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World Index of BioMolecular Visualization Resources
World Index of BioMolecular Visualization Resources

... Cross-indexing terms: deoxyribonucleic acid, DNA, major groove, minor groove. This Chime resource contains animations to illustrate the structure of DNA. The animations are initiated by clicking buttons on the right pannel. They show a base pair in the context of a larger helix and highlight the bas ...
DOC-file of additional text
DOC-file of additional text

... IV. Receiver Operating Characteristic Curve (ROC) method Two values were assigned to each E. coli metabolic gene: a binary variable representing presence or absence of the gene in a given Buchnera genome, and the number of occurrences of the gene in 500 simulated reduced genomes. For each cut-off ( ...
Statistical Analysis of Amino Acid Patterns in Transmembrane
Statistical Analysis of Amino Acid Patterns in Transmembrane

... conformations suitable for interaction. The existence of correlations between residues has been suggested in previous statistical studies on predicted TM sequence databases (Arkin & Brunger, 1998; Landolt-Marticorena et al., 1993; Samatey et al., 1995). Here, we present a rigorous analysis of the fr ...
Prokaryotic proteins of antioxidant defense in Trichomonas vaginalis
Prokaryotic proteins of antioxidant defense in Trichomonas vaginalis

... (O2-), hydroxyl radical (HO) and hydrogen peroxide (H2O2), all of which are normal byproducts of oxygen metabolism. Oxygen has a unique molecular structure with unique electron configuration resulting from two unpaired electrons in ground state of O2 molecule (triplet oxygen). It readily accepts el ...
9. proteins i
9. proteins i

... (enzymes) are largely responsible for determining the phenotype or properties of a cell in a particular environment. The total hereditary material of the cell or genotype dictates which type of protein the cell can produce. In fact, the proteins have built into their structure the information that i ...
Development of Software Package for Determining Protein
Development of Software Package for Determining Protein

... Asp102 of Chymotrypsin – hydrogen bond with His57 – increases pKa His57 can accepts proton from Ser195 – activates serine protease for cleavage of substrate pKa shift important for each chemical reaction in catalytic mechanism Necessary to donate and abstract protons from neighboring groups Without ...


... it is in the hydrophobic core. Since this Thr would form an H-bond to water in the unfolded state, it will cost about 20 kJ/mole of instability since a hydrogen bond to water is broken during folding, but not reformed. (6 pts) Additional factors (1 pt for either, unless the main reason was missed an ...
Crystallization and X Ray Diffraction Data Analyses of the Enzyme
Crystallization and X Ray Diffraction Data Analyses of the Enzyme

... people in the Americas.1 Over the past two decades, as a result of the genome sequencing of the protozoan Trypanosoma cruzi, specific metabolic pathways have been and are presently being studied to better understand their relationship with different aspects of its biology.2 In this point, the uptake ...
The Role of Nucleoside Diphosphate Kinase in Plant Mitochondria
The Role of Nucleoside Diphosphate Kinase in Plant Mitochondria

... organisms from bacteria to human. It was discovered that the genes nm23 and awd, which encode NDPKs are involved in tumour metastasis and Drosophila development, respectively. Thus, NDPK isoforms have been suggested to have specific regulatory functions in addition to their catalytic activity. Plant ...
Sequence and evolutionary analysis of the human trypsin subfamily
Sequence and evolutionary analysis of the human trypsin subfamily

... the catalytic type, S for serine, C for cysteine, A for aspartic, and so forth (with the letter ‘‘P’’ being used for a clan containing families of more than one of the catalytic types serine, threonine and cysteine). Some clans are divided into ‘‘subclans’’ because there is evidence of a very ancien ...
PDF
PDF

... has a predominantly S = 3 / 2 ground state which gives rise to an approx, g = 5 EPR signal [12]. This unusual property is thought to be related to the partial non-cysteinyl coordination to the cluster, a property not shared by the ferredoxin of the hyperthermophile T. litoralis (see Fig. 3). ...
Test Example
Test Example

... (a) List the types of noncovalent interactions that are important in providing stability to the threedimensional structures of macromolecules. (b) Why is it important that these interactions be noncovalent, rather than covalent, bonds? Ans: (a) Noncovalent interactions include hydrogen bonds, ionic ...
Canola Meal for Pig Feeding
Canola Meal for Pig Feeding

