Esam Z. Dajani, Ph.D., FACG
... Illinois. 1980-1985. Responsibilities included development of clinical plans, budgets, writing protocols, study placements, monitoring and preparation of clinical and regulatory reports. Interacted with clinical, regulatory affairs, consumer products, marketing, business development and licensing gr ...
... Illinois. 1980-1985. Responsibilities included development of clinical plans, budgets, writing protocols, study placements, monitoring and preparation of clinical and regulatory reports. Interacted with clinical, regulatory affairs, consumer products, marketing, business development and licensing gr ...
A review on pharmacological property of Mimusops elengi Linn.
... renewable sources of energy [8]. The aim of this review is to compile the information about pharmacological properties of Mimusops elengi so that researchers will get in detail about pharmacological properties for their further research. 2. Material and Methods Literature was searched on databases s ...
... renewable sources of energy [8]. The aim of this review is to compile the information about pharmacological properties of Mimusops elengi so that researchers will get in detail about pharmacological properties for their further research. 2. Material and Methods Literature was searched on databases s ...
Position Paper: Ipecac Syrup
... samples were collected for 24 hours. The mean time to onset of emesis was 14.3 ±1.2 minutes. For acetaminophen the mean peak serum concentration was reduced significantly (p < 0.01) to 4.4 ± 1.5 mg/L (control 14.9 ± 2.0 mg/L) by the administration of ipecac at 5 minutes. Under these conditions the m ...
... samples were collected for 24 hours. The mean time to onset of emesis was 14.3 ±1.2 minutes. For acetaminophen the mean peak serum concentration was reduced significantly (p < 0.01) to 4.4 ± 1.5 mg/L (control 14.9 ± 2.0 mg/L) by the administration of ipecac at 5 minutes. Under these conditions the m ...
Timolol Metabolism in Human Liver Microsomes Is Mediated
... cytochrome P450 CYP2D6. The matter has not, however, been extensively studied. The aim here was to tentatively identify timolol metabolites and to determine the P450-associated metabolic and interaction properties of timolol in vitro. Four metabolites were identified, the most abundant being a hydro ...
... cytochrome P450 CYP2D6. The matter has not, however, been extensively studied. The aim here was to tentatively identify timolol metabolites and to determine the P450-associated metabolic and interaction properties of timolol in vitro. Four metabolites were identified, the most abundant being a hydro ...
IDENTIFICATION OF NATURAL PRODUCTS AS ANTIDIABETIC AGENTS Laura Guasch Pàmies
... Both T1DM and T2DM are chronic conditions that typically cannot be cured. However, all forms of diabetes have been treatable since the development of readily available insulin in 1921. The enhancement of insulin secretion by pancreatic islet βcells is a major goal for the treatment of T2DM. Antidiab ...
... Both T1DM and T2DM are chronic conditions that typically cannot be cured. However, all forms of diabetes have been treatable since the development of readily available insulin in 1921. The enhancement of insulin secretion by pancreatic islet βcells is a major goal for the treatment of T2DM. Antidiab ...
levocarb CR
... and risperidone) may reduce the therapeutic effects of levodopa. The beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with levodopa/carbidopa controlled-release tablets should be observed carefully for lo ...
... and risperidone) may reduce the therapeutic effects of levodopa. The beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with levodopa/carbidopa controlled-release tablets should be observed carefully for lo ...
Evaluation of different mycobacterial species for drug discovery and
... Tuberculosis (Tb) has plagued mankind for many centuries and is still a leading cause of death worldwide. A worrying development is the emergence of drug-resistant Tb that poses further challenges to the control of the disease. The global Tb burden and high mortality rate indicate that new drugs are ...
... Tuberculosis (Tb) has plagued mankind for many centuries and is still a leading cause of death worldwide. A worrying development is the emergence of drug-resistant Tb that poses further challenges to the control of the disease. The global Tb burden and high mortality rate indicate that new drugs are ...
DRUGDEX DRUG EVALUATIONS
... acetaminophen resulted in significantly lower plasma levels when compared to acetaminophen given alone (Dordoni et al, 1973). 2. Adverse Effect: decreased acetaminophen effectiveness 3. Clinical Management: If both drugs are required, give acetaminophen one hour prior to or three to four hours after ...
... acetaminophen resulted in significantly lower plasma levels when compared to acetaminophen given alone (Dordoni et al, 1973). 2. Adverse Effect: decreased acetaminophen effectiveness 3. Clinical Management: If both drugs are required, give acetaminophen one hour prior to or three to four hours after ...
