L5 ADHD
... • No psychostimulant drug • Contraindication: MAO inhibitors • Metabolism: • P450 pathway ...
... • No psychostimulant drug • Contraindication: MAO inhibitors • Metabolism: • P450 pathway ...
A molecular basis of the therapeutic and psychoactive
... fluidize the cell membrane (Bloom et al., 1997), and one might expect that AEA might play a role in the regulation of membrane function. The full profile of AEA has activity yet to be elucidated and there are conflicting theories (Stanford and Mitchell, 1999), AEA, like THC may be a long-acting endo ...
... fluidize the cell membrane (Bloom et al., 1997), and one might expect that AEA might play a role in the regulation of membrane function. The full profile of AEA has activity yet to be elucidated and there are conflicting theories (Stanford and Mitchell, 1999), AEA, like THC may be a long-acting endo ...
Adrenergic Agonists
... 1. Tyrosine is transported by a Na+-linked carrier into the axoplasm of the adrenergic neuron 2. Tyrosine is hydroxylated to dihydroxyphenylalanine (DOPA) by tyrosine hydroxylase. 3. DOPA is then decarboxylated by the enzyme dopa decarboxylase (aromatic l-amino acid decarboxylase) to form dopamine i ...
... 1. Tyrosine is transported by a Na+-linked carrier into the axoplasm of the adrenergic neuron 2. Tyrosine is hydroxylated to dihydroxyphenylalanine (DOPA) by tyrosine hydroxylase. 3. DOPA is then decarboxylated by the enzyme dopa decarboxylase (aromatic l-amino acid decarboxylase) to form dopamine i ...
IB Bio / Neurobiology and Behavior Unit “Drugs of Abuse” Chart
... release their GABA on VTA neurons. GABA normally inhibits VTA neurons. Inhibiting the release of inhibitor (“disinhibition”) is like taking your foot off the brakes and allowing your car to speed ahead. The result is to make VTA neurons fire more & release more dopamine. Among its many effects on th ...
... release their GABA on VTA neurons. GABA normally inhibits VTA neurons. Inhibiting the release of inhibitor (“disinhibition”) is like taking your foot off the brakes and allowing your car to speed ahead. The result is to make VTA neurons fire more & release more dopamine. Among its many effects on th ...
Antidepressants and neuroleptic
... Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate adenylyl cyclase, often exciting neurons, whereas D2, D3 and D4 receptors inhibit adenylyl cyclase, or mediate membrane K+ channel opening leading to neuronal hyperpolarization. The neuroleptic drugs bind to these recept ...
... Dopamine receptor blocking activity in the brain:. D1 and D5 receptors activate adenylyl cyclase, often exciting neurons, whereas D2, D3 and D4 receptors inhibit adenylyl cyclase, or mediate membrane K+ channel opening leading to neuronal hyperpolarization. The neuroleptic drugs bind to these recept ...
DRUG RECEPTOR AND PHARMCODYNAMICS
... only binds to one single type of receptor and cause one single effect. Selectivity means that a drug binds to one or a few types of receptors with higher affinity than to other receptors. Selectivity due to the drug chemical structure Chemical structure, shape and electrical charge of a drug determi ...
... only binds to one single type of receptor and cause one single effect. Selectivity means that a drug binds to one or a few types of receptors with higher affinity than to other receptors. Selectivity due to the drug chemical structure Chemical structure, shape and electrical charge of a drug determi ...
Parasympathetic nervous system
... 1/ pilocarpine is alkaloid that causes contraction of musculus ciliaris leading to relieving of Schlemm´s canal Indications: glaucoma with narrow angle, glaucoma attack, induction of miosis during intraocular procedures 2/ carbachol only for induction of miosis, not antiglaucomatic drug [Additional ...
... 1/ pilocarpine is alkaloid that causes contraction of musculus ciliaris leading to relieving of Schlemm´s canal Indications: glaucoma with narrow angle, glaucoma attack, induction of miosis during intraocular procedures 2/ carbachol only for induction of miosis, not antiglaucomatic drug [Additional ...
Print
... – Usually from opiates acting in the brain and/or the spinal cord – Can also impact other areas as well. ...
... – Usually from opiates acting in the brain and/or the spinal cord – Can also impact other areas as well. ...
File
... Shift blood from pulm to systemic circuit Relieves air hunger by depressing resp centre Calms pt - decreases symp response – decrease workload ...
... Shift blood from pulm to systemic circuit Relieves air hunger by depressing resp centre Calms pt - decreases symp response – decrease workload ...
Hallucinogens & Perception
... Carter OL, Pettigrew JD, Hasler F, et al (2005b) Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin. Neuropsychopharmacology 30: 1154-62 Gonzalez-Maeso J, Weisstaub NV, et al (2007) Hallucinogens Recruit Specific Cortical 5-HT(2 ...
... Carter OL, Pettigrew JD, Hasler F, et al (2005b) Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin. Neuropsychopharmacology 30: 1154-62 Gonzalez-Maeso J, Weisstaub NV, et al (2007) Hallucinogens Recruit Specific Cortical 5-HT(2 ...
The Fluorine Boom Continues as Benefits Become More Widespread
... The high electronegative charge of fluorine causes a large electronic effect on neighboring carbon centers, and has an appreciable effect on the molecule’s dipole moment and the acidity or basicity of other groups nearby, not to mention the molecule’s overall reactivity and stability. The fluorine a ...
... The high electronegative charge of fluorine causes a large electronic effect on neighboring carbon centers, and has an appreciable effect on the molecule’s dipole moment and the acidity or basicity of other groups nearby, not to mention the molecule’s overall reactivity and stability. The fluorine a ...
