UTEROTONIC PROPERTIES OF NYMPHAEA ALBA ON ISOLATED MYOMETRIUM MODEL Original Article
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
NIH Public Access
... and contextual fear induced freezing in rats (Pamplona et al., 2006). In addition, increasing availability of endogenous cannabinoids (eCB) by blocking eCB reuptake and breakdown (Chhatwal et al., 2005) or activating this receptor with an agonist (Pamplona et al., 2006) both facilitate fear extincti ...
... and contextual fear induced freezing in rats (Pamplona et al., 2006). In addition, increasing availability of endogenous cannabinoids (eCB) by blocking eCB reuptake and breakdown (Chhatwal et al., 2005) or activating this receptor with an agonist (Pamplona et al., 2006) both facilitate fear extincti ...
patrick_tb_ch22
... d. The structure binds to the receptor, prevents the natural messenger from binding and eliminates any inherent activity associated with the receptor. Feedback: incorrect. This describes an inverse agonist which binds to stabilise an inactive conformation of the receptor. Page reference: 646-648 Typ ...
... d. The structure binds to the receptor, prevents the natural messenger from binding and eliminates any inherent activity associated with the receptor. Feedback: incorrect. This describes an inverse agonist which binds to stabilise an inactive conformation of the receptor. Page reference: 646-648 Typ ...
Using Psilocybin to Investigate the Relationship between Attention
... was no difference between the placebo and ketanserin conditions ( p = .99) (Figure 3B). To ensure that the effects observed did not simply reflect the use of this particular model, the data were also analyzed in a more direct way. Similar to previous studies using this task, proportion of correct re ...
... was no difference between the placebo and ketanserin conditions ( p = .99) (Figure 3B). To ensure that the effects observed did not simply reflect the use of this particular model, the data were also analyzed in a more direct way. Similar to previous studies using this task, proportion of correct re ...
Dopamine Receptor Antagonists Reverse Amphetamine
... mediated by dopamine released in the brain (26). Thus, it might be expected that dopamine receptor antagonists could block the effects of amphetamine for a specific DRL behavior. However, surprisingly, there has been no study testing the effects of amphetamine in combination with specific dopamine r ...
... mediated by dopamine released in the brain (26). Thus, it might be expected that dopamine receptor antagonists could block the effects of amphetamine for a specific DRL behavior. However, surprisingly, there has been no study testing the effects of amphetamine in combination with specific dopamine r ...
Pharmacological Characterization of Nicotine`s Interaction with
... that, vice versa, cocaine users consume more cigarettes than nonusers (Higgins et al., 1994). However, little is known about mechanisms that would support such interactions. Major pharmacological actions of cocaine include inhibition of neuronal synaptic reuptake of dopamine, serotonin, and norepine ...
... that, vice versa, cocaine users consume more cigarettes than nonusers (Higgins et al., 1994). However, little is known about mechanisms that would support such interactions. Major pharmacological actions of cocaine include inhibition of neuronal synaptic reuptake of dopamine, serotonin, and norepine ...
Anti-emetic drug maropitant induces intestinal motility disorder but
... experiment to measure the luminal pressure-induced neurogenic motility, maropitant increased frequency of motility whereas decreased the amplitude, indicating hyperactivity of the neurogenic motility. The segmented luminal content labeled with phenol red in maropitant-treated mice in in vivo may be ...
... experiment to measure the luminal pressure-induced neurogenic motility, maropitant increased frequency of motility whereas decreased the amplitude, indicating hyperactivity of the neurogenic motility. The segmented luminal content labeled with phenol red in maropitant-treated mice in in vivo may be ...
Dopamine Hypothesis of Mania
... severe mania hyperactivity shifts to more dorsal nigrostriatal paths. This shift may correspond to the development of psychotic features or catatonic symptoms. Hence mild mania may respond to an atypical antipsychotic with low propensity to impair extrapyramidal function, but severe or psychotic man ...
... severe mania hyperactivity shifts to more dorsal nigrostriatal paths. This shift may correspond to the development of psychotic features or catatonic symptoms. Hence mild mania may respond to an atypical antipsychotic with low propensity to impair extrapyramidal function, but severe or psychotic man ...
accuracy of biological activity spectra predicting
... Basic elements of PASS include: presentation of biological activity, description of chemical structure, training set of compounds, training procedure, prediction procedure. The current version of PASS differs essentially from the previous11. Biological Activity. Biological activities in PASS are des ...
