Kwartaalbericht
... latanoprost eye drops. Buprenorphine was discontinued. Follow up information was requested. The patient had not yet recovered six months after discontinuation. Enclosed pictures show several square-shaped 3x3 cm depigmented areas on upper chest and back. As also some small depigmented spots are obse ...
... latanoprost eye drops. Buprenorphine was discontinued. Follow up information was requested. The patient had not yet recovered six months after discontinuation. Enclosed pictures show several square-shaped 3x3 cm depigmented areas on upper chest and back. As also some small depigmented spots are obse ...
comparison ofsuppressive activity of the central nervous system from
... acyclic ureid, have the central nervous system suppresants activities, the barbituric acids derivatives also haves. The urea derivatives which have the pharmacophoric moieties acyclic ureid can be seen on figure 1. Further development of active compounds urea derivatives is Nbenzoylphenylurea, which ...
... acyclic ureid, have the central nervous system suppresants activities, the barbituric acids derivatives also haves. The urea derivatives which have the pharmacophoric moieties acyclic ureid can be seen on figure 1. Further development of active compounds urea derivatives is Nbenzoylphenylurea, which ...
neuro 2007 - addiction education home
... ("endocannabinoids") functionally related to Delta9-tetrahydrocannabinol, the psychoactive ingredient of marijuana (cannabis), along with proteins that modulate the endocannabinoids, including enzymes, transporters, and receptors. The endocannabinoid system's ubiquitous regulatory actions ...
... ("endocannabinoids") functionally related to Delta9-tetrahydrocannabinol, the psychoactive ingredient of marijuana (cannabis), along with proteins that modulate the endocannabinoids, including enzymes, transporters, and receptors. The endocannabinoid system's ubiquitous regulatory actions ...
DOCTORAL THESIS
... ones blocking the “pain signal” in an uncompetitive manner have attracted the attention of researchers working in the field. Based on previously obtained results for several peptoid hits that showed activity as uncompetitive TRPV1 antagonists, and that allowed to propose a basic pharmacophoric hypot ...
... ones blocking the “pain signal” in an uncompetitive manner have attracted the attention of researchers working in the field. Based on previously obtained results for several peptoid hits that showed activity as uncompetitive TRPV1 antagonists, and that allowed to propose a basic pharmacophoric hypot ...
Smoking
... Only limited data on the effects of variations in these enzymes on smoking behaviour are available. ...
... Only limited data on the effects of variations in these enzymes on smoking behaviour are available. ...
MK-801 Limits Neurovascular Dysfunction during Experimental
... treatment resulted in elevated endogenous corticosterone levels (table 1) similar to previous values recorded in untreated EAE-inoculated rats during the early onset of disease (Mackenzie et al., 1989; Elderfield et al., 1993). Both prophylactic MK-801 treatments had circulating glucocorticoid level ...
... treatment resulted in elevated endogenous corticosterone levels (table 1) similar to previous values recorded in untreated EAE-inoculated rats during the early onset of disease (Mackenzie et al., 1989; Elderfield et al., 1993). Both prophylactic MK-801 treatments had circulating glucocorticoid level ...
Ibogaine in opioid detoxification
... 2. Gibson, A.E. and Degenhardt, L.J., (2007). Mortality related to pharmacotherapies for opioid dependence: a comparative analysis of coronial records. Drug and Alcohol Review 26, 405-410. 3. Gibson, A. and Degenhardt, L.,(2005). Mortality related to naltrexone in the treatment of opioid dependence: ...
... 2. Gibson, A.E. and Degenhardt, L.J., (2007). Mortality related to pharmacotherapies for opioid dependence: a comparative analysis of coronial records. Drug and Alcohol Review 26, 405-410. 3. Gibson, A. and Degenhardt, L.,(2005). Mortality related to naltrexone in the treatment of opioid dependence: ...
