fullcvenglish_tmavromous
... work of the group on virgin olive oil adulteration is worthy of note”). LMA is involved in both activities. 8. Reference of my research activity on peptidomimetism by the company Synergix Ltd in the software of «Molecular Conceptor”. A chapter is written on the synthesis of Bioactive Molecules with ...
... work of the group on virgin olive oil adulteration is worthy of note”). LMA is involved in both activities. 8. Reference of my research activity on peptidomimetism by the company Synergix Ltd in the software of «Molecular Conceptor”. A chapter is written on the synthesis of Bioactive Molecules with ...
Corticotropin-Releasing Factor: Physiology, Pharmacology, And
... (Ser to Pro) (21). In addition to the homology between the species, the deduced amino acid sequence of rat and human urocortin exhibits sequence identity with urotensin I (63%) and human CRF (45%) (20). Consistent with the other CRF-related peptides, urocortin is also amidated at its carboxy termina ...
... (Ser to Pro) (21). In addition to the homology between the species, the deduced amino acid sequence of rat and human urocortin exhibits sequence identity with urotensin I (63%) and human CRF (45%) (20). Consistent with the other CRF-related peptides, urocortin is also amidated at its carboxy termina ...
Beta adrenergic influence on oesophageal peristalsis
... conditions. Non-selective beta blockade increases peristaltic pressure at the level of the lower oesophageal sphincter.4 Our findings that peristaltic pressure is increased after metoprolol compared with placebo treatment indicate that beta-1 receptors are involved. At present it is not known how se ...
... conditions. Non-selective beta blockade increases peristaltic pressure at the level of the lower oesophageal sphincter.4 Our findings that peristaltic pressure is increased after metoprolol compared with placebo treatment indicate that beta-1 receptors are involved. At present it is not known how se ...
clinical pharmacology of a urotensin-II receptor antagonist in Type 2
... vasoconstrictor identified up to date [4,7]. However, it was observed that response to UII varies between species, between types of blood vessel, and even between individual vessels of the same type, which is unlike the response of vascular tissues to endothelin1 and make the role of U-II in vascula ...
... vasoconstrictor identified up to date [4,7]. However, it was observed that response to UII varies between species, between types of blood vessel, and even between individual vessels of the same type, which is unlike the response of vascular tissues to endothelin1 and make the role of U-II in vascula ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
... ilar conclusions for mouse macrophages were published by Joseph et al.24 Joseph et al also showed that the synthetic LXR agonist GW3965 decreased atherosclerosis in mice.24 This promising data must be interpreted cautiously given the significant species differences in LXR-responsive genes between mi ...
... ilar conclusions for mouse macrophages were published by Joseph et al.24 Joseph et al also showed that the synthetic LXR agonist GW3965 decreased atherosclerosis in mice.24 This promising data must be interpreted cautiously given the significant species differences in LXR-responsive genes between mi ...
acetylcholine
... Tertiary amine, so can cross the blood/brain barrier. Central effects can be combated by atropine. ...
... Tertiary amine, so can cross the blood/brain barrier. Central effects can be combated by atropine. ...
Opioids analgesics and antagonists
... no analgesic activity at all competitive antagonist at mu, kappa, and sigma receptor displaces morphine and other OPIOID from receptor site reverses all actions of the OPIOID and does it rather quickly it will precipitate withdrawal person on heroin, then naloxone will precipitate withdrawal, but na ...
... no analgesic activity at all competitive antagonist at mu, kappa, and sigma receptor displaces morphine and other OPIOID from receptor site reverses all actions of the OPIOID and does it rather quickly it will precipitate withdrawal person on heroin, then naloxone will precipitate withdrawal, but na ...
N-Methyl-D-Aspartate Receptor Antagonist APV Blocks
... Because o f the rapidity with which it can be established and because of its longevity, LTP has been proposed as a physiological mechanism for learning and memory (Bliss & Lomo, 1973; Lynch & Baudry, 1984). N-methyl-D-aspartate (NMDA) receptors appear to play an important role in the development o f ...
... Because o f the rapidity with which it can be established and because of its longevity, LTP has been proposed as a physiological mechanism for learning and memory (Bliss & Lomo, 1973; Lynch & Baudry, 1984). N-methyl-D-aspartate (NMDA) receptors appear to play an important role in the development o f ...
pdf
... Female rats show enhanced maternal responsiveness toward their young if they have had maternal experiences before. This kind of maternal experience-based memory is critically dependent on the mesolimbic dopamine (DA) system, especially the nucleus accumbens (NA) shell. However, the relative contribu ...
