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Correlating ribosome function with high
... Translation of the genetic code into proteins is the second stage of protein biosynthesis. It is performed by a complex apparatus comprising ribosomes, mRNA, tRNAs and accessory protein factors. The ribosome (Box 1), a universal dynamic cellular ribonucleoprotein complex, is the key player in this p ...
... Translation of the genetic code into proteins is the second stage of protein biosynthesis. It is performed by a complex apparatus comprising ribosomes, mRNA, tRNAs and accessory protein factors. The ribosome (Box 1), a universal dynamic cellular ribonucleoprotein complex, is the key player in this p ...
The Effect of a Limited Supply of Phenylalanine, Threonine, or
... Lys and Val; these are extracted by the mammary secretory cells from the blood in excess relative to the amount secreted in milk protein. These excess EAA might be used as a potential energy precursor or as a source of carbon (C) and N for synthesis of other components, especially NEAA and fatty aci ...
... Lys and Val; these are extracted by the mammary secretory cells from the blood in excess relative to the amount secreted in milk protein. These excess EAA might be used as a potential energy precursor or as a source of carbon (C) and N for synthesis of other components, especially NEAA and fatty aci ...
A Patch of Surface-Exposed Residues Mediates
... pathogens, is associated with precise recognition events described in genetic terms by the gene-for-gene hypothesis (Flor, 1971). In such cases, plant resistance is inherited as a single dominant or semidominant gene. For the plant resistance (R) gene to be functional the pathogen must carry a compl ...
... pathogens, is associated with precise recognition events described in genetic terms by the gene-for-gene hypothesis (Flor, 1971). In such cases, plant resistance is inherited as a single dominant or semidominant gene. For the plant resistance (R) gene to be functional the pathogen must carry a compl ...
CBS domains: structure, function, and pathology in human proteins
... the currently available structural data, it is unlikely that a CBS domain in one subunit interacts with a CBS domain in another subunit, but an association between two CBS pairs located in two different subunits cannot be excluded and could contribute, either directly or indirectly, to the formation ...
... the currently available structural data, it is unlikely that a CBS domain in one subunit interacts with a CBS domain in another subunit, but an association between two CBS pairs located in two different subunits cannot be excluded and could contribute, either directly or indirectly, to the formation ...
REDESIGN OF CARNITINE ACETYLTRANSFERASE SPECIFICITY BY PROTEIN ENGINEERING UNIVERSIDAD DE BARCELONA
... Choline acetyltransferase (ChAT) catalyzes a similar reaction to CrAT, with the difference that in ChAT the acetyl group from acetyl-CoA is transferred to choline instead of carnitine. Cronin (1998) successfully redesigned ChAT to use carnitine instead of its natural substrate choline. In the presen ...
... Choline acetyltransferase (ChAT) catalyzes a similar reaction to CrAT, with the difference that in ChAT the acetyl group from acetyl-CoA is transferred to choline instead of carnitine. Cronin (1998) successfully redesigned ChAT to use carnitine instead of its natural substrate choline. In the presen ...
Regulation of Translation by Essential Amino Acids and Glucose in
... A special thank you to the staff at the Burford Dairy Research farm for their help with all aspects of this study. Specifically to Michelle Carson, who held my hand more than once through late-night pump checks and guided me through the many small details of conducting iii ...
... A special thank you to the staff at the Burford Dairy Research farm for their help with all aspects of this study. Specifically to Michelle Carson, who held my hand more than once through late-night pump checks and guided me through the many small details of conducting iii ...
The Shwachman-Diamond SBDS protein localizes to the nucleolus
... contains deletions and nucleotide changes that prevent the generation of a functional protein.9 The majority of patients (nearly 75%) with Shwachman-Diamond syndrome were found to harbor SBDS mutations arising from a gene conversion event with this pseudogene.9 The SBDS gene is predicted to encode a ...
