Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A
... assays.[16] In this study, C. caudatus and Oenanthe javanica (Selom) aqueous extracts were found to have the highest DPPH and FRAP values. This finding has further indicated that C. caudatus is a good source of anti-oxidant. Anti-diabetic activity A previous study on obese, C. caudatus extract-treat ...
... assays.[16] In this study, C. caudatus and Oenanthe javanica (Selom) aqueous extracts were found to have the highest DPPH and FRAP values. This finding has further indicated that C. caudatus is a good source of anti-oxidant. Anti-diabetic activity A previous study on obese, C. caudatus extract-treat ...
Pharmacological Characterization of Nicotine`s Interaction with
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 17, 2017 ...
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 17, 2017 ...
PDF - Cosmetic Ingredient Review
... (Figure 1). Malic acid and the malates are monohydroxy succinic acids. Except for the free acids and salts, these ingredients are esterified with an alkyl group at each end of the molecule. For instance, diisostearyl malate is monohydroxy substituted succinic acid, which is esterified at each end wi ...
... (Figure 1). Malic acid and the malates are monohydroxy succinic acids. Except for the free acids and salts, these ingredients are esterified with an alkyl group at each end of the molecule. For instance, diisostearyl malate is monohydroxy substituted succinic acid, which is esterified at each end wi ...
6-keto, 7,8
... Importance to structural modification of morphine In the structure of morphine (or any other opioid) are likely to cause a change in the affinity and intrinsic activity of the new compound for each of the opioid receptor types, i.e., a selective μ agonist may shift to become a selective К agonist ...
... Importance to structural modification of morphine In the structure of morphine (or any other opioid) are likely to cause a change in the affinity and intrinsic activity of the new compound for each of the opioid receptor types, i.e., a selective μ agonist may shift to become a selective К agonist ...
Evaluation of different mycobacterial species for drug discovery and
... The main objectives of this study were to identify an appropriate in vitro model that could be used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set ...
... The main objectives of this study were to identify an appropriate in vitro model that could be used for anti-Tb drug high-throughput screening (HTS), and to use this model to identify a novel candidate anti-tubercular drug and its cognate cellular target. A sensitive growth inhibition assay was set ...
SLCO1B1 polymorphism markedly affects the pharmacokinetics of
... pharmacokinetics of simvastatin acid Marja K. Pasanen, Mikko Neuvonen, Pertti J. Neuvonen and Mikko Niemi Background and objective Organic anion transporting polypeptide 1B1 (OATP1B1) is an uptake transporter located at the sinusoidal membrane of human hepatocytes. This study aimed to investigate th ...
... pharmacokinetics of simvastatin acid Marja K. Pasanen, Mikko Neuvonen, Pertti J. Neuvonen and Mikko Niemi Background and objective Organic anion transporting polypeptide 1B1 (OATP1B1) is an uptake transporter located at the sinusoidal membrane of human hepatocytes. This study aimed to investigate th ...
QA84_3_Folic_acid_methotrexate
... methotrexate decreased by 20% after co-administration with folic acid (25). In the US a small study of 36 RA patients found methotrexate doses were increased following mandatory supplementation of enriched flour, rice, pasta, cornmeal, and other grain products with folic acid. The mean dose increase ...
... methotrexate decreased by 20% after co-administration with folic acid (25). In the US a small study of 36 RA patients found methotrexate doses were increased following mandatory supplementation of enriched flour, rice, pasta, cornmeal, and other grain products with folic acid. The mean dose increase ...
Download CV
... II: discovery of an orally active GCP II inhibitor." J Med Chem, 2003, 46(10):1989-96 Popik P, Kozela E, Wrobel M, Wozniak KM, Slusher BS. "Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibit ...
... II: discovery of an orally active GCP II inhibitor." J Med Chem, 2003, 46(10):1989-96 Popik P, Kozela E, Wrobel M, Wozniak KM, Slusher BS. "Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibit ...
Interactions between the cytochrome P450 system and
... 48.5% inhibition of clozapine metabolism; 42.0% inhibition was observed with the chemical CYP1A2 furafyline. Similarly, Olesen and Linnet42 noted significant inhibition of clozapine demethylation in vitro after incubation with fluvoxamine, a reaction catalyzed in vitro by CYP1A2, CYP2C9, CYP2C19, CY ...
