A Noise Trimming and Positional Significance of
... sites from zero to many. An individual site may attract insertions from one to many depending on the coverage depth of sequencing as well as the genetic property of a gene. The number of insertions at the same site is called insertion count or simply count. The significance of mutation of a gene sho ...
... sites from zero to many. An individual site may attract insertions from one to many depending on the coverage depth of sequencing as well as the genetic property of a gene. The number of insertions at the same site is called insertion count or simply count. The significance of mutation of a gene sho ...
The Co-Evolution of Genes and Culture Pedigrees
... lactase switch in several individuals. They found many differences. For example, at one particular position in the sequence of DNA, some individuals might have an adenine (A) nucleotide and others a thymine (T) nucleotide. Most of the differences in DNA sequence have no effect on lactase production. ...
... lactase switch in several individuals. They found many differences. For example, at one particular position in the sequence of DNA, some individuals might have an adenine (A) nucleotide and others a thymine (T) nucleotide. Most of the differences in DNA sequence have no effect on lactase production. ...
2010 HSC Biology Sample Answers
... gene cascades occur, we can use this knowledge to produce new technologies such as artificial organs. However, this is a very expensive technology and is not available to most of the world. The example above shows a new use for cloning technology where only one gene is inserted into an organism for ...
... gene cascades occur, we can use this knowledge to produce new technologies such as artificial organs. However, this is a very expensive technology and is not available to most of the world. The example above shows a new use for cloning technology where only one gene is inserted into an organism for ...
Chapter 25 RNA Metabolism
... mRNA-DNA hybrids by electron microscopy. Such single-stranded DNA loops was widely observed when examining such RNA-DNA hybrids. Intron sequences were proposed to be present on the template DNA sequences, which are removed during RNA processing, with exons linked together precisely. ...
... mRNA-DNA hybrids by electron microscopy. Such single-stranded DNA loops was widely observed when examining such RNA-DNA hybrids. Intron sequences were proposed to be present on the template DNA sequences, which are removed during RNA processing, with exons linked together precisely. ...
Genome Projector: zoomable genome map with multiple views
... biological context for the visualisation and interpretation of data, and serve as a gateway to information stored in a database [2]. For example, the popular two-dimensional genome map viewer, Gbrowse, provides an entry point for browsing the model organism genome database, GMOD [3], and biochemical ...
... biological context for the visualisation and interpretation of data, and serve as a gateway to information stored in a database [2]. For example, the popular two-dimensional genome map viewer, Gbrowse, provides an entry point for browsing the model organism genome database, GMOD [3], and biochemical ...
Bacterial Genetics
... b. This is In an operon because all 4 genes are in the control of the promoter i. This promoter region controls the expression of ABC and D ii. This is the start of the operon and this is the end of the operon c. RNA polymerase binds to promoter region in a particular way and switches the genes on a ...
... b. This is In an operon because all 4 genes are in the control of the promoter i. This promoter region controls the expression of ABC and D ii. This is the start of the operon and this is the end of the operon c. RNA polymerase binds to promoter region in a particular way and switches the genes on a ...
thalassaemia mutations in Sardinians
... diagnosis in this population is therefore carried out at present in the great majority of cases by the analysis of amniocyte or chorionic villus DNA with an oligonucleotide probe able to detect the 13039 mutation.3 The remaining cases, in whom the molecular defect has not yet been characterised, are ...
... diagnosis in this population is therefore carried out at present in the great majority of cases by the analysis of amniocyte or chorionic villus DNA with an oligonucleotide probe able to detect the 13039 mutation.3 The remaining cases, in whom the molecular defect has not yet been characterised, are ...
Normalization of gene expression measurements in tumor tissues
... In our study, the cDNA generated from each sample was split into 13 equal parts for the measurement of 13 different housekeeping genes. The standardized cDNA input for the measurement of each gene linked expression patterns (represented by Ct values) in a sample directly. This provided the basis for ...
... In our study, the cDNA generated from each sample was split into 13 equal parts for the measurement of 13 different housekeeping genes. The standardized cDNA input for the measurement of each gene linked expression patterns (represented by Ct values) in a sample directly. This provided the basis for ...
Biosynthesis of the Antibiotic Nonribosomal Peptide Penicillin in
... well as hundreds of non-proteinogenic amino acids, including D-enantiomers24. Thus by combining different modules together it should be possible make chimeric NRPS enzymes that produce thousands of novel Nrp molecules predisposed by evolution for bioactivity25. However, determining the structural bo ...
... well as hundreds of non-proteinogenic amino acids, including D-enantiomers24. Thus by combining different modules together it should be possible make chimeric NRPS enzymes that produce thousands of novel Nrp molecules predisposed by evolution for bioactivity25. However, determining the structural bo ...