... Female rats show enhanced maternal responsiveness toward their young if they have had maternal experiences before. This kind of maternal experience-based memory is critically dependent on the mesolimbic dopamine (DA) system, especially the nucleus accumbens (NA) shell. However, the relative contribu ...
American Society of Clinical Oncology Guideline for Antiemetics in
... dexamethasone, and aprepitant is recommended before chemotherapy. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended. The Update Committee no longer recommends the combination of a 5-HT3 serotonin rece ...
... dexamethasone, and aprepitant is recommended before chemotherapy. In all patients receiving cisplatin and all other agents of high emetic risk, the two-drug combination of dexamethasone and aprepitant is recommended. The Update Committee no longer recommends the combination of a 5-HT3 serotonin rece ...
μ-Opioid Receptor-Mediated Depression of the Hypothalamic
... Arousal and maintenance of a wake state is dependent on the hypothalamic hypocretin/orexin system. We found that hypocretin neurons are depressed by opiates, drugs of abuse that reduce cognitive alertness. Met-enkephalin (mENK), an endogenous opioid, and exogenous opiates such as morphine inhibited ...
... Arousal and maintenance of a wake state is dependent on the hypothalamic hypocretin/orexin system. We found that hypocretin neurons are depressed by opiates, drugs of abuse that reduce cognitive alertness. Met-enkephalin (mENK), an endogenous opioid, and exogenous opiates such as morphine inhibited ...
Functional Group Characteristics and Roles
... bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both muscarinic and nicotinic receptors, is rapidly metabolized by acetylcholinesterase, and is not orally active. The additional methyl group in bethanechol allows it to selective ...
... bethanchol offers several advantages for bethanechol over acetylcholine as acetylcholine non-selectively interacts with both muscarinic and nicotinic receptors, is rapidly metabolized by acetylcholinesterase, and is not orally active. The additional methyl group in bethanechol allows it to selective ...
contents - Médecins d`Afrique
... alter the observed pharmacokinetics of drugs. Objective: The purpose of this paper is to focus on how chronic exercise can change pharmacokinetics. Results: Chronic exercise can affect drug absorption by the increase in collateral blood flow and absorption may also be affected by changes in gastroin ...
... alter the observed pharmacokinetics of drugs. Objective: The purpose of this paper is to focus on how chronic exercise can change pharmacokinetics. Results: Chronic exercise can affect drug absorption by the increase in collateral blood flow and absorption may also be affected by changes in gastroin ...
Synthetic cannabinoids in herbal products
... compounds with cannabimimetic activity. Initially, only classical cannabinoids (e. g. Levonantradol [17] and HU‐ 210 [18]) were synthesized. Non ‐classical cannabinoids (e. g. CP‐59,540 and CP‐47,497 [19, 20]) and AAIs [21] were developed in the 80’s and 90’s after the so‐called cannabino ...
... compounds with cannabimimetic activity. Initially, only classical cannabinoids (e. g. Levonantradol [17] and HU‐ 210 [18]) were synthesized. Non ‐classical cannabinoids (e. g. CP‐59,540 and CP‐47,497 [19, 20]) and AAIs [21] were developed in the 80’s and 90’s after the so‐called cannabino ...
Receptor af峪ity and potency of non-steroidal antiandrogens
... al 31 have reported comparable af®nities for these agents at both wild-type rat and human prostate androgen receptors (Table 1). However, compared with other studies, the IC50 values (calculated as the concentration of drug required to produce 50% displacement of [3H]R1881) were generally over three ...
... al 31 have reported comparable af®nities for these agents at both wild-type rat and human prostate androgen receptors (Table 1). However, compared with other studies, the IC50 values (calculated as the concentration of drug required to produce 50% displacement of [3H]R1881) were generally over three ...
Dopamine and Benzodiazepine-Dependent Mechanisms
... While the direct reinforcing actions of alcohol have been investigated in the operant chamber (June, 2002), alcohol’s acute reinforcing actions, as with other abused drugs (Di Chiara and Imperato, 1985), have also been indirectly inferred/investigated via the use of locomotor activational effects (W ...
... While the direct reinforcing actions of alcohol have been investigated in the operant chamber (June, 2002), alcohol’s acute reinforcing actions, as with other abused drugs (Di Chiara and Imperato, 1985), have also been indirectly inferred/investigated via the use of locomotor activational effects (W ...
RESPIRATORY-FINAL
... represent a specialized type of stretch receptor) located in the tracheobronchial passages. ...
... represent a specialized type of stretch receptor) located in the tracheobronchial passages. ...
