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... 1. Contrast saturated and unsaturated fatty acids. Understand how and why they influence membrane fluidity. Know the general structure of membrane lipids. Know the names of the fatty acids and lipids presented in class. You do NOT need to memorize the structure of the individual fatty acids, ethanol ...
... 1. Contrast saturated and unsaturated fatty acids. Understand how and why they influence membrane fluidity. Know the general structure of membrane lipids. Know the names of the fatty acids and lipids presented in class. You do NOT need to memorize the structure of the individual fatty acids, ethanol ...
Cadherin adhesion depends on a salt bridge at the N
... exchange is a primary event in cadherin-mediated cell adhesion. The exchange process is an example of the ‘3D domain swap’ mechanism for oligomerization that has been described for a heterogeneous group of proteins and involves mutual exchange of one or more structural components (Liu and Eisenberg, ...
... exchange is a primary event in cadherin-mediated cell adhesion. The exchange process is an example of the ‘3D domain swap’ mechanism for oligomerization that has been described for a heterogeneous group of proteins and involves mutual exchange of one or more structural components (Liu and Eisenberg, ...
MPN+, a putative catalytic motif found in a subset of MPN domain
... signalosome (CSN) and the eukaryotic translation initiation factor 3 (eIF3). The functions of these domains are not known, but they are necessary for proper interactions between subunits of these complexes [12,13]. The lid appears to be required for the degradation of polyubiquitinated substrates bu ...
... signalosome (CSN) and the eukaryotic translation initiation factor 3 (eIF3). The functions of these domains are not known, but they are necessary for proper interactions between subunits of these complexes [12,13]. The lid appears to be required for the degradation of polyubiquitinated substrates bu ...
Selection at the Wobble Position of Codons Read by the Same tRNA
... pair can entail variations in the energetics of codon-anticodon interaction. These variations depend on the identity of the first anticodon base and on the use of wobbling for a given organism. For example, in the case of a G-starting anticodon, three or two hydrogen bonds can be formed at the wobbl ...
... pair can entail variations in the energetics of codon-anticodon interaction. These variations depend on the identity of the first anticodon base and on the use of wobbling for a given organism. For example, in the case of a G-starting anticodon, three or two hydrogen bonds can be formed at the wobbl ...
A study of archaeal enzymes involved in polar lipid
... function has been experimentally determined, was used as a query to collect ASS candidates. In the case of Bacteria, two PSS types have been reported (Matsumoto 1997), which are hereafter referred to as PSS-I and -II. They have evolved from different evolutionary origins and belong to different prot ...
... function has been experimentally determined, was used as a query to collect ASS candidates. In the case of Bacteria, two PSS types have been reported (Matsumoto 1997), which are hereafter referred to as PSS-I and -II. They have evolved from different evolutionary origins and belong to different prot ...
The use of deuteration for the structural study of larger proteins
... Advantages of selective protonation • protonation sites are part of the protein core • scheme adaptable for the system under study • varying number of residues can be labeled • labeling techniques unproblematic (add precursors: amino acids or α-ketoacids) • aromatic residues give many structurally i ...
... Advantages of selective protonation • protonation sites are part of the protein core • scheme adaptable for the system under study • varying number of residues can be labeled • labeling techniques unproblematic (add precursors: amino acids or α-ketoacids) • aromatic residues give many structurally i ...
Whey Products - New Zealand Institute of Chemistry
... molecular weight. The rest of the whey stream passes through the membrane, driven by the applied pressure and is called “permeate”. The permeate contains most of the lactose, minerals and water from the whey. The retentate, the volume of which is about 1-4% that of the feed whey, is spray dried to a ...
... molecular weight. The rest of the whey stream passes through the membrane, driven by the applied pressure and is called “permeate”. The permeate contains most of the lactose, minerals and water from the whey. The retentate, the volume of which is about 1-4% that of the feed whey, is spray dried to a ...