Goldmine: Integrating information to place sets of genomic ranges
... proportions across the range set is also demonstrated. A list of variable-size genomic ranges representing regions with changes in DNA methylation is used as an example. This query range set can be interchanged for any set of interest. ...
... proportions across the range set is also demonstrated. A list of variable-size genomic ranges representing regions with changes in DNA methylation is used as an example. This query range set can be interchanged for any set of interest. ...
Warren-Proposal-Mining-TF-Genes-Disease-2007-07
... age of onset, primary etiology, episodic occurrence and their mode of inheritance. Similarity between two disease is the weighted contributions of each of these indices. Once the clusters are determined (using a strategy that involves manual thresholding by a human expert), the candidate genes are c ...
... age of onset, primary etiology, episodic occurrence and their mode of inheritance. Similarity between two disease is the weighted contributions of each of these indices. Once the clusters are determined (using a strategy that involves manual thresholding by a human expert), the candidate genes are c ...
Mutator Transposon in Maize and MULEs in the Plant Genome
... Mu insertions, especially germinally transmitted insertions [14]. Only two maize lines with active MuDR elements have been identified so far, but all maize lines carry MuDR elements derivatives, or homologous MuDR sequences (hMuDRs), whose coding sequences are 80%–99% identical to those of MuDR. Sur ...
... Mu insertions, especially germinally transmitted insertions [14]. Only two maize lines with active MuDR elements have been identified so far, but all maize lines carry MuDR elements derivatives, or homologous MuDR sequences (hMuDRs), whose coding sequences are 80%–99% identical to those of MuDR. Sur ...
Fine Mapping of Two Wheat Powdery Mildew Resistance Genes
... cluster. Mlm2033 and Mlm80 from einkorn wheat (T. monococcum L.) were two of the R genes belonging to this cluster. This study was initiated to fine map these two genes toward map-based cloning. Comparative genomics study showed that macrocolinearity exists between Brachypodium distachyon L. chromos ...
... cluster. Mlm2033 and Mlm80 from einkorn wheat (T. monococcum L.) were two of the R genes belonging to this cluster. This study was initiated to fine map these two genes toward map-based cloning. Comparative genomics study showed that macrocolinearity exists between Brachypodium distachyon L. chromos ...
Phylogenetic analysis of members of the genus Rickettsia using the
... Nei, 1987). The data were also examined by using parsimony and maximum-likelihood methods (, and in ). A bootstrap analysis was performed to investigate the stability of the trees obtained. Bootstrap values were obtained for a consensus tree based on 100 randomly generate ...
... Nei, 1987). The data were also examined by using parsimony and maximum-likelihood methods (, and in ). A bootstrap analysis was performed to investigate the stability of the trees obtained. Bootstrap values were obtained for a consensus tree based on 100 randomly generate ...
Phylogenetic Motif Detection by Expectation
... transcription factors with few characterized targets and/or poorly defined motifs In several cases, for a given motif size, our algorithm ranked a plausible motif first, and MEME ranked a polyT motif first (see Table 1). ...
... transcription factors with few characterized targets and/or poorly defined motifs In several cases, for a given motif size, our algorithm ranked a plausible motif first, and MEME ranked a polyT motif first (see Table 1). ...
Fine Mapping of Two Wheat Powdery Mildew Resistance Genes
... cluster. Mlm2033 and Mlm80 from einkorn wheat (T. monococcum L.) were two of the R genes belonging to this cluster. This study was initiated to fine map these two genes toward map-based cloning. Comparative genomics study showed that macrocolinearity exists between Brachypodium distachyon L. chromos ...
... cluster. Mlm2033 and Mlm80 from einkorn wheat (T. monococcum L.) were two of the R genes belonging to this cluster. This study was initiated to fine map these two genes toward map-based cloning. Comparative genomics study showed that macrocolinearity exists between Brachypodium distachyon L. chromos ...
Chapter 9
... • Genetically modified crops must be safe for consumption and for the environment • Who will have access to an individual's genetic ...
... • Genetically modified crops must be safe for consumption and for the environment • Who will have access to an individual's genetic ...
Package `TCGAbiolinks`
... Description The aim of TCGAbiolinks is : i) facilitate the GDC open-access data retrieval, ii) prepare the data using the appropriate pre-processing strategies, iii) provide the means to carry out different standard analyses and iv) to easily reproduce earlier research results. In more detail, the p ...
... Description The aim of TCGAbiolinks is : i) facilitate the GDC open-access data retrieval, ii) prepare the data using the appropriate pre-processing strategies, iii) provide the means to carry out different standard analyses and iv) to easily reproduce earlier research results. In more detail, the p ...