... contains deletions and nucleotide changes that prevent the generation of a functional protein.9 The majority of patients (nearly 75%) with Shwachman-Diamond syndrome were found to harbor SBDS mutations arising from a gene conversion event with this pseudogene.9 The SBDS gene is predicted to encode a ...
Multiple Roles of the Cytoskeleton in Bacterial Autophagy
... cytoplasmic material to the lysosome for degradation (Figure 1A). The different steps of canonical autophagy have been well characterized and involve the assembly of at least 36 autophagyrelated (ATG) proteins into distinct complexes [5]. The ATG1UNC-51-like kinase (ULK) complex initiates formation ...
... cytoplasmic material to the lysosome for degradation (Figure 1A). The different steps of canonical autophagy have been well characterized and involve the assembly of at least 36 autophagyrelated (ATG) proteins into distinct complexes [5]. The ATG1UNC-51-like kinase (ULK) complex initiates formation ...
End-product control of enzymes of branched
... isoleucine-valine pathway, the combination of all three amino acids gave in individual experiments activities 0.12-0.19 of those with no supplementation, the ratio of the means being 0.16. Supplementation with threonine, or with leucine, isoleucine or valine singly or in pairwise combinations, gave ...
... isoleucine-valine pathway, the combination of all three amino acids gave in individual experiments activities 0.12-0.19 of those with no supplementation, the ratio of the means being 0.16. Supplementation with threonine, or with leucine, isoleucine or valine singly or in pairwise combinations, gave ...
Protein metabolism in exercising human with special reference to
... The lengths of polypeptide chains vary widely. A hormone called thyrotropin-releasing hormone, for example, is only three amino acids long, whereas myosin, a muscle protein, contains approximately 4500 amino acids. When the length of a polypeptide chain becomes very long (containing more than approx ...
... The lengths of polypeptide chains vary widely. A hormone called thyrotropin-releasing hormone, for example, is only three amino acids long, whereas myosin, a muscle protein, contains approximately 4500 amino acids. When the length of a polypeptide chain becomes very long (containing more than approx ...
infected nodule cells
... roots, nodulation appeared to cause no significant change in transcript levels. However, the expression maximum was reached in nodules, with over four times the levels detected in nitrogen-fertilized, non-inoculated roots. Sequence comparison of the 16 ZIP proteins encoded in M. truncatula genome wi ...
... roots, nodulation appeared to cause no significant change in transcript levels. However, the expression maximum was reached in nodules, with over four times the levels detected in nitrogen-fertilized, non-inoculated roots. Sequence comparison of the 16 ZIP proteins encoded in M. truncatula genome wi ...
Potassium starvation responses in yeast highlight novel potassium-related functions
... cells to the proper redox state. Yeast cells growing on ammonium as nitrogen source but lacking potassium accumulate large amounts of intracellular ammonium, which is transported through Trk1 taking advantage of the chemical similarity of both cations. Ammonium accumulation activates the retrograde ...
... cells to the proper redox state. Yeast cells growing on ammonium as nitrogen source but lacking potassium accumulate large amounts of intracellular ammonium, which is transported through Trk1 taking advantage of the chemical similarity of both cations. Ammonium accumulation activates the retrograde ...
Chloroplast structure: from chlorophyll granules to supra
... that the crystal structures alone cannot explain many known functional properties of thylakoid membranes. What is needed now is more precise information on how the different complexes are organized in thylakoid membranes and how this organization is altered in response to short-term (seconds to hour ...
... that the crystal structures alone cannot explain many known functional properties of thylakoid membranes. What is needed now is more precise information on how the different complexes are organized in thylakoid membranes and how this organization is altered in response to short-term (seconds to hour ...
Invariant amino acids essential for decoding function of polypeptide
... activities are not affected at all and the GTPase activity of eRF3 which is entirely dependent on the binding of eRF1 and eRF3 to the ribosome as mentioned above remains as in the presence of the wild-type eRF1 (Figure 2). Most likely, invariant Tyr125 is essential for the UAG stop codon recognition ...
