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CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative

Pharmacological Effects
Pharmacological Effects

Aprotinin
Aprotinin

... This follows a full review of the benefits and risks of all antifibrinolytic medicines, which found that the results of the BART study on which the suspension was based are unreliable. The Committee found that there were a number of problems with the way the BART study was conducted, which cast doub ...
Journal of Forensic Toxicology and Pharmacology
Journal of Forensic Toxicology and Pharmacology

Essential fatty acids in health and chronic disease1,2 - Direct-MS
Essential fatty acids in health and chronic disease1,2 - Direct-MS

... tissue cultures, and cells (Table 2; 34). As expected, earlier studies focused on mechanisms that involve eicosanoid metabolites. More recently, however, the effects of fatty acids on gene expression have been investigated and this focus of interest has led to studies at the molecular level (Tables ...
Valproic acid metabolism and its effects on mitochondrial fatty acid
Valproic acid metabolism and its effects on mitochondrial fatty acid

The Glycine Transporter-1 Inhibitor SSR103800 Displays a
The Glycine Transporter-1 Inhibitor SSR103800 Displays a

Prodrugs for Amines
Prodrugs for Amines

... particularly those, such as amides, in which the capacity to ionize has been obviated. On the other hand, the very robustness of amino derivatives means that subtle drug targeting effects can be achieved if an appropriate local vector can be identified and accommodated in the design process. A numbe ...
Is there a role for EGFR Tyrosine Kinase Inhibitors in recurrent
Is there a role for EGFR Tyrosine Kinase Inhibitors in recurrent

...  Cohort A will include 32 patients at first recurrence with EGFRVIII mutations.  Cohort B will include 32 patients at first recurrence with EGFR gene amplification but no EGFRVIII mutation ...
Valproic acid metabolism and its effects
Valproic acid metabolism and its effects

... These properties are predominantly determined by the mode of VPA administration, and the condition of the patient (particularly age) (Battino et al 1995; Dutta et al 2004). Detailed information concerning VPA absorption, distribution and elimination can be found in these reviews and other sources (s ...
Apixaban in patients with Atrial Fibrillation: A Systematic Review
Apixaban in patients with Atrial Fibrillation: A Systematic Review

Hypertension Medications
Hypertension Medications

Dissociable effects of monoamine reuptake inhibitors on distinct
Dissociable effects of monoamine reuptake inhibitors on distinct

formulation development and stability studies of vitamin D3
formulation development and stability studies of vitamin D3

distribution kinetics of salicylic acid in the dual
distribution kinetics of salicylic acid in the dual

... Salicylic acid is metabolized in man and animals to salicyluric acid, salicyl phenolic, and acyl glucuronides, gentisic acid and gentisuric acid. In man and rat, the main metabolite is the glycine conjugate, salicyluric acid. Available data suggest that salicyluric acid and salicyl phenolic glucuron ...
Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice
Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice

Slide 1
Slide 1

PART III
PART III

Selective serotonin reuptake inhibitors and risk for gastrointestinal
Selective serotonin reuptake inhibitors and risk for gastrointestinal

... aged above 50 years the risk of upper gastrointestinal bleeding occurred after a median of 25 weeks with SSRIs. Approximately 67% of these patients were on NSAIDs at the same time. A meta-analysis concluded that SSRIs use, alone or in combination with NSAIDs, substantially increases the risk of uppe ...
Pharmaceutical Development Case Study: “ACE Tablets”
Pharmaceutical Development Case Study: “ACE Tablets”

Statins Transport, side effects and cytoxicity_Rev2
Statins Transport, side effects and cytoxicity_Rev2

Doctoral Thesis
Doctoral Thesis



... cholic acid to patients with gallstones decreases cholesterol saturation of gallbladder bile and may induce gallstone dissolution (1 -4). T h e exact mechanisms of action of the two bile acids in man have not been completely elucidated. According to several investigations chenodeoxycholic acid reduc ...
fullcvenglish_tmavromous
fullcvenglish_tmavromous

... 7.Participation as a co-ordinator in a research project funded by the Institute of Promotion of Research in Cyprus entitled “New Approaches to face Psoriasis” and bilateral collaborations between Cyprus with Slovenia and Romania. 8.Co-organisation with S. Mavromoustakos in Cyprus a scientific confer ...
Protein Kinase C Mediates the Synergistic Interaction Between
Protein Kinase C Mediates the Synergistic Interaction Between

... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
< 1 2 3 4 5 6 7 8 9 10 ... 70 >

Discovery and development of ACE inhibitors



The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.
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