Stability Indicating HPTLC Method Development for
... degradation of a new drug in acidic and alkaline conditions can be studied by exposing the drug in 0.1 N HCl / NaOH for 1-7 days [23, 24]. If reasonable degradation is seen, testing can be stopped at this point. However, in case no degradation is seen under these conditions, the drug should be expos ...
... degradation of a new drug in acidic and alkaline conditions can be studied by exposing the drug in 0.1 N HCl / NaOH for 1-7 days [23, 24]. If reasonable degradation is seen, testing can be stopped at this point. However, in case no degradation is seen under these conditions, the drug should be expos ...
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... echinacea did. The authors concluded that preventive treatment of athletes with the E. purpurea juice preparation counteracts the immunosuppressant effects of exhaustive exercise and reduces risk of URI in athletes. There is evidence to suggest that echinacea is a reliable supportive therapy for peo ...
... echinacea did. The authors concluded that preventive treatment of athletes with the E. purpurea juice preparation counteracts the immunosuppressant effects of exhaustive exercise and reduces risk of URI in athletes. There is evidence to suggest that echinacea is a reliable supportive therapy for peo ...
Mechanistic Studies on Metabolic Interactions between Gemfibrozil
... esterase-catalyzed hydrolysis of statin lactones to their respective hydroxy acids could also result in an increase in the plasma AUC of statin hydroxy acids and should be considered as a second potential mechanism of the observed GFZstatin pharmacokinetic interaction. Unlike SV and LV, all other ma ...
... esterase-catalyzed hydrolysis of statin lactones to their respective hydroxy acids could also result in an increase in the plasma AUC of statin hydroxy acids and should be considered as a second potential mechanism of the observed GFZstatin pharmacokinetic interaction. Unlike SV and LV, all other ma ...
Martindale: The Complete Drug Reference
... Drug Nomenclature (Latest modification: 07-Feb-2011) Synonyms: Diclofenac Diethylammonium; Diclofenaco dietilamina; ...
... Drug Nomenclature (Latest modification: 07-Feb-2011) Synonyms: Diclofenac Diethylammonium; Diclofenaco dietilamina; ...
Mrs - Vitrodiagnostic.com
... Clearly, before any drug circulating in plasma can be discharged into the salivary duct it must pass through the capillary wall, the basement membrane and the membrane of the glandular epithelial cells. The rate-determining step for this transportation is the passage of the drug through the lipophil ...
... Clearly, before any drug circulating in plasma can be discharged into the salivary duct it must pass through the capillary wall, the basement membrane and the membrane of the glandular epithelial cells. The rate-determining step for this transportation is the passage of the drug through the lipophil ...
An investigation of the effects of fulvic and humic acids... the absorption of selected drugs, vitamins and minerals
... medicinal and therapeutic properties. For this reason, alternative or “natural” medicinal preparations rich in these substances are being self-administered, often concomitantly with conventional drugs. The possibility exists that these humic substances, found in the alternative medicinal products, m ...
... medicinal and therapeutic properties. For this reason, alternative or “natural” medicinal preparations rich in these substances are being self-administered, often concomitantly with conventional drugs. The possibility exists that these humic substances, found in the alternative medicinal products, m ...
Full-Text PDF
... As well as other nanocarriers, the use of CD can increase drug solubility, bioavailability, safety, and stability of drug formulations [60]. Polymers provide even more versatility in nanocarriers engineering, being nanoparticles (NP), nanocapsules (NC), dendrimers and copolymer micelles among the nu ...
... As well as other nanocarriers, the use of CD can increase drug solubility, bioavailability, safety, and stability of drug formulations [60]. Polymers provide even more versatility in nanocarriers engineering, being nanoparticles (NP), nanocapsules (NC), dendrimers and copolymer micelles among the nu ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin; IC50, ligand concentration yielding 50% of the maximum response; Kp,uu, ratio of unbound drug concentration within a tissue to ...
... metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin; IC50, ligand concentration yielding 50% of the maximum response; Kp,uu, ratio of unbound drug concentration within a tissue to ...
Martindale: The Complete Drug Reference
... Uses and Administration (Latest modification: 05-Sep-2009) Cefuroxime is a second-generation cephalosporin antibacterial used in the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria, including infections of the bones and joints, CNS, skin and skin structures, re ...
