Chapter 16 Cholinesterase Inhibitors
... Type (or types) of receptor through which the drug acts (alpha1, alpha2, beta1, etc) Normal response to activation of those receptors (agonist versus antagonist) What the drug in question does to receptor function ...
... Type (or types) of receptor through which the drug acts (alpha1, alpha2, beta1, etc) Normal response to activation of those receptors (agonist versus antagonist) What the drug in question does to receptor function ...
Atypical Neuroleptics Enhance Histamine Turnover in Brain Via 5
... include a lower propensity to elicit extrapyramidal side-effects, an improved therapeutic efficacy on negative and affective symptomatology of schizophrenia as well as on refractory forms of the disease. These drugs, often designated “atypical” antipsychotics, a rather vague terminology, were mostly ...
... include a lower propensity to elicit extrapyramidal side-effects, an improved therapeutic efficacy on negative and affective symptomatology of schizophrenia as well as on refractory forms of the disease. These drugs, often designated “atypical” antipsychotics, a rather vague terminology, were mostly ...
Action - جامعة الكوفة
... phsiologic control of the involuntary organs but are directly influenced by only afew drugs 11-spinal roots of origin: The parasympathetic preganglionic motor fibers originate in cranial nerve and sacral segments of the spinal cord. The sympathetic preganglionic fibers originate in the thoracic and ...
... phsiologic control of the involuntary organs but are directly influenced by only afew drugs 11-spinal roots of origin: The parasympathetic preganglionic motor fibers originate in cranial nerve and sacral segments of the spinal cord. The sympathetic preganglionic fibers originate in the thoracic and ...
CURRICULUM VITAE
... 9-Tetrahydrocannabinol ( 9-THC), the major psychoactive constituent of marijuana (Cannabis Sativa L.) produces its physiological effects by interaction with cannabinoid receptors (CB1 and CB2). Cannabinoid receptors influence diverse cellular signal-transduction pathways. CB1 receptors are mainly ...
... 9-Tetrahydrocannabinol ( 9-THC), the major psychoactive constituent of marijuana (Cannabis Sativa L.) produces its physiological effects by interaction with cannabinoid receptors (CB1 and CB2). Cannabinoid receptors influence diverse cellular signal-transduction pathways. CB1 receptors are mainly ...
镇静催眠药sedative-hypnotic drugs
... channel , leading to the cell membrane hyperpolarization . Different from BZ drugs which increase Cl－channel opening frequence ，barbiturates mainly extend the Cl－channel opening time . In addition ，barbiturates can weaken or block the excited reaction resulted from depolarization caused by the glu ...
... channel , leading to the cell membrane hyperpolarization . Different from BZ drugs which increase Cl－channel opening frequence ，barbiturates mainly extend the Cl－channel opening time . In addition ，barbiturates can weaken or block the excited reaction resulted from depolarization caused by the glu ...
STRUCTURAL ACTIVITY RELATIONSHIP AMONG THE
... the anticholinergics, the following structure-activity relationships are found: ...
... the anticholinergics, the following structure-activity relationships are found: ...
PharmII Block I Handouts
... V. Mucosal Protective Agents A. Sucralfate (Carafate ®) is aluminum sucrose sulfate. B. It is thought to polymerize and bind selectively to necrotic tissue, thereby creating a barrier between the gastric contents and the gastric mucosa. C. Sucralfate is very effective for treating duodenal ulcers, a ...
... V. Mucosal Protective Agents A. Sucralfate (Carafate ®) is aluminum sucrose sulfate. B. It is thought to polymerize and bind selectively to necrotic tissue, thereby creating a barrier between the gastric contents and the gastric mucosa. C. Sucralfate is very effective for treating duodenal ulcers, a ...
ANXIOLYTICS AND HYPNOTICS
... LEARNING OUTCOMES By the end of the lecture, students will be able to… ...
... LEARNING OUTCOMES By the end of the lecture, students will be able to… ...
Withdrawal
... 1. Receptor Downregulation- Opioid receptors in the body are actively reduced due to overexposure to opioids. This can also have an effect on endogenous opioid peptide function (i.e. regular functioning of endorphins) 2. Antiopiates- Chemicals like neuropeptide FF, orphanin FQ/nociceptin, and Tyr-W- ...
... 1. Receptor Downregulation- Opioid receptors in the body are actively reduced due to overexposure to opioids. This can also have an effect on endogenous opioid peptide function (i.e. regular functioning of endorphins) 2. Antiopiates- Chemicals like neuropeptide FF, orphanin FQ/nociceptin, and Tyr-W- ...
L11- ANTIPLATELET DRUGS
... (released by endothelial cells lining the blood vessels) inhibit platelets aggregation. • An injury to vascular system leads to interaction between Platelets, Endothelial system and Coagulation factors which lead to formation of the CLOT ...
... (released by endothelial cells lining the blood vessels) inhibit platelets aggregation. • An injury to vascular system leads to interaction between Platelets, Endothelial system and Coagulation factors which lead to formation of the CLOT ...
73737373 - Restless Legs Syndrome Foundation
... • Methods: Changes in blood oxygen level dependent (BOLD) haemodynamic signal following intravenous infusion of GBP (equivalent to 30 mg kg-1 p.o., followed by 100 mg kg-1 p.o.), compared to saline control, were studied in isofluorane anaesthetized rats (n=8 per group). • Results: – Significant (P<0 ...
... • Methods: Changes in blood oxygen level dependent (BOLD) haemodynamic signal following intravenous infusion of GBP (equivalent to 30 mg kg-1 p.o., followed by 100 mg kg-1 p.o.), compared to saline control, were studied in isofluorane anaesthetized rats (n=8 per group). • Results: – Significant (P<0 ...
