Class XIX Tissues and organ systems I – Epithelial tissues To Grow
... culture plates) they will dye. We therefore transfer an “oncogene” into a normal parietal cell or grow a cell from a “parietal cell cancer”. The cell then becomes immortal and it grows to form a uniform cell population. It becomes a “parietal cell-line” We can make cell-lines from cells of almost an ...
... culture plates) they will dye. We therefore transfer an “oncogene” into a normal parietal cell or grow a cell from a “parietal cell cancer”. The cell then becomes immortal and it grows to form a uniform cell population. It becomes a “parietal cell-line” We can make cell-lines from cells of almost an ...
RECEPTORS STRUCTURE AND FUNCTION Chapter 4
... Implies a fine balance Designing molecules with stronger binding interactions results in drugs that block the binding site - antagonists M ...
... Implies a fine balance Designing molecules with stronger binding interactions results in drugs that block the binding site - antagonists M ...
Objectives 25
... Class IB: GF – fibroblast growth factors (FGF) - acidic (16 kD) and basic (17 kD); FGF proteins are found associated with ECM and stimulate proliferation of endothelial, epithelia, mesenchymal and neuronal cells Class II: IGF- insulin-like growth factors* - 7 kD; include IGF-1 and IGF-2; related to ...
... Class IB: GF – fibroblast growth factors (FGF) - acidic (16 kD) and basic (17 kD); FGF proteins are found associated with ECM and stimulate proliferation of endothelial, epithelia, mesenchymal and neuronal cells Class II: IGF- insulin-like growth factors* - 7 kD; include IGF-1 and IGF-2; related to ...
“ Signal Transduction”?
... Molecules for targeted therapies (1) Small molecules: target the ATP binding site or other regions in protein kinase domain, e.g. Gleevec (to BCR-Abl) (2) Monoclonal Abs: target receptors, cytokines, other surface proteins, e.g. Herceptin (to Her), Erbitux (to EGFR) (3) Others: Decoy receptors (sol ...
... Molecules for targeted therapies (1) Small molecules: target the ATP binding site or other regions in protein kinase domain, e.g. Gleevec (to BCR-Abl) (2) Monoclonal Abs: target receptors, cytokines, other surface proteins, e.g. Herceptin (to Her), Erbitux (to EGFR) (3) Others: Decoy receptors (sol ...
2.3: Carbon-Based Molecules
... • Allows only certain reactants to bind to the enzyme – An organism may have thousands of different enzymes – Each is specific to one chemical reaction ...
... • Allows only certain reactants to bind to the enzyme – An organism may have thousands of different enzymes – Each is specific to one chemical reaction ...
syllabus
... for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline National Academy Press, Washington, D.C. 5. 國人膳食營養素參考攝取量及其說明 行政院衛生署 修訂第六版 92 年 9 月 6. Handouts from NS103 course in the Department of Nutritional Sciences and Toxicology, UC Berkeley ...
... for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline National Academy Press, Washington, D.C. 5. 國人膳食營養素參考攝取量及其說明 行政院衛生署 修訂第六版 92 年 9 月 6. Handouts from NS103 course in the Department of Nutritional Sciences and Toxicology, UC Berkeley ...
Sites of hormone production
... will decrease to modulate the response. 3. Third level of control: cellular mechanisms of action. Once they arrive at a target cell, peptide and steroid hormones have different mechanisms of action. The difference is based on fat-solubility, which determines whether or not the hormone can penetrate ...
... will decrease to modulate the response. 3. Third level of control: cellular mechanisms of action. Once they arrive at a target cell, peptide and steroid hormones have different mechanisms of action. The difference is based on fat-solubility, which determines whether or not the hormone can penetrate ...
Lanosterol Biosynthesis in the Membrane Environment
... substrates are part of the membrane. These enzymes must actively influence the structure of the lipid bilayer in order to access, steer, and release their reactants. Among the enzymes specialized in lipidic substrates, is the family of monotopic enzymes. Members of this family permanently reside in ...
... substrates are part of the membrane. These enzymes must actively influence the structure of the lipid bilayer in order to access, steer, and release their reactants. Among the enzymes specialized in lipidic substrates, is the family of monotopic enzymes. Members of this family permanently reside in ...
phospholipids
... • Phosphatidylinositol 4,5-bisphosphate (PIP2) participates in hormonal signal transduction via activated phospholipase C formation of inositol-P3 and diacylglycerol, followed by mobilization of Ca+2 and activation of protein kinase C ...
... • Phosphatidylinositol 4,5-bisphosphate (PIP2) participates in hormonal signal transduction via activated phospholipase C formation of inositol-P3 and diacylglycerol, followed by mobilization of Ca+2 and activation of protein kinase C ...
Lipids (lect 5, 6))
... Sphingomyeline is formed of sphingosine base, fatty acyl CoA, phosphate and choline. (Remembr structure, first lecture). Steps of synthesis: see figure 1- Palmitic acid is activated by CoA to give palmitoyl CoA. 2- Combination of palmitoyl CoA with serine to form sphingosine base. 3- Then sphingosin ...
... Sphingomyeline is formed of sphingosine base, fatty acyl CoA, phosphate and choline. (Remembr structure, first lecture). Steps of synthesis: see figure 1- Palmitic acid is activated by CoA to give palmitoyl CoA. 2- Combination of palmitoyl CoA with serine to form sphingosine base. 3- Then sphingosin ...
B2.5 Proteins objectives
... 1. Know that protein molecules are made up of long chains of amino acids. These long chains are folded to produce a specific shape that enables other molecules to fit into the protein. Proteins act as: structural components of tissues such as muscles hormones antibodies catalysts 2. Know tha ...