... and Australian Oilseeds Federation. This work was able to demonstrate that under typical processing conditions as used by GrainCorp Oilseeds, the effects of processing have a minimal impact upon meal quality. It is during more extreme or less controlled oil extraction that protein heat damage occurs ...
Identification of enzymes involved in anaerobic benzene
Identification of enzymes involved in anaerobic benzene

... 159, 168 and 178; Table 1) were expressed. The expressed bam-like genes were located on different contigs of the metagenome sequence. Some of these genes were also expressed in benzene- and phenol-grown cells (ORFs 56, 86, 155, 168, 178 and 194). In addition, specific genes probably encoding enzymes ...
Fulltext - Jultika
Fulltext - Jultika

Guideline on Immunogenicity assessment of - EMA
Guideline on Immunogenicity assessment of - EMA

Full-Text PDF
Full-Text PDF

... The data coming from other plant models deal more with PR1 proteins possible function in defense. When PR1 genes were over-expressed in tobacco, the transformed plants were slightly more resistant to certain pathogens [13] and conversely, plants with silenced PR1s were more susceptible than wild-typ ...
as a PDF
as a PDF

... Neurofibrillary tangles are one of the major lesions that accumulate in Alzheimer's disease brain . The main components of neurofibrillary tangles are the paired helical filaments (PHFs), which consist mainly of the microtubule-associated protein T (Brion et al ., 1985 ; Kosik et al ., 1986 ; Yen et ...
Journal of Biological Chemistry
Journal of Biological Chemistry

... of the liver ribosome system (Table II) just as effectively as it does the decrease in hepatic ATP concentration induced by the same analogue (3). These results tend to implicate cellular BTP deficiency as being important in the inhibition of protein synthesis, and they pose several questions concer ...
Capacitation-associated Changes in Protein
Capacitation-associated Changes in Protein

... different groups: modified TALP (Tyrode’s albumin lactate pyruvate) or TALP without one of the medium constituents (Ca2+, HCO3- and BSA). After incubation for the required time (0 h, 0.5 h, 1 h, 3 h, 5 h, and 7 h), sperm were removed for further experiment. The capacitation effect was assessed by CT ...
Herculex® I Product Overview
Herculex® I Product Overview

... rootworm. The European corn borer alone destroys an estimated $1 to $2 billion worth of corn each year. Insects cause many other forms of damage when they feed on parts of the corn plant, including breakage of the plant, eardrop and kernel damage. Damaged kernels can lead to growth of fungi, which m ...
Responses of cows to abomasal infusion of lysine and methionine at
Responses of cows to abomasal infusion of lysine and methionine at

The DNA Binding Properties of Saccharomyces cerevisiae Rad51
The DNA Binding Properties of Saccharomyces cerevisiae Rad51

... In vitro, the most extensively investigated DNA pairing reaction is the three-strand exchange reaction, in which the pairing of circular ssDNA and homologous dsDNA yields nicked circular dsDNA and linear ssDNA. During the formation of a presynaptic complex in the first phase of the reaction, the Rec ...
Nucleus-Encoded Genes for Plastid
Nucleus-Encoded Genes for Plastid

... cDNA sequences produced from an ongoing Helicosporidium sp. (strain AT2000, originally isolated from the black fly, Simulium jonesii) EST project. Genes were identified for further characterization based on the following three criteria: (i) their association with pathways known to occur in the plast ...
Molecular characterization of carnitine palmitoyltransferase 1C Esther Gratacòs i Batlle
Molecular characterization of carnitine palmitoyltransferase 1C Esther Gratacòs i Batlle

... WARNING. On having consulted this thesis you’re accepting the following use conditions: Spreading this thesis by the TDX (www.tesisenxarxa.net) service has been authorized by the titular of the intellectual property rights only for private uses placed in investigation and teaching activities. Reprod ...
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Interactome



In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein-protein interactions) but can also describe sets of indirect interactions among genes (genetic interactions). Mathematically, interactomes are generally displayed as graphs.The word ""interactome"" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq. Though interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.
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