Large-scale association studies
... • For meta-analysis, need to impute to the same set of SNPs before analysis – most people us 2.5 million HapMap Phase II SNPs – starting to use 38 million 1000 Genomes SNPs – for additive genetic model, doesn’t matter whether SNPs are measured or imputed. – slightly more work needed for non-additive ...
... • For meta-analysis, need to impute to the same set of SNPs before analysis – most people us 2.5 million HapMap Phase II SNPs – starting to use 38 million 1000 Genomes SNPs – for additive genetic model, doesn’t matter whether SNPs are measured or imputed. – slightly more work needed for non-additive ...
The mutagenic chain reaction: A method for converting heterozygous
... mutations of essential genes, or targeting other nonessential sequences. The method may also be adaptable to targeting essential genes if an in-frame recoded gRNAresistant copy of the gene providing sufficient activity to support survival is included. In addition to these positive applications of MC ...
... mutations of essential genes, or targeting other nonessential sequences. The method may also be adaptable to targeting essential genes if an in-frame recoded gRNAresistant copy of the gene providing sufficient activity to support survival is included. In addition to these positive applications of MC ...
Genome-sequence analysis of Acinetobacter johnsonii MB44
... Acinetobacter johnsonii is generally recognized as a nonpathogenic bacterium although it is often found in hospital environments. However, a newly identified isolate of this species from a frost-plant-tissue sample, namely, A. johnsonii MB44, showed significant nematicidal activity against the model ...
... Acinetobacter johnsonii is generally recognized as a nonpathogenic bacterium although it is often found in hospital environments. However, a newly identified isolate of this species from a frost-plant-tissue sample, namely, A. johnsonii MB44, showed significant nematicidal activity against the model ...
Chromosome Analysis Suite 3.1 (ChAS 3.1)
... ChAS 3.1 includes a table with the following calls made for each mutation: “high confidence,”, “lower confidence,” and “undetected.” The thresholds for the “high-confidence” calls were established based on separations between the normal reference and mutant calls that resulted in 95% sensitivity and ...
... ChAS 3.1 includes a table with the following calls made for each mutation: “high confidence,”, “lower confidence,” and “undetected.” The thresholds for the “high-confidence” calls were established based on separations between the normal reference and mutant calls that resulted in 95% sensitivity and ...
Chromosomal G + C Content Evolution in Yeasts
... reduced. We propose that these GC-poor troughs indicate the positions of centromeres because in Y. lipolytica they coincide with the five experimentally identified centromeres. In P. stipitis, the troughs contain clusters of the retrotransposon Tps5. Likewise, in Debaryomyces hansenii, there is one ...
... reduced. We propose that these GC-poor troughs indicate the positions of centromeres because in Y. lipolytica they coincide with the five experimentally identified centromeres. In P. stipitis, the troughs contain clusters of the retrotransposon Tps5. Likewise, in Debaryomyces hansenii, there is one ...
module 3: transcription part ii
... using a chemical method to tag the special structure that occurs at 5’ ends of transcript, fishing out the RNA molecules using these tags, and mapping the sequence back to the genome, a method called “CAGE” (cap analysis of gene expression). In addition, we will also display the "D. mel. cDNA" track ...
... using a chemical method to tag the special structure that occurs at 5’ ends of transcript, fishing out the RNA molecules using these tags, and mapping the sequence back to the genome, a method called “CAGE” (cap analysis of gene expression). In addition, we will also display the "D. mel. cDNA" track ...
Figure 2 - GEP Community Server
... using a chemical method to tag the special structure that occurs at 5’ ends of transcript, fishing out the RNA molecules using these tags, and mapping the sequence back to the genome, a method called “CAGE” (cap analysis of gene expression). In addition, we will also display the "D. mel. cDNA" track ...
... using a chemical method to tag the special structure that occurs at 5’ ends of transcript, fishing out the RNA molecules using these tags, and mapping the sequence back to the genome, a method called “CAGE” (cap analysis of gene expression). In addition, we will also display the "D. mel. cDNA" track ...
Metagenomics
Metagenomics is the study of genetic material recovered directly from environmental samples. The broad field may also be referred to as environmental genomics, ecogenomics or community genomics. While traditional microbiology and microbial genome sequencing and genomics rely upon cultivated clonal cultures, early environmental gene sequencing cloned specific genes (often the 16S rRNA gene) to produce a profile of diversity in a natural sample. Such work revealed that the vast majority of microbial biodiversity had been missed by cultivation-based methods. Recent studies use either ""shotgun"" or PCR directed sequencing to get largely unbiased samples of all genes from all the members of the sampled communities. Because of its ability to reveal the previously hidden diversity of microscopic life, metagenomics offers a powerful lens for viewing the microbial world that has the potential to revolutionize understanding of the entire living world. As the price of DNA sequencing continues to fall, metagenomics now allows microbial ecology to be investigated at a much greater scale and detail than before.