Symposium Report Correlating Structure and Function of Drug
... structures are now available for most major human drug-metabolizing P450 enzymes (Fig. 1). A synthesis of our basic understanding of common and divergent elements among these enzymes was presented by Eric Johnson. It has become obvious that the flexibility of many xenobiotic-metabolizing P450 active ...
... structures are now available for most major human drug-metabolizing P450 enzymes (Fig. 1). A synthesis of our basic understanding of common and divergent elements among these enzymes was presented by Eric Johnson. It has become obvious that the flexibility of many xenobiotic-metabolizing P450 active ...
APO–KETOCONAZOLE
... Cases of idiosyncratic hepatocellular dysfunction have been reported during ketoconazole treatment. It is important to recognize that liver disorders can occur during therapy with APO– KETOCONAZOLE (ketoconazole). The occurrence of liver disorders while on APO–KETOCONAZOLE could be fatal unless prop ...
... Cases of idiosyncratic hepatocellular dysfunction have been reported during ketoconazole treatment. It is important to recognize that liver disorders can occur during therapy with APO– KETOCONAZOLE (ketoconazole). The occurrence of liver disorders while on APO–KETOCONAZOLE could be fatal unless prop ...
Full Text
... Using scn1a mutant zebrafish larvae with a gene homologous to human and spontaneously occurring seizures (Baraban et al., 2013), we screened, in a blinded manner, a repurposed library of ⬃1000 compounds for drugs that inhibit unprovoked seizure events. We also screened two compounds (huperzine A and ...
... Using scn1a mutant zebrafish larvae with a gene homologous to human and spontaneously occurring seizures (Baraban et al., 2013), we screened, in a blinded manner, a repurposed library of ⬃1000 compounds for drugs that inhibit unprovoked seizure events. We also screened two compounds (huperzine A and ...
Effect of St John`s Wort on Drug Metabolism by Induction of
... Main Outcome Measures Changes in plasma pharmacokinetics of alprazolam as a probe for CYP 3A4 activity and the ratio of dextromethorphan to its metabolite, dextrorphan, in urine as a probe for CYP 2D6 activity. Results A 2-fold decrease in the area under the curve for alprazolam plasma concentration ...
... Main Outcome Measures Changes in plasma pharmacokinetics of alprazolam as a probe for CYP 3A4 activity and the ratio of dextromethorphan to its metabolite, dextrorphan, in urine as a probe for CYP 2D6 activity. Results A 2-fold decrease in the area under the curve for alprazolam plasma concentration ...
Peridex and PerioMed Oral Rinse Brochure
... inflammation following treatment with Peridex oral rinse should not be used as a major indicator of underlying periodontitis. 2. Peridex oral rinse can cause staining of oral surfaces, such as tooth surfaces, restorations, and the dorsum of the tongue. Not all patients will experience a visu ...
... inflammation following treatment with Peridex oral rinse should not be used as a major indicator of underlying periodontitis. 2. Peridex oral rinse can cause staining of oral surfaces, such as tooth surfaces, restorations, and the dorsum of the tongue. Not all patients will experience a visu ...
hydrocodone bitartrate and acetaminophen tablets, usp
... acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Hydrocodone Bitartrate ...
... acetaminophen. Clinical signs included swelling of the face, mouth, and throat, respiratory distress, urticaria, rash, pruritus, and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention. Instruct patients to discontinue Hydrocodone Bitartrate ...
Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A
... volunteers, a fatty meal caused a small but statistically significant reduction of mean LZD plasma concentration [6]. The Cmax decreased by 23% and tmax increased from 1.5 hours to 2.2 hours, probably due to prolonged gastric residence time. An open-label cross-over study in 28 healthy volunteers te ...
... volunteers, a fatty meal caused a small but statistically significant reduction of mean LZD plasma concentration [6]. The Cmax decreased by 23% and tmax increased from 1.5 hours to 2.2 hours, probably due to prolonged gastric residence time. An open-label cross-over study in 28 healthy volunteers te ...
Enhanced Therapeutic Benefit of Quercetin–Phospholipid Complex
... Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absor ...
... Quercetin is a typical flavonoid with diverse biological effects, attributable to its free radical scavenging activity. Bioavailability of quercetin aglycone and its glycosides is an important factor for its antioxidant activity in vivo. A severe limitation exists and is imputable to very poor absor ...