Effects of cannabidiol on schizophrenia
... Convergent evidence suggests a link between cannabis use and psychosis.1 However, cannabis comprises a combination of cannabinoids and these different constituents may have distinct effects, not all of which are detrimental to mental health. The main component of smoked cannabis is D9-tetrahydrocann ...
... Convergent evidence suggests a link between cannabis use and psychosis.1 However, cannabis comprises a combination of cannabinoids and these different constituents may have distinct effects, not all of which are detrimental to mental health. The main component of smoked cannabis is D9-tetrahydrocann ...
Pharmacology of Serotonin Reuptake Inhibitors (SRIs):
... Neurotransmitters are depleted Up-regulation of post-synaptic receptors Antidepressants increase neurotransmitter activity Post-synaptic receptors down-regulate (desensitization) → tolerance of side effects ...
... Neurotransmitters are depleted Up-regulation of post-synaptic receptors Antidepressants increase neurotransmitter activity Post-synaptic receptors down-regulate (desensitization) → tolerance of side effects ...
Pharmacotherapy for Smoking Cessation
... Patient factors? The smoker’s level of dependence on nicotine influences NRT effectiveness heavy smokers (>30 cigarettes/day) benefit from higher doses of nicotine replacement e.g. 4mg gum vs 2mg or combinations of NRT limited evidence of NRT effectiveness in those who smoke less than 10-15 ciga ...
... Patient factors? The smoker’s level of dependence on nicotine influences NRT effectiveness heavy smokers (>30 cigarettes/day) benefit from higher doses of nicotine replacement e.g. 4mg gum vs 2mg or combinations of NRT limited evidence of NRT effectiveness in those who smoke less than 10-15 ciga ...
Neurotransmitters
... Neurotransmitters are chemicals that take a nerve signal across the synaptic gap (Figure 02a) between a sending neuron, and a receiving one. On the receiving neuron are receptors into which the neurotransmitters fit like a key in a lock. Once a neuro-transmitter is bound to its specific receptor, th ...
... Neurotransmitters are chemicals that take a nerve signal across the synaptic gap (Figure 02a) between a sending neuron, and a receiving one. On the receiving neuron are receptors into which the neurotransmitters fit like a key in a lock. Once a neuro-transmitter is bound to its specific receptor, th ...
Mechanism underlying the efficacy of combination therapy
... Hypertension is the most prevalent modifiable risk factor for cardiovascular disease and the most common risk factor for death from any cause worldwide.1,2 Achievement of the target blood pressure is the key objective of antihypertensive treatment. Angiotensin receptor blockers (ARBs) exert an antih ...
... Hypertension is the most prevalent modifiable risk factor for cardiovascular disease and the most common risk factor for death from any cause worldwide.1,2 Achievement of the target blood pressure is the key objective of antihypertensive treatment. Angiotensin receptor blockers (ARBs) exert an antih ...
Acute Effects of d-Amphetamine on the Differential Reinforcement of
... Amphetamine, in general, causes rats to respond with shorter IRTs leading a leftward shift in the IRT frequency distribution. Although the pharmacological properties remain controversial, it has been suggested that these behavioral changes in the DRL schedule produced by amphetamine are predominatel ...
... Amphetamine, in general, causes rats to respond with shorter IRTs leading a leftward shift in the IRT frequency distribution. Although the pharmacological properties remain controversial, it has been suggested that these behavioral changes in the DRL schedule produced by amphetamine are predominatel ...
Dopaminergic Key to Homeostasis and
... aDepartment of Psychiatry McKnight Brain Institute, University of Florida School of Medicine, Gainesvill,Fl. USA; bDivision of Applied Clinical Research & Education, Dominion Diagnostics, LLC., North Kingstown, RI, USA; cDivision of Neuroscience-Based Therapy, Summit Estate Recovery Center, Los Gato ...
... aDepartment of Psychiatry McKnight Brain Institute, University of Florida School of Medicine, Gainesvill,Fl. USA; bDivision of Applied Clinical Research & Education, Dominion Diagnostics, LLC., North Kingstown, RI, USA; cDivision of Neuroscience-Based Therapy, Summit Estate Recovery Center, Los Gato ...
drugs of abuse
... Naturally occurring in brain tissue – neurotransmitter-like substance – dopamine release in substantia nigra ...