... Uses and Administration (Latest modification: 05-Sep-2009) Cefuroxime is a second-generation cephalosporin antibacterial used in the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria, including infections of the bones and joints, CNS, skin and skin structures, re ...
LC-Tandem MS Detection of Covalent Binding of Acetaminophen to
... taken in overdoses, the high levels of NAPQI produced will deplete the glutathione stores resulting in strongly increased covalent binding to liver proteins, oxidative stress and ultimately to severe hepatotoxicity (Bessems and Vermeulen, 2001). We propose a general strategy which consists of the bi ...
... taken in overdoses, the high levels of NAPQI produced will deplete the glutathione stores resulting in strongly increased covalent binding to liver proteins, oxidative stress and ultimately to severe hepatotoxicity (Bessems and Vermeulen, 2001). We propose a general strategy which consists of the bi ...
Pobierz PDF - Problems of Forensic Sciences
... 2 cases were directed to the Institute of Forensic Research, and in 2006 - 3 cases in which mCPP was detected. These cases originated from various regions of the country, i.e. from Krakow, Lublin, Boles³awiec and Gryfów. 53 tablets of average mass 0.28 g and diameter 8 mm, usually cream coloured, wi ...
... 2 cases were directed to the Institute of Forensic Research, and in 2006 - 3 cases in which mCPP was detected. These cases originated from various regions of the country, i.e. from Krakow, Lublin, Boles³awiec and Gryfów. 53 tablets of average mass 0.28 g and diameter 8 mm, usually cream coloured, wi ...
INHIBITION OF OAT3-MEDIATED RENAL UPTAKE AS A
... Identification of the basolateral transporters provides a clue to understanding the molecular mechanisms of drug-drug interactions involving tubular secretion. Takeda et al. (2002) and Nozaki et al. (2004) have shown that rOat3/hOAT3-mediated renal uptake can be a potential drug-drug interaction sit ...
... Identification of the basolateral transporters provides a clue to understanding the molecular mechanisms of drug-drug interactions involving tubular secretion. Takeda et al. (2002) and Nozaki et al. (2004) have shown that rOat3/hOAT3-mediated renal uptake can be a potential drug-drug interaction sit ...
Pharmaceutical Technology
... Some of the disadvantages with using gelatin for hard capsules include: it has a high moisture content, which is essential because this is the plasticizer for the film and, under International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (IC ...
... Some of the disadvantages with using gelatin for hard capsules include: it has a high moisture content, which is essential because this is the plasticizer for the film and, under International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (IC ...
polyalthia longifolia and its pharmacological activities : review
... P. longifolia leaf was evaluated using acute inflammatory studies in Wistar albino rats. Methanolic extract revealed most potential antinflammatory effect hence; three doses of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an antiinflammatory agent. The three doses ...
... P. longifolia leaf was evaluated using acute inflammatory studies in Wistar albino rats. Methanolic extract revealed most potential antinflammatory effect hence; three doses of methanolic extract (300, 600, 900 mg/kg) were used to evaluate its potential as an antiinflammatory agent. The three doses ...
Toward Understanding the Biology of a Complex Phenotype: Rat
... odological details can be found in published material (Geyer and Swerdlow, 1998). Startle testing procedures. In our testing apparatus, reliable measures of startle could first be obtained in pups at 14 d of age. At 14 d of age, different groups of rat pups were exposed to a brief “matching” startle ...
... odological details can be found in published material (Geyer and Swerdlow, 1998). Startle testing procedures. In our testing apparatus, reliable measures of startle could first be obtained in pups at 14 d of age. At 14 d of age, different groups of rat pups were exposed to a brief “matching” startle ...
Preparation and Evaluation of Soft Gellan Gum Gel Containing
... the soft gel was same because the co-solutes were used at same level in all the batches. It is clearly observed from the results shown in Table 2 that change in the viscosity and consistency of soft gel is strongly influenced by gellan gum concentration. Batch PG3 consisting of 0.3% gellan gum and 0 ...
... the soft gel was same because the co-solutes were used at same level in all the batches. It is clearly observed from the results shown in Table 2 that change in the viscosity and consistency of soft gel is strongly influenced by gellan gum concentration. Batch PG3 consisting of 0.3% gellan gum and 0 ...