International Journal of Ayurveda and Pharma Research
... In vitvo and in vitro studies on T. chebula demonstrated its ‘anti-vata’ or ‘antispasmodic’ properties by the reduction of abnormal blood pressure as well as intestinal spasms. This confirm its traditional usefulness for spastic colon and other intestinal disorders[47]. Antiulcerogenic activity ...
... In vitvo and in vitro studies on T. chebula demonstrated its ‘anti-vata’ or ‘antispasmodic’ properties by the reduction of abnormal blood pressure as well as intestinal spasms. This confirm its traditional usefulness for spastic colon and other intestinal disorders[47]. Antiulcerogenic activity ...
Pharmacology of platelet inhibition in humans: implications of the
... cyclooxygenase to aspirin inhibition. If it had been, the "aspirin dilemma" could have been solved easily by using low doses of the drug. Unfortunately, studies with endothelial cells in culture, laboratory animals, and man have not completely dissociated the inhibitory effect of aspirin on platelet ...
... cyclooxygenase to aspirin inhibition. If it had been, the "aspirin dilemma" could have been solved easily by using low doses of the drug. Unfortunately, studies with endothelial cells in culture, laboratory animals, and man have not completely dissociated the inhibitory effect of aspirin on platelet ...
sodium bicarbonate - PAN Pesticide Database
... [American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994. 909]**PEER REVIEWED** In neutralizing gastric acid, distention and possible damage or rupture of the stomach may occur from carbon dioxide release. [Gosselin, R.E., R.P ...
... [American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994. 909]**PEER REVIEWED** In neutralizing gastric acid, distention and possible damage or rupture of the stomach may occur from carbon dioxide release. [Gosselin, R.E., R.P ...
Review Advances in nucleoside monophosphate prodrugs as anti
... use of a substituted MP prodrug strategy that would be converted, initially, to the NMP and then further to the NTP. It was suggested during the study of potential prodrugs for HIV in the 1990s that nucleosides with a 5′-phosphoramidate group might be able to bypass the problematic initial kinase-pr ...
... use of a substituted MP prodrug strategy that would be converted, initially, to the NMP and then further to the NTP. It was suggested during the study of potential prodrugs for HIV in the 1990s that nucleosides with a 5′-phosphoramidate group might be able to bypass the problematic initial kinase-pr ...
ERGOLINE ALKALOIDS ERGOT ALKALOIDS ÇAVDAR MAHMUZU
... mystery of its development cycle was not elucidated until ...
... mystery of its development cycle was not elucidated until ...
Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in
... UGT2B7 (formation ratio: 2.8), although the ratios in all UGT isozymes other than UGT2B7 were comparable (Fig. 2). The finding in this study is considered to be important because it strongly suggests that UGT2B7 is the primary UGT isozyme involved in flurbiprofen glucuronidation. Although the study ...
... UGT2B7 (formation ratio: 2.8), although the ratios in all UGT isozymes other than UGT2B7 were comparable (Fig. 2). The finding in this study is considered to be important because it strongly suggests that UGT2B7 is the primary UGT isozyme involved in flurbiprofen glucuronidation. Although the study ...
... chemotherapy [1]. For example, anticancer platinum drugs appear in more chemotherapy regimens than any other class of anticancer agents and have contributed substantially to the success achieved in treating cancer over the past three decades. Metals can play an important role in modifying the pharma ...
Mucosal Protective Agents Prevent Exacerbation of NSAID
... H2-receptor antagonist; IRS, irsogladine; LI, lesion index; MIS, misoprostol; MPA, mucosal protective agent; MUC, mucin; NSAID, nonsteroidal antiinflammatory drug; OPZ, omeprazole; PAS, periodic acid–Schiff; PG, prostaglandin; PO, by mouth; PPI, proton pump inhibitor; RAN, ranitidine; REB, rebamipid ...
... H2-receptor antagonist; IRS, irsogladine; LI, lesion index; MIS, misoprostol; MPA, mucosal protective agent; MUC, mucin; NSAID, nonsteroidal antiinflammatory drug; OPZ, omeprazole; PAS, periodic acid–Schiff; PG, prostaglandin; PO, by mouth; PPI, proton pump inhibitor; RAN, ranitidine; REB, rebamipid ...
Overview of Drug Testing Methods I: ADME - BIDD
... • CYP 2C19 individuals with inactive enzyme (3-6 % of the caucasian and 15-20 % of the asian population) • CYP 2D6 poor metabolizers in 5-8 % of the european, 10 % of the caucasian, and <1% of the japanese population. Over expression (gene duplication) among parts of the african and oriental ...