... Naturally occurring in brain tissue – neurotransmitter-like substance – dopamine release in substantia nigra ...
Drugs affecting the respiratory system - Lectures
... Difficult to identify whether cause is viral or bacterial Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Difficult to identify whether cause is viral or bacterial Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Mecamylamine (Inversine )
... smokers, future studies could be designed to determine the safety and efficacy of low-dose mecamylamine therapy in smokers with mild to moderate hypertension. In a recent pharmacokinetic study by Zevin, Jacob and Benowitz,37 mecamylamine was found to reduce the volume of distribution of nicotine and ...
... smokers, future studies could be designed to determine the safety and efficacy of low-dose mecamylamine therapy in smokers with mild to moderate hypertension. In a recent pharmacokinetic study by Zevin, Jacob and Benowitz,37 mecamylamine was found to reduce the volume of distribution of nicotine and ...
Cannabidiol as a Potential Treatment for Anxiety Disorders
... studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties (see [11, 12, 16–19] for reviews). A review of potential side effects in hu ...
... studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties (see [11, 12, 16–19] for reviews). A review of potential side effects in hu ...
Protein Kinase C Mediates the Synergistic Interaction Between
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
Curr.Med. Chem._Martínez, A._2015 - digital
... The main goal of this review is to describe the evolution from the first dual binding site AChE inhibitors to molecules where an AChE inhibitor is linked to other active compounds and finally to compounds able to interact simultaneously with two targets involved in AD. The importance of the multitar ...
... The main goal of this review is to describe the evolution from the first dual binding site AChE inhibitors to molecules where an AChE inhibitor is linked to other active compounds and finally to compounds able to interact simultaneously with two targets involved in AD. The importance of the multitar ...
- University of Mississippi
... encouraged by the media with little or no evidence based support and require further investigation to determine the effectiveness of such treatment plans. One such alternative treatment for epilepsy is marijuana, also known as cannabis. Specifically, there are two compounds of interest in marijuana: ...
... encouraged by the media with little or no evidence based support and require further investigation to determine the effectiveness of such treatment plans. One such alternative treatment for epilepsy is marijuana, also known as cannabis. Specifically, there are two compounds of interest in marijuana: ...
Hypoglossal Nerve Response to 5-HT3 Drugs Injected into the XII
... Adult male Sprague-Dawley rats (Charles River) weighing 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
... Adult male Sprague-Dawley rats (Charles River) weighing 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
pharmacological manipulation of cb1 receptor
... Chronic EtOH inhalation procedure Mice were made EtOH-tolerant by continuous exposure to EtOH vapours following the procedure described below. The infusion chambers were 52 · 34 · 27 cm and made of Lucite. A syringe pump delivered absolute EtOH at 25.5 mg/ min onto a gauze wick in a flask. An air pu ...
... Chronic EtOH inhalation procedure Mice were made EtOH-tolerant by continuous exposure to EtOH vapours following the procedure described below. The infusion chambers were 52 · 34 · 27 cm and made of Lucite. A syringe pump delivered absolute EtOH at 25.5 mg/ min onto a gauze wick in a flask. An air pu ...
Cannabinoid receptor antagonist
The discovery of the endogenous cannabinoid system led to the development of CB1 receptor antagonists. The first cannabinoid receptor antagonist, rimonabant, was described in 1994. Rimonabant blocks the CB1 receptor selectively and it has been shown to decrease food intake and regulate body-weight gain. The prevalence of obesity worldwide is increasing dramatically and has a great impact on public health. The lack of efficient and well-tolerated drugs to cure obesity has led to an increased interest in research and development of cannabinoid antagonists. Cannabidiol, a naturally occurring cannabinoid, is a non-competitive CB1/2 antagonist.