Psychopharmacology - Ohio State University
... Addiction can occur to THC, but only at dose and use levels far above what is now used recreationally. ...
... Addiction can occur to THC, but only at dose and use levels far above what is now used recreationally. ...
Practice Questions
... the concentration gradient driving K+ ions _______the neuron is ______ mV. a) b) c) d) e) ...
... the concentration gradient driving K+ ions _______the neuron is ______ mV. a) b) c) d) e) ...
Pharmacology 2004
... except: a. It does not decrease the blood pressure significantly b. It blocks steroid synthesis in the adrenal c. The duration of action of etomidate is short d. It can be used to induce anesthesia in hemodynamically unstable patient e. Etomidate can be used in prolonged use for several days 40. Wha ...
... except: a. It does not decrease the blood pressure significantly b. It blocks steroid synthesis in the adrenal c. The duration of action of etomidate is short d. It can be used to induce anesthesia in hemodynamically unstable patient e. Etomidate can be used in prolonged use for several days 40. Wha ...
Articles - The Vespiary
... action at both serotonin and dopamine (DA) receptors,37,38 and because hallucinogenic activity has generally been correlated with the overall hydrophobicity of the drug molecule,39-41 it was hypothesized that 8 and 9 could ultimately have potential as probes of 5-HT, DA, or other central neurotransm ...
... action at both serotonin and dopamine (DA) receptors,37,38 and because hallucinogenic activity has generally been correlated with the overall hydrophobicity of the drug molecule,39-41 it was hypothesized that 8 and 9 could ultimately have potential as probes of 5-HT, DA, or other central neurotransm ...
Narcotic analgesics
... It is believed that there are two subtypes of µ receptors : µ1 and µ2 . µ1 mediates the analgesia whereas µ2 mediates other effects like respiratory depression , emesis …etc. The delta receptors have the greatest binding affinity for enkephalins. They mediate cardiovascular depressant , respiratory ...
... It is believed that there are two subtypes of µ receptors : µ1 and µ2 . µ1 mediates the analgesia whereas µ2 mediates other effects like respiratory depression , emesis …etc. The delta receptors have the greatest binding affinity for enkephalins. They mediate cardiovascular depressant , respiratory ...
Midterm review - February 26, 2004
... Anesthetics come in two basic chemical flavors. They are composed of an aromatic group linked to an amine by either an ester bond or an amide bond. Esters: Procaine, Tetracaine, Benzocaine (topical), Cocaine (vasoconstrictor!) Amides: Bupivicaine, Lidocaine, Mepivacaine, Etidocaine (amides always ha ...
... Anesthetics come in two basic chemical flavors. They are composed of an aromatic group linked to an amine by either an ester bond or an amide bond. Esters: Procaine, Tetracaine, Benzocaine (topical), Cocaine (vasoconstrictor!) Amides: Bupivicaine, Lidocaine, Mepivacaine, Etidocaine (amides always ha ...
CNS Stimulants
... last time being 10 hours previously. He was given a drug which seated him and fell asleep. The drug very likely used to counter this patient’s ...
... last time being 10 hours previously. He was given a drug which seated him and fell asleep. The drug very likely used to counter this patient’s ...
Adrenergic Drugs
... vasoconstriction caused by α1 and α 2 adrenoceptors). Coronary arteries have only β2 receptors. Relaxation of Bronchioles ...
... vasoconstriction caused by α1 and α 2 adrenoceptors). Coronary arteries have only β2 receptors. Relaxation of Bronchioles ...
Regulation of Brain Reward by the Endocannabinoid System: A
... receptors are also expressed in the brain under pathological conditions, such as tumors [28] or Alzheimer’s disease [29], as well as under normal physiological conditions [30-34]. On the basis of numerous studies showing certain behavioral and pharmacological effects of cannabinoid compounds that ca ...
... receptors are also expressed in the brain under pathological conditions, such as tumors [28] or Alzheimer’s disease [29], as well as under normal physiological conditions [30-34]. On the basis of numerous studies showing certain behavioral and pharmacological effects of cannabinoid compounds that ca ...
Preclinical evaluation of AVN-322, novel and highly selective 5
... against AD. Herein, we present the preclinical development of AVN-322, novel and highly selective 5-HT6R antagonist, for the treatment of AD. While having nanomolar binding affinity, the lead compound demonstrated the best selectivity index as compared to reference drug candidates. During the pharma ...
... against AD. Herein, we present the preclinical development of AVN-322, novel and highly selective 5-HT6R antagonist, for the treatment of AD. While having nanomolar binding affinity, the lead compound demonstrated the best selectivity index as compared to reference drug candidates. During the pharma ...
Addiction: brain mechanisms and their treatment implications
... provide any reinforcement, there is little incentive for addicts to stay on them. Naltrexone is useful in highly motivated individuals in whom relapse to opioid use could portend the end of their career (eg, doctors and pharmacists). This antagonist is also used in some countries under probation ord ...
... provide any reinforcement, there is little incentive for addicts to stay on them. Naltrexone is useful in highly motivated individuals in whom relapse to opioid use could portend the end of their career (eg, doctors and pharmacists). This antagonist is also used in some countries under probation ord ...
Pharmacology II – Respiratory and Oxygenation
... What drug error has occurred, and how could this be avoided ?? ...
... What drug error has occurred, and how could this be avoided ?? ...
C. Isoproterenol
... drug abusers as its only action. However, the drug can increase blood pressure significantly by α agonist action on the vasculature as well as β stimulatory effects on the heart. Its peripheral actions are mediated primarily through the blockade of norepinephrine uptake and cellular release of store ...
... drug abusers as its only action. However, the drug can increase blood pressure significantly by α agonist action on the vasculature as well as β stimulatory effects on the heart. Its peripheral actions are mediated primarily through the blockade of norepinephrine uptake and cellular release of store ...
PPT Version - OMICS International
... The biological activities of alnustone as well as their synthesis have been the subject of numerous studies. Remarkable antihepatotoxic actions of alnustone amongst many natural diarylheptanoids were reported. Anti-inflammatory activity of alnustone isolated from Curcuma xanthorrhizawas reported. A ...
... The biological activities of alnustone as well as their synthesis have been the subject of numerous studies. Remarkable antihepatotoxic actions of alnustone amongst many natural diarylheptanoids were reported. Anti-inflammatory activity of alnustone isolated from Curcuma xanthorrhizawas reported. A ...
FUN2: 10:00-11:00 Scribe: Joan
... cause unexpected changes and that at first wouldn’t make much sense. Today, think about how the body is introduced to and handles drugs. Someone once told him that pharmacology is just one big dose-response curve. II. Concepts for you to learn: [S2] a. What are drugs? i. Response: things you take wh ...
... cause unexpected changes and that at first wouldn’t make much sense. Today, think about how the body is introduced to and handles drugs. Someone once told him that pharmacology is just one big dose-response curve. II. Concepts for you to learn: [S2] a. What are drugs? i. Response: things you take wh ...
Week 3 Questions
... The receptors for neurotransmitters located in peripheral tissues are given below. This table can be used to predict the actions of drugs on these tissues. Note that skeletal muscle is excited by the Somatic Nervous System (ACh on nicotinic receptors). Histamine, the final agent in the table, utiliz ...
... The receptors for neurotransmitters located in peripheral tissues are given below. This table can be used to predict the actions of drugs on these tissues. Note that skeletal muscle is excited by the Somatic Nervous System (ACh on nicotinic receptors). Histamine, the final agent in the table, utiliz ...
DOPAMINE ANTAGONISTS: PHENOTHIAZINE/THIOXANTHENE SAR
... IM use provides 4 to 10 times more active drug than oral doses (limited first pass) IM use provides prolonged plasma levels of active drugs (WEEKS!) enhancing compliance (a major problem in the psychotic patient population Ester prodrug products are presented in the table below: ...
... IM use provides 4 to 10 times more active drug than oral doses (limited first pass) IM use provides prolonged plasma levels of active drugs (WEEKS!) enhancing compliance (a major problem in the psychotic patient population Ester prodrug products are presented in the table below: ...
sedation and pain management for routine
... be responsible for the adverse effects of opioid administration such as dysphoria, excitement, restlessness and anxiety. Opioid drugs are classified as agonists (meaning they stimulate the opioid receptors) or antagonists (meaning they block particular opioid receptors). There are also mixed ag ...
... be responsible for the adverse effects of opioid administration such as dysphoria, excitement, restlessness and anxiety. Opioid drugs are classified as agonists (meaning they stimulate the opioid receptors) or antagonists (meaning they block particular opioid receptors). There are also mixed ag ...
351 Pharmacology PNS 5th Lecture F
... is readily absorbed, form the basis for the use of nicotine as an insecticide. These drugs are not used clinically, but only as experimental tools. They cause complex peripheral responses associated with generalized stimulation of ALL autonomic ganglia (sympathetic & parasympathetic) ...
... is readily absorbed, form the basis for the use of nicotine as an insecticide. These drugs are not used clinically, but only as experimental tools. They cause complex peripheral responses associated with generalized stimulation of ALL autonomic ganglia (sympathetic & parasympathetic) ...
H2-receptor antagonists proton pump inhibitors
... reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. • These drugs are less potent than proton pump inhibitors but still suppress 24-hour gastric acid secretion by about 70%. The H2receptor antagonists predominantly inhibit basal acid secreti ...
... reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells. • These drugs are less potent than proton pump inhibitors but still suppress 24-hour gastric acid secretion by about 70%. The H2receptor antagonists predominantly inhibit basal acid secreti ...
Biosketch - UNC School of Medicine
... propose the first mechanism to explain biased receptor signaling (this mechanism is still considered to explain the effect and recent 19F-NMR data directly support the mechanism). The stabilization of unique receptor conformations by ligands that go then go on to differentially active cellular funct ...
... propose the first mechanism to explain biased receptor signaling (this mechanism is still considered to explain the effect and recent 19F-NMR data directly support the mechanism). The stabilization of unique receptor conformations by ligands that go then go on to differentially active cellular funct ...
Phencyclidine
... Only short-term tolerance to LSD, no withdrawal, dependence or addiction LSD not lethal at very high doses Cross tolerance for hallucinogenic effect Focus on 5-HT systems (structural similarity) ...
... Only short-term tolerance to LSD, no withdrawal, dependence or addiction LSD not lethal at very high doses Cross tolerance for hallucinogenic effect Focus on 5-HT systems (structural similarity) ...
delta receptor
... • Opioid Antagonists are used to treat opioid overdose cases. • Most are derived from Thebaine (an alkaloid of Opium) • The have strong binding affinity for the mu receptors • They work by competitive inhibition at the binding site (It binds but does not change the receptor while at the same time bl ...
... • Opioid Antagonists are used to treat opioid overdose cases. • Most are derived from Thebaine (an alkaloid of Opium) • The have strong binding affinity for the mu receptors • They work by competitive inhibition at the binding site (It binds but does not change the receptor while at the same time bl ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.