Epinephrine increases facility of outflow and cyclic AMP
... tents were exchanged with perfusion solution containing 10"6, 5 X 1(T6, 10"5, 2.5 X 10"5, or 5 X 10"5 epinephrine bitartrate. After volume equilibration, post epinephrine facility measurements were made for at least 3 hr. In early studies, the fellow eye was used as a medium-only control to ensure t ...
... tents were exchanged with perfusion solution containing 10"6, 5 X 1(T6, 10"5, 2.5 X 10"5, or 5 X 10"5 epinephrine bitartrate. After volume equilibration, post epinephrine facility measurements were made for at least 3 hr. In early studies, the fellow eye was used as a medium-only control to ensure t ...
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... Unpaired mice, suggesting that this dose non-specifically decreased locomotor activity. However, On Test Day 1 (Conditioning Test), paired mice pretreated with the moderate (1.0 mg/kg) and high (2.0 mg/kg) prazosin doses during conditioning did not differ from their unpaired counterparts, suggesti ...
... Unpaired mice, suggesting that this dose non-specifically decreased locomotor activity. However, On Test Day 1 (Conditioning Test), paired mice pretreated with the moderate (1.0 mg/kg) and high (2.0 mg/kg) prazosin doses during conditioning did not differ from their unpaired counterparts, suggesti ...
Introduction to Anabolic Steroids
... supported by the dose/response curve. But this type of response is to be expected if there are other variables besides receptor binding. This can be explained if one or more of the mechanisms is saturated at lower levels of drug, and one or more other mechanisms do not become saturated until much hi ...
... supported by the dose/response curve. But this type of response is to be expected if there are other variables besides receptor binding. This can be explained if one or more of the mechanisms is saturated at lower levels of drug, and one or more other mechanisms do not become saturated until much hi ...
Lesson 24: Cannabis student notes cannabislessonStudent
... reputable sources will claim that one cannabinoid, 9-THC or delta-9 tetra-hydro-cannabinol is THE psychoactive cannabinoid. Since more than 60 cannabinoids have been identified, and since some are present in Cannabis sativa and not Cannabis indica (and the converse), it is probably too simple to im ...
... reputable sources will claim that one cannabinoid, 9-THC or delta-9 tetra-hydro-cannabinol is THE psychoactive cannabinoid. Since more than 60 cannabinoids have been identified, and since some are present in Cannabis sativa and not Cannabis indica (and the converse), it is probably too simple to im ...
Calcium and Beta Receptor Antagonist Overdose
... BBs and CCBs, whether ingested accidentally or intentionally, are the two most common cardiovascular medication classes reported to the database of the American Association of Poison Control Centers Toxic Exposure Surveillance System (AAPCC-TESS). In 1999 there were 9,502 BB cases and 8,844 CCB case ...
... BBs and CCBs, whether ingested accidentally or intentionally, are the two most common cardiovascular medication classes reported to the database of the American Association of Poison Control Centers Toxic Exposure Surveillance System (AAPCC-TESS). In 1999 there were 9,502 BB cases and 8,844 CCB case ...
Pregnane X Receptor Up-Regulation of P
... ABBREVIATIONS: CNS, central nervous system; PXR, pregnane X receptor; SXR, steroid and xenobiotic receptor; PCN, pregnenolone-16␣carbonitrile; DPBS, Dulbecco’s phosphate-buffered saline; BSA, bovine serum albumin; NBD-CSA, [N-⑀(4-nitrobenzofurazan-7-yl)-D-Lys8]cyclosporine A; PSC-833, valspodar; DMS ...
... ABBREVIATIONS: CNS, central nervous system; PXR, pregnane X receptor; SXR, steroid and xenobiotic receptor; PCN, pregnenolone-16␣carbonitrile; DPBS, Dulbecco’s phosphate-buffered saline; BSA, bovine serum albumin; NBD-CSA, [N-⑀(4-nitrobenzofurazan-7-yl)-D-Lys8]cyclosporine A; PSC-833, valspodar; DMS ...
100 Essential Drugs - University of Toledo
... MOA: accelerates antithrombin III binding to thrombin and antithrombin III, inactivates thrombin, as well as factors IXa, Xa, XIa, XIIa, and kallikrein; inhibits clot formation, but does not dissolve existing clots (only drug that produces anticoagulation within minutes) I: used in pts. at high risk ...
... MOA: accelerates antithrombin III binding to thrombin and antithrombin III, inactivates thrombin, as well as factors IXa, Xa, XIa, XIIa, and kallikrein; inhibits clot formation, but does not dissolve existing clots (only drug that produces anticoagulation within minutes) I: used in pts. at high risk ...