Aqueous fraction of Opuntia elatior
... I am thankful to my honorable teacher and supervisor, Abdullah-Al-Faysal, Lecturer, Department of Pharmacy, East West University, for his amiability to provide me with untiring guidance, whole hearted cooperation and for his extensive knowledge in research that helped me in all the spheres to perfor ...
... I am thankful to my honorable teacher and supervisor, Abdullah-Al-Faysal, Lecturer, Department of Pharmacy, East West University, for his amiability to provide me with untiring guidance, whole hearted cooperation and for his extensive knowledge in research that helped me in all the spheres to perfor ...
Hepatotoxicity in rats induced by aqueous extract of
... China) (production certificate number: SCXK (JING) 20110012). The dose of PMR for animal treatment is based on previous animal experiments, which found that receiving an oral administration of PMR at low dose (20 g/kg BW) or high dose (40 g/kg BW) for 60 days did not affect rat serum ALT or AST leve ...
... China) (production certificate number: SCXK (JING) 20110012). The dose of PMR for animal treatment is based on previous animal experiments, which found that receiving an oral administration of PMR at low dose (20 g/kg BW) or high dose (40 g/kg BW) for 60 days did not affect rat serum ALT or AST leve ...
effect of cytochrome p450 2d6 and 3a enzyme inhibition on
... Cytochrome P450 (CYP) enzymes are important for the metabolism of many drugs. The inhibition or induction of the CYP enzymes has been found to be a major mechanism behind pharmacokinetic drug-drug interactions. Oxycodone is an opioid analgesic used increasingly in the treatment of moderate and sever ...
... Cytochrome P450 (CYP) enzymes are important for the metabolism of many drugs. The inhibition or induction of the CYP enzymes has been found to be a major mechanism behind pharmacokinetic drug-drug interactions. Oxycodone is an opioid analgesic used increasingly in the treatment of moderate and sever ...
Pharmacological Significance of Synthetic Heterocycles
... Two hundred years ago, the chemical science was an undivided field; around 1900 a division into inorganic, organic and physical chemistry became necessary. The increase of factual material enforced a progressive segmentation into sub disciplines. A map shows countries and regions neatly separated; s ...
... Two hundred years ago, the chemical science was an undivided field; around 1900 a division into inorganic, organic and physical chemistry became necessary. The increase of factual material enforced a progressive segmentation into sub disciplines. A map shows countries and regions neatly separated; s ...
XP13512 [()-1-([(α-Isobutanoyloxyethoxy
... postherpetic neuralgia, and diabetic neuropathy (McLean, 1995; Backonja et al., 1998; Rice and Maton, 2001). Following oral absorption, gabapentin is excreted in the urine without significant metabolism (Radulovic et al., 1995). The plasma half-life of gabapentin in humans is relatively short (5–7 h ...
... postherpetic neuralgia, and diabetic neuropathy (McLean, 1995; Backonja et al., 1998; Rice and Maton, 2001). Following oral absorption, gabapentin is excreted in the urine without significant metabolism (Radulovic et al., 1995). The plasma half-life of gabapentin in humans is relatively short (5–7 h ...
Naproxen Naproxen Sodium
... for treatment of acute gout because of the delayed absorption of the drug from this preparation. Relief of pain and tenderness and decreases in heat and swelling have been reported to occur within 24–48 hours. For the relief of tendinitis or bursitis, the usual initial adult dose of naproxen is 500 ...
... for treatment of acute gout because of the delayed absorption of the drug from this preparation. Relief of pain and tenderness and decreases in heat and swelling have been reported to occur within 24–48 hours. For the relief of tendinitis or bursitis, the usual initial adult dose of naproxen is 500 ...
Neuroendocrine Control of Growth Hormone Secretion
... the endogenous hormone secretory rate and clearance kinetics (1063), showed that pulsatile GH secretion continued in all subjects in the awake and fed state, despite undetectable serum GH in daytime samples analyzed by a conventional IRMA, run for comparison. Interestingly, the CL assay also reveale ...
... the endogenous hormone secretory rate and clearance kinetics (1063), showed that pulsatile GH secretion continued in all subjects in the awake and fed state, despite undetectable serum GH in daytime samples analyzed by a conventional IRMA, run for comparison. Interestingly, the CL assay also reveale ...
Saurashtra University
... gynecological infections, intra-abdominal infections, and in the treatment of meningococcal meningitis 1, 3 . With some exceptions, agents in the 4-fluoroquinolone classes can also be grouped by their clinical indications. The drugs can be further differentiated based on available formulations, requ ...
... gynecological infections, intra-abdominal infections, and in the treatment of meningococcal meningitis 1, 3 . With some exceptions, agents in the 4-fluoroquinolone classes can also be grouped by their clinical indications. The drugs can be further differentiated based on available formulations, requ ...
