Potential medicinal benefits of Cosmos caudatus (Ulam Raja): A
... inhibitory activity against the growth of the five tested human pathogenic microbes.[8] These results indicate that both polar and nonpolar C. caudatus extracts have highly anti-microbial and anti-fungal properties. Toxicological limits In the cell toxicity test, ethanol extracts of C. caudatus exhi ...
... inhibitory activity against the growth of the five tested human pathogenic microbes.[8] These results indicate that both polar and nonpolar C. caudatus extracts have highly anti-microbial and anti-fungal properties. Toxicological limits In the cell toxicity test, ethanol extracts of C. caudatus exhi ...
PRODUCT MONOGRAPH Pilocarpine Hydrochloride Tablets, USP
... Pilocarpine Hydrochloride Tablets, USP are made from the naturally-occurring alkaloid pilocarpine which is obtained from the leaflets of the South American shrub Pilocarpus jaborandi. Pilocarpine hydrochloride is a cholinomimetic (cholinergic parasympathomimetic) agent capable of exerting a broad sp ...
... Pilocarpine Hydrochloride Tablets, USP are made from the naturally-occurring alkaloid pilocarpine which is obtained from the leaflets of the South American shrub Pilocarpus jaborandi. Pilocarpine hydrochloride is a cholinomimetic (cholinergic parasympathomimetic) agent capable of exerting a broad sp ...
ranitidine oral
... concentration-time curve (AUC) decreased from 3613 to 2394 g hour/L. The time to reach the peak and the rate of absorption of the drug were not substantially altered by concurrent administration of the antacid in this study; elimination half-life and renal clearance of ranitidine remained unchanged ...
... concentration-time curve (AUC) decreased from 3613 to 2394 g hour/L. The time to reach the peak and the rate of absorption of the drug were not substantially altered by concurrent administration of the antacid in this study; elimination half-life and renal clearance of ranitidine remained unchanged ...
Clinical Manual Part 2 Drug Infusion Guidelines
... standard 500 mL fluid bags are offered. 500 mL formats are generally for use through an intravenous rate controlling device such as an IVAC infusion pump. Although greater fluid volumes are necessary, there is a greater margin of safety in controlling rates, especially during transport and handover. ...
... standard 500 mL fluid bags are offered. 500 mL formats are generally for use through an intravenous rate controlling device such as an IVAC infusion pump. Although greater fluid volumes are necessary, there is a greater margin of safety in controlling rates, especially during transport and handover. ...
ACETYLCYSTEINE Solution, USP
... concomitantly administered by nebulization, direct instillation, or topical application, has been studied. Acetylcysteine should not be mixed with certain antibiotics. For example, the antibiotics tetracycline hydrochloride, oxytetracycline hydrochloride, and erythromycin lactobionate were found to ...
... concomitantly administered by nebulization, direct instillation, or topical application, has been studied. Acetylcysteine should not be mixed with certain antibiotics. For example, the antibiotics tetracycline hydrochloride, oxytetracycline hydrochloride, and erythromycin lactobionate were found to ...
Aggarwal Shweta et al. IRJP 2013, 4 (2) INTERNATIONAL
... fields2. Modification does not change the fundamental skeleton of chitosan but brings new or improved properties for e.g., mucoadhesion and permeation enhancement. The advantage of chitosan over other polysaccharides is that its chemical structure allows specific modifications without too many diffi ...
... fields2. Modification does not change the fundamental skeleton of chitosan but brings new or improved properties for e.g., mucoadhesion and permeation enhancement. The advantage of chitosan over other polysaccharides is that its chemical structure allows specific modifications without too many diffi ...
Methadone-Drug Interactions
... generally remained within acceptable limits (Maremmani et al. 2005; Martell et al. 2005). Often, these heart rhythm changes were in patients taking medications or drugs in addition to methadone, or having cardiac risk factors that might normally be of concern (Leavitt and Krantz 2003). In the larges ...
