An intersubunit lock-and-key `Clasp` motif in the dimer interface of
... Structural investigations of a GST (glutathione transferase), adGSTD4-4, from the malaria vector Anopheles dirus show a novel lock-and-key ‘Clasp’ motif in the dimer interface of the Delta class enzyme. This motif also appears to be highly conserved across several insect GST classes, but differs fro ...
... Structural investigations of a GST (glutathione transferase), adGSTD4-4, from the malaria vector Anopheles dirus show a novel lock-and-key ‘Clasp’ motif in the dimer interface of the Delta class enzyme. This motif also appears to be highly conserved across several insect GST classes, but differs fro ...
SQA Higher Biology Unit 1 Cell Biology
... different functions. Eukaryotic multicellular organisms are composed of many types of cell that are differentiated to carry out distinct functions (Figure 1.1). The organism therefore works more efficiently. In other words, there are levels of organisation in multicellular organisms (Figure 1.2). ...
... different functions. Eukaryotic multicellular organisms are composed of many types of cell that are differentiated to carry out distinct functions (Figure 1.1). The organism therefore works more efficiently. In other words, there are levels of organisation in multicellular organisms (Figure 1.2). ...
Cell and Molecular Biology
... Proteins are marked for destruction by the addition of a small molecule called ubiquitin on exposed lysine residues ...
... Proteins are marked for destruction by the addition of a small molecule called ubiquitin on exposed lysine residues ...
ILA: DIABETES
... • Although the blood glucose level is high but glucose is not taken up by the cells due to insulin deficiency therefore the cells are starved • The patient will take more food (polyphagia) to compensate for the loss of glucose and also loss of protein ...
... • Although the blood glucose level is high but glucose is not taken up by the cells due to insulin deficiency therefore the cells are starved • The patient will take more food (polyphagia) to compensate for the loss of glucose and also loss of protein ...
Identification of Functional Connections Between Calmodulin and the Yeast Actin Cytoskeleton.
... 12 random nucleotides. Three independent libraries containing CMD1 random substitution mutations (i.e., altered sequences still capable of producing functional calmodulin) at positions 89–92 were used in this study. Plasmids containing these CMD1 mutations were recovered from yeast, amplified in E. ...
... 12 random nucleotides. Three independent libraries containing CMD1 random substitution mutations (i.e., altered sequences still capable of producing functional calmodulin) at positions 89–92 were used in this study. Plasmids containing these CMD1 mutations were recovered from yeast, amplified in E. ...
Enzymes of the mevalonate pathway of isoprenoid
... for this metabolism been reported. The biosynthetic acetoacetyl-CoA thiolase and HMG-CoA synthase reactions rely on key amino acids that are different but are situated in active sites that are similar throughout the family of initial condensation enzymes. Both bacterial and animal HMG-CoA reductases ...
... for this metabolism been reported. The biosynthetic acetoacetyl-CoA thiolase and HMG-CoA synthase reactions rely on key amino acids that are different but are situated in active sites that are similar throughout the family of initial condensation enzymes. Both bacterial and animal HMG-CoA reductases ...
Origin of Life
... acted on by the guiding hand of natural selection So what are the resources available for the production of the first/simplest organism? Is it really the universe? “The Monera (for instance, chromacea and bacteria), which consist only of this primitive protoplasm, and which arise by spontaneous gene ...
... acted on by the guiding hand of natural selection So what are the resources available for the production of the first/simplest organism? Is it really the universe? “The Monera (for instance, chromacea and bacteria), which consist only of this primitive protoplasm, and which arise by spontaneous gene ...
Journal of Bacteriology
... the concentrations recommended by Cutting and van der Horn (8) and confirmed by Southern hybridization and colony PCR with appropriate primers. Bioautography. Bioautographs were prepared as previously described (15). In short, supernatants from bacteria grown in Landy medium were loaded onto an XAD7 ...
... the concentrations recommended by Cutting and van der Horn (8) and confirmed by Southern hybridization and colony PCR with appropriate primers. Bioautography. Bioautographs were prepared as previously described (15). In short, supernatants from bacteria grown in Landy medium were loaded onto an XAD7 ...
Two Models of Catabolite Repression Signal Transduction
... In the glycolytic flux model, movement of glucose through the glucose transporter is not essential for catabolite repression. Instead, what is important in the flux of carbon through glycolysis (Fig 2.) Glycolysis is the metabolic pathway that catabolizes glucose to pyruvate. When glucose is being a ...
... In the glycolytic flux model, movement of glucose through the glucose transporter is not essential for catabolite repression. Instead, what is important in the flux of carbon through glycolysis (Fig 2.) Glycolysis is the metabolic pathway that catabolizes glucose to pyruvate. When glucose is being a ...
Book Review Layout
... in fully understanding the pathway that leads from DNA to RNA to protein. An RNA can form stable structures with only a small number of nucleotides. For example, a dozen nucleotides are sufficient to form a stable hairpin loop under physiological conditions. The more complex secondary structural mot ...
... in fully understanding the pathway that leads from DNA to RNA to protein. An RNA can form stable structures with only a small number of nucleotides. For example, a dozen nucleotides are sufficient to form a stable hairpin loop under physiological conditions. The more complex secondary structural mot ...
