Novel psychoactive substances of interest for psychiatry
... are also available (10-12). Within any given “Spice” package, usually a range of different SC molecules (13) and/ or further psychoactives (14-20) can be identified. Batches of the same brand may possess highly variable SC concentrations (21). It is likely that a few hundreds of SC molecules are cur ...
... are also available (10-12). Within any given “Spice” package, usually a range of different SC molecules (13) and/ or further psychoactives (14-20) can be identified. Batches of the same brand may possess highly variable SC concentrations (21). It is likely that a few hundreds of SC molecules are cur ...
Opioid and Cannabinoid Modulation of Precipitated Withdrawal in
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 18, 2017 ...
... Downloaded from jpet.aspetjournals.org at ASPET Journals on June 18, 2017 ...
Serotonin or 5-hydroxytryptamine
... treatment; not recommended for patients with coronary vascular disease risk. • formulations: subcutaneous injection, oral, nasal spray • selective serotonin-receptor agonist (short duration of action) • probably more effective than ergotamine for management of acute migraine attacks (relief: 10 to 1 ...
... treatment; not recommended for patients with coronary vascular disease risk. • formulations: subcutaneous injection, oral, nasal spray • selective serotonin-receptor agonist (short duration of action) • probably more effective than ergotamine for management of acute migraine attacks (relief: 10 to 1 ...
Antidepressant drugs - Dr Lynch
... Symptoms: Neurological (confusion, agitation, coma), Neuromuscular (rigidity, tremors, myoclonus, hyperreflexia), Autonomic (hyperthermia, tachycardia, hyper/hypotension, GI upset) ...
... Symptoms: Neurological (confusion, agitation, coma), Neuromuscular (rigidity, tremors, myoclonus, hyperreflexia), Autonomic (hyperthermia, tachycardia, hyper/hypotension, GI upset) ...
Depression and Suicide
... Symptoms: Neurological (confusion, agitation, coma), Neuromuscular (rigidity, tremors, myoclonus, hyperreflexia), Autonomic (hyperthermia, tachycardia, hyper/hypotension, GI upset) ...
... Symptoms: Neurological (confusion, agitation, coma), Neuromuscular (rigidity, tremors, myoclonus, hyperreflexia), Autonomic (hyperthermia, tachycardia, hyper/hypotension, GI upset) ...
Pharm 22, 23- Drugs for Affective Disorders Depression
... Injection of norepinephrine, epinephrine or dopamine may be successful in treating priapism In approximately one-third of the cases reported, surgical intervention was required in a portion of these cases, permanent impairment of erectile function or impotence resulted WARN all men of slow d ...
... Injection of norepinephrine, epinephrine or dopamine may be successful in treating priapism In approximately one-third of the cases reported, surgical intervention was required in a portion of these cases, permanent impairment of erectile function or impotence resulted WARN all men of slow d ...
Control Mechanisms of the GI Tract
... May decrease gastric emptying (which may increase the tendency to vomit) Side effects include dry mouth, constipation, urinary retention, and tachycardia Examples: Aminopentamide Atropine Propantheline ...
... May decrease gastric emptying (which may increase the tendency to vomit) Side effects include dry mouth, constipation, urinary retention, and tachycardia Examples: Aminopentamide Atropine Propantheline ...
Opioid Presentation pt2(updated) [Read
... Sedation is a better indicator and should be monitored using a sedation score. This method has limitations if a patient who is deeply sedated is assessed as being in “normal sleep.” “Normal sleep” means patient is asleep but rousable. (eg ...
... Sedation is a better indicator and should be monitored using a sedation score. This method has limitations if a patient who is deeply sedated is assessed as being in “normal sleep.” “Normal sleep” means patient is asleep but rousable. (eg ...
A fatty acid in the MCT ketogenic diet for epilepsy treatment blocks
... MCT diet: A dietary treatment for epilepsy more commonly used in Europe than in the United States that is high in fats containing predominantly medium chain triglycerides; causes ketosis, a state where there are elevated concentrations of ketone bodies in the blood. Non-competitive antagonist: In th ...
... MCT diet: A dietary treatment for epilepsy more commonly used in Europe than in the United States that is high in fats containing predominantly medium chain triglycerides; causes ketosis, a state where there are elevated concentrations of ketone bodies in the blood. Non-competitive antagonist: In th ...
2015 PK and PD
... • At the cellular level: Most drugs exert their effects on the body by interacting with macromolecule “targets” which are usually on the surface or within cells. ...
... • At the cellular level: Most drugs exert their effects on the body by interacting with macromolecule “targets” which are usually on the surface or within cells. ...
Simultaneous Inhibition of Fatty Acid Amide Hydrolase and
... Response rate was averaged (6 S.E.M.) among mice and plotted as a function of dose. Response rate for an individual mouse was calculated by expressing the response rate during a test as a percentage of control; the control response rate was defined as the average response rate for the five preceding ...
... Response rate was averaged (6 S.E.M.) among mice and plotted as a function of dose. Response rate for an individual mouse was calculated by expressing the response rate during a test as a percentage of control; the control response rate was defined as the average response rate for the five preceding ...
Chapter 18 Opioid Analgesics
... Opioid Analgesics--- Pethidine (哌替啶) • Pethidine/meperidine and fentanyl(芬太尼) are the most widely used agents in this family of synthetic opioids. • The principal effects of pethidine with affinity for mu receptors are on the central nervous system. [Pharmacological Effects] The pharmacological eff ...
