ASP2151, a novel helicase–primase inhibitor
... complex as a new class of anti-herpesvirus agents. Our medicinal chemistry process was initiated based upon a 2-amino thiazole-containing HSV HPI23 to create more potent virusspecific agents with broader spectra and we consequently selected ASP2151 as a candidate for a novel anti-herpes agent. ASP21 ...
... complex as a new class of anti-herpesvirus agents. Our medicinal chemistry process was initiated based upon a 2-amino thiazole-containing HSV HPI23 to create more potent virusspecific agents with broader spectra and we consequently selected ASP2151 as a candidate for a novel anti-herpes agent. ASP21 ...
Review on Prodrugs
... to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or pr ...
... to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or pr ...
The Dopamine Transporter and Cocaine Medication Development
... use of nonhuman subjects that are anatomically and physiologically similar to humans have allowed for the development of a clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The pro ...
... use of nonhuman subjects that are anatomically and physiologically similar to humans have allowed for the development of a clear and clinically relevant characterization of medication effectiveness in subjects with a documented history of drug use under well controlled laboratory conditions. The pro ...
Prodrugs—from Serendipity to Rational Design
... to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or pr ...
... to release the active parent drug, which can then elicit its desired pharmacological effect in the body. In most cases, prodrugs are simple chemical derivatives that are only one or two chemical or enzymatic steps away from the active parent drug. However, some prodrugs lack an obvious carrier or pr ...
GLYCYRRHIZA GLABRA Review Article LAKSHMI T
... Glycyrrhizinic acid, a major component of licorice, has antiulcer effect by raising the local concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach. In vitro activity of Extractum liquiritiae (EL), glycyrrhizic acid (G ...
... Glycyrrhizinic acid, a major component of licorice, has antiulcer effect by raising the local concentration of prostaglandins that promote mucous secretion and cell proliferation in the stomach. In vitro activity of Extractum liquiritiae (EL), glycyrrhizic acid (G ...
Neurochemical Neutralization of Methamphetamine With High
... on both dopaminergic and serotonergic nerves requires the transport of METH into the nerve terminals (Seiden et al., 1993). Thus, transport of METH into nerve terminals is the crucial first step in the production of METH-associated pharmacological and toxicological effects. Compounds that bind to bi ...
... on both dopaminergic and serotonergic nerves requires the transport of METH into the nerve terminals (Seiden et al., 1993). Thus, transport of METH into nerve terminals is the crucial first step in the production of METH-associated pharmacological and toxicological effects. Compounds that bind to bi ...
Morphine Glucuronidation and Glucosidation Represent
... 12 rpm for 4 hours. Control experiments were also performed with phosphate buffer or HLM (0.5 mg/ml) and BSA (2% w/v) on both sides of the dialysis cells at low and high concentrations of morphine to ensure that equilibrium was attained. A 200-ml aliquot was collected from each compartment, treated ...
... 12 rpm for 4 hours. Control experiments were also performed with phosphate buffer or HLM (0.5 mg/ml) and BSA (2% w/v) on both sides of the dialysis cells at low and high concentrations of morphine to ensure that equilibrium was attained. A 200-ml aliquot was collected from each compartment, treated ...
Uptake of Methotrexate, Aminopterin, and
... which have recently been described, the 3 drugs are stoichiometrically equivalent in potency between 0 and 80% inhibition ofenzyme activity (17). Enzyme Assay. Folate reductase in intestinal supernatants from untreated mice was titrated with drugs in a manner similar to that described by Werkheiser3 ...
... which have recently been described, the 3 drugs are stoichiometrically equivalent in potency between 0 and 80% inhibition ofenzyme activity (17). Enzyme Assay. Folate reductase in intestinal supernatants from untreated mice was titrated with drugs in a manner similar to that described by Werkheiser3 ...
www.chembio.umich.edu
... Statistical analysis. For comparisons of treatment groups, a one-way ANOVA followed by Bonferroni post hoc analysis using GraphPad Prism Software (version 4.01) was done. Statistical significance was achieved when P < 0.05. ...
... Statistical analysis. For comparisons of treatment groups, a one-way ANOVA followed by Bonferroni post hoc analysis using GraphPad Prism Software (version 4.01) was done. Statistical significance was achieved when P < 0.05. ...
low-dose diuretics for first-line and combined treatment of
... with a reduced risk of CHD in the clinical trials. There are also other possible explanations. Hyperglycemia It has been known for decades that thiazide diuretics are associated with an increased risk of the development of diabetes. At lower doses of chlorthalidone (12.5-25 mg/day), this effect is m ...
... with a reduced risk of CHD in the clinical trials. There are also other possible explanations. Hyperglycemia It has been known for decades that thiazide diuretics are associated with an increased risk of the development of diabetes. At lower doses of chlorthalidone (12.5-25 mg/day), this effect is m ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.