Protein Structure Prediction Based on Neural Networks
... and knowledge of a protein’s 3D structure improves the analysis of protein functions, particularly for drug design [2]. Being aware of the 3D structure of a protein enables pharmacologists to select a binding protein to moderate its functions. Pharmacologists may choose a drug which is easy to synt ...
... and knowledge of a protein’s 3D structure improves the analysis of protein functions, particularly for drug design [2]. Being aware of the 3D structure of a protein enables pharmacologists to select a binding protein to moderate its functions. Pharmacologists may choose a drug which is easy to synt ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... link tissue injury and local generation of active coagulation proteases to cellular responses that help to regulate haemostasis, thrombosis, inflammation and tissue repair. (13,20) PARs also participate in progression of specific types of cancers.(21,22) In contrast to typical receptor-agonist bindi ...
... link tissue injury and local generation of active coagulation proteases to cellular responses that help to regulate haemostasis, thrombosis, inflammation and tissue repair. (13,20) PARs also participate in progression of specific types of cancers.(21,22) In contrast to typical receptor-agonist bindi ...
Functions of the liver Assessment and interpretation of liver function
... • Hepatic microsomal enzyme, UDPglucuronyl transferase mediates the transfer of glucoronic acid from UDP glucuronic acid to the functional group on the xenobiotics • Drug handled by phase-II – morphine, propofol, thiopentone (initially ...
... • Hepatic microsomal enzyme, UDPglucuronyl transferase mediates the transfer of glucoronic acid from UDP glucuronic acid to the functional group on the xenobiotics • Drug handled by phase-II – morphine, propofol, thiopentone (initially ...
Enzymatic activation of sulfur for incorporation into biomolecules in
... Characterization of the NifS protein as a cysteine desulfurase that generates an enzyme-based cysteinyl persulfide as a crucial intermediate emerged from the work of Dennis Dean and coworkers dedicated to the maturation of nitrogenase (Zheng et al., 1993). The NifS protein was suggested to provide t ...
... Characterization of the NifS protein as a cysteine desulfurase that generates an enzyme-based cysteinyl persulfide as a crucial intermediate emerged from the work of Dennis Dean and coworkers dedicated to the maturation of nitrogenase (Zheng et al., 1993). The NifS protein was suggested to provide t ...
BMC Struct Biol. BMC Struct Biol. 2003
... The dissociation constant for the interaction was determined to be ~10 nM in a 3:5 (v/v) mix of dimethyl sulfoxide and water [3] but the interaction is likely to be even tighter in a more aqueous medium. HSA may provide a reserve binding capacity for situations when hemopexin becomes saturated. The ...
... The dissociation constant for the interaction was determined to be ~10 nM in a 3:5 (v/v) mix of dimethyl sulfoxide and water [3] but the interaction is likely to be even tighter in a more aqueous medium. HSA may provide a reserve binding capacity for situations when hemopexin becomes saturated. The ...
Section III (pdf)
... You can enter just the wireframe command and create a “sticks” appearance, but you cannot enter just the spacefill command. If you enter just the spacefill command, the atoms will be displayed as little spheres and the spheres may not be securely connected to one another. The image MAY look fine on ...
... You can enter just the wireframe command and create a “sticks” appearance, but you cannot enter just the spacefill command. If you enter just the spacefill command, the atoms will be displayed as little spheres and the spheres may not be securely connected to one another. The image MAY look fine on ...
Drug-Resistant Variants of Escherichia coli Thymidylate Synthase
... mechanisms are involved in the resistance phenotype. A Pro to Leu substitution at residue 303 of human TS was identified and shown to be the effector of 5-fluoro-2⬘-deoxyuridine (FdUrd) resistance. Crystal structures and rate constants governing individual steps in the catalytic mechanism of human T ...
... mechanisms are involved in the resistance phenotype. A Pro to Leu substitution at residue 303 of human TS was identified and shown to be the effector of 5-fluoro-2⬘-deoxyuridine (FdUrd) resistance. Crystal structures and rate constants governing individual steps in the catalytic mechanism of human T ...
