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Buspirone and Pindolol Effects on the EEG Frequency Spectrum in
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... 2. Smith C.E., Ware C.J., & Cowen P.J. (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharm. 103, 140-142. 3. Blier P., Seletti B., Young S.N., Benkelfat C., & de Montigny C. (1994) Serotonin 1A receptor activation and hypothermia: Evidence for a ...
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Cannabinoid receptor antagonist



The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.
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