Modification of Practice-dependent Plasticity in Human Motor Cortex
... by inhibitory interneurons via the neurotransmitter gammaaminobutyric acid (GABA). In addition, cortical function is strongly influenced by neuromodulating transmitters like norepinephrine (NE), dopamine (DA) or acetylcholine (ACh). These systems have in common that their axons originate from nuclei ...
... by inhibitory interneurons via the neurotransmitter gammaaminobutyric acid (GABA). In addition, cortical function is strongly influenced by neuromodulating transmitters like norepinephrine (NE), dopamine (DA) or acetylcholine (ACh). These systems have in common that their axons originate from nuclei ...
Endocrine disrupting substances
... disrupters. At the recent European workshop on the impact of endocrine disrupters on human health and wildlife, held in December 1996 in Weybridge, UK, (EUR 17549, 1996) it was agreed that “An endocrine disrupter is an exogenous substance that causes adverse health effects in an intact organism, or ...
... disrupters. At the recent European workshop on the impact of endocrine disrupters on human health and wildlife, held in December 1996 in Weybridge, UK, (EUR 17549, 1996) it was agreed that “An endocrine disrupter is an exogenous substance that causes adverse health effects in an intact organism, or ...
Woolley et al - University of California, San Francisco
... on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient content or its flavor per se. In order to isolate the effect of flavor, we manipulated opioid si ...
... on consumption of highly palatable foods. Since macronutrient content may contribute to palatability, it is uncertain whether opioid regulation of food consumption is based primarily on its macronutrient content or its flavor per se. In order to isolate the effect of flavor, we manipulated opioid si ...
Review of Opioids and Treatment of Opioid Dependence Medical Director, PCSS-O
... Types of opioids and their effects Pharmacology of opioids Treatment modalities Pregnancy and other special groups ...
... Types of opioids and their effects Pharmacology of opioids Treatment modalities Pregnancy and other special groups ...
Adrenergic agonists:-
... of increased glycogenolysis in the liver (β2 effect), increased release of glucagon (β2 effect), and a decreased release of insulin (α2 effect). These effects are mediated via the cAMP mechanism. Lipolysis: Epinephrine initiates lipolysis through its agonist activity on the β receptors of adipose ti ...
... of increased glycogenolysis in the liver (β2 effect), increased release of glucagon (β2 effect), and a decreased release of insulin (α2 effect). These effects are mediated via the cAMP mechanism. Lipolysis: Epinephrine initiates lipolysis through its agonist activity on the β receptors of adipose ti ...
Pharmacology
... E. Treatment with acetylcysteine tremor, thyroid enlargement, and leukocytosis. The drug he is taking is most likely to be 1298. The first local anesthetic used clinically was A. Clomipramine (Anafranil®) A. Cocaine B. Haloperidol (Haldol®) B. Tetracaine C. Imipramine(Tofranil®) C. Lidocaine D. Lith ...
... E. Treatment with acetylcysteine tremor, thyroid enlargement, and leukocytosis. The drug he is taking is most likely to be 1298. The first local anesthetic used clinically was A. Clomipramine (Anafranil®) A. Cocaine B. Haloperidol (Haldol®) B. Tetracaine C. Imipramine(Tofranil®) C. Lidocaine D. Lith ...
STUDY OF THE ROLE OF THE BED NUCLEUS OF
... sessions) and cocaine (270-minute sessions) self-administering rats. Injections of SCH23390 (3.2 & 6.4 µg) to the cocaine group significantly reduced the final ratio of operant lever responding (0.75 mg/kg/i.v. injection; progressive ratio schedule of reinforcement (PR); timeout 20 sec); there was n ...
... sessions) and cocaine (270-minute sessions) self-administering rats. Injections of SCH23390 (3.2 & 6.4 µg) to the cocaine group significantly reduced the final ratio of operant lever responding (0.75 mg/kg/i.v. injection; progressive ratio schedule of reinforcement (PR); timeout 20 sec); there was n ...
Path Chapter 24 p1148-1163 [4-20
... seen after treatment with antihypertensive drug spironolactone (diuretic) There’s no atrophy in the rest of the gland or opposite adrenal o Bilateral idiopathic hyperplasia – shows both diffuse and focal hyperplasia with cells resembling the glomerulosa More common in kids and young adults, and ...