... Opioid Analgesics--- Pethidine (哌替啶) • Pethidine/meperidine and fentanyl(芬太尼) are the most widely used agents in this family of synthetic opioids. • The principal effects of pethidine with affinity for mu receptors are on the central nervous system. [Pharmacological Effects] The pharmacological eff ...
Pharmacology Study Guide – Test 2
... Tx…can stimulate or depress CNS, depending on does…bradycardia, spastic GI, asthma: ATROPINE o ATROPINE primarily used for CV disorders i.e. dx of sinus node dysfx, tx of PT w/ symptomatic 2nd degree AV block & adv life support for tx of sinus bradycardia accomp by hemodynamic compromise o Know th ...
... Tx…can stimulate or depress CNS, depending on does…bradycardia, spastic GI, asthma: ATROPINE o ATROPINE primarily used for CV disorders i.e. dx of sinus node dysfx, tx of PT w/ symptomatic 2nd degree AV block & adv life support for tx of sinus bradycardia accomp by hemodynamic compromise o Know th ...
Chronic WIN55,212-2 elicits sustained and conditioned increases in
... and pathways of the brain, which are collectively known as brain reward systems. In most cases, these drugs also yield reinforcing and rewarding effects in experimental animals, as assessed by relevant animal models, such as self-administration, conditioned place preference and intracranial self-sti ...
... and pathways of the brain, which are collectively known as brain reward systems. In most cases, these drugs also yield reinforcing and rewarding effects in experimental animals, as assessed by relevant animal models, such as self-administration, conditioned place preference and intracranial self-sti ...
Opioid Pharmacology Definitions 1. Opium – a mixture of alkaloids
... Emotional response to pain altered by opioid actions on the limbic cortex. ...
... Emotional response to pain altered by opioid actions on the limbic cortex. ...
Antipsychotics - Yorkshire and the Humber Deanery
... atypicals, greatest in those with dementia and within first month of starting treatment and with higher doses ...
... atypicals, greatest in those with dementia and within first month of starting treatment and with higher doses ...
Subtype-selective GABAA receptor mimetics—novel
... least in mice and rats. The two pertinent questions at present are, can other unwanted effects besides sedation also be avoided with subtype-selective (or partial) agonists and does the concept of a benzodiazepine-mediated antihyperalgesia also work in humans. Both questions are at present difficult ...
... least in mice and rats. The two pertinent questions at present are, can other unwanted effects besides sedation also be avoided with subtype-selective (or partial) agonists and does the concept of a benzodiazepine-mediated antihyperalgesia also work in humans. Both questions are at present difficult ...
Sedation & Analgesia - Pediatric Critical Care Education
... Paradoxical effects (less than midazolam) ...
... Paradoxical effects (less than midazolam) ...
schizophrenia
... chlorpromazine and thioridazine, studies showed that only a few atypical medications (clozapine, olanzapine, and risperidone) caused fewer movement disorders, but the low-potency drugs also tended to induce weight gain and sedation like the atypicals. ...
... chlorpromazine and thioridazine, studies showed that only a few atypical medications (clozapine, olanzapine, and risperidone) caused fewer movement disorders, but the low-potency drugs also tended to induce weight gain and sedation like the atypicals. ...
PSY650-Antipsychotics-Sedative-Hypnotics
... Mechanisms of Action • Classicals are usually D2 and D2-like receptor antagonists • Atypicals antagonize D2-like receptors plus some 5-HTa action – LSD – The serotonin hypothesis of negative symptoms ...
... Mechanisms of Action • Classicals are usually D2 and D2-like receptor antagonists • Atypicals antagonize D2-like receptors plus some 5-HTa action – LSD – The serotonin hypothesis of negative symptoms ...
Narcan Overview - Telco House Bed & Breakfast
... push; repeat as indicated (per protocol) SC; repeat as indicated (per protocol) ...
... push; repeat as indicated (per protocol) SC; repeat as indicated (per protocol) ...
Basic concepts in clinical pharmacology
... 1. You are the OOH drug information scientist / pharmacist / GP / on-call officer for the pharmaceutical company / nurse / etc. 2. The (male) patient has a longstanding history of kidney stones. They are usually small, they usually pass within 48 h, and the patient has been responsibly using 10 mg m ...
... 1. You are the OOH drug information scientist / pharmacist / GP / on-call officer for the pharmaceutical company / nurse / etc. 2. The (male) patient has a longstanding history of kidney stones. They are usually small, they usually pass within 48 h, and the patient has been responsibly using 10 mg m ...
Effects of different drugs of different - Sun Yat
... receptor antagonist and the proton pump inhibitor. Being the H2 receptor antagonist,Cimetidine can compete the H2receptors with histamine.Thereby,it can block the histamine’s function of promoting the secretion of gastric acid. Being the proton pump inhibitor, Omeprazole can block the last step of s ...
... receptor antagonist and the proton pump inhibitor. Being the H2 receptor antagonist,Cimetidine can compete the H2receptors with histamine.Thereby,it can block the histamine’s function of promoting the secretion of gastric acid. Being the proton pump inhibitor, Omeprazole can block the last step of s ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.