Effects of grapefruit juice on the pharmacokinetics of selected
... juice to interact with the CYP3A4 substrates buspirone, cisapride, simvastatin, atorvastatin, and pravastatin was studied in healthy human volunteers in randomized cross-over studies. In addition, the effect of grapefruit juice dose in pharmacokinetic interaction and the duration of grapefruit juice ...
... juice to interact with the CYP3A4 substrates buspirone, cisapride, simvastatin, atorvastatin, and pravastatin was studied in healthy human volunteers in randomized cross-over studies. In addition, the effect of grapefruit juice dose in pharmacokinetic interaction and the duration of grapefruit juice ...
Paediatric formulations of L-arginine for the use in urea cycle disorders
... HCL and masking the unpleasant taste of the L-arginine HCL. The L-arginine HCL oral solutions are intended for the long-term therapy or treatment of urea cycle disorders to be administered by the oral route. The stability of those formulations under different storage conditions should be investigate ...
... HCL and masking the unpleasant taste of the L-arginine HCL. The L-arginine HCL oral solutions are intended for the long-term therapy or treatment of urea cycle disorders to be administered by the oral route. The stability of those formulations under different storage conditions should be investigate ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... allyl, the Latin name for garlic. Four years later, Louis Pasteur in Paris showed that allyl could inhibit the growth of bacteria. This was a great discovery because 150 years ago, doctors had nothing to eradicate bacteria. .Garlic was used as a remedy for intestinal disorders, flatulence, worms, re ...
... allyl, the Latin name for garlic. Four years later, Louis Pasteur in Paris showed that allyl could inhibit the growth of bacteria. This was a great discovery because 150 years ago, doctors had nothing to eradicate bacteria. .Garlic was used as a remedy for intestinal disorders, flatulence, worms, re ...
ABSTRACT Title of Dissertation: ENERGETICS OF DRUG INTERACTIONS
... become entropically-driven. These binding reactions also manifest enthalpy-entropy compensation where changes in the binding enthalpies are compensated by changes in the binding entropies. In drug binding to the more flexible p38α MAP kinase mutants, a single-point C→S mutation distal from the bind ...
... become entropically-driven. These binding reactions also manifest enthalpy-entropy compensation where changes in the binding enthalpies are compensated by changes in the binding entropies. In drug binding to the more flexible p38α MAP kinase mutants, a single-point C→S mutation distal from the bind ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
... The serious threat of tuberculosis, especially XDR-TB, is a reality in Southern Africa particularly in individuals with HIV/AIDS. Therefore the importance of development of new or improved anti-TB treatment must now be emphasized more than ever. In this study, a model was created to target isoniazid ...
Bioavailability & Bioequivalence
... Drug metabolism/biotransformation This mainly occurs in the liver, via liver enzymes. But it can also occur in the blood plasma or at various other places (stomach, intestines, lungs, skin, or kidneys) directly by various enzymes at those locations In any case, these metabolites are then excre ...
... Drug metabolism/biotransformation This mainly occurs in the liver, via liver enzymes. But it can also occur in the blood plasma or at various other places (stomach, intestines, lungs, skin, or kidneys) directly by various enzymes at those locations In any case, these metabolites are then excre ...
Methadone-Drug Interactions
... Avoiding these can be difficult, since the number of potential interactions among diverse drugs used in clinical practice can be overwhelming; more than 2,000 such interactions have been described in the literature and new cases appear monthly (Levy et al. 2000). As the tables in this document indic ...
... Avoiding these can be difficult, since the number of potential interactions among diverse drugs used in clinical practice can be overwhelming; more than 2,000 such interactions have been described in the literature and new cases appear monthly (Levy et al. 2000). As the tables in this document indic ...
Medicinal uses of licorice through the millennia
... and West. Studies over the past 50 years have yielded information which has prompted new interest in the pharmacological and physiological effects of this plant. This research has revealed that the chemical structure of one of the principle agents in the root of the licorice plant is a glycoside of ...
... and West. Studies over the past 50 years have yielded information which has prompted new interest in the pharmacological and physiological effects of this plant. This research has revealed that the chemical structure of one of the principle agents in the root of the licorice plant is a glycoside of ...
Download CV
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
... Slusher BS, Vornov JJ, Thomas AG, Hurn PD, Traystman RJ, Robinson MB, Britton P, Lu M, Tortella FC, Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov ...
Discovery and development of proton pump inhibitors
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+,K+-ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are finding applications in the reduction of cancer cell acid efflux and reduction of chemotherapy drug resistance.