... generally remained within acceptable limits (Maremmani et al. 2005; Martell et al. 2005). Often, these heart rhythm changes were in patients taking medications or drugs in addition to methadone, or having cardiac risk factors that might normally be of concern (Leavitt and Krantz 2003). In the larges ...
phytochemical and pharmacological
... human diseases. History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of scientists; however, the basis of its development remains rooted in traditional medicine and the ...
... human diseases. History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of scientists; however, the basis of its development remains rooted in traditional medicine and the ...
C 3 R
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
6-keto, 7,8
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
Mepivacaine - Academy of General Dentistry
... in vitro conditions.17 However, these measurements were derived under controlled conditions and do not directly reflect in vivo anesthetic potency. They also do not correctly reflect the clinical end-points of mepivacaine use, where success is measured by an adequate conduction block, and the physio ...
... in vitro conditions.17 However, these measurements were derived under controlled conditions and do not directly reflect in vivo anesthetic potency. They also do not correctly reflect the clinical end-points of mepivacaine use, where success is measured by an adequate conduction block, and the physio ...
The Pharmacology of Lysergic Acid Diethylamide: A Review
... With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all ...
... With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all ...
EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME
... complete inhibition of carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%). The inhibition potency of pomegranate juice was similar to that of grapefruit juice, and it depended on the amount of juice added to the reaction mixture (0.6% to 6.0% v/v). We examined whether the component(s) of p ...
... complete inhibition of carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%). The inhibition potency of pomegranate juice was similar to that of grapefruit juice, and it depended on the amount of juice added to the reaction mixture (0.6% to 6.0% v/v). We examined whether the component(s) of p ...
BIAXIN® Filmtab® (clarithromycin tablets, USP) BIAXIN
... led to increases in the mean steady-state clarithromycin Cmin and AUC of 33% and 18%, respectively. Steady-state concentrations of 14-OH clarithromycin were not significantly affected by concomitant administration of fluconazole. No clarithromycin dose adjustment is necessary. Concomitant administra ...
... led to increases in the mean steady-state clarithromycin Cmin and AUC of 33% and 18%, respectively. Steady-state concentrations of 14-OH clarithromycin were not significantly affected by concomitant administration of fluconazole. No clarithromycin dose adjustment is necessary. Concomitant administra ...
Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir
... combination packs with different strengths of ribavirin (Submission number PM-201401438-1-2). The data in these submissions overlap and was considered concurrently and therefore the AusPARs are mostly the same except for the administrative information, detailed description of the ribavirin component ...
... combination packs with different strengths of ribavirin (Submission number PM-201401438-1-2). The data in these submissions overlap and was considered concurrently and therefore the AusPARs are mostly the same except for the administrative information, detailed description of the ribavirin component ...
Platelet inhibitory activity and pharmacokinetics of prasugrel
... Ticlopidine and clopidogrel are thienopyridine prodrugs which following oral administration are metabolized to an active sulfhydryl form that binds to and irreversibly antagonizes the P2Y12 class of platelet ADP receptor [8]. Where approved, clopidogrel is the thienopyridine of choice due to its mor ...
... Ticlopidine and clopidogrel are thienopyridine prodrugs which following oral administration are metabolized to an active sulfhydryl form that binds to and irreversibly antagonizes the P2Y12 class of platelet ADP receptor [8]. Where approved, clopidogrel is the thienopyridine of choice due to its mor ...
Ketoconazole and Itraconazole Pharmacokinetic
... KTC is known to be a potent inhibitor of the metabolism of variety of drugs such as cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes ...
... KTC is known to be a potent inhibitor of the metabolism of variety of drugs such as cyclosporine, phenytoin and warfarin. It is therefore, possible that the increases in AUC0-∞, Cmax, tl/2 and MRT, seen in this study, when CIP was given together with KTC may be due to the inhibition of cytochromes ...
effect of piperine, a major component of black pepper, on the
... given orally or intraperitoneally. Relevant to this is the study which showed that grapefruit juice, an inhibitor of P-glycoprotein (28) instead of increasing plasma levels of fexofenadine, a Pglycoprotein substrate, it decreased its plasma levels (29). On the other hand, it appears that there is a ...
