Review of Organic Functional Groups: Introduction to Medicinal
... creativity, enthusiasm, and helpful suggestions in addition to their case studies to this edition of the book. I also want to thank the excellent staff, past and present, at LWW who have made this project seem more like an academic undertaking rather than a commercial process. Many of the staff memb ...
... creativity, enthusiasm, and helpful suggestions in addition to their case studies to this edition of the book. I also want to thank the excellent staff, past and present, at LWW who have made this project seem more like an academic undertaking rather than a commercial process. Many of the staff memb ...
Mechanism of endothelial nitric oxide synthase
... has also been a serious public health burden all over the world. Thus, there is a critical need for developing anti-hypertensive drugs to control the blood pressure. However, many synthetic antihypertensive drugs are confirmed to have certain side effects, such as dizziness, headache, coughing, ang ...
... has also been a serious public health burden all over the world. Thus, there is a critical need for developing anti-hypertensive drugs to control the blood pressure. However, many synthetic antihypertensive drugs are confirmed to have certain side effects, such as dizziness, headache, coughing, ang ...
Exploitation of Bile Acid Transport Systems in Prodrug Design
... Bile acids, which are steroidal molecules derived from the catabolism of cholesterol and essential for the digestion and absorption of lipids and lipid-soluble vitamins [2], pass through several cellular membranes via both active and passive transport processes during enterohepatic circulation [3-8] ...
... Bile acids, which are steroidal molecules derived from the catabolism of cholesterol and essential for the digestion and absorption of lipids and lipid-soluble vitamins [2], pass through several cellular membranes via both active and passive transport processes during enterohepatic circulation [3-8] ...
Chapter 23
... Mosby items and derived items © 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2010, 2007, 2004 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Min2008 online
... commonly referred to as the two isoforms of GSK3 (Woodgett, 1990). The use of the terms ‘‘GSK3’’ or ‘‘GSK3a/b’’ henceforth is meant to refer to both GSK3 paralogs, since all GSK3 inhibitory agents, including lithium, affect both proteins. Among the many cellular functions regulated by GSK3 are gene ...
... commonly referred to as the two isoforms of GSK3 (Woodgett, 1990). The use of the terms ‘‘GSK3’’ or ‘‘GSK3a/b’’ henceforth is meant to refer to both GSK3 paralogs, since all GSK3 inhibitory agents, including lithium, affect both proteins. Among the many cellular functions regulated by GSK3 are gene ...
Blood Coagulation Pathway
... Why thrombin is an excellent target? Forms & stabilizes the clot Further generation of thrombin Stimulates thrombus- activated fibrinolysis ...
... Why thrombin is an excellent target? Forms & stabilizes the clot Further generation of thrombin Stimulates thrombus- activated fibrinolysis ...
September 2001
... anhydride method. The antisera having the relatively higher titre value among the antisera obtained were used for subsequent study. The antibodies were raised in rabbits and showed cross-reactivity with a few structurally similar steroids. Especially those steroids having a 17a-methyl group such as ...
... anhydride method. The antisera having the relatively higher titre value among the antisera obtained were used for subsequent study. The antibodies were raised in rabbits and showed cross-reactivity with a few structurally similar steroids. Especially those steroids having a 17a-methyl group such as ...
Prozac Paper (Second Draft)
... characterized by a prominent and persistent depressed or dysphoric mood that significantly affects the ability of the individual to function. Depression in children and adolescents has also been effectively treated with Prozac (FDA 7-8). Another indication for this prominent antidepressant is in the ...
... characterized by a prominent and persistent depressed or dysphoric mood that significantly affects the ability of the individual to function. Depression in children and adolescents has also been effectively treated with Prozac (FDA 7-8). Another indication for this prominent antidepressant is in the ...
FLT3 ligand impedes the efficacy of FLT3 inhibitors
... Acute myeloid leukemia (AML) patients who harbor the FLT3/ITD mutation have an exceptionally poor prognosis.1,2 During the past decade, efforts have been underway to develop FLT3 inhibitors in the hopes of improving outcomes for these patients.3 Several agents have now been studied as monotherapy fo ...
... Acute myeloid leukemia (AML) patients who harbor the FLT3/ITD mutation have an exceptionally poor prognosis.1,2 During the past decade, efforts have been underway to develop FLT3 inhibitors in the hopes of improving outcomes for these patients.3 Several agents have now been studied as monotherapy fo ...
D4/D5 The Miracle Drug It`s springtime. Imagine yourself walking
... pus in your finger. You go to the doctor and he suggests cutting your finger off before the infection spreads elsewhere. Does this scare you? This was the world’s nightmare before penicillin was discovered. Penicillin is the world’s first naturally occurring antibiotic discovered. Before its discove ...
... pus in your finger. You go to the doctor and he suggests cutting your finger off before the infection spreads elsewhere. Does this scare you? This was the world’s nightmare before penicillin was discovered. Penicillin is the world’s first naturally occurring antibiotic discovered. Before its discove ...
sertraline is metabolized by multiple cytochrome p450 enzymes
... Such data can be used both retrospectively, to provide a mechanistic understanding of pharmacokinetic observations, and prospectively, to predict drug interactions or pharmacokinetics that are highly variable because of metabolism by enzymes subject to genetic polymorphism. The objective of the stud ...
... Such data can be used both retrospectively, to provide a mechanistic understanding of pharmacokinetic observations, and prospectively, to predict drug interactions or pharmacokinetics that are highly variable because of metabolism by enzymes subject to genetic polymorphism. The objective of the stud ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.