... 1. Know that protein molecules are made up of long chains of amino acids. These long chains are folded to produce a specific shape that enables other molecules to fit into the protein. Proteins act as: structural components of tissues such as muscles hormones antibodies catalysts 2. Know tha ...
Addition of the following reactions responsible for the synthesis of
... a. phosphatidate, old: C1836H3398O400P50, new: C1682H3116O413P50 b. phosphatidylglycerol, old: C1986H3748O500P50, new: C1832H3466O513P50 c. phosphatidylserine, old: C1986H3698N50O500P50, new: C1832H3416N50O513P50 d. CDP-diacylglycerol, old: C2286H3998N150O750P100, new: C2132H3716N150O763P100 e. card ...
... a. phosphatidate, old: C1836H3398O400P50, new: C1682H3116O413P50 b. phosphatidylglycerol, old: C1986H3748O500P50, new: C1832H3466O513P50 c. phosphatidylserine, old: C1986H3698N50O500P50, new: C1832H3416N50O513P50 d. CDP-diacylglycerol, old: C2286H3998N150O750P100, new: C2132H3716N150O763P100 e. card ...
G-protein-mediated pathway
... High moleular weight G-protein (trimeric GTP-binding regulatory protein） ...
... High moleular weight G-protein (trimeric GTP-binding regulatory protein） ...
worksheet - SCWIBLES - University of California, Santa Cruz
... 1. Cut out the all the shapes from the two pages of cut-outs. 2. Put the three catabolic enzymes aside for later. Anabolic enzymes 3. Build a carbohydrate - Use the appropriate carbohydrate anabolic enzyme as a guide to organize and connect all the sugar (glucose) molecules together. 4. Build a lipi ...
... 1. Cut out the all the shapes from the two pages of cut-outs. 2. Put the three catabolic enzymes aside for later. Anabolic enzymes 3. Build a carbohydrate - Use the appropriate carbohydrate anabolic enzyme as a guide to organize and connect all the sugar (glucose) molecules together. 4. Build a lipi ...
Document
... A condensation reaction chemically bonds monomers to create polymers by the release of a water molecules. A hydrolysis reaction breaks polymers apart into individual monomers by the addition of water. 6. What is the major function of a monosaccharide, such as glucose? To provide immediate energy 7. ...
... A condensation reaction chemically bonds monomers to create polymers by the release of a water molecules. A hydrolysis reaction breaks polymers apart into individual monomers by the addition of water. 6. What is the major function of a monosaccharide, such as glucose? To provide immediate energy 7. ...
Sphingolipid homeostasis in the web of metabolic routes
... human diseases generated by the defects in these pathways [3]. 2.3. Regulation of sphingolipid synthesis Although SLs are essential players in cell homeostasis the regulatory mechanisms controlling this pathway have only recently begun to emerge. The initial advances in the network of enzymatic cont ...
... human diseases generated by the defects in these pathways [3]. 2.3. Regulation of sphingolipid synthesis Although SLs are essential players in cell homeostasis the regulatory mechanisms controlling this pathway have only recently begun to emerge. The initial advances in the network of enzymatic cont ...
2.3: Carbon-Based Molecules
... • Allows only certain reactants to bind to the enzyme – An organism may have thousands of different enzymes – Each is specific to one chemical reaction ...
... • Allows only certain reactants to bind to the enzyme – An organism may have thousands of different enzymes – Each is specific to one chemical reaction ...
Positive vs Negative Feedback Control
... 2) State how the activity of pepsin will most likely change after it moves with the food from the stomach to the small intestine. ...
... 2) State how the activity of pepsin will most likely change after it moves with the food from the stomach to the small intestine. ...
Lipids General function
... a- Insolubility in water and solubility in organic solvents like chloroform-,etc b- some relation to fatty acids esters, either actual or potential phospholipids have very little solubility in water total body lipid in man is ...
... a- Insolubility in water and solubility in organic solvents like chloroform-,etc b- some relation to fatty acids esters, either actual or potential phospholipids have very little solubility in water total body lipid in man is ...
Document
... Relate the shape of an enzyme to its function Describe how high temperatures affect enzymes Describe how enzymes work at different pH values Describe examples of enzymes that work outside of body cells, such as digestive enzymes, including details of where they are produced, where they go, and what ...
... Relate the shape of an enzyme to its function Describe how high temperatures affect enzymes Describe how enzymes work at different pH values Describe examples of enzymes that work outside of body cells, such as digestive enzymes, including details of where they are produced, where they go, and what ...
Catecholamines (dopamine, norepinephrine, epinephrine)
... 1. Enzyme can metabolize both intra- or extracellularly 2. Requires Mg2+ and substrate of S-adenosylmethionine ...
... 1. Enzyme can metabolize both intra- or extracellularly 2. Requires Mg2+ and substrate of S-adenosylmethionine ...
Function of prostaglandins
... They cause mobilization of intracellular calcium, vasoconstriction, and contraction of smooth muscles. They also decreases production of cAMP in platelets and cause platelets aggregation,thus promoting the formation of blood clots (thrombi) ( opposite effect to PGI. This limit formation to site of v ...
... They cause mobilization of intracellular calcium, vasoconstriction, and contraction of smooth muscles. They also decreases production of cAMP in platelets and cause platelets aggregation,thus promoting the formation of blood clots (thrombi) ( opposite effect to PGI. This limit formation to site of v ...
Document
... 4. Other specific functions such as Hemoglobin: carry O2 in red blood cells 5. Regulate cell processes ...
... 4. Other specific functions such as Hemoglobin: carry O2 in red blood cells 5. Regulate cell processes ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.