... seen after treatment with antihypertensive drug spironolactone (diuretic) There’s no atrophy in the rest of the gland or opposite adrenal o Bilateral idiopathic hyperplasia – shows both diffuse and focal hyperplasia with cells resembling the glomerulosa More common in kids and young adults, and ...
Reasons for Delegate`s final decision, July 2011
... Synthetic cannabinoids (or synthetic cannabinomimetics) comprise a number of groups of chemically unrelated structures, all of which are functionally similar to the active principle in cannabis, delta-9-tetrahydrocannabinol (THC). Effects of synthetic cannabinoids are due to their agonist activity a ...
... Synthetic cannabinoids (or synthetic cannabinomimetics) comprise a number of groups of chemically unrelated structures, all of which are functionally similar to the active principle in cannabis, delta-9-tetrahydrocannabinol (THC). Effects of synthetic cannabinoids are due to their agonist activity a ...
... increases in the LSD (dysphoria), stimulant (A) and marijuana (M) scales. Similar increases were observed with smoked cannabis. Several participants did not experience psychological effects following oral dronabinol at these doses. Psychological and psychomotor effects only appear if an individually ...
biochemical pharmacology - WatCut
... significance of a drug’s action. Finally, we have tried to heed Bacon’s advice and point out some of the open questions that will need to be solved by future researchers. In selecting the topics for a teaching text, one has to balance breadth and depth. We chose to forgo comprehensive coverage in fa ...
... significance of a drug’s action. Finally, we have tried to heed Bacon’s advice and point out some of the open questions that will need to be solved by future researchers. In selecting the topics for a teaching text, one has to balance breadth and depth. We chose to forgo comprehensive coverage in fa ...
Potential role of N-methyl-D-aspartate receptors as executors of
... severe AD. Hence, memantine offers a unique tool to verify clinically the findings obtained from animal experiments and therefore is the focus of the current review. Given our current understanding of the multiplicative role of the NMDA receptors in numerous disease states, we propose that memantine ...
... severe AD. Hence, memantine offers a unique tool to verify clinically the findings obtained from animal experiments and therefore is the focus of the current review. Given our current understanding of the multiplicative role of the NMDA receptors in numerous disease states, we propose that memantine ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... Kratom has long been considered unusual in its dual properties as a stimulant and sedative. Kratom was used in Thailand and Malaysia by manual laborers to enhance productivity, and for its euphoric (also called “coca-like”) effect at low doses (33). At higher doses, Kratom has opioid-like effects, a ...
... Kratom has long been considered unusual in its dual properties as a stimulant and sedative. Kratom was used in Thailand and Malaysia by manual laborers to enhance productivity, and for its euphoric (also called “coca-like”) effect at low doses (33). At higher doses, Kratom has opioid-like effects, a ...
The pharmacotherapy of smoking cessation
... to support this. A range of studies have shown that bupropion increases the chance of success 2.1-fold, with the number needed to treat to achieve an extra successful quitter being 7.5[1]. The one comparative study published found that bupropion (150 mg twice daily) produced a higher cessation rate ...
... to support this. A range of studies have shown that bupropion increases the chance of success 2.1-fold, with the number needed to treat to achieve an extra successful quitter being 7.5[1]. The one comparative study published found that bupropion (150 mg twice daily) produced a higher cessation rate ...
Psychedelic Drugs - American College of Neuropsychopharmacology
... relationships of the ergoline hallucinogens (20,21). Substitution at the N(1) position of LSD abolishes activity, as does substitution at the C(2) position with a halogen. (R)stereochemistries are essential at both C(5) and C(8) for activity. Reduction of the double bond at the 9,10 position abolish ...
... relationships of the ergoline hallucinogens (20,21). Substitution at the N(1) position of LSD abolishes activity, as does substitution at the C(2) position with a halogen. (R)stereochemistries are essential at both C(5) and C(8) for activity. Reduction of the double bond at the 9,10 position abolish ...
Dopamine, behavioral economics, and effort
... cost is too high), the animal reaches the point at which additional responses being required actually tend to suppress responding. For normal rats, responding at levels of FR64, FR100 or higher, even if there is only one 45 mg food pellet being delivered, does not seem to be problematic. A completel ...
... cost is too high), the animal reaches the point at which additional responses being required actually tend to suppress responding. For normal rats, responding at levels of FR64, FR100 or higher, even if there is only one 45 mg food pellet being delivered, does not seem to be problematic. A completel ...
Angiotensin II Increases Norepinephrine Release
... Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D-23538 Lubeck, FRG. ...
... Medizinische Universitat zu Lubeck, Ratzeburger Allee 160, D-23538 Lubeck, FRG. ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.