Synopsis of Some Recent Tactical Application of Bioisosteres in
... -CHdCH-, -S-CHd and -NdC nonclassical bioisosteres are structurally distinct, usually comprise different number of atoms and exhibit different steric and electronic properties compared to the functionality being emulated have been divided into two subgroups:2 1. cyclic and noncyclic isosteres 2. excha ...
... -CHdCH-, -S-CHd and -NdC nonclassical bioisosteres are structurally distinct, usually comprise different number of atoms and exhibit different steric and electronic properties compared to the functionality being emulated have been divided into two subgroups:2 1. cyclic and noncyclic isosteres 2. excha ...
Antidote–Opioids
... When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including yawning, lacrimation, diaphoresis, rhinorrhea, piloerection, mydriasis, vomiting, diarrhea, myalgias, mild elevations in heart rate and ...
... When patients dependent on opioid agonists are exposed to opioid antagonists or agonist– antagonists such as pentazocine, they exhibit opioid withdrawal, including yawning, lacrimation, diaphoresis, rhinorrhea, piloerection, mydriasis, vomiting, diarrhea, myalgias, mild elevations in heart rate and ...
HUMAN PHARMACOLOGY AYAHUASCA Director de la Tesi:
... been estimated to extend from Panama to Amazonian Peru and Bolivia and from the coastal areas of Colombia and Ecuador to the Río Negro in Brazil (Ott, 1993). While the term ayahuasca, which also designates the plant the beverage is made from, is used in Peru and some areas of Ecuador and Colombia, t ...
... been estimated to extend from Panama to Amazonian Peru and Bolivia and from the coastal areas of Colombia and Ecuador to the Río Negro in Brazil (Ott, 1993). While the term ayahuasca, which also designates the plant the beverage is made from, is used in Peru and some areas of Ecuador and Colombia, t ...
Antipsychotic dosing: found in translation
... the risk of relapse. In fact, by the late 1950s depot anti psychotic formulations were introduced as a means of addressing nonadherence and ensuring gaps in treatment were avoided.55 It is still recommended that drugs with shorter half-lives be administered several times daily to ensure steady state ...
... the risk of relapse. In fact, by the late 1950s depot anti psychotic formulations were introduced as a means of addressing nonadherence and ensuring gaps in treatment were avoided.55 It is still recommended that drugs with shorter half-lives be administered several times daily to ensure steady state ...
Differential Cardiovascular and Renal Responses Produced by
... 1993). Despite evidence supporting a central action, the specific brain site(s) where -opioids act to affect the renal handling of water and electrolytes has not been established in vivo. Using compartmentalized rat hypothalamoneurohypophysial explants in culture, Rossi and Brooks (1996) showed tha ...
... 1993). Despite evidence supporting a central action, the specific brain site(s) where -opioids act to affect the renal handling of water and electrolytes has not been established in vivo. Using compartmentalized rat hypothalamoneurohypophysial explants in culture, Rossi and Brooks (1996) showed tha ...
Volume 50 Number 1
... Katerina Akassoglou, Ph.D., Assistant Professor of Pharmacology at the University of California at San Diego, is the recipient of the 2008 John J. Abel Award, sponsored by Eli Lilly & Co. The Award is given to a single young investigator for original, outstanding research contributions in the field ...
... Katerina Akassoglou, Ph.D., Assistant Professor of Pharmacology at the University of California at San Diego, is the recipient of the 2008 John J. Abel Award, sponsored by Eli Lilly & Co. The Award is given to a single young investigator for original, outstanding research contributions in the field ...
REVIEWS
... incidence of coronary events in association with an increase in plasma HDL levels in patients treated with fibrate drugs. Epidemiological studies indicate that a 1 mg dl–1 increase in the HDL-cholesterol concentration is associated with a 2–3% decrease in cardiovascular risk9–11. These studies indic ...
... incidence of coronary events in association with an increase in plasma HDL levels in patients treated with fibrate drugs. Epidemiological studies indicate that a 1 mg dl–1 increase in the HDL-cholesterol concentration is associated with a 2–3% decrease in cardiovascular risk9–11. These studies indic ...
Morphine - ISpatula
... *in lab preparations we obtain both isomers: dextromethorphan and levomethorphan but it has been found that dextromethorphan is lacking the analgetic activity with potentiated antitussive activity. While levomethorphan is possessing analgetic and antitussive activities. In fact, since this combinat ...
... *in lab preparations we obtain both isomers: dextromethorphan and levomethorphan but it has been found that dextromethorphan is lacking the analgetic activity with potentiated antitussive activity. While levomethorphan is possessing analgetic and antitussive activities. In fact, since this combinat ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.