... Basic elements of PASS include: presentation of biological activity, description of chemical structure, training set of compounds, training procedure, prediction procedure. The current version of PASS differs essentially from the previous11. Biological Activity. Biological activities in PASS are des ...
Lack of Susceptibility of Bicyclic Nucleoside Analogs, Highly Potent
... dihydropyrimidine dehydrogenase (DPD), the key catabolic enzyme in the degradation of pyrimidine nucleosides (Desgranges et al., 1986). The latter property underlies the severe toxicity that led to a number of deaths of persons who were exposed to the anticancer drug 5-fluorouracil (FU) in combinati ...
... dihydropyrimidine dehydrogenase (DPD), the key catabolic enzyme in the degradation of pyrimidine nucleosides (Desgranges et al., 1986). The latter property underlies the severe toxicity that led to a number of deaths of persons who were exposed to the anticancer drug 5-fluorouracil (FU) in combinati ...
here - National Medicinal Chemistry Symposium
... multiple clinical programs. This presentation will highlight select case study examples of clinical failures due to poor oral drug exposure and unexpected toxicology, as well as the many confounding factors associated with confirming a role for AO in the metabolism of a candidate d ...
... multiple clinical programs. This presentation will highlight select case study examples of clinical failures due to poor oral drug exposure and unexpected toxicology, as well as the many confounding factors associated with confirming a role for AO in the metabolism of a candidate d ...
Piracetam reverses haloperidol-induced - Tubitak Journals
... processes, the aforementioned nootropic drugs might also affect motor circuits in the brain and could therefore be used in the treatment of movement disorders or with conditions that have adverse motor influences. For example, piracetam has been used in the cortical myoclonus, where it resulted in a ...
... processes, the aforementioned nootropic drugs might also affect motor circuits in the brain and could therefore be used in the treatment of movement disorders or with conditions that have adverse motor influences. For example, piracetam has been used in the cortical myoclonus, where it resulted in a ...
The Antinociceptive Effects of Nicotinic Receptors a7
... Male ICR mice obtained from Harlan Laboratories (Indianapolis, IN) and male C57BL/6 mice from The Jackson Laboratory (Bar Harbor, ME) were used throughout the study. Mice null for the a7 subunits (The Jackson Laboratory) and their wild-type (WT) littermates were bred in an animal care facility at Vi ...
... Male ICR mice obtained from Harlan Laboratories (Indianapolis, IN) and male C57BL/6 mice from The Jackson Laboratory (Bar Harbor, ME) were used throughout the study. Mice null for the a7 subunits (The Jackson Laboratory) and their wild-type (WT) littermates were bred in an animal care facility at Vi ...
PDF - Romanian Journal of Anaesthesia and Intensive Care
... occupancy characteristics and may induce tolerance more readily than a high intrinsic efficacy agonist [18]. The intrinsic activity of tapentadol at the μ receptor showed a greater receptor reserve that lies between that of buprenorphine, oxycodone and morphine potentially explaining the favorable p ...
... occupancy characteristics and may induce tolerance more readily than a high intrinsic efficacy agonist [18]. The intrinsic activity of tapentadol at the μ receptor showed a greater receptor reserve that lies between that of buprenorphine, oxycodone and morphine potentially explaining the favorable p ...
Neural mechanisms underlying morphine withdrawal in addicted
... various types of chronic pain. Nevertheless, development of tolerance and dependence on morphine by repeated application is a major concern in pain therapy. It was shown that combined treatment of nalbuphine with morphine affects the development of tolerance and dependence on morphine. The use of na ...
... various types of chronic pain. Nevertheless, development of tolerance and dependence on morphine by repeated application is a major concern in pain therapy. It was shown that combined treatment of nalbuphine with morphine affects the development of tolerance and dependence on morphine. The use of na ...
Chemotherapy-Induced Nausea and Vomiting
... substance P, neurokinin A, and neurokinin B, which preferentially bind to the receptors neurokinin-1, neurokinin-2, and neurokinin-3, respectively.47,48 Neurokinin-1 receptors are widely distributed throughout the central nervous system, including the area postrema and the nucleus tractus solitarius ...
... substance P, neurokinin A, and neurokinin B, which preferentially bind to the receptors neurokinin-1, neurokinin-2, and neurokinin-3, respectively.47,48 Neurokinin-1 receptors are widely distributed throughout the central nervous system, including the area postrema and the nucleus tractus solitarius ...
Document
... substance P, neurokinin A, and neurokinin B, which preferentially bind to the receptors neurokinin-1, neurokinin-2, and neurokinin-3, respectively.47,48 Neurokinin-1 receptors are widely distributed throughout the central nervous system, including the area postrema and the nucleus tractus solitarius ...