What is mental life
... myocarditis and seizures at very high doses o Sedation, weight gain, orthostatic hypotension. o This is a GREAT drug but you must first fail two other drugs before you can be started on this because of serious side effect risks. ...
... myocarditis and seizures at very high doses o Sedation, weight gain, orthostatic hypotension. o This is a GREAT drug but you must first fail two other drugs before you can be started on this because of serious side effect risks. ...
Document
... ADP and Platelets • The secretory vesicles of blood platelets store both ATP and ADP in high concentrations, and release them when the platelets are activated. • One of the many effects of ADP is to promote platelet aggregation, so this system provides positive feedback-an important mechanism for c ...
... ADP and Platelets • The secretory vesicles of blood platelets store both ATP and ADP in high concentrations, and release them when the platelets are activated. • One of the many effects of ADP is to promote platelet aggregation, so this system provides positive feedback-an important mechanism for c ...
Sedatives
... o Receptor: do not compete for BZ or GABA binding; appear to interact with other sites on GABAA receptor chloride ion channel o Receptor Binding: ...
... o Receptor: do not compete for BZ or GABA binding; appear to interact with other sites on GABAA receptor chloride ion channel o Receptor Binding: ...
PHARMACOTHERAPY OF HYPERTENSION
... Less effective in elderly patients Side effects: Bradycardia, cause rebound hypertension on sudden withdrawal Fatigue sleep disturbances and depression Propranolol mask the hypoglycemic symptoms produced by insulin and oral hypoglycemic ...
... Less effective in elderly patients Side effects: Bradycardia, cause rebound hypertension on sudden withdrawal Fatigue sleep disturbances and depression Propranolol mask the hypoglycemic symptoms produced by insulin and oral hypoglycemic ...
this PDF file - Journal of the Indian Institute of Science
... and membranes containing opiate receptorsL1: (1) A non-specific saturable binding consisting primarily of interactions between thc protonated nitrogen atom of Lhe opiate and anionic group:, of monbrntlc niacromolecules. (2) A non-saturable interaction (trapped and disaolvcd) having the physical soht ...
... and membranes containing opiate receptorsL1: (1) A non-specific saturable binding consisting primarily of interactions between thc protonated nitrogen atom of Lhe opiate and anionic group:, of monbrntlc niacromolecules. (2) A non-saturable interaction (trapped and disaolvcd) having the physical soht ...
Targets and the Renin Angiotensin Aldosterone System
... Dual Effect of ACE‐Is • ACE = kininase II • Responsible for degrading bradykinin, therefore ACE‐Is increase bradykinin • Responsible for two main adverse effects 1. Dry cough 2. Angioedema ...
... Dual Effect of ACE‐Is • ACE = kininase II • Responsible for degrading bradykinin, therefore ACE‐Is increase bradykinin • Responsible for two main adverse effects 1. Dry cough 2. Angioedema ...
Biosteres and You
... If only acting as a H-bond acceptor, can make it a tertiary amine or heterocyclic Nitrogen (ie: pyridine, imidazole). If replaced by an RO-H the H-bond donor effect is kept, but no longer a basic residue to bind acidic (an example is GHB as a biostere for GABA, see next ...
... If only acting as a H-bond acceptor, can make it a tertiary amine or heterocyclic Nitrogen (ie: pyridine, imidazole). If replaced by an RO-H the H-bond donor effect is kept, but no longer a basic residue to bind acidic (an example is GHB as a biostere for GABA, see next ...
Naturally Occurring and Related Synthetic Cannabinoids and their
... uniquely produced by the highly variable plant, Cannabis sativa L. Natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to !9-THC. However, cannabinoids exert pharmacological actions on other biological systems ...
... uniquely produced by the highly variable plant, Cannabis sativa L. Natural and synthetic cannabinoids have been extensively studied since the discovery that the psychotropic effects of cannabis are mainly due to !9-THC. However, cannabinoids exert pharmacological actions on other biological systems ...
Lecture Contents -
... space (depending on flow rate and MW) • Dialysis solution can be “spiked” with metabolically active compounds • Continuous, real-time monitoring ...
... space (depending on flow rate and MW) • Dialysis solution can be “spiked” with metabolically active compounds • Continuous, real-time monitoring ...
LÉČIVA OVLIVŇUJÍCÍ CHOLINERGNÍ RECEPTORY
... 1/ pilocarpine is alkaloid that causes contraction of musculus ciliaris leading to relieving of Schlemm´s canal Indications: glaucoma with narrow angle, glaucoma attack, induction of miosis during intraocular procedures 2/ carbachol only for induction of miosis, not antiglaucomatic drug [Additional ...
... 1/ pilocarpine is alkaloid that causes contraction of musculus ciliaris leading to relieving of Schlemm´s canal Indications: glaucoma with narrow angle, glaucoma attack, induction of miosis during intraocular procedures 2/ carbachol only for induction of miosis, not antiglaucomatic drug [Additional ...
Lecture 12, computers CORRECTED
... model receptor: 1. The known structure is used as a template. The backbone of the new receptor is constructed on a computer to match that of the known protein. 2. Side chains are added in favorable conformations, and the energy is minimized by computer. 3. Key residues in the new receptor are identi ...
... model receptor: 1. The known structure is used as a template. The backbone of the new receptor is constructed on a computer to match that of the known protein. 2. Side chains are added in favorable conformations, and the energy is minimized by computer. 3. Key residues in the new receptor are identi ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.