PDF
... has a predominantly S = 3 / 2 ground state which gives rise to an approx, g = 5 EPR signal [12]. This unusual property is thought to be related to the partial non-cysteinyl coordination to the cluster, a property not shared by the ferredoxin of the hyperthermophile T. litoralis (see Fig. 3). ...
... has a predominantly S = 3 / 2 ground state which gives rise to an approx, g = 5 EPR signal [12]. This unusual property is thought to be related to the partial non-cysteinyl coordination to the cluster, a property not shared by the ferredoxin of the hyperthermophile T. litoralis (see Fig. 3). ...
PDF - University of California, San Francisco
... Reductase-Hydrophobicity plots of the amino acid sequence were FIG. 1. Amino acid sequence and domain map of hamster generated by the method of Kyte and Doolittle (10). The hydrophoHMG-CoA reductase. Panel A , amino acid sequence. Amino acid bicity values used for each amino acid were those of Eisen ...
... Reductase-Hydrophobicity plots of the amino acid sequence were FIG. 1. Amino acid sequence and domain map of hamster generated by the method of Kyte and Doolittle (10). The hydrophoHMG-CoA reductase. Panel A , amino acid sequence. Amino acid bicity values used for each amino acid were those of Eisen ...
Arginine-induced stimulation of protein synthesis and survival in
... growth is mainly due to its role as a constituent amino acid for protein synthesis in cells where arginine synthesis is negligible. However, recent studies also suggest that arginine may directly activate anabolic cellular signaling pathways (6, 32, 44). One of the major amino acid-responsive signal ...
... growth is mainly due to its role as a constituent amino acid for protein synthesis in cells where arginine synthesis is negligible. However, recent studies also suggest that arginine may directly activate anabolic cellular signaling pathways (6, 32, 44). One of the major amino acid-responsive signal ...
Statistical analysis of atomic contacts at RNA– protein
... been statistically surveyed for the number of contacts between RNA components (phosphate, ribose and the four bases) and amino acid side chains. Three groups of complexes were defined: the tRNA synthetases; the ribosomal complexes; and a third group containing a variety of complexes. The types of at ...
... been statistically surveyed for the number of contacts between RNA components (phosphate, ribose and the four bases) and amino acid side chains. Three groups of complexes were defined: the tRNA synthetases; the ribosomal complexes; and a third group containing a variety of complexes. The types of at ...
Pairwise sequence alignments
... This value also depends strongly on how the two sequences are aligned, as well as on the substitution matrix used. Homology Two sequences are homologous if and only if they have a common ancestor. There is no such thing as a level of homology ! (It's either yes or no) ...
... This value also depends strongly on how the two sequences are aligned, as well as on the substitution matrix used. Homology Two sequences are homologous if and only if they have a common ancestor. There is no such thing as a level of homology ! (It's either yes or no) ...
subunits of succinyl CoA ligase of tomato
... differing greatly with tissue type in rat (Lambeth et al., 2004). In contrast Saccharomyces cerevisiae and Escherichia coli contain only single b-genes but are able to utilize both GDP and ADP (Przybyla-Zawislak et al., 1998; Fraser et al., 1999). In contrast to the microbial and mammalian enzymes w ...
... differing greatly with tissue type in rat (Lambeth et al., 2004). In contrast Saccharomyces cerevisiae and Escherichia coli contain only single b-genes but are able to utilize both GDP and ADP (Przybyla-Zawislak et al., 1998; Fraser et al., 1999). In contrast to the microbial and mammalian enzymes w ...
IDENTIFICATION OF LEAD COMPOUNDS WITH COBRA VENOM NEUTRALISING ACTIVITY IN
... effects, cost effective and need not require sophisticated storage system when compared to the antivenom therapy. There is also a growing realization that diseases have multifactorial causation, a combination of drugs acting at a number of targets simultaneously is likely to be more effective than d ...
... effects, cost effective and need not require sophisticated storage system when compared to the antivenom therapy. There is also a growing realization that diseases have multifactorial causation, a combination of drugs acting at a number of targets simultaneously is likely to be more effective than d ...
Two-hybrid screening
Two-hybrid screening (also known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay.