DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Block action of histamine at the H1 receptor sites Compete with histamine for binding at unoccupied receptors Cannot push histamine off the receptor if already bound The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine ...
... Block action of histamine at the H1 receptor sites Compete with histamine for binding at unoccupied receptors Cannot push histamine off the receptor if already bound The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine ...
Tutorial - 4: Respiratory Drug Development
... The R-enantiomer of terbutaline has more biological activity than S-enantiomer. R-enantiomer of terbutaline forms the following interactions with the β2 receptor: The hydroxyl group (OH) attached to meta-position of the aromatic ring forms essential hydrogen bonding interaction with the Ser207 at ...
... The R-enantiomer of terbutaline has more biological activity than S-enantiomer. R-enantiomer of terbutaline forms the following interactions with the β2 receptor: The hydroxyl group (OH) attached to meta-position of the aromatic ring forms essential hydrogen bonding interaction with the Ser207 at ...
Slide 5
... Relaxes both arterial and venous vascular smooth muscle & smooth muscle in the prostate, due to blockade of α1 receptors with no or little tachycardia Bioavailability 50% & the half-life is 3 hours. ...
... Relaxes both arterial and venous vascular smooth muscle & smooth muscle in the prostate, due to blockade of α1 receptors with no or little tachycardia Bioavailability 50% & the half-life is 3 hours. ...
Sympathomimetic Drugs
... • Adrenergic receptors locate on smooth muscle, cardiac muscle, exocrine glands, endocrine glands and on nerve terminals. • the transmitter in all adrenergic neurons was NE • When NE and Epi interacted with an adrenoceptor, in some tissues the response was excitatory while in other tissues it was in ...
... • Adrenergic receptors locate on smooth muscle, cardiac muscle, exocrine glands, endocrine glands and on nerve terminals. • the transmitter in all adrenergic neurons was NE • When NE and Epi interacted with an adrenoceptor, in some tissues the response was excitatory while in other tissues it was in ...
Drug receptors and Pharmacodynamics
... conformational change in the receptor. Thus the effects of full agonists may be more efficiently coupled to receptor occupancy than those of partial agonists. However, coupling efficiency is also determined by the biochemical events that transduce receptor occupancy into cellular response. High effi ...
... conformational change in the receptor. Thus the effects of full agonists may be more efficiently coupled to receptor occupancy than those of partial agonists. However, coupling efficiency is also determined by the biochemical events that transduce receptor occupancy into cellular response. High effi ...
Psychology 250 - Rio Hondo College
... May be self medicating May also be that nicotine contributes to mental disorders ...
... May be self medicating May also be that nicotine contributes to mental disorders ...
Module 4
... Pernicious anemia is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production. ...
... Pernicious anemia is caused by loss of gastric parietal cells, and subsequent inability to absorb vitamin B12. Megaloblastic anemia is an anemia (of macrocytic classification) that results from inhibition of DNA synthesis in red blood cell production. ...
Adverse effects
... inhibitors, and thiazides. It can also be combined other antihypertensive, such diuretics, ACE inhibitors, ARBs, or calcium-channel blockers. ...
... inhibitors, and thiazides. It can also be combined other antihypertensive, such diuretics, ACE inhibitors, ARBs, or calcium-channel blockers. ...
Theodore-SSADH - SSADH Association
... high-affinity targets for GHB. The metabotropic GABAB receptors are activated by millimolar GHB. Elusive GHB high-affinity sites are activated by nM to mM GHB, consistent with normal endogenous concentrations. ...
... high-affinity targets for GHB. The metabotropic GABAB receptors are activated by millimolar GHB. Elusive GHB high-affinity sites are activated by nM to mM GHB, consistent with normal endogenous concentrations. ...
Document
... lice). Lindane acts through a GABA-A receptor. The problem with Lindane is that insects have become resistant and that it is very toxic. The latter can be explained by the fact that the neurotransmitter GABA has an identical structure in all animals. However, if we could develop selective insecticid ...
... lice). Lindane acts through a GABA-A receptor. The problem with Lindane is that insects have become resistant and that it is very toxic. The latter can be explained by the fact that the neurotransmitter GABA has an identical structure in all animals. However, if we could develop selective insecticid ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Block action of histamine at the H1 receptor sites Compete with histamine for binding at unoccupied receptors Cannot push histamine off the receptor if already bound The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine ...
... Block action of histamine at the H1 receptor sites Compete with histamine for binding at unoccupied receptors Cannot push histamine off the receptor if already bound The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine ...
Drug Information Summary - Nalbuphine
... Both the partial mu antagonism and the kappa agonism are useful for opioid-induced itch (OII), a phenomenon which has both central and peripheral mechanisms. (The commonly used option, diphenhydramine or Benadryl, is sedating, and potentially dangerous in the elderly.) Nalbuphine also has analgesic ...
... Both the partial mu antagonism and the kappa agonism are useful for opioid-induced itch (OII), a phenomenon which has both central and peripheral mechanisms. (The commonly used option, diphenhydramine or Benadryl, is sedating, and potentially dangerous in the elderly.) Nalbuphine also has analgesic ...
document
... – excessive catecholamine action is an important aspect of the pathophysiology of hyperthyroidism, especially in relation to the heart. – Blockade of adrenergic receptors – inhibition of the peripheral conversion of thyroxine to triiodothyronine??? Perhaps also contributing to antihyperthyroidism ac ...
... – excessive catecholamine action is an important aspect of the pathophysiology of hyperthyroidism, especially in relation to the heart. – Blockade of adrenergic receptors – inhibition of the peripheral conversion of thyroxine to triiodothyronine??? Perhaps also contributing to antihyperthyroidism ac ...
Inotropes & Vasopressors
... – Short term treatment for acute on chronic severe CCF – Synergistic effect with beta agonists – Role in cardiopulmonary bypass ...
... – Short term treatment for acute on chronic severe CCF – Synergistic effect with beta agonists – Role in cardiopulmonary bypass ...
Herbal Compositions for Appetite Suppression and Weight
... effective to slice the excess weight. However, for most, besides being too expensive, the long term uses of these drugs are marred by their severe adverse toxicities. In fact, the principal reason for drug withdrawals has been due to concerns over safety rather than the effect on body weight. For ex ...
... effective to slice the excess weight. However, for most, besides being too expensive, the long term uses of these drugs are marred by their severe adverse toxicities. In fact, the principal reason for drug withdrawals has been due to concerns over safety rather than the effect on body weight. For ex ...
Dose-Response Concept
... CCl4 and ethanol are hepatotoxic alone but when given together produce much more liver injury than the mathematical sum of their individual effects. (2 + 2 = 20). Smoking and asbestos exposure is another example. Cocaine use with alcohol use is a third example. ...
... CCl4 and ethanol are hepatotoxic alone but when given together produce much more liver injury than the mathematical sum of their individual effects. (2 + 2 = 20). Smoking and asbestos exposure is another example. Cocaine use with alcohol use is a third example. ...
Non-depolarizing blocking agents
... system and sympathetic nervous system, the effect of these drugs depends upon the dominant one in the organ system. Examples The first ganglion-blocker to be used clinically was tetraethylammonium, although it was soon superseded by better drugs. Nicotinic receptor antagonists: ...
... system and sympathetic nervous system, the effect of these drugs depends upon the dominant one in the organ system. Examples The first ganglion-blocker to be used clinically was tetraethylammonium, although it was soon superseded by better drugs. Nicotinic receptor antagonists: ...
Opiates and Respiratory Depression - index
... Morris, A.J., et al., Physiological regulation of G protein-linked signaling. Physiol. Rev., 79, 1373-1430 (1999). ...
... Morris, A.J., et al., Physiological regulation of G protein-linked signaling. Physiol. Rev., 79, 1373-1430 (1999). ...
Lecture 4
... • Broad-spectrum sodium channel blockers are used as local anaesthetics, but they are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. • Opioid painkillers such as morphine are highly effective at reducing pain, but longterm use ...
... • Broad-spectrum sodium channel blockers are used as local anaesthetics, but they are not suitable for long-term pain management as they cause complete numbness and can have serious side-effects over time. • Opioid painkillers such as morphine are highly effective at reducing pain, but longterm use ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.