... given orally or intraperitoneally. Relevant to this is the study which showed that grapefruit juice, an inhibitor of P-glycoprotein (28) instead of increasing plasma levels of fexofenadine, a Pglycoprotein substrate, it decreased its plasma levels (29). On the other hand, it appears that there is a ...
PRODUCT MONOGRAPH UNIPHYL Theophylline Sustained
... Therefore, it is advisable to individualize the dosage regimen. Ideally, all patients should have serum theophylline levels measured which would enable doses and dosing regimens to be tailored for each patient in order to maintain therapeutic levels, ensure optimal clinical response and avoid toxici ...
... Therefore, it is advisable to individualize the dosage regimen. Ideally, all patients should have serum theophylline levels measured which would enable doses and dosing regimens to be tailored for each patient in order to maintain therapeutic levels, ensure optimal clinical response and avoid toxici ...
Ewrramt~amm=nts I
... overcrowded with new drugs. ” But ASA was marketed in tablet form in 1899. Hoffmann obtained a US patent for ASA in 1900. However, a trade name had to be found since acetylsalicylic acid was too hard to say or remember. Bayer hit upon a commercial name that derives from acelyl and the German word fo ...
... overcrowded with new drugs. ” But ASA was marketed in tablet form in 1899. Hoffmann obtained a US patent for ASA in 1900. However, a trade name had to be found since acetylsalicylic acid was too hard to say or remember. Bayer hit upon a commercial name that derives from acelyl and the German word fo ...
Syllabus of Eclectic Materia Medica and Therapeutics
... on the Lectures of Prof. Locke" was issued by members of the class, and since it has become necessary to supplant that work with this one. These notes have been corrected and are embodied in this work, with many additions. This book is therefore offered merely as a series of notes upon the drugs her ...
... on the Lectures of Prof. Locke" was issued by members of the class, and since it has become necessary to supplant that work with this one. These notes have been corrected and are embodied in this work, with many additions. This book is therefore offered merely as a series of notes upon the drugs her ...
... (PL 00039/0561). The reference product has been authorised in the EEA for over 10 years. The Marketing Authorisation Holder has provided adequate justification for not submitting an Environmental Risk Assessment (ERA). Cetirizine Dihydrochloride is a wellestablished active substance that has had wid ...
Diclofenac Sodium 4% Spray Gel
... Diclofenac Sodium 4 % Spray Gel should be massaged gently into the skin. After this the hands should be washed unless they are the site to be treated. After application some minutes for drying should be allowed before dressing or binding the treated area. The treatment may be discontinued when the s ...
... Diclofenac Sodium 4 % Spray Gel should be massaged gently into the skin. After this the hands should be washed unless they are the site to be treated. After application some minutes for drying should be allowed before dressing or binding the treated area. The treatment may be discontinued when the s ...
Is there Evidence to Support the use of Enteric Coated (EC) Aspirin
... The evidence for this issue consists of small randomised controlled trials conducted over 7-14 days and larger cohort studies. Participants were in the most part healthy volunteers, and outcome measures consisted of in vitro measurement of the bleeding times, extent of platelet aggregation, or inhib ...
... The evidence for this issue consists of small randomised controlled trials conducted over 7-14 days and larger cohort studies. Participants were in the most part healthy volunteers, and outcome measures consisted of in vitro measurement of the bleeding times, extent of platelet aggregation, or inhib ...
Pharmacokinetics of Erythromycin Ethylsuccinate
... to acid degradation than either the estolate ester or microencapsulated erythromycin base when comparing peak plasma concentrations of anhydroerythromycin and the respective area under the plasma concentration versus time curves.4,6 Concentrations of anhydroerythromycin were considerably higher at a ...
... to acid degradation than either the estolate ester or microencapsulated erythromycin base when comparing peak plasma concentrations of anhydroerythromycin and the respective area under the plasma concentration versus time curves.4,6 Concentrations of anhydroerythromycin were considerably higher at a ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.