Two-Piece Hard Capsules for Pharmaceutical
... printing is an additional means of product identification and is even required by the US Food and Drug Administration for pharmaceutical capsules. Patient acceptance. Finally, patient acceptance is the third key consideration in color choice. With distinct colors, patients can more easily identify t ...
... printing is an additional means of product identification and is even required by the US Food and Drug Administration for pharmaceutical capsules. Patient acceptance. Finally, patient acceptance is the third key consideration in color choice. With distinct colors, patients can more easily identify t ...
Evaluation of the use of static and dynamic models to predict drug
... Clinical pharmacokinetic and drug interaction data Intravenous (iv) PK data were obtained from Phase I studies. Clinical PK parameters obtained from study reports were calculated using compartmental or non-compartmental analysis. Metabolic clearance was estimated by subtracting any measured renal cl ...
... Clinical pharmacokinetic and drug interaction data Intravenous (iv) PK data were obtained from Phase I studies. Clinical PK parameters obtained from study reports were calculated using compartmental or non-compartmental analysis. Metabolic clearance was estimated by subtracting any measured renal cl ...
KEY and EXPLANATION for SET-A
... (D) Thiamine Answer: C Explanation: L-DOPA (Levo-3,4-dihydroxyphenylalanine) is a drug used in the treatment of parkinson’s disease and dopamine responsive dystonia. Levo DOPA crosses the protective BBB (blood brain barrier), whereas dopamine itself cannot. Once L-DOPA has entered the central nervou ...
... (D) Thiamine Answer: C Explanation: L-DOPA (Levo-3,4-dihydroxyphenylalanine) is a drug used in the treatment of parkinson’s disease and dopamine responsive dystonia. Levo DOPA crosses the protective BBB (blood brain barrier), whereas dopamine itself cannot. Once L-DOPA has entered the central nervou ...
The use of natural and synthetic phospholipids as pharmaceutical
... at pH values of about 7, whereas, e.g., PG is negatively charged. The most common phospholipid is PC, and PC is the main component of lecithin. Lecithin is described, e.g., in the United States Pharmacopoeia (USP) as a “complex mixture of acetone‐insoluble phosphatides, which consists chiefly of PC, ...
... at pH values of about 7, whereas, e.g., PG is negatively charged. The most common phospholipid is PC, and PC is the main component of lecithin. Lecithin is described, e.g., in the United States Pharmacopoeia (USP) as a “complex mixture of acetone‐insoluble phosphatides, which consists chiefly of PC, ...
effect of single oral dose of melatonin on plasma concentration of
... melatonin on cortisol release after melatonin administration.27 Their results are in total agreement with our results in which melatonin cause no effect on cortisol secretion. In another study Stefan et al, has shown different results with humans. It was concluded from their data that in totally bli ...
... melatonin on cortisol release after melatonin administration.27 Their results are in total agreement with our results in which melatonin cause no effect on cortisol secretion. In another study Stefan et al, has shown different results with humans. It was concluded from their data that in totally bli ...
Modelling of tolerance and rebound in normal and
... taken prior to a meal, rapidly decreases NEFA concentrations substantially with short effect duration (e.g. around 2 h) and no rebound might be a compound to aim for. With reduced NEFA concentration, glucose will be used as a source of energy, which may result in improved insulin sensitivity. Short ...
... taken prior to a meal, rapidly decreases NEFA concentrations substantially with short effect duration (e.g. around 2 h) and no rebound might be a compound to aim for. With reduced NEFA concentration, glucose will be used as a source of energy, which may result in improved insulin sensitivity. Short ...
Effects of different doses of venlafaxine on serotonin and
... plasma protein binding of venlafaxine when compared to those of paroxetine and desipramine, being y30 % for venlafaxine vs. 95 % for the latter two drugs (Ereshefsky and Dugan, 2000 ; Puozzo and Leonard, 1996). Presumably, the greater free fraction of venlafaxine may allow greater brain penetration. ...
... plasma protein binding of venlafaxine when compared to those of paroxetine and desipramine, being y30 % for venlafaxine vs. 95 % for the latter two drugs (Ereshefsky and Dugan, 2000 ; Puozzo and Leonard, 1996). Presumably, the greater free fraction of venlafaxine may allow greater brain penetration. ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.