infections [7, 13–19]. Similar to these studies, we found a relationship between age and symptoms. Our analysis showed that, in children ,12 months ...
Professor Anthony Monaco - AWARES, the All Wales Autism Resource
... abnormalities associated with autism. • Familial clustering of autism is well above the normal population prevalence. • Twin based studies. ...
... abnormalities associated with autism. • Familial clustering of autism is well above the normal population prevalence. • Twin based studies. ...
14.1 The lacI Gene Encodes a Diffusible Repressor
... Now that we have an understanding of the lac operon, let’s consider one of the experimental approaches that was used to elucidate its regulation. In the 1950s, Jacob, Monod, and their colleague Arthur Pardee had identified a few rare mutant strains of bacteria that had abnormal lactose adaptation. O ...
... Now that we have an understanding of the lac operon, let’s consider one of the experimental approaches that was used to elucidate its regulation. In the 1950s, Jacob, Monod, and their colleague Arthur Pardee had identified a few rare mutant strains of bacteria that had abnormal lactose adaptation. O ...
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... dye, and hybridized to the homologous sequences on the human X (Glas et al., 1999) (Figure 2C). However, a large region (equivalent to the rest of the short arm and including the pseudoautosomal region) is autosomal in marsupials and monotremes, implying that it was added to the placental X between ...
... dye, and hybridized to the homologous sequences on the human X (Glas et al., 1999) (Figure 2C). However, a large region (equivalent to the rest of the short arm and including the pseudoautosomal region) is autosomal in marsupials and monotremes, implying that it was added to the placental X between ...
The evolution of selfing from outcrossing ancestors in Brassicaceae
... responsible for mating system evolution. This approach was made possible by the discovery of the molecular determinants of plant mating systems, in particular in several families exhibiting homomorphic self-incompatibility (SI; Takayama & Isogai, 2005; Charlesworth, 2010). Indeed, the S-locus exhibi ...
... responsible for mating system evolution. This approach was made possible by the discovery of the molecular determinants of plant mating systems, in particular in several families exhibiting homomorphic self-incompatibility (SI; Takayama & Isogai, 2005; Charlesworth, 2010). Indeed, the S-locus exhibi ...
The evolution of selfing from outcrossing ancestors in Brassicaceae
... responsible for mating system evolution. This approach was made possible by the discovery of the molecular determinants of plant mating systems, in particular in several families exhibiting homomorphic self-incompatibility (SI; Takayama & Isogai, 2005; Charlesworth, 2010). Indeed, the S-locus exhibi ...
... responsible for mating system evolution. This approach was made possible by the discovery of the molecular determinants of plant mating systems, in particular in several families exhibiting homomorphic self-incompatibility (SI; Takayama & Isogai, 2005; Charlesworth, 2010). Indeed, the S-locus exhibi ...
Identification of a Novel Streptococcal Gene
... and YqjH of Bacillus subtilis (19, 62) and SACOL1400 of Staphylococcus aureus (16), there is little functional data on UmuC-like proteins from gram-positive bacteria. Thus, it remains to be determined which of the gram-positive orthologs identified in silico (45) are indeed functional homologs of E. ...
... and YqjH of Bacillus subtilis (19, 62) and SACOL1400 of Staphylococcus aureus (16), there is little functional data on UmuC-like proteins from gram-positive bacteria. Thus, it remains to be determined which of the gram-positive orthologs identified in silico (45) are indeed functional homologs of E. ...
TEACHING NOTE
... Several student projects are possible. Two examples are: 1. Determining if the genes are linked. The recombinant frequency (RF) is quite variable, depending on background, but its Usually between 30 and 50%. A null hypothesis of independent assortment can be tested. 2. Comparison of recombination fr ...
... Several student projects are possible. Two examples are: 1. Determining if the genes are linked. The recombinant frequency (RF) is quite variable, depending on background, but its Usually between 30 and 50%. A null hypothesis of independent assortment can be tested. 2. Comparison of recombination fr ...