Inhaled Adrenergic Bronchodilators: Historical
... enzyme, adenylyl cyclase. Adenylyl cyclase in turn produces cyclic adenosine monophosphate, which is the “second messenger” considered to be responsible for the activity of  agonists, such as bronchodilation. Development of  Agonist Bronchodilators The prototypical drug in the adrenergic bronchodi ...
... enzyme, adenylyl cyclase. Adenylyl cyclase in turn produces cyclic adenosine monophosphate, which is the “second messenger” considered to be responsible for the activity of  agonists, such as bronchodilation. Development of  Agonist Bronchodilators The prototypical drug in the adrenergic bronchodi ...
Activation instead of blocking mesolimbic dopaminergic reward
... as self-medicating and leads to a preferential release of DA, which overcomes the hypodopaminergic state for that individual. The resultant self-medication provides a temporary relief of discomfort and a "pseudo feeling" of well-being [17]. Unfortunately, chronic abuse of these psychoactive substanc ...
... as self-medicating and leads to a preferential release of DA, which overcomes the hypodopaminergic state for that individual. The resultant self-medication provides a temporary relief of discomfort and a "pseudo feeling" of well-being [17]. Unfortunately, chronic abuse of these psychoactive substanc ...
P21 The role of ethanol containing lotions on ethylglucuronide in
... 38106 Braunschweig, [email protected] On January 22nd 2009, the German Health Authorities prohibited several nontraditional cannabinoids that proved to be the active components in popular “Bio-Designer-Drugs” like “Spice” and analogous products [1, 2]. While the regulation included several homologu ...
... 38106 Braunschweig, [email protected] On January 22nd 2009, the German Health Authorities prohibited several nontraditional cannabinoids that proved to be the active components in popular “Bio-Designer-Drugs” like “Spice” and analogous products [1, 2]. While the regulation included several homologu ...
CBD - NYU
... Species • Cannabis sativa – oldest known species used by humans (China) • >420 compounds: e.g. Eugenol: acts at GABAA receptors • 80 terpeno-phenol compounds, “cannabinoids” ...
... Species • Cannabis sativa – oldest known species used by humans (China) • >420 compounds: e.g. Eugenol: acts at GABAA receptors • 80 terpeno-phenol compounds, “cannabinoids” ...
Chapter 17 Antipsychotic Agents
... Several important dopaminergic pathway • Several important dopaminergic pathway are now recognized in the brain. • (1)The first pathway the one most closely related to behavior is the mesolimbic-mesocortical pathway. • (2) Nigrostriatal pathway, involving in the coordination of voluntary自主 movement ...
... Several important dopaminergic pathway • Several important dopaminergic pathway are now recognized in the brain. • (1)The first pathway the one most closely related to behavior is the mesolimbic-mesocortical pathway. • (2) Nigrostriatal pathway, involving in the coordination of voluntary自主 movement ...
IN-SILICO PROTEIN LIGAND INTERACTION STUDY OF TYPICAL ANTIPSYCHOTIC DRUGS
... appropriate term to use to describe the new drugs [2]. In the late 1950s the most widely used term was "neuroleptic", followed by "major tranquilizer" and then "ataraxic" [2]. The first recorded use of the term tranquilizer dates from the early nineteenth century [2]. Antipsychotics are broadly divi ...
... appropriate term to use to describe the new drugs [2]. In the late 1950s the most widely used term was "neuroleptic", followed by "major tranquilizer" and then "ataraxic" [2]. The first recorded use of the term tranquilizer dates from the early nineteenth century [2]. Antipsychotics are broadly divi ...
Zomig Rapimelt
... severe liver disease. The corresponding t½ values for the 183C91 metabolite were 5.7 hours, 7.5 hours and 7.8 hours respectively. Following intravenous administration, the mean total plasma clearance is approximately 10 ml/min/kg, of which one third is renal clearance. Renal clearance is greater th ...
... severe liver disease. The corresponding t½ values for the 183C91 metabolite were 5.7 hours, 7.5 hours and 7.8 hours respectively. Following intravenous administration, the mean total plasma clearance is approximately 10 ml/min/kg, of which one third is renal clearance. Renal clearance is greater th ...
11/19/2014 Sedative‐Hypnotic and Anxiolytic Medications
... Neurotransmitter binding to receptor can cause ion channels to open, leading to depolarization or hyperpolarization. ...
... Neurotransmitter binding to receptor can cause ion channels to open, leading to depolarization or hyperpolarization. ...
A1984SU44500001
... some actions clearly related to phencyclidine, we have tried to find ways to reduce the 'bad effects' of ketamine —or to 'tame the tiger' with diazepam premedication.3 I remain convinced that some day new ketamine analogues will be synthesized which will be much more useful than ketamine itself. "Pe ...
... some actions clearly related to phencyclidine, we have tried to find ways to reduce the 'bad effects' of ketamine —or to 'tame the tiger' with diazepam premedication.3 I remain convinced that some day new ketamine analogues will be synthesized which will be much more useful than ketamine itself. "Pe ...
Low efficacy diuretics
... Osmotic diuretics:Are small molecular weight hydrophilic substances that are filtered by the glumerulus but not reabsorbed by the renal tubules → ↑ osmolarity of urine. They prevent reabsorption of water (and by complex mechanisms, Only a small amount of additional salt may also be excreted), Act pr ...
... Osmotic diuretics:Are small molecular weight hydrophilic substances that are filtered by the glumerulus but not reabsorbed by the renal tubules → ↑ osmolarity of urine. They prevent reabsorption of water (and by complex mechanisms, Only a small amount of additional salt may also be excreted), Act pr ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.