... • CYP 2C19 individuals with inactive enzyme (3-6 % of the caucasian and 15-20 % of the asian population) • CYP 2D6 poor metabolizers in 5-8 % of the european, 10 % of the caucasian, and <1% of the japanese population. Over expression (gene duplication) among parts of the african and oriental ...
Modification of Microbial Polyacids for Drug Delivery Systems U
... derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery systems since they were able to encapsulate the anticancer drugs Temozolomide and Doxorubicin, as well as the model drugs Theophylline and Carbamazepine. Drug release was assessed u ...
... derivatives, except for the ionic complex which formed microparticles. Nanoparticles showed potential as drug delivery systems since they were able to encapsulate the anticancer drugs Temozolomide and Doxorubicin, as well as the model drugs Theophylline and Carbamazepine. Drug release was assessed u ...
The Pharmacology of Psychedelic Drugs
... important factor for hallucinogenic effect is the length of the chain between the diphenyl and the piperidine molecule. As that begins to increase, then the hallucinogenic properties diminish, although the atropine-like or anticholinergic properties persist, and do not seem to be altered perceptibly ...
... important factor for hallucinogenic effect is the length of the chain between the diphenyl and the piperidine molecule. As that begins to increase, then the hallucinogenic properties diminish, although the atropine-like or anticholinergic properties persist, and do not seem to be altered perceptibly ...
Preclinical Absorption, Distribution, Metabolism, and Excretion of an
... cleaved in vivo, releasing gemcitabine and valproic acid [25]. Amide prodrugs, although less commonly used during drug development possibly due to their high enzymatic stability in vivo [26], are usually hydrolysed by ubiquitous carboxylesterases, peptidases or proteases to release the active drug m ...
... cleaved in vivo, releasing gemcitabine and valproic acid [25]. Amide prodrugs, although less commonly used during drug development possibly due to their high enzymatic stability in vivo [26], are usually hydrolysed by ubiquitous carboxylesterases, peptidases or proteases to release the active drug m ...
Synthesis, Characterisation, and Evaluation of a Cross
... The efficiency of drug delivery of a pharmaceutical dosage can be maximised by employing the strategy of site-specific drug delivery [1]. Treatment of medical conditions such as inflammatory bowel diseases (IBD and Crohn’s disease) or colon cancer would benefit from improved delivery of drugs select ...
... The efficiency of drug delivery of a pharmaceutical dosage can be maximised by employing the strategy of site-specific drug delivery [1]. Treatment of medical conditions such as inflammatory bowel diseases (IBD and Crohn’s disease) or colon cancer would benefit from improved delivery of drugs select ...
Public Assessment Report Mutual Recognition Procedure DALSAN
... isozyme CYP2D6 and, unlike some other SSRIs, citalopram is only a weak inhibitor of this important enzyme system which is involved in the metabolism of many drugs (including antiarrhythmics, neuroleptics, beta-blockers, tricyclic antidepressants and some SSRIs). In addition, protein-binding is relat ...
... isozyme CYP2D6 and, unlike some other SSRIs, citalopram is only a weak inhibitor of this important enzyme system which is involved in the metabolism of many drugs (including antiarrhythmics, neuroleptics, beta-blockers, tricyclic antidepressants and some SSRIs). In addition, protein-binding is relat ...
Doc - World Noni Research Foundation
... cyproheptadine. Thus anti-inflammatory effect of aqueous extract of Noni might be due to the inhibition of endogenous histamine which increased by pretreatment with cimetidine. The results further revealed that besides histamine, prostaglandins also play a role in controlling anti-inflammatory activ ...
... cyproheptadine. Thus anti-inflammatory effect of aqueous extract of Noni might be due to the inhibition of endogenous histamine which increased by pretreatment with cimetidine. The results further revealed that besides histamine, prostaglandins also play a role in controlling anti-inflammatory activ ...
sodium valproate - World Health Organization
... Saudi Arabia7), 57% (patients 12 years and over in Hong Kong8), 50% (German adults1), 47% (children up to ten years in India9), 42% (USA, all ages4) and 27% (children in Finland – almost one third had an episode of either febrile or acute symptomatic status epilepticus prior to the onset of epilepsy ...
... Saudi Arabia7), 57% (patients 12 years and over in Hong Kong8), 50% (German adults1), 47% (children up to ten years in India9), 42% (USA, all ages4) and 27% (children in Finland – almost one third had an episode of either febrile or acute symptomatic status epilepticus prior to the onset of epilepsy ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.