W0=2, a stable aneuploid derivative of Candida
... Some early studies suggested that most isolates contained many balanced recessive lethal mutations (Whelan & Soll, 1982) and hence that diploidy was obligatory and that haploidy or even significant aneuploidy would not be possible. Evidence against this view was provided by the experiments of Barton ...
... Some early studies suggested that most isolates contained many balanced recessive lethal mutations (Whelan & Soll, 1982) and hence that diploidy was obligatory and that haploidy or even significant aneuploidy would not be possible. Evidence against this view was provided by the experiments of Barton ...
Multiple domestications of Asian rice
... Huang and Han1 also contend that the presence of similar haplotypes, including identical coding sequences, in cultivated groups for loci such as sh4 and PROG1 argues against multiple domestication. In our Supplementary Information2 we explained how selection of similar haplotypes that are geographic ...
... Huang and Han1 also contend that the presence of similar haplotypes, including identical coding sequences, in cultivated groups for loci such as sh4 and PROG1 argues against multiple domestication. In our Supplementary Information2 we explained how selection of similar haplotypes that are geographic ...
Document
... such selection ought to be very week. In fact, it may be so week that random genetic drift would dominate the evolutionary dynamics of codon substitution in species with a small effective population size, whereas selection would be the dominant force in species with ...
... such selection ought to be very week. In fact, it may be so week that random genetic drift would dominate the evolutionary dynamics of codon substitution in species with a small effective population size, whereas selection would be the dominant force in species with ...
Species matter: the role of competition in the assembly of
... bacterial community assembly has gone undetected at least partly because overly broad measures of bacterial diversity units were used in previous studies. First, we tested our hypothesis in a simulation where we showed that how species are defined can dramatically affect whether phylogenetic overdis ...
... bacterial community assembly has gone undetected at least partly because overly broad measures of bacterial diversity units were used in previous studies. First, we tested our hypothesis in a simulation where we showed that how species are defined can dramatically affect whether phylogenetic overdis ...
Your Genes, Your Choices
... At the same time, you have traits, or ways of looking, thinking, and being, that you share with some other people on earth. For example, you may look like your father or share your mother’s sense of humor. You also have traits that you share with every other person on earth. For example, every perso ...
... At the same time, you have traits, or ways of looking, thinking, and being, that you share with some other people on earth. For example, you may look like your father or share your mother’s sense of humor. You also have traits that you share with every other person on earth. For example, every perso ...
Trichoderma reesei RUT-C30 – thirty years of strain
... From that time to the present day, RUT-C30 has been used as a paradigm for developing processes for the production of cellulolytic enzymes (Olsson et al., 2003; Bailey & Tähtiharju, 2003; Juhász et al., 2004; Singhania et al., 2007), engineering of hypercellulolytic strains (e.g. Collén et al., 2 ...
... From that time to the present day, RUT-C30 has been used as a paradigm for developing processes for the production of cellulolytic enzymes (Olsson et al., 2003; Bailey & Tähtiharju, 2003; Juhász et al., 2004; Singhania et al., 2007), engineering of hypercellulolytic strains (e.g. Collén et al., 2 ...
Journal of Molecular Biology
... genes phoB and phoK of the Eschrrichin coli K-12 pho regulon have been cloned using two types of selection. The genes were localized on one of the hybrid plasmids, pJP,50. by analysis of mutant, plasmids generat,ed by Tn5 insertions. Restriction mappmg of the other plasmid, pPRX0, indicated that the ...
... genes phoB and phoK of the Eschrrichin coli K-12 pho regulon have been cloned using two types of selection. The genes were localized on one of the hybrid plasmids, pJP,50. by analysis of mutant, plasmids generat,ed by Tn5 insertions. Restriction mappmg of the other plasmid, pPRX0, indicated that the ...