... activities are not affected at all and the GTPase activity of eRF3 which is entirely dependent on the binding of eRF1 and eRF3 to the ribosome as mentioned above remains as in the presence of the wild-type eRF1 (Figure 2). Most likely, invariant Tyr125 is essential for the UAG stop codon recognition ...
Nonribosomal peptide synthesis in Aspergillus
... 49-PPTases are classified according to their structure and carrier protein specificity and form three main groups: AcpS type, Sfp type and those present in fatty acid synthase II (Sanchez et al., 2001). AcpS type are those 49-PPTases commonly involved in fatty acid synthesis, while Sfp type are comm ...
... 49-PPTases are classified according to their structure and carrier protein specificity and form three main groups: AcpS type, Sfp type and those present in fatty acid synthase II (Sanchez et al., 2001). AcpS type are those 49-PPTases commonly involved in fatty acid synthesis, while Sfp type are comm ...
Turnover of protein phosphorylation evolving under
... estimated that the average constraint imposed on proteins by their phosphorylation is relatively weak (e.g., Landry et al., 2009; studies reviewed in Levy et al., 2012). Beyond the fact that variation in the different methods and datasets may contribute to some of the disagreements in estimating pho ...
... estimated that the average constraint imposed on proteins by their phosphorylation is relatively weak (e.g., Landry et al., 2009; studies reviewed in Levy et al., 2012). Beyond the fact that variation in the different methods and datasets may contribute to some of the disagreements in estimating pho ...
PeptidePicker: a Tool for Determining Most Appropriate Peptides for
... an XIC signal, the ESP predictor, however, correctly selected on average only two out of the top five experimentally validated MRM peptides per protein (#9).12 PeptideAtlas5, 16 has combined its database of observed peptides with PABST (Peptide Atlas Best SRM Transition)17 to select the best peptide ...
... an XIC signal, the ESP predictor, however, correctly selected on average only two out of the top five experimentally validated MRM peptides per protein (#9).12 PeptideAtlas5, 16 has combined its database of observed peptides with PABST (Peptide Atlas Best SRM Transition)17 to select the best peptide ...
Novel regulatory roles of cAMP receptor proteins in
... et al., 2004). Consequently, intracellular cAMP concentrations in mycobacterial cells are considered to be ~100-fold higher than those of other bacteria (Dass et al., 2008; Padh & Venkitasubramanian, 1976, 1980), but the significance of this is not known. Secretion of cAMP directly into host macroph ...
... et al., 2004). Consequently, intracellular cAMP concentrations in mycobacterial cells are considered to be ~100-fold higher than those of other bacteria (Dass et al., 2008; Padh & Venkitasubramanian, 1976, 1980), but the significance of this is not known. Secretion of cAMP directly into host macroph ...
The Drosophila Planar Polarity Proteins Inturned and
... hrs). The accumulation of Mwh appeared decreased in all of the mutant clones (Figure 1), particularly in the PPE mutant clones (Figure 1 C-H). Our results are consistent with those reported by (STRUTT and WARRINGTON 2008). We extended the analysis and quantified the decrease in two ways (see Methods ...
... hrs). The accumulation of Mwh appeared decreased in all of the mutant clones (Figure 1), particularly in the PPE mutant clones (Figure 1 C-H). Our results are consistent with those reported by (STRUTT and WARRINGTON 2008). We extended the analysis and quantified the decrease in two ways (see Methods ...
Get PDF - Wiley Online Library
... The poly(A) tail is bound by the poly(A)-binding protein (PABP), which is necessary for efficient translation (for reviews, see Jacobson, 1996; Sachs et al., 1997). In yeast, eIF4G was found to associate with PABP (Tarun and Sachs, 1996). The PABP-binding site was mapped to an N-terminal region prox ...
... The poly(A) tail is bound by the poly(A)-binding protein (PABP), which is necessary for efficient translation (for reviews, see Jacobson, 1996; Sachs et al., 1997). In yeast, eIF4G was found to associate with PABP (Tarun and Sachs, 1996). The PABP-binding site was mapped to an N-terminal region prox ...