... 48.5% inhibition of clozapine metabolism; 42.0% inhibition was observed with the chemical CYP1A2 furafyline. Similarly, Olesen and Linnet42 noted significant inhibition of clozapine demethylation in vitro after incubation with fluvoxamine, a reaction catalyzed in vitro by CYP1A2, CYP2C9, CYP2C19, CY ...
Inhibitio¡ of GLutathione S-Õransferases Studies
... in section 1.1 Èhe enzl¡me kinetics of GST and thus Èhe reversibre inhibition of GST may be adequately described by a sirnple unireactant system (with one substrate saturating). In this simple case, there are three main trpes of reversibre inhibition: competitive (inhibitor combines with free enz¡rm ...
... in section 1.1 Èhe enzl¡me kinetics of GST and thus Èhe reversibre inhibition of GST may be adequately described by a sirnple unireactant system (with one substrate saturating). In this simple case, there are three main trpes of reversibre inhibition: competitive (inhibitor combines with free enz¡rm ...
Discriminative Stimulus Properties of Cocaine
... to discriminate either low or high doses of cocaine from saline, although it has not been reported to antagonize the DS effects of cocaine in rats. It could be that species and/or training conditions are important determinants of the extent that NE is involved in the DS effects of cocaine. Nonethele ...
... to discriminate either low or high doses of cocaine from saline, although it has not been reported to antagonize the DS effects of cocaine in rats. It could be that species and/or training conditions are important determinants of the extent that NE is involved in the DS effects of cocaine. Nonethele ...
Very long chain omega3 (n3) fatty acids and
... like brain are rich in very long chain n‐3 fatty acids but again these are rarely eaten in most populations. EPA, DPA, and DHA are found in modest amounts in animal‐derived foods like eggs and meat (Table 1). Among foods, including fatty fish, the relative distribution of EPA, DPA, and DHA differs su ...
... like brain are rich in very long chain n‐3 fatty acids but again these are rarely eaten in most populations. EPA, DPA, and DHA are found in modest amounts in animal‐derived foods like eggs and meat (Table 1). Among foods, including fatty fish, the relative distribution of EPA, DPA, and DHA differs su ...
Clinical Pharmacology of Boceprevir (BOC): Metabolism
... • Many drugs are CYP3A4 inhibitors o These interactions are understood and managed appropriately o CYP3A4 substrate drugs with toxicities often dose-titrated as standard practice o Many drug classes include alternatives that are not CYP3A4 substrates o No interaction with drugs metabolized by other ...
... • Many drugs are CYP3A4 inhibitors o These interactions are understood and managed appropriately o CYP3A4 substrate drugs with toxicities often dose-titrated as standard practice o Many drug classes include alternatives that are not CYP3A4 substrates o No interaction with drugs metabolized by other ...
Simvastatin
... increased and the specific binding of LDL to the cells was increased, suggesting increased expression of the LDL receptor.1 In the rat the drug blocked cholesterol synthesis after a single oral dose with ID50 values of less than 0.2 mg.kg-1. Studies have been carried out in the dog to assess the eff ...
... increased and the specific binding of LDL to the cells was increased, suggesting increased expression of the LDL receptor.1 In the rat the drug blocked cholesterol synthesis after a single oral dose with ID50 values of less than 0.2 mg.kg-1. Studies have been carried out in the dog to assess the eff ...
In Vivo Criteria To Differentiate Monoamine Reuptake Inhibitors from
... al., 1995). It is unlikely that this would be a property of releasing agents, assuming that they produce depolarizationindependent release of 5-HT. 4) Because both reuptake inhibitors and releasing agents such as fenfluramine bind to the 5-HT carrier, pretreatment with reuptake inhibitors can attenu ...
... al., 1995). It is unlikely that this would be a property of releasing agents, assuming that they produce depolarizationindependent release of 5-HT. 4) Because both reuptake inhibitors and releasing agents such as fenfluramine bind to the 5-HT carrier, pretreatment with reuptake inhibitors can attenu ...
assessment of the opiate properties of two constituents of a toxic
... l-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenyl-4-propionoxypiperidine (MPPP). The opiate properties of these two compounds have been assessed using in vitro receptor binding techniques as well as behavioral tests indicative of opiate action, including analgesia, catatonia, ...
... l-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenyl-4-propionoxypiperidine (MPPP). The opiate properties of these two compounds have been assessed using in vitro receptor binding techniques as well as behavioral tests indicative of opiate action, including analgesia, catatonia, ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.