... substance P, neurokinin A, and neurokinin B, which preferentially bind to the receptors neurokinin-1, neurokinin-2, and neurokinin-3, respectively.47,48 Neurokinin-1 receptors are widely distributed throughout the central nervous system, including the area postrema and the nucleus tractus solitarius ...
Buprenorphine for Pain and for Addiction
... dissociation from opioid receptors. It produces a blockade effect at the mu-opioid receptor so that subsequently administered opioids do not produce their full euphoric effect. • It appears to produce less physical dependence than a full opioid agonist (such as methadone), and it may be easier to di ...
... dissociation from opioid receptors. It produces a blockade effect at the mu-opioid receptor so that subsequently administered opioids do not produce their full euphoric effect. • It appears to produce less physical dependence than a full opioid agonist (such as methadone), and it may be easier to di ...
article in press
... the search for new atypical antipsychotics presenting low cost and the understanding of the mechanism of action leading to atypical antipsychotic profile. The results obtained are presented in two distinct parts based on their nature, namely, experimental (first part) or theoretical (second part). F ...
... the search for new atypical antipsychotics presenting low cost and the understanding of the mechanism of action leading to atypical antipsychotic profile. The results obtained are presented in two distinct parts based on their nature, namely, experimental (first part) or theoretical (second part). F ...
Multiple mechanisms involved in the large-spectrum
... model [15]. In this same paradigm, it can also impair reconsolidation, resulting in the attenuation of the aversive memory trace. In this study, the impairment of contextual fear memory did not show reinstatement and was long-lasting (22 days) [23]. Contrasting with these results, Elbatsh et al. [22 ...
... model [15]. In this same paradigm, it can also impair reconsolidation, resulting in the attenuation of the aversive memory trace. In this study, the impairment of contextual fear memory did not show reinstatement and was long-lasting (22 days) [23]. Contrasting with these results, Elbatsh et al. [22 ...
Drug Testing: Answers to Frequently Asked
... with structural features which allow binding to one of the known cannabinoid receptors, i.e. CB1 or CB2, present in human cells The CB1 receptor is located mainly in the brain and spinal cord and is responsible for the typical physiological and particularly the psychotropic effects of cannabis T ...
... with structural features which allow binding to one of the known cannabinoid receptors, i.e. CB1 or CB2, present in human cells The CB1 receptor is located mainly in the brain and spinal cord and is responsible for the typical physiological and particularly the psychotropic effects of cannabis T ...
An Introduction to Medicinal Chemistry
... interested in a future career in the pharmaceutical industry. It attempts to convey something of the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, cell biology, and pharmacology. No previous knowledge of biology is assumed and the first six chapters cov ...
... interested in a future career in the pharmaceutical industry. It attempts to convey something of the fascination of working in a field which overlaps the disciplines of chemistry, biochemistry, cell biology, and pharmacology. No previous knowledge of biology is assumed and the first six chapters cov ...
Case History - Children`s Hospital of Michigan
... the PCP (phencyclidine) site. In fact, the structural similarities between DXM and PCP may cause a false positive drug screen for PCP. DXM has also been shown to block N- and L-type voltage-dependent calcium channels and nicotinic receptors. In addition to the NMDA receptor, dextrorphan binds to sig ...
... the PCP (phencyclidine) site. In fact, the structural similarities between DXM and PCP may cause a false positive drug screen for PCP. DXM has also been shown to block N- and L-type voltage-dependent calcium channels and nicotinic receptors. In addition to the NMDA receptor, dextrorphan binds to sig ...
Caffeine
... • Students may use caffeine to stay up late studying • It is primarily used as a mild CNS stimulant to aid in staying awake and restore mental alertness ...
... • Students may use caffeine to stay up late studying • It is primarily used as a mild CNS stimulant to aid in staying awake and restore mental alertness ...
Lipid mediators of tumor necrosis factor-alpha-induced uveitis.
... MO). Injections were made through a 30-g needle that was attached to a syringe, approximately 3 mm posterior to the limbus. Animals were divided into five treatment groups: group I animals received injections of drug vehicles. The schedule and route of administration of vehicle injections correspond ...
... MO). Injections were made through a 30-g needle that was attached to a syringe, approximately 3 mm posterior to the limbus. Animals were divided into five treatment groups: group I animals received injections of drug vehicles. The schedule and route of administration of vehicle injections correspond ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.