Crystal structure of the S187F variant of human liver alanine
... The substitution of Ser187, a residue located far from the active site of human liver peroxisomal alanine:glyoxylate aminotransferase (AGT), by Phe gives rise to a variant associated with primary hyperoxaluria type I. Unexpectedly, previous studies revealed that the recombinant form of S187F exhibit ...
... The substitution of Ser187, a residue located far from the active site of human liver peroxisomal alanine:glyoxylate aminotransferase (AGT), by Phe gives rise to a variant associated with primary hyperoxaluria type I. Unexpectedly, previous studies revealed that the recombinant form of S187F exhibit ...
Adaptations of protein structure and function to temperature: there is
... attributes. The results of these efforts indicate that ligand binding affinity and catalytic rate are key targets during temperature adaptation: ligand affinity decreases during cold adaptation to allow more rapid catalysis. Structural changes causing these functional shifts often comprise only a si ...
... attributes. The results of these efforts indicate that ligand binding affinity and catalytic rate are key targets during temperature adaptation: ligand affinity decreases during cold adaptation to allow more rapid catalysis. Structural changes causing these functional shifts often comprise only a si ...
COURSE SYLLABUS CHM 521 Biochemistry I 3(3
... The pentose phosphate pathway Glycogen breakdown and synthesis Regulation of carbohydrate metabolism Hormones and second messengers Oxidation of pyruvate The citric acid cycle Anabolic TCA cycle and glyoxylate cycle Regulation of the citric acid cycle Di- and oligosaccharide metabolism Mitochondria ...
... The pentose phosphate pathway Glycogen breakdown and synthesis Regulation of carbohydrate metabolism Hormones and second messengers Oxidation of pyruvate The citric acid cycle Anabolic TCA cycle and glyoxylate cycle Regulation of the citric acid cycle Di- and oligosaccharide metabolism Mitochondria ...
Chapter 2: Biochemistry Problems
... • The structures of some important biomolecules that you will see again and again. • Translations between the 2-d representations you see in this and other books and the 3-d reality of biomolecules. • The kind of representation used by the MolVis software that you will use in this book. • The user i ...
... • The structures of some important biomolecules that you will see again and again. • Translations between the 2-d representations you see in this and other books and the 3-d reality of biomolecules. • The kind of representation used by the MolVis software that you will use in this book. • The user i ...
Consequences of Stop Codon Reassignment on
... a million of being more minimized than the standard code. In their study, Freeland et al. (2000) used the PAM74100 matrix (Benner et al. 1994) to determine the distance between a pair of amino acids. PAM stands for point accepted mutations, for example, a PAM1 matrix is determined from the alignment ...
... a million of being more minimized than the standard code. In their study, Freeland et al. (2000) used the PAM74100 matrix (Benner et al. 1994) to determine the distance between a pair of amino acids. PAM stands for point accepted mutations, for example, a PAM1 matrix is determined from the alignment ...
Defining the complementarities between antibodies and haptens to
... the primary repertoire diversity is enhanced by combinatorial linkage of heavy and light chains. This second phase of diversification is antigen dependent, occurs in the activated B-cells, and arises from three mechanisms: somatic mutations, gene conversion, and class-switching [4–6]. Despite the po ...
... the primary repertoire diversity is enhanced by combinatorial linkage of heavy and light chains. This second phase of diversification is antigen dependent, occurs in the activated B-cells, and arises from three mechanisms: somatic mutations, gene conversion, and class-switching [4–6]. Despite the po ...
Cell Biophysics II - Univerzita Pavla Jozefa Šafárika v Košiciach
... COURSE OBJECTIVES 1. General knowledge of the principles of cellular ...
... COURSE OBJECTIVES 1. General knowledge of the principles of cellular ...
How to move an amphipathic molecule across a lipid
... activity of ABCD transporters is currently unclear, since these proteins do not exhibit sequence similarity to soluble thioesterases. However, thioesterases are a diverse class of enzymes which fall into 23 different families, with different folds and mechanisms and little primary sequence identity ...
... activity of ABCD transporters is currently unclear, since these proteins do not exhibit sequence similarity to soluble thioesterases. However, thioesterases are a diverse class of enzymes which fall into 23 different families, with different folds and mechanisms and little primary sequence identity ...
BGFK Blue Segment Student Handout
... each other and are called alpha (α) subunits or α−globin. The other two subunits are also identical to each other and are called beta (β) subunits or β−globin. The α− and β−globins are similar to each other, but not identical. Each subunit has a heme group with an iron (Fe) atom in the center. (See ...
... each other and are called alpha (α) subunits or α−globin. The other two subunits are also identical to each other and are called beta (β) subunits or β−globin. The α− and β−globins are similar to each other, but not identical. Each subunit has a heme group with an iron (Fe) atom in the center. (See ...
Regulation of Cytochrome bd Expression in Mycobacterium
... ten individuals develops active disease (169). Environmental factors, such as poor ...
... ten individuals develops active disease (169). Environmental factors, such as poor ...
Two-hybrid screening
Two-hybrid screening (also known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay.