Pharmacology - Shelbye's CSON Notes Blog
... – Opiod means they act like an opiate – Opiates are from poppy seeds ...
... – Opiod means they act like an opiate – Opiates are from poppy seeds ...
Atypical Antipsychotic Drugs: Clozapine, olanzapine
... Clozapine is the prototype. Risperidone is rapidly converted to 9- ...
... Clozapine is the prototype. Risperidone is rapidly converted to 9- ...
PowerPoint - 埼玉医科大学総合医療センター 内分泌・糖尿病内科
... Dexfenfluramine is believed to be solely responsible for the appetite suppressant properties of fenfluramine, of which it has been demonstrated to mediate predominantly via activation of postsynaptic 5-HT1B and 5-HT2C receptors through a combination of indirect serotonin releasing agent and direct ...
... Dexfenfluramine is believed to be solely responsible for the appetite suppressant properties of fenfluramine, of which it has been demonstrated to mediate predominantly via activation of postsynaptic 5-HT1B and 5-HT2C receptors through a combination of indirect serotonin releasing agent and direct ...
OPIOID ANALGESICS
... Meperidine(pethidine) Loperamide(over the counter for diarrhea) Diphenoxylate Dextromethorphan ...
... Meperidine(pethidine) Loperamide(over the counter for diarrhea) Diphenoxylate Dextromethorphan ...
Gastro17-GIPharm2
... (aka. Neuroleptics, psychotics, benzoamides) o Metoclopramide (Reglan) – KNOW THIS ONE!!! o Trimethobenzamide (Tigan) – similar, but less efficacious Important prokinetic effects = increases gastric emptying and motility of GI tract Blocks both D2 and 5-HT3 receptors, 5-HT4 agonist o Serotonin b ...
... (aka. Neuroleptics, psychotics, benzoamides) o Metoclopramide (Reglan) – KNOW THIS ONE!!! o Trimethobenzamide (Tigan) – similar, but less efficacious Important prokinetic effects = increases gastric emptying and motility of GI tract Blocks both D2 and 5-HT3 receptors, 5-HT4 agonist o Serotonin b ...
GABA-A receptor subtypes in the brain: a paradigm for CNS drug
... them all. As a result, it causes seizures as a result of over There is an obvious parallel here to the previous discusexcitement of large parts of the brain. By contrast, the two sion on the benzodiazepines. If one could make a genetimouse models with modified α5-subunit expression do not cally modi ...
... them all. As a result, it causes seizures as a result of over There is an obvious parallel here to the previous discusexcitement of large parts of the brain. By contrast, the two sion on the benzodiazepines. If one could make a genetimouse models with modified α5-subunit expression do not cally modi ...
4a-Pharmacodynamics,ADRs (Lec.1 & 2)
... GDP; slow hydrolysis of GTP allows signal to persist long after ligand has dissociated from receptor •G Proteins: Gs stimulates adenylyl cyclase; Gi inhibits adenylyl cyclase & opens a K+ channel; Gq stimulates phospholipase C; Go closes a Ca2+ channel ...
... GDP; slow hydrolysis of GTP allows signal to persist long after ligand has dissociated from receptor •G Proteins: Gs stimulates adenylyl cyclase; Gi inhibits adenylyl cyclase & opens a K+ channel; Gq stimulates phospholipase C; Go closes a Ca2+ channel ...
Local anesthetics
... Poisoning: overdoses can cause death, depression of respiration and central cardiovascular depression. ...
... Poisoning: overdoses can cause death, depression of respiration and central cardiovascular depression. ...
Parkinson’s Disease
... Rapid oral absorption – 95% converted to DA in plasma DA doesn’t cross BBB from plasma into CNS Precursor L-dopa does cross BBB via active transport system (about 5%) Most effective current treatment ...
... Rapid oral absorption – 95% converted to DA in plasma DA doesn’t cross BBB from plasma into CNS Precursor L-dopa does cross BBB via active transport system (about 5%) Most effective current treatment ...
Analgesia
... Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage ...
... Most common reason people seek health care Tissue damage activates free nerve endings (pain receptors) Generally indicates tissue damage ...
sedative-hypnotic
... Barbiturates are able to enhance the action of GABA by prolonging the duration of chloride channel opening. At high doses, barbiturates can actually act directly on GABA’s receptor. They have a depressant effect similar to general anesthetics due to their broad inhibitory effect on various CNS recep ...
... Barbiturates are able to enhance the action of GABA by prolonging the duration of chloride channel opening. At high doses, barbiturates can actually act directly on GABA’s receptor. They have a depressant effect similar to general anesthetics due to their broad inhibitory effect on various CNS recep ...
Untitled
... signal transduction is done using second messengers, molecules that relay signals from cellular surface receptors to target intracellular molecules. For instance, one of the most abundant receptors found in ...
... signal transduction is done using second messengers, molecules that relay signals from cellular surface receptors to target intracellular molecules. For instance, one of the most abundant receptors found in ...
GENERAL ANESTHETICS INHALATION ANESTHETICS
... Distribution: All over, but esp. in the head (in general) and the base of the brain (specific) Receptor effector mechanisms (opioid receptors): G protein-linked, inhibition adenylyl cyclase, activation of K+ channels, suppression of voltage-gated Ca++ channels Leads to blockade of NT release (e. ...
... Distribution: All over, but esp. in the head (in general) and the base of the brain (specific) Receptor effector mechanisms (opioid receptors): G protein-linked, inhibition adenylyl cyclase, activation of K+ channels, suppression of voltage-gated Ca++ channels Leads to blockade of NT release (e. ...
Document
... emesis (In Preclinical studies) Augment the antiemetic activity of 5HT3 receptor antagonists and dexamethasone Inhibit both acute and delayed CINV ...
... emesis (In Preclinical studies) Augment the antiemetic activity of 5HT3 receptor antagonists and dexamethasone Inhibit both acute and delayed CINV ...
Document
... *work :succinylcholine Bind nicotinic cholinergic receptors at end plate lead to depolarization of muscle fibers (so called depolarizing)>>In contrast to Ach ,it resists the hydrolysis by Ach-estrase enzyme so remains attached to receptors for longer time>>constant, continuous stimulation of recepto ...
... *work :succinylcholine Bind nicotinic cholinergic receptors at end plate lead to depolarization of muscle fibers (so called depolarizing)>>In contrast to Ach ,it resists the hydrolysis by Ach-estrase enzyme so remains attached to receptors for longer time>>constant, continuous stimulation of recepto ...
Lester-BMB170C
... A molecular coincidence detector leading to Na+ and Ca2+ influx, with many intracellular effects Including long-term potention (LTP) ...
... A molecular coincidence detector leading to Na+ and Ca2+ influx, with many intracellular effects Including long-term potention (LTP) ...
1 The Neuromuscular Junction: Pharmacology
... anaesthesia. These derivatives include pancuronium and atracurium. In addition, allosteric (conformational) changes in ACh receptors, or steric hindrance to ACh binding, reduce the affinity of receptors for ACh and therefore its effects. These non-competitive antagonists include phencyclidine (PCP, ...
... anaesthesia. These derivatives include pancuronium and atracurium. In addition, allosteric (conformational) changes in ACh receptors, or steric hindrance to ACh binding, reduce the affinity of receptors for ACh and therefore its effects. These non-competitive antagonists include phencyclidine (PCP, ...
Opiate receptors, endogenous opioid systems in brain, Analgesia
... Professor of Pharmacology D425 HSB ...
... Professor of Pharmacology D425 HSB ...
Pharmacology of the autonomic nervous system for dental students
... stimulating effect. As a peroral drug , it is used to stimulate the detrusor muscle of the bladder, and relieves difficulty in urination. Carbachol is a direct agonist of both muscarinic and nicotinic receptors. It is useful only as an eye drop. Adverse effects of cholinergic agonists are practicall ...
... stimulating effect. As a peroral drug , it is used to stimulate the detrusor muscle of the bladder, and relieves difficulty in urination. Carbachol is a direct agonist of both muscarinic and nicotinic receptors. It is useful only as an eye drop. Adverse effects of cholinergic agonists are practicall ...
Drug Chart Part 1 - Website of Neelay Gandhi
... (relapse of ulcer after shortterm tx or abrupt cessation) -GERD -Peptic ulcers-hiatal hernia -Tylenol O.D. (Cimetidine) ...
... (relapse of ulcer after shortterm tx or abrupt cessation) -GERD -Peptic ulcers-hiatal hernia -Tylenol O.D. (Cimetidine) ...
View Dr. Liu`s presentation file.
... from the FDA for Suvorexant in June 2013. The company is evaluating the requests in the CRL and plans to submit definitive data in response to the FDA in early 2014. Mechanism of Action: Orexin receptor antagonist designed to inhibit the binding of the neuropeptide orexin to its receptor ...
... from the FDA for Suvorexant in June 2013. The company is evaluating the requests in the CRL and plans to submit definitive data in response to the FDA in early 2014. Mechanism of Action: Orexin receptor antagonist designed to inhibit the binding of the neuropeptide orexin to its receptor ...
Pharmacology Review
... • Drugs that interact with receptors must be appropriate size, charge, and shape to interact with a given receptor ...
... • Drugs that interact with receptors must be appropriate size, charge, and shape to interact with a given receptor ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.