The so-called „designer steroids“ Nor
... assays. The synthesis of Norbolethone starts with Norgestrel and its nickel-catalyzed hydrogenation resulting in Norbolethone. Norbolethone caused a lot of bleeding disorders and many androgenizing side effects. DMT is an anabolic steroid, which was synthesized and patented in 1961. The synthesis of ...
... assays. The synthesis of Norbolethone starts with Norgestrel and its nickel-catalyzed hydrogenation resulting in Norbolethone. Norbolethone caused a lot of bleeding disorders and many androgenizing side effects. DMT is an anabolic steroid, which was synthesized and patented in 1961. The synthesis of ...
full text
... point to be discussed is the higher Ki value reported for calcium uptake compared to that obtained for Ca-ATPase activity. It should be noted that CaATPase activity was measured in the presence of a calcium ionophore while calcium uptake was measured in its absence. As a consequence, the relative di ...
... point to be discussed is the higher Ki value reported for calcium uptake compared to that obtained for Ca-ATPase activity. It should be noted that CaATPase activity was measured in the presence of a calcium ionophore while calcium uptake was measured in its absence. As a consequence, the relative di ...
Full-Text PDF
... (FXa) has remained the center of attention in the last decade. In this study, 16 ginsenosides and two sapogenins were isolated, identified and quantified. To determine the inhibitory potential on FXa, the chromogenic substrates method was used. The assay suggested that compounds 5, 13 and 18 were ma ...
... (FXa) has remained the center of attention in the last decade. In this study, 16 ginsenosides and two sapogenins were isolated, identified and quantified. To determine the inhibitory potential on FXa, the chromogenic substrates method was used. The assay suggested that compounds 5, 13 and 18 were ma ...
SYNTHESIS AND CHARACTERIZATION OF NEW AZO DYE (1
... spectrophotometer .The purity of the dye was cheeked by TLC using the solvent system (Sec.Butanol-wateracetic acid) (2:2:1).The melting point of the purified dye was measured in an open capillary tube. 2-Study of anti bacterial activity of dye. ...
... spectrophotometer .The purity of the dye was cheeked by TLC using the solvent system (Sec.Butanol-wateracetic acid) (2:2:1).The melting point of the purified dye was measured in an open capillary tube. 2-Study of anti bacterial activity of dye. ...
study
... Narrowing the animal kingdom down to reptiles, the snakes have also proven to be useful sources of medicine. The angiotensin converting enzyme inhibitor Captopril was first isolated from the venom of the Brazilian arrowhead viper (4). Ancrod, an anticoagulant which destroys fibrinogen, hence, deplet ...
... Narrowing the animal kingdom down to reptiles, the snakes have also proven to be useful sources of medicine. The angiotensin converting enzyme inhibitor Captopril was first isolated from the venom of the Brazilian arrowhead viper (4). Ancrod, an anticoagulant which destroys fibrinogen, hence, deplet ...
The Role of Ligand Efficiency Measures in Drug Discovery
... intermolecular interaction to the ligand alone. Secondly, it assumes the binding energies per atom are additive. Thus for a given ligand efficiency (the gradient) there is a linear relationship between the free energy of binding and the number of heavy atoms, where it is assumed a ligand with zero a ...
... intermolecular interaction to the ligand alone. Secondly, it assumes the binding energies per atom are additive. Thus for a given ligand efficiency (the gradient) there is a linear relationship between the free energy of binding and the number of heavy atoms, where it is assumed a ligand with zero a ...
министерство здравоохранения республики беларусь
... — schistosoma haematobium — half-life period — thromboxane A2 — transfer ribonucleic acid — wuchereria bancrofti ...
... — schistosoma haematobium — half-life period — thromboxane A2 — transfer ribonucleic acid — wuchereria bancrofti ...
ANTIINFLAMMATORY AND ANTIBACTERIAL ACTIVITIES OF DIFFERENT EXTRACTS OF GYNANDROPSIS GYNANDRA
... bone marrow depression, water and salt retention. For this reason there is a need to find and develop new antiinflammatory drugs with low side effects. Now in the present study, the systemic antiinflammatory effect was tested at 100, 200 and 400 mg/kg for hydroalcoholic, methanolic, ethyl acetate an ...
... bone marrow depression, water and salt retention. For this reason there is a need to find and develop new antiinflammatory drugs with low side effects. Now in the present study, the systemic antiinflammatory effect was tested at 100, 200 and 400 mg/kg for hydroalcoholic, methanolic, ethyl acetate an ...
- Wiley Online Library
... OXA-type enzymes are not as well inhibited by sulbactam as TEM-1 and other clinically used inhibitors. In general, b-lactamase inhibitors have negligible antimicrobial activity themselves, but restore antimicrobial activity to other b-lactams when used in combination. However, sulbactam is exception ...
... OXA-type enzymes are not as well inhibited by sulbactam as TEM-1 and other clinically used inhibitors. In general, b-lactamase inhibitors have negligible antimicrobial activity themselves, but restore antimicrobial activity to other b-lactams when used in combination. However, sulbactam is exception ...
Uses
... acetylation of 1-OH & 3-OH 1-acetoxy & 1,3-diacetoxy derivatives inactive. (5) Inability of the drug to penetrate m.o. ...
... acetylation of 1-OH & 3-OH 1-acetoxy & 1,3-diacetoxy derivatives inactive. (5) Inability of the drug to penetrate m.o. ...
Medical University of Lodz USE OF DENDRIMERS IN THE
... safety of their use I decided to examine the toxicity and biocompatibility with particular emphasis on effects on hemostasis and function of endothelium. I determined in vitro the influence of G1 – G4 PAMAM dendrimers, iminodiacetic acid derivatives and synthesized compounds on the process of clot f ...
... safety of their use I decided to examine the toxicity and biocompatibility with particular emphasis on effects on hemostasis and function of endothelium. I determined in vitro the influence of G1 – G4 PAMAM dendrimers, iminodiacetic acid derivatives and synthesized compounds on the process of clot f ...
Discovery and development of ACE inhibitors
The discovery of an orally inactive peptide from snake venom established the important role of angiotensin converting enzyme (ACE) inhibitors in regulating blood pressure. This led to the development of Captopril, the first ACE inhibitor. When the adverse effects of Captopril became apparent new derivates were designed. Then after the discovery of two active sites of ACE: N-domain and C-domain, the